Query: CNT0020381
Subject: sp|E7FAW3|NBEL2_DANRE Neurobeachin-like protein 2 OS=Danio rerio

OS=Dictyostelium discoideum GN=lvsC PE=3 SV=2

 Score =  455 bits (1170), Expect = e-127,   Method: Compositional matrix adjust.
Identities = 253/655 (38%), Positives = 364/655 (55%), Gaps = 69/655 (10%)

Query: 2086 ELFMVDRSNFFFDFADIDARKNAYRAIVHTKPPNLNDIFLATQRAEQILKRTQLMERWAN 2145
E+FM D++N+ F+F + R Y I K + T +LK+ W
Sbjct: 1792 EIFMRDKTNYLFNFKK-NERNKVYNKINSVKREFSKE---PTLSPSDMLKKA--TSEWQA 1845

Query: 2146 WEINNFEYLMELNTLAGRSYNDITQYPVFPWVVADYKSRVLNLDDPLSYRDLSKPIGALN 2205
I+NF+YLM LNT+AGR+YND+TQYPVFPWV+ADY S VL+L+ ++RDLSKPIGALN
Sbjct: 1846 RRISNFDYLMTLNTIAGRTYNDLTQYPVFPWVIADYTSPVLDLNKAETFRDLSKPIGALN 1905

Query: 2206 PERLKKFQERYSTFEDPIIPKFHYGSHYSSAGTVLYYLFRVEPFTTLSIQLQDGKFDHAD 2265
+RL+ F++RY +F+DP+IPKF+YGSHYSSAG VL+YL R+EPFTT + LQ G+FDH D
Sbjct: 1906 EKRLEIFKDRYESFDDPVIPKFYYGSHYSSAGIVLFYLIRLEPFTTQFLNLQGGRFDHPD 1965

Query: 2266 RMFSDLSGTWDSVLEDMSDVKELVPEMFYLPEVFTNINGIDFGTTQLGGKLDSVELPPWA 2325
RMF ++ WD+ L +DVKEL+PE +Y+PE TN N I+FG Q G ++ V LPPWA
Sbjct: 1966 RMFDSIALAWDNSLTSSTDVKELIPEFYYMPEFLTNHNHINFGIKQNGIGIEDVLLPPWA 2025

Query: 2326 ENHVDFVHKHRKALESEHVSAHLHEWIDLIFGYKQRGKEAIMANNVFFYITYEGTVDIDK 2385
+ DF+ +R+ALES++VS+HLHEWIDLIFG KQRGK+A NVF+Y+TYEG+VDID
Sbjct: 2026 SSPSDFIRINREALESDYVSSHLHEWIDLIFGIKQRGKQAKEVFNVFYYLTYEGSVDIDS 2085

Query: 2386 ITNPVDRRATQDQIAYFGQTPSQLLTVP-HMKRKPLAEVLQLQTIFRNPSELKSYVLPHS 2444
I + RRAT+ QI FGQTP+QL + H++R PL E + + P++L++Y L +
Sbjct: 2086 IEDETTRRATESQINNFGQTPTQLFSKKHHIQRDPLNES-HISILKTPPNQLQAYFLKIT 2144

Query: 2445 DR-----CNVPASAMLXXXXXXXXXXXXAPAAHVALHQWQANTPDGQGTPFLFHHGRNST 2499
++ +P + + H+W +TP+ + +PF F +ST
Sbjct: 2145 NKNPIVYVYIPEPNPIMSYLVADKVTVIDKSRTTTNHKWFPSTPNDKISPFTFELDPSST 2204

Query: 2500 NSTSGALMRIFKGSAGSAEDYGFPXXXXXXXXXXXXXXXXXXTCD-KEIITGGHVDGSLK 2558
+ G P T D + +I+ H D S K
Sbjct: 2205 ----------------TKRRIGLP----FANDVTISPNCFAITSDGRYVISCAHWDNSFK 2244

Query: 2559 LISLDGAKTIETASGHIAPVTCLALSPDSNYLVTGSRDTTVILWRIHQTGSSHKKNAQEX 2618
L +D AK I++ H VTCL+L+ D L+TGS+DTTV++WRI T S +
Sbjct: 2245 LSFVDSAKLIQSVVKHKDTVTCLSLASDGQTLITGSKDTTVMVWRIATTNKSGAPKFNDV 2304

Query: 2619 XXXXXXXXXXXXXXXXXXXXXXXETKRRRVEGPMHVMRGHLGEVTCCSVSPDLGLVASSS 2678
P H++ GH E+TC V+ L + S S
Sbjct: 2305 --------------------------------PDHILYGHDDEITCVDVNVGLDISISGS 2332

Query: 2679 NATGILLHSLRTGRLIRRLDVDEAHAICL---SSQGIILVWNGTKKTLSTFTVNG 2730
++H+L+ G +R + + I L S+QG I++++ + +++NG
Sbjct: 2333 KDGTCIIHNLKHGEYVRSIYLPRQSPISLIAISNQGYIVIYSQADLMIYLYSING 2387



Score = 119 bits (297), Expect = 5e-25, Method: Compositional matrix adjust.
Identities = 115/507 (22%), Positives = 198/507 (39%), Gaps = 81/507 (15%)

Query: 88 GADLLREVVSQEQGELAHSVVDVLLGTMGGVDEAGDATGTGAPPTVMISSRAAVAAAELL 147
G D +++++ + +G ++ + +++L D D V+ + + + LL
Sbjct: 71 GYDTIKDLIIKSEGIVSETTMNILF------DMIVDGEFDIEYKYVIQNPDSCLLIFNLL 124

Query: 148 PYLPEDDEPSPRTRTALGLHAALRACTRNRAMCXXXXXXXXXXXXXEKLFVEMDQGSRWD 207
Y P + R + + CT N+++C L + +G +
Sbjct: 125 KYFPTKLQHEILDRFTV----MVEKCTTNQSVCCNCHLIY-------NLLEAIYKGQPME 173

Query: 208 -GTPLLQCIQMLGGHSLSVKDLHSWLDLVRKSLGTSW--ATPLMLALEKAMGSMEAKGPA 264
T +L+ I+ LG HS++V++L L++ G T +L + + + GP
Sbjct: 174 VTTKILKLIERLGIHSVTVRELKKLFGLLKSEQGDYLPPTTSALLTTLQNISNSRNPGPQ 233

Query: 265 VTFEFDGESSGLLGPGDSRWPFLNGYGFATWIYIESFSDTLXXXXXXXXXXXXXXXXXXX 324
V F+FDG+ S ++ P +WPF G+ F TW+ IESF D
Sbjct: 234 VYFDFDGKDSCIILPTFDKWPFPKGFSFCTWVRIESFVD--------------------- 272

Query: 325 XXXXXXXXXXXXXXGEGT-THMPRLFSFLSSDNQGVEAYFHGQFLVVESVGGRGKKASLH 383
GT + PRLFSFLS G+E F Q L V +V KA
Sbjct: 273 --------------PTGTPEYKPRLFSFLSDSGCGIEVLFIYQQLQVLTVNNHQSKAVFQ 318

Query: 384 FTYAFKPQCWYFVGLEHTNKHSLLGKDDSELSLYVDGSLYESRPFEFPRISKPLAFCCIG 443
F + WYFV + +S+ +E+ +Y++G + IG
Sbjct: 319 SPPTFVEREWYFVSV----VYSINLISSNEIRIYINGQQSAKSSIKLNISGTLWNHFKIG 374

Query: 444 TNPPPTIAGLQRRRRQCPLFAEMGPVYIFKEPIGPDRMRRLASRGGDTLPSFGNGAGLPW 503
N ++G R+CPL+ +MG IF E + P +++ + + G + SF +
Sbjct: 375 NNSKK-MSG----ERECPLYGQMGAFNIFDESLSPSQIQAIYTLGPNFNTSFQD------ 423

Query: 504 KATNDQVKSMAEESFSLNNGIGGSLHLLYHPSLLTGRFCPDASPSGSSGTHRRPAEVLGL 563
V+ + + + + + L L Y+ L G C D +P + L
Sbjct: 424 ------VEGSTKSAHTFESSLTSHLFLNYNCRALDGDLCLDNTPDIGGDKNYDAT----L 473

Query: 564 VHVSPRVRPSESLWALAYGGPMALLPL 590
V ++P V GG L PL
Sbjct: 474 VSINPCVSRDIKDIIYCLGGIKVLFPL 500

Query: CNT0020381
Subject: sp|P50851|LRBA_HUMAN Lipopolysaccharide-responsive and beige-like

GN=nbeal2 PE=1 SV=1

 Score =  446 bits (1147), Expect = e-124,   Method: Compositional matrix adjust.
Identities = 248/636 (38%), Positives = 346/636 (54%), Gaps = 90/636 (14%)

Query: 2086 ELFMVDRSNFFFDFADIDARKNAYRAIVHTKPPNLNDIFLATQRAEQILKRTQLMERWAN 2145
ELF +D+S++F +F R Y I+ +PPNL + ++ +++LK + L RW
Sbjct: 2060 ELFFIDQSHYFINFRK-GVRNKVYSRILGLRPPNL--FYFGSRSPQELLKASNLTHRWVC 2116

Query: 2146 WEINNFEYLMELNTLAGRSYNDITQYPVFPWVVADYKSRVLNLDDPLSYRDLSKPIGALN 2205
EI+NFEYLM+LNT+AGR+YND++QYPVFPWV+ DY S L+LDDP +RDLSKPIG +N
Sbjct: 2117 REISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLCDYTSAELDLDDPAVFRDLSKPIGVVN 2176

Query: 2206 PERLKKFQERYSTFEDPI--IPKFHYGSHYSSAGTVLYYLFRVEPFTTLSIQLQDGKFDH 2263
P + +E+Y +FEDP I KFHYG+HYS+A V++Y+ R EPFT+L IQLQ GKFD
Sbjct: 2177 PRHAQNVREKYESFEDPTGTIDKFHYGTHYSNAAGVMHYMIRTEPFTSLHIQLQSGKFDC 2236

Query: 2264 ADRMFSDLSGTWDSVLEDMSDVKELVPEMFYLPEVFTNINGIDFGTTQLGG-KLDSVELP 2322
ADR F ++ W + +E +DVKEL+PE FY PE N+NG D G Q+ K+++V LP
Sbjct: 2237 ADRQFHSIAAAWQARMESPADVKELIPEFFYFPEFLENMNGFDLGCLQISQEKVNNVLLP 2296

Query: 2323 PWAENHVDFVHKHRKALESEHVSAHLHEWIDLIFGYKQRGKEAIMANNVFFYITYEGTVD 2382
PWA + DF+ KHRKALESEHVSAHLHEWIDLIFGYKQRG EA+ A NVF+Y TYEG VD
Sbjct: 2297 PWASSREDFIRKHRKALESEHVSAHLHEWIDLIFGYKQRGPEAVEALNVFYYCTYEGAVD 2356

Query: 2383 IDKITNPVDRRATQDQIAYFGQTPSQLLTVPH---------MKRKPLAEVLQLQTIFRNP 2433
+D I N +R+A + I+ FGQTP QLL PH +R ++L +F
Sbjct: 2357 LDAIANETERKALEGIISNFGQTPCQLLKEPHPPRMSAENAFRRAARLDILP-PNLFDQL 2415

Query: 2434 SELKSY-------------VLPHSDRCN--VPASAMLXXXXXXXXXXXXAPAAHVALHQW 2478
S+L+S+ V+P + + +P S +L + + H W
Sbjct: 2416 SKLRSFKEVVSDGLALVQAVVPRNQTRSFIIPGSDIL---------VTVSANGMIGTHSW 2466

Query: 2479 QANTPDGQGTPFLFHHGRNSTNSTSGALMRIFKGSAGSAEDYGFPXXXXXXXXXXXXXXX 2538
P + F R+ + S R G + G
Sbjct: 2467 ---LPYDKNIANYFTFTRDPSVSNPKT-QRFLSGPFSPGVEMG-------------SQVL 2509

Query: 2539 XXXTCDKEIITGGHVDGSLKLISLDGAKTIETASGHIAPVTCLALSPDSNYLVTGSRDTT 2598
+ + + +GGH D SL++ L AK + HI VTCLAL YL++GSRDTT
Sbjct: 2510 VVSSDGRLLFSGGHWDCSLRVTMLGKAKLVGRICRHIDVVTCLALDLCGIYLISGSRDTT 2569

Query: 2599 VILWRIHQTGSSHKKNAQEXXXXXXXXXXXXXXXXXXXXXXXXETKRRRVEGPMHVMRGH 2658
++W++ Q G + P+ V+ GH
Sbjct: 2570 CMVWQVLQQGGFSSGLSPR---------------------------------PIQVLCGH 2596

Query: 2659 LGEVTCCSVSPDLGLVASSSNATGILLHSLRTGRLI 2694
EVTC ++S +L + S S +++HS+R G+ +
Sbjct: 2597 DQEVTCVAISTELDMAISGSKDGTVIVHSVRRGQYL 2632



Score = 60.1 bits (144), Expect = 4e-07, Method: Compositional matrix adjust.
Identities = 55/246 (22%), Positives = 99/246 (40%), Gaps = 38/246 (15%)

Query: 211 LLQCIQMLGGHSLSVKDLHSWLDLVRKSLGTSWATPLMLALEKAMGSMEAKGPA-----V 265
LL +Q LG SL +L S L L+R G P + + + +M A+G
Sbjct: 537 LLGLLQDLGSLSLRPCELKSLLKLLRTEPGAP-PHPYCGRVVRVLSAMAARGEGGCSALQ 595

Query: 266 TFEFDGESSGLLGPGDSRWPFLNGYGFATWIYIESFSDTLXXXXXXXXXXXXXXXXXXXX 325
F+ +G++ P RWP + + F W+ + +
Sbjct: 596 YFDLTPPMAGIMVPAIQRWPG-SAFAFHAWLCLNT----------------------DFP 632

Query: 326 XXXXXXXXXXXXXGEGTTHM---PR---LFSFLSSDNQGVEAYFHGQFLVVESVGGRGKK 379
+ T M PR L+SF ++ G EA+F + ++V +V + +
Sbjct: 633 PPQHHYSESHLTNMDNTVRMAKGPRRKQLYSFFTASGTGFEAFFTTEEVLVVAVCTKKEY 692

Query: 380 ASLHF-TYAFKPQCWYFVGLEHTNKHSLLGKDDSELSLYVDGSLYESRPFEFPRISKPLA 438
++ + F W+ V + H G++ +++YVDG ++ P FP +++P
Sbjct: 693 MAVSLPEHPFNDCAWHSVAIVHVPGRRPFGQN--VVTVYVDGVQCKTAPLRFPSLNEPFT 750

Query: 439 FCCIGT 444
CCIG+
Sbjct: 751 SCCIGS 756

Query: CNT0020381
Subject: sp|Q9W4E2|NBEA_DROME Neurobeachin OS=Drosophila melanogaster GN=rg

anchor protein OS=Homo sapiens GN=LRBA PE=1 SV=4

 Score =  434 bits (1115), Expect = e-121,   Method: Compositional matrix adjust.
Identities = 292/793 (36%), Positives = 391/793 (49%), Gaps = 122/793 (15%)

Query: 2012 PSLMVRPLKVVRGTFQVTSKRINFIIDERS-NDSNIDDA--ASTSGQCDQQDKDRSWLVX 2068
P+ +V P VV+GT VTS + F +DE N ID A T G + WL
Sbjct: 2083 PAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGK------WLFT 2136

Query: 2069 XXXXXXXXXXXXXXXXXELFMVDRSNFFFDFADIDARKNAY----RAIVHTK--PPNLND 2122
E+FM +R F+F D K R V T P
Sbjct: 2137 EIRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRR 2196

Query: 2123 IFLATQRAEQILKRTQLMERWANWEINNFEYLMELNTLAGRSYNDITQYPVFPWVVADYK 2182
I LA+ R Q+ K + + +RW + EI+NFEYLM LNT+AGRSYND+ QYPVFPWV+ +Y+
Sbjct: 2197 ISLASPR--QLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYE 2254

Query: 2183 SRVLNLDDPLSYRDLSKPIGALNPERLKKFQERYSTFEDPIIPKFHYGSHYSSAGTVLYY 2242
S L+L P ++RDLSKPIGALNP+R F ERY ++ED +PKFHYG+HYS+A VL +
Sbjct: 2255 SEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAW 2314

Query: 2243 LFRVEPFTTLSIQLQDGKFDHADRMFSDLSGTWDSVLEDMSDVKELVPEMFYLPEVFTNI 2302
L R+EPFTT + LQ GKFDHADR FS +S W + D SD+KEL+PE +YLPE+F N
Sbjct: 2315 LLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNF 2374

Query: 2303 NGIDFGTTQLGGKLDSVELPPWAENHVDFVHKHRKALESEHVSAHLHEWIDLIFGYKQRG 2362
N + G G + VELPPWA+ +FVH +R ALESE VS LH+WIDLIFGYKQ+G
Sbjct: 2375 NNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQG 2434

Query: 2363 KEAIMANNVFFYITYEGTVDIDKITNPVDRRATQDQIAYFGQTPSQLLTVPHMKRKPLAE 2422
EA+ A NVF+Y+TYEG V+++ IT+PV R A + QI FGQTPSQLL PH R +
Sbjct: 2435 PEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQ 2494

Query: 2423 VLQLQTIFRNPSELKSYVLPHSDRCNVPASAMLXXXXXXXXXXXXAPAAHVALHQWQANT 2482
V L +F + ++ ++ P++ +P HVA ANT
Sbjct: 2495 VSPL--MFTDKAQQDVIMV-----LKFPSN---------------SPVTHVA-----ANT 2527

Query: 2483 PDGQGTPFLFHHGRNSTNSTSGALMRIFK-----GSAGSAED--YGFPXXXXXXXXXXXX 2535
G TP + T+ L + K G+ +D Y P
Sbjct: 2528 QPGLATPAVI-------TVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTG 2580

Query: 2536 XXXXXXT------------C------DKEIITGGHVDGSLKLISLDGAKTIETASGHIAP 2577
T C ++ I+ G D S ++ S D + I+ GH
Sbjct: 2581 MHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDV 2640

Query: 2578 VTCLALSPD----SNYLVTGSRDTTVILWRIHQTGSSHKKNAQEXXXXXXXXXXXXXXXX 2633
VTCLA S + Y+++GSRD T++LW + S N
Sbjct: 2641 VTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGS---------------- 2684

Query: 2634 XXXXXXXXETKRRRVEGPMHVMRGHLGEVTCCSVSPDLGLVASSSNATGILLHSLRTGRL 2693
P ++ GH EVTC +V +LGLV S S L+HS+ G L
Sbjct: 2685 -------------ETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSM-NGDL 2730

Query: 2694 IRRLDVDE----AHAICLSSQG--IILVWNGTKKTLSTFTVNGLPIANSVLLPFSGQVSC 2747
+R L+ E I S +G +I NG TF+VNG A + +
Sbjct: 2731 LRTLEGPENCLKPKLIQASREGHCVIFYENG---LFCTFSVNGKLQAT---METDDNIRA 2784

Query: 2748 IEISTDGHFALFG 2760
I++S DG + L G
Sbjct: 2785 IQLSRDGQYLLTG 2797



Score = 74.3 bits (181), Expect = 2e-11, Method: Compositional matrix adjust.
Identities = 89/426 (20%), Positives = 153/426 (35%), Gaps = 65/426 (15%)

Query: 168 AALRACTRNRAMCXXXXXXXXXXXXXEKLFVEMDQGSRWDGTPLLQCIQMLGGHSLSVKD 227
A L+ RN +C EK+ ++++ L+ + +L ++L+V++
Sbjct: 116 AILKKSIRNLQVCTEVGLV-------EKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRE 168

Query: 228 LHSWLDLVRKSLGTSWATPLMLALEKAMGSMEAK-GPAVTFEFDGESSGLLGPGDS-RWP 285
L + ++ G W P L + M K GP F F G+S+ + +WP
Sbjct: 169 LKLFFSKLQGDKG-RWP-PHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWP 226

Query: 286 FLNGYGFATWIYIESFSDTLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGEGTTHM 345
+ NG+ F TW+ ++ ++
Sbjct: 227 YQNGFTFHTWLRMDPVNNI-----------------------------------NVDKDK 251

Query: 346 PRLFSFLSSDNQGVEAYFHGQFLVVESVGGRGKKASLHFTYAFKPQCWYFVGLEHTNKHS 405
P L+ F +S G A+F G L+V S+ +GK + FKPQ WY V + H
Sbjct: 252 PYLYCFRTSKGLGYSAHFVGGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNR- 310

Query: 406 LLGKDDSELSLYVDGSLYESRPFE-FPRISKPLAFCCIGTNPPPTIAGLQRRRRQCPLFA 464
+SEL YV+G L F S C +G++ R C
Sbjct: 311 ---WKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETA-----DANRVFC---G 359

Query: 465 EMGPVYIFKEPIGPDRMRRLASRGGDTLPSFGNGAGLPWKATNDQVKSMAEESFSLNNGI 524
+M VY+F E + ++ + G G +KA +D + + + +
Sbjct: 360 QMTAVYLFSEALNAAQIFAIYQLG------LGYKGTFKFKAESDLFLAEHHKLLLYDGKL 413

Query: 525 GGSLHLLYHPSLLTGRFCPDASPSGSSGTHRRPAEVLGLVHVSPRVRPSESLWALAYGGP 584
++ Y+P + C ++SP + L L V + S + GG
Sbjct: 414 SSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQSAMHSIGGV 473

Query: 585 MALLPL 590
L PL
Sbjct: 474 QVLFPL 479

Query: CNT0020381
Subject: sp|Q9ESE1|LRBA_MOUSE Lipopolysaccharide-responsive and beige-like

PE=1 SV=3

 Score =  413 bits (1061), Expect = e-114,   Method: Compositional matrix adjust.
Identities = 264/780 (33%), Positives = 384/780 (49%), Gaps = 96/780 (12%)

Query: 2015 MVRPLKVVRGTFQVTSKRINFIIDERSNDSNIDDAASTSGQCDQQDKDRSWLVXXXXXXX 2074
++ P V GT +TS + F +DE + D CD W
Sbjct: 2791 LIAPGLVAPGTVSITSTEMFFEVDEEHPEFQKIDG-EVLKYCDHLHG--KWYFSEVRAIF 2847

Query: 2075 XXXXXXXXXXXELFMVDRSNFFFDFADIDARKNAYRAI------VHTKPPNLNDIFLATQ 2128
E+F+ R++ F F D K +A+ + P + +
Sbjct: 2848 SRRYLLQNVALEIFLASRTSILFAFPDQHTVKKVIKALPRVGVGIKYGIPQTRRASMMSP 2907

Query: 2129 RAEQILKRTQLMERWANWEINNFEYLMELNTLAGRSYNDITQYPVFPWVVADYKSRVLNL 2188
R Q+++ + + ++W EI+NFEYLM LNT+AGR+YND+ QYP+FPWV+ +Y+S+ L+L
Sbjct: 2908 R--QLMRNSNMTQKWQRREISNFEYLMFLNTIAGRTYNDLNQYPIFPWVLTNYESKDLDL 2965

Query: 2189 DDPLSYRDLSKPIGALNPERLKKFQERYSTFEDPIIPKFHYGSHYSSAGTVLYYLFRVEP 2248
P +YRDLSKPIGALNP R F+ERY +++ IP FHYG+HYS+A L +L RVEP
Sbjct: 2966 SLPSNYRDLSKPIGALNPSRRAYFEERYESWDSDTIPPFHYGTHYSTAAFTLNWLVRVEP 3025

Query: 2249 FTTLSIQLQDGKFDHADRMFSDLSGTWDSVLEDMSDVKELVPEMFYLPEVFTNINGIDFG 2308
FTT+ + LQ GKFD+ DR+FS +S +W + D SDVKEL+PE ++LPE+F N +G G
Sbjct: 3026 FTTMFLALQGGKFDYPDRLFSSVSLSWKNCQRDTSDVKELIPEWYFLPEMFYNSSGYRLG 3085

Query: 2309 TTQLGGKLDSVELPPWAENHVDFVHKHRKALESEHVSAHLHEWIDLIFGYKQRGKEAIMA 2368
+ G +D +ELPPWA++ +FV +R ALESE VS LH+WIDLIFGYKQRG EAI A
Sbjct: 3086 HREDGALVDDIELPPWAKSPEEFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAIRA 3145

Query: 2369 NNVFFYITYEGTVDIDKITNPVDRRATQDQIAYFGQTPSQLLTVPHMKRKPLAEVLQLQT 2428
NVF+Y+TYEG+VD+D + +PV R A ++QI FGQTPSQLL PH P + + L
Sbjct: 3146 TNVFYYLTYEGSVDLDGVLDPVMREAVENQIRNFGQTPSQLLMEPH---PPRSSAMHLSP 3202

Query: 2429 IFRN--PSELKSYVLPHSDRCNVPASAMLXXXXXXXXXXXXAPAAHVALHQWQAN----- 2481
+ + P +L + + + + SA A+++W N
Sbjct: 3203 MMFSAMPEDLCQMLKFYQNSPVIHISANTYPQLSLPSVVTVTAGHQFAVNRWNCNYTASV 3262

Query: 2482 -------TPDGQGT-------PFLFHHGRNSTNSTSGALMRIFKGSAGSAEDYGFPXXXX 2527
+P G+ P L HG TN+ S A R G S
Sbjct: 3263 QSPSYAESPQSPGSNQPLTIDPVLAVHG---TNNNSNAASRRHLGDNFS----------- 3308

Query: 2528 XXXXXXXXXXXXXXTCDKE-IITGGHVDGSLKLISLDGAKTIETASGHIAPVTCLALS-- 2584
T D +I G D S ++ + + AK ++ GH VTC+A S
Sbjct: 3309 --QMLKIRSNCFVTTVDSRFLIACGFWDNSFRVFATETAKIVQIVFGHFGVVTCMARSEC 3366

Query: 2585 --PDSNYLVTGSRDTTVILWRIHQTGSSHKKNAQEXXXXXXXXXXXXXXXXXXXXXXXXE 2642
Y+ +GS D TV+LW + S
Sbjct: 3367 NITSDCYIASGSADCTVLLWHWNARTQSIVGEGD-------------------------- 3400

Query: 2643 TKRRRVEGPMHVMRGHLGEVTCCSVSPDLGLVASSSNATGILLHSLRTGRLIRRLDVD-E 2701
V P + GH VT +S +LGLV S S+ +L+H+ G L+R LD E
Sbjct: 3401 -----VPTPRATLTGHEQAVTSVVISAELGLVVSGSSNGPVLIHT-TFGDLLRSLDPPAE 3454

Query: 2702 AHA---ICLSSQGIILVWNGTKKTLSTFTVNGLPIANSVLLPFSGQVSCIEISTDGHFAL 2758
H+ I +S +G I++ N K ++ +T+NG + + + + C+ +S DG + +
Sbjct: 3455 FHSPELITMSREGFIVI-NYDKGNVAAYTINGKKLRHET---HNDNLQCMLLSRDGEYLM 3510

Query: CNT0020381
Subject: sp|Q9EPN1|NBEA_MOUSE Neurobeachin OS=Mus musculus GN=Nbea PE=2 SV=1

anchor protein OS=Mus musculus GN=Lrba PE=1 SV=1

 Score =  389 bits (999), Expect = e-107,   Method: Compositional matrix adjust.
Identities = 245/623 (39%), Positives = 323/623 (51%), Gaps = 94/623 (15%)

Query: 1815 ERQTLVDVLIR------HRASTGLRAWRHLLHCLTEMGRLYGPFEHLCTPDRVFWKLDFT 1868
E + + D LIR H +T L + +++ LT+ +G + R FW+LD+
Sbjct: 1934 EEEKMCDHLIRAAKYRDHVTATQL--IQKIINLLTDKHGAWG--SSAVSRPREFWRLDYW 1989

Query: 1869 ESSSRMRRFVKRNYKGCDH----LGAAADYE-DRKLLNTSAQSNEHNSEDANXXXXXXXX 1923
E R RR RN G H L A ++ D +L QS
Sbjct: 1990 EDDLRRRRRFVRNPLGSTHPEATLKTAVEHAADEDILAKGKQS----------------- 2032

Query: 1924 XXXXVIMADAMSMNDRNVENEQLETDTTRSSVDDDQLQHSSAADQQSVKGSIGSRTSDIC 1983
+ ++ ++N ENE L DDD L D +++ G + T
Sbjct: 2033 -------IKSQALGNQNSENEALLEG------DDDTLSSVDEKDLENLAGPVSLST---- 2075

Query: 1984 ADRNLVRSTVLAPSYVPSEADERIIVELPSLMVRPLKVVRGTFQVTSKRINFIIDERS-N 2042
P+ +V P VV+GT VTS + F +DE N
Sbjct: 2076 ----------------------------PAQLVAPSVVVKGTLSVTSSELYFEVDEEDPN 2107

Query: 2043 DSNIDDA--ASTSGQCDQQDKDRSWLVXXXXXXXXXXXXXXXXXXELFMVDRSNFFFDFA 2100
ID A T G + WL E+FM +R F+F
Sbjct: 2108 FKKIDPKILAYTEGLHGK------WLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFP 2161

Query: 2101 DIDARKNAY----RAIVHTK--PPNLNDIFLATQRAEQILKRTQLMERWANWEINNFEYL 2154
D K R V T P I LAT R Q+ K + + +RW + EI+NFEYL
Sbjct: 2162 DPATVKKVVNYLPRVGVGTSFGLPQTRRISLATPR--QLFKASNMTQRWQHREISNFEYL 2219

Query: 2155 MELNTLAGRSYNDITQYPVFPWVVADYKSRVLNLDDPLSYRDLSKPIGALNPERLKKFQE 2214
M LNT+AGRSYND+ QYPVFPWV+ +Y+S L+L P ++RDLSKPIGALNP+R F E
Sbjct: 2220 MFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPSNFRDLSKPIGALNPKRAAFFAE 2279

Query: 2215 RYSTFEDPIIPKFHYGSHYSSAGTVLYYLFRVEPFTTLSIQLQDGKFDHADRMFSDLSGT 2274
R+ ++ED +PKFHYG+HYS+A VL +L R+EPFTT + LQ GKFDHADR FS +S
Sbjct: 2280 RFESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSVSRA 2339

Query: 2275 WDSVLEDMSDVKELVPEMFYLPEVFTNINGIDFGTTQLGGKLDSVELPPWAENHVDFVHK 2334
W + D SD+KEL+PE +YLPE+F N N + G G + VELPPWA+ +FV
Sbjct: 2340 WRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVRI 2399

Query: 2335 HRKALESEHVSAHLHEWIDLIFGYKQRGKEAIMANNVFFYITYEGTVDIDKITNPVDRRA 2394
+R ALESE VS LH+WIDLIFGYKQ+G EA+ A NVF+Y+TYEG V+++ IT+PV R A
Sbjct: 2400 NRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREA 2459

Query: 2395 TQDQIAYFGQTPSQLLTVPHMKR 2417
+ QI FGQTPSQLL PH R
Sbjct: 2460 VEAQIRSFGQTPSQLLIEPHPPR 2482



Score = 74.3 bits (181), Expect = 2e-11, Method: Compositional matrix adjust.
Identities = 88/426 (20%), Positives = 154/426 (36%), Gaps = 65/426 (15%)

Query: 168 AALRACTRNRAMCXXXXXXXXXXXXXEKLFVEMDQGSRWDGTPLLQCIQMLGGHSLSVKD 227
A L+ RN +C EK+ ++++ L+ + +L ++L+V++
Sbjct: 116 AILKKSIRNLQVCTEVGLV-------EKVLGKIEKVDSMIADLLVDMLGVLASYNLTVRE 168

Query: 228 LHSWLDLVRKSLGTSWATPLMLALEKAMGSMEAK-GPAVTFEFDGESSGLLGPGDS-RWP 285
L + ++ G W P L + M K GP F F G+S+ + RWP
Sbjct: 169 LKLFFSKLQGDKG-QWP-PHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIARWP 226

Query: 286 FLNGYGFATWIYIESFSDTLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGEGTTHM 345
+ NG+ F TW+ ++ ++
Sbjct: 227 YQNGFTFHTWLRMDPVNNI-----------------------------------NVDKDK 251

Query: 346 PRLFSFLSSDNQGVEAYFHGQFLVVESVGGRGKKASLHFTYAFKPQCWYFVGLEHTNKHS 405
P L+ F +S G A+F G L++ S+ +GK + FKPQ WY V + H
Sbjct: 252 PYLYCFRTSKGLGYSAHFVGGCLIITSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNR- 310

Query: 406 LLGKDDSELSLYVDGSLYESRPFE-FPRISKPLAFCCIGTNPPPTIAGLQRRRRQCPLFA 464
+SEL YV+G L F S C +G++ R C
Sbjct: 311 ---WKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETA-----DANRVFC---G 359

Query: 465 EMGPVYIFKEPIGPDRMRRLASRGGDTLPSFGNGAGLPWKATNDQVKSMAEESFSLNNGI 524
+M VY+F + + ++ + G G +KA +D + + + +
Sbjct: 360 QMTAVYLFSDALNAAQIFAIYQLG------LGYKGTFKFKAESDLFLAEHHKLLLYDGKL 413

Query: 525 GGSLHLLYHPSLLTGRFCPDASPSGSSGTHRRPAEVLGLVHVSPRVRPSESLWALAYGGP 584
++ +Y+P + C ++SP + L L V + S + GG
Sbjct: 414 SSAIAFMYNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQSAMHSIGGV 473

Query: 585 MALLPL 590
L PL
Sbjct: 474 QVLFPL 479