Query: CNT0034087
Subject: sp|Q6VNB8|WDFY3_MOUSE WD repeat and FYVE domain-containing protein 3OS=Homo sapiens GN=WDFY3 PE=1 SV=2
Score = 676 bits (1745), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 434/1292 (33%), Positives = 640/1292 (49%), Gaps = 174/1292 (13%)
Query: 2450 GVRIKPLEGRRKREMTRRSRDISKIDHSHREQVAKSRSGLAQVRESIAAELRMLRQDKYS 2509
G + L G R+ R+ ++K S +E + +A VR+ + + + ++ + +
Sbjct: 2279 GFGLSKLTGSRR---NRKESGLNKHSLSTQEISQWMFTHIAVVRDLVDTQYKEYQERQQN 2335
Query: 2510 WILHSESEWAEQIQQLVHERGLWPMTAANGKPNWQLCATEGPFRMRKKLERQKI--NQID 2567
+ + EW + +L+ ERGLW + W L TEGP RMRKK+ R + N
Sbjct: 2336 ALKYVTEEWCQIECELLRERGLWGPPIGSHLDKWMLEMTEGPCRMRKKMVRNDMFYNHYP 2395
Query: 2568 IYQTRLEGEDTPGPEYCRRDSLEKEATP--PPLSMDHLIIPLSKDFNMAMEEEEYQSKAE 2625
Y E E E + + P P + SK++ M + +
Sbjct: 2396 -YVPETEQETNVASEIPSKQPETPDDIPQKKPARYRRAVSYDSKEYYMRLASGNPAIVQD 2454
Query: 2626 GVDDDRDSSYALGQRVDDQRSNSAIQESQIPDRGRSERGSQAGGKEVLESPRDSKDNEPI 2685
+ + + A + + + + ++ P RS G +E E +D I
Sbjct: 2455 AIVESSEGEAAQQEPEHGEDTIAKVKGLVKPPLKRSRSAPDGGDEENQEQLQDQ-----I 2509
Query: 2686 MDAQNTKVAALEDGEYLIRPFLEPGEKLKFRYNCERVLGLEKRDGIFLIGEQCLYMIDNY 2745
+ + + D L+R LE GEK++ Y C RV GL+ +G+ L G++ Y+ID
Sbjct: 2510 AEGSSIEEEEKTDNATLLR-LLEEGEKIQHMYRCARVQGLDTSEGLLLFGKEHFYVID-- 2566
Query: 2746 FIDEEDGCIKEKGDEGDISVIDKALGVSMVGSNDSQDGMKQSSGSIAESGPISWAGGRAW 2805
G +M + + +D ++ ++ E PI G R
Sbjct: 2567 -------------------------GFTMTATREIRD-IETLPPNMHE--PIIPRGARQ- 2597
Query: 2806 AYDGGAWGKEKVRAGPN-LRRRWRTWKLDSVHELLKRQYQLRPVAIELFSVNGSNDLLVF 2864
GP+ L+R + + + E+ KR+Y L+P+A+E+FS +G N LL F
Sbjct: 2598 --------------GPSQLKRTCSIFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAF 2643
Query: 2865 HKNERDEVFKNLLAQNLPRNSMLDTTISGASKQEGNE-GGRLFKILA--RSFSKRWQNGE 2921
K R++V++ LA +P + ++SG E G L L +S ++RW+ GE
Sbjct: 2644 QKGIRNKVYQRFLAV-VPSLTDSSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWERGE 2702
Query: 2922 ISNFQYLMHLNTLAGRGYNDLTQYPVFPWILADYESEELDLSKPETFRCLEKPMGALHPP 2981
ISNFQYLMHLNTLAGR YNDL QYPVFPWILADY+SEE+DL+ P+TFR L KPMGA
Sbjct: 2703 ISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDE 2762
Query: 2982 REESFKTRYENWDD--SDIPRFHYGSHYSSAGIVLFYLIRLPPFSWENMKLQGGEFDHAD 3039
R +K RY++W+D + P +HYG+HYSSA IV YL+R+ PF+ ++LQGG FD AD
Sbjct: 2763 RLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLAD 2822
Query: 3040 RLFSSLLDTWLSASQGNTADVKELIPEFFYLPEFLENQFNFDLGMTQSGEKVDHVQLPPW 3099
R+F S+ + W SAS+ N ADVKELIPEFFYLPEFL N NFDLG Q+G K+ V LPPW
Sbjct: 2823 RMFHSVREAWYSASKHNMADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPW 2882
Query: 3100 AKGSAREFIRKHREALESQYVSENLHHWIDLIFGYKQRGKAAVEATNVFYHLTYEGAVNI 3159
AKG REFIR HREALE YVS +LH WIDLIFGYKQ+G AAVEA NVF+HL YEG V+I
Sbjct: 2883 AKGDPREFIRVHREALECDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDI 2942
Query: 3160 DSVTDSAMKAAILAQINHFGQTPRQLFPKPHPKRKWVPR-----PAVTLVPYSNH----- 3209
++ D + A + IN+FGQ P+QLF KPHP ++ R ++++P S
Sbjct: 2943 YNINDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSRLNGDNAGISVLPGSTSDKIFF 3002
Query: 3210 --------TIVPQEIRMMGSRVSQILLYQNTPFIAIKNRVLRPPTYDKYVAWGFPDRSLR 3261
++ P ++ + V QI+ +N+VL PPT++K AWG+ D S R
Sbjct: 3003 HHLDNLRPSLTP--VKELKEPVGQIVCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCR 3060
Query: 3262 LMSYDQDKVLSTHENLHDDGPVTCAGFSRDGQILVTGGEDGVVAVWRFIAPMNNSSPLQL 3321
L +Y+ DK ++ +E L + G + CA + ++++TGG VV VW + + L
Sbjct: 3061 LGTYESDKAMTVYECLSEWGQILCA-ICPNPKLVITGGTSTVVCVWEMGTSKEKAKTVTL 3119
Query: 3322 QRALCAHTQAVTCLAVSQSYSLVVSASKDRTIIFWDLTSLEYVRQLPELPTPATSLHIND 3381
++AL HT VTC S +Y ++VS S+DRT I WDL L ++ QL P ++L IN+
Sbjct: 3120 KQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINE 3179
Query: 3382 MSGEVVTAVGLILTVWSINGDCLAAVNTSHAYSDLILSITSPQVPEWTEAGWYITGHQSG 3441
++G++V+ G + VWSING+ + +VNT S I+ ++ EW +TGH G
Sbjct: 3180 LTGDIVSCAGTYIHVWSINGNPIVSVNTFTGRSQQIICCCMSEMNEWDTQNVIVTGHSDG 3239
Query: 3442 MIRLWCMQF-------------------------------DSHSSSNRMTLLRTKCDPLT 3470
++R W M+F D SS + DP
Sbjct: 3240 VVRFWRMEFLQVPETPAPEPAEVLEMQEDCPEAQIGQEAQDEDSSDSEADEQSISQDPKD 3299
Query: 3471 TPGK----------AGNKARTSWFTLPASSGIKRMNSG-----------VEVTEDSTKFC 3509
TP + A +A +W T S +R + V +E T+
Sbjct: 3300 TPSQPSSTSHRPRAASCRATAAWCTDSGSDDSRRWSDQLSLDEKDGFIFVNYSEGQTRAH 3359
Query: 3510 ITGG-----------------TPEY----QLTLIKVLTWHK--------EPVTALCLG-- 3538
+ G P Y QL LT H P LG
Sbjct: 3360 LQGPLSHPHPNPIEVRNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNAHPAEVTALGIS 3419
Query: 3539 NDLKQLCSGDSGGHVVSWTLLDDVSKSPP---LLVSQSDTCNSCQIQIMASDTRHHCKNC 3595
D ++ GDS G V SW++ D +S + D+C+ C ++ ++ RHHC+NC
Sbjct: 3420 KDHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNC 3479
Query: 3596 GQVLCFNCAYSYELPLEDLGHFLPVRICERCY 3627
GQ+ C C+ ++ ++ L PVR+C+ CY
Sbjct: 3480 GQLFCQKCS-RFQSEIKRLKISSPVRVCQNCY 3510
Score = 58.2 bits (139), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 57/238 (23%), Positives = 98/238 (41%), Gaps = 58/238 (24%)
Query: 1024 SFIEFRMSRVGHACIRVPL---------------------------ANRTWPPATGYSFA 1056
+F+EF S G C+ +P R +PP +G S++
Sbjct: 1044 AFVEFDTSLEGFGCLFLPSLAPHNAPTNNTVTTGLIDGAVVSGIGSGERFFPPPSGLSYS 1103
Query: 1057 CWIRFENLRS----HAL---------TASEHNSTGRKLDSSGPTIRIFSVCTAEEKSSTC 1103
W E+ S H + +SE + + S R V T EE
Sbjct: 1104 SWFCIEHFSSPPNNHPVRLLTVVRRANSSEQHYVCLAIVLSAKD-RSLIVSTKEELLQNY 1162
Query: 1104 VELFMDDTGGLKLVTSPTSFLSFKGVHLEECRWYHLVVVHNKPNALAGLFQSSFAYLYLN 1163
V+ F +++ +++ F G + E +W+HLV+V +K G+ ++S A LY++
Sbjct: 1163 VDDFSEESSFYEILPCCARFRC--GELIIEGQWHHLVLVMSK-----GMLKNSTAALYID 1215
Query: 1164 GRLCHTGKLGY----------SATPIGKPLQVTIGTTSSEAELCSMSWRLGSCYLYEE 1211
G+L +T KL Y + P+ + IGT ++ ++ S+ WRLG + EE
Sbjct: 1216 GQLVNTVKLHYVHSTPGGSGSANPPVVSTVYAYIGTPPAQRQIASLVWRLGPTHFLEE 1273
Query: CNT0034087
Subject: sp|Q55DM1|LVSA_DICDI BEACH domain-containing protein lvsAOS=Mus musculus GN=Wdfy3 PE=1 SV=1
Score = 672 bits (1734), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 449/1371 (32%), Positives = 673/1371 (49%), Gaps = 193/1371 (14%)
Query: 2370 VWRALVTYRSSALEDILIWRGTQGALNV-DVLHNGFNLLLTVGSKAFYEWIEDNYEKVRK 2428
VW L+ + LE++ + +L V D H L + +A + +++ +K
Sbjct: 2202 VWTELIHSKKQVLEELF-----KVSLPVNDRGHVDIALARPLIEEAGLKCWQNHLAHEKK 2256
Query: 2429 VLEQRAAVVWKEYVQGASRFPGVRIKPLEGRRKREMTRRSRDISKIDHSHREQVAKSRSG 2488
+ + A+V + + G + L G R+ R+ + K S +E +
Sbjct: 2257 CISRGEALVPTTQSKLSRVSSGFGLSKLTGSRR---NRKESGLHKHSPSPQEISQWMFTH 2313
Query: 2489 LAQVRESIAAELRMLRQDKYSWILHSESEWAEQIQQLVHERGLWPMTAANGKPNWQLCAT 2548
+A VR+ + + + ++ + + + + EW + +L+ ERGLW + W L T
Sbjct: 2314 IAVVRDLVDTQYKEYQERQQNALKYVTEEWCQIECELLRERGLWGPPIGSHLDKWMLEMT 2373
Query: 2549 EGPFRMRKKLERQKI--NQIDIYQTRLEGEDTPGPEYCRRDSLEKEATPPPLSMDHLIIP 2606
EGP RMRKK+ R + N Y E E + G R ++ ++ L +
Sbjct: 2374 EGPCRMRKKMVRNDMFYNHYP-YVPETEQEASVGKPARYRRAISYDSKEYYLRL------ 2426
Query: 2607 LSKDFNMAMEEEEYQSKAEGVDDDRDSSYALGQRVDDQRSNSAIQESQIPDRGRSERGSQ 2666
N A+ ++ +EG ++ + + + + ++ P RS
Sbjct: 2427 --ASGNPAIVQDAIVESSEGEATQQEPEHG-------EDTIAKVKGLVKPPLKRSRSAPD 2477
Query: 2667 AGGKEVLESPRDSKDNEPIMDAQNTKVAALEDGEYLIRPFLEPGEKLKFRYNCERVLGLE 2726
G +E E +D I ++ + + D L+R LE GEK++ Y C RV GL+
Sbjct: 2478 GGDEETQEQLQDQ-----IAESGSIEEEEKTDNATLLR-LLEEGEKIQHMYRCARVQGLD 2531
Query: 2727 KRDGIFLIGEQCLYMIDNYFIDEEDGCIKEKGDEGDISVIDKALGVSMVGSNDSQDGMKQ 2786
+G+ L G++ Y+ID G +M + + +D ++
Sbjct: 2532 TSEGLLLFGKEHFYVID---------------------------GFTMTATREIRD-IET 2563
Query: 2787 SSGSIAESGPISWAGGRAWAYDGGAWGKEKVRAGPN-LRRRWRTWKLDSVHELLKRQYQL 2845
++ E PI G R GP+ L+R + + + E+ KR+Y L
Sbjct: 2564 LPPNMHE--PIIPRGARQ---------------GPSQLKRTCSIFAYEDIKEVHKRRYLL 2606
Query: 2846 RPVAIELFSVNGSNDLLVFHKNERDEVFKNLLAQNLPRNSMLDTTISGASKQEGNE-GGR 2904
+P+A+E+FS +G N LL F K R++V++ LA +P + ++SG E G
Sbjct: 2607 QPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAV-VPSLTDSSESVSGQRPNTSVEQGSG 2665
Query: 2905 LFKILA--RSFSKRWQNGEISNFQYLMHLNTLAGRGYNDLTQYPVFPWILADYESEELDL 2962
L L +S ++RW+ GEISNFQYLMHLNTLAGR YNDL QYPVFPWIL+DY+SEE+DL
Sbjct: 2666 LLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILSDYDSEEVDL 2725
Query: 2963 SKPETFRCLEKPMGALHPPREESFKTRYENWDD--SDIPRFHYGSHYSSAGIVLFYLIRL 3020
+ P+TFR L KPMGA R +K RY++W+D + P +HYG+HYSSA IV YL+R+
Sbjct: 2726 TNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVASYLVRM 2785
Query: 3021 PPFSWENMKLQGGEFDHADRLFSSLLDTWLSASQGNTADVKELIPEFFYLPEFLENQFNF 3080
PF+ ++LQGG FD ADR+F S+ + W SAS+ N ADVKELIPEFFYLPEFL N NF
Sbjct: 2786 EPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIPEFFYLPEFLFNSNNF 2845
Query: 3081 DLGMTQSGEKVDHVQLPPWAKGSAREFIRKHREALESQYVSENLHHWIDLIFGYKQRGKA 3140
DLG Q+G K+ V LPPWAKG REFIR HREALE YVS +LH WIDLIFGYKQ+G A
Sbjct: 2846 DLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGYKQQGPA 2905
Query: 3141 AVEATNVFYHLTYEGAVNIDSVTDSAMKAAILAQINHFGQTPRQLFPKPHPKRKW----- 3195
AVEA NVF+HL YEG V+I ++ D + A + IN+FGQ P+QLF KPHP ++
Sbjct: 2906 AVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSRLN 2965
Query: 3196 -------VPRPAVTLVPYSNH------TIVPQEIRMMGSRVSQILLYQNTPFIAIKNRVL 3242
VP A + + +H ++ P ++ + V QI+ +N+VL
Sbjct: 2966 GDNIGISVPPGATSDKIFFHHLDNLRPSLTP--VKELKEPVGQIVCTDKGILAVEQNKVL 3023
Query: 3243 RPPTYDKYVAWGFPDRSLRLMSYDQDKVLSTHENLHDDGPVTCAGFSRDGQILVTGGEDG 3302
PP ++K AWG+ D S RL +Y+ DK ++ +E L + G + CA + ++++TGG
Sbjct: 3024 IPPAWNKTFAWGYADLSCRLGTYESDKAVTVYECLSEWGQILCA-VCPNPKLVITGGTST 3082
Query: 3303 VVAVWRFIAPMNNSSPLQLQRALCAHTQAVTCLAVSQSYSLVVSASKDRTIIFWDLTSLE 3362
VV VW + PL L++AL HT VTC S +Y ++VS S+DRT I WDL L
Sbjct: 3083 VVCVWEMGTSKEKAKPLTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLS 3142
Query: 3363 YVRQLPELPTPATSLHINDMSGEVVTAVGLILTVWSINGDCLAAVNTSHAYSDLILSITS 3422
++ QL P ++L IN+++G++V+ G + VWSING+ + +VNT S I+
Sbjct: 3143 FLTQLRGHRAPVSALCINELTGDIVSCAGTYIHVWSINGNPIVSVNTFTGRSQQIVCCCM 3202
Query: 3423 PQVPEWTEAGWYITGHQSGMIRLWCMQF-------------------------------D 3451
++ EW +TGH G++R W M+F D
Sbjct: 3203 SEMNEWDTQNVIVTGHSDGVVRFWRMEFLQVPETPAPEPVEDLEMQEGCPEAQIGQQAQD 3262
Query: 3452 SHSSSNRMTLLRTKCDPLTT----------PGKAGNKARTSWFTLPASSGIKRMNSG--- 3498
SS + DP T P A +A +W T S +R +
Sbjct: 3263 DDSSDSETEEPSVSQDPKDTSSQPSSTSHRPRAASCRATATWCTDSGSDDSRRWSDQLSL 3322
Query: 3499 --------VEVTEDSTKFCITGG-----------------TPEY----QLTLIKVLTWH- 3528
V +E T+ + G P Y QL LT H
Sbjct: 3323 DEKDGFIFVNYSEGQTRAHLQGPLAHPHPNPIEARSYSRLKPGYRWERQLVFRSKLTMHT 3382
Query: 3529 -------KEPVTALCLG--NDLKQLCSGDSGGHVVSWTLLDDVSKSPP---LLVSQSDTC 3576
P LG D ++ GDS G V SW++ D +S + D+C
Sbjct: 3383 AFDRKDNTHPAEVTALGVSKDHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSC 3442
Query: 3577 NSCQIQIMASDTRHHCKNCGQVLCFNCAYSYELPLEDLGHFLPVRICERCY 3627
+ C ++ ++ RHHC+NCGQ+ C C+ ++ ++ L PVR+C+ CY
Sbjct: 3443 SGCSVRFSLTERRHHCRNCGQLFCQKCS-RFQSEIKRLKISSPVRVCQNCY 3492
Score = 57.4 bits (137), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 59/238 (24%), Positives = 100/238 (42%), Gaps = 58/238 (24%)
Query: 1024 SFIEFRMSRVGHACIRVPL---------------------------ANRTWPPATGYSFA 1056
+F+EF S G C+ +P R +PP +G S++
Sbjct: 1044 AFVEFDTSLEGFGCLFLPSLAPHNAPTNNTVTTGLTDGAVVSGMGSGERFFPPPSGLSYS 1103
Query: 1057 CWIRFENLRS----HAL---------TASEHNSTGRKLDSSGPTIRIFSVCTAEEKSSTC 1103
CW E+ S H + +SE + + S R V T EE
Sbjct: 1104 CWFCIEHFSSPPNNHPVRLLTVVRRANSSEQHYVCLAIVLSAKD-RSLIVSTKEELLQNY 1162
Query: 1104 VELFMDDTGGLKLVTSPTSFLSFKGVHLEECRWYHLVVVHNKPNALAGLFQSSFAYLYLN 1163
V+ F +++ +++ F G + E +W+HL ++ ++ G+ ++S A LYL+
Sbjct: 1163 VDDFSEESSFYEILPCCARFRC--GELVVEGQWHHLALLMSR-----GMLKNSTAALYLD 1215
Query: 1164 GRLCHTGKLGY-SATPIGK-----PLQVTI----GTTSSEAELCSMSWRLGSCYLYEE 1211
G+L T KL Y +TP G P+ T+ GT ++ ++ S+ WRLG + EE
Sbjct: 1216 GQLVSTVKLHYVHSTPGGSGSANPPVLSTVYAYVGTPPAQRQIASLVWRLGPTHFLEE 1273
Query: CNT0034087
Subject: sp|Q6ZS81|WDFY4_HUMAN WD repeat- and FYVE domain-containing protein 4OS=Dictyostelium discoideum GN=lvsA PE=3 SV=2
Score = 611 bits (1576), Expect = e-174, Method: Compositional matrix adjust.
Identities = 321/762 (42%), Positives = 445/762 (58%), Gaps = 95/762 (12%)
Query: 2717 YNCERVLGLEKRDGIFLIGEQCLYMIDNYFIDEEDGCIKEKGDEGDISVIDKALGVSMVG 2776
YNC V G++K +GI + +Y+ D Y+ DE + GDIS +++ +
Sbjct: 2816 YNCGSVDGMDKIEGILIFCPVYMYIFDGYYKDE---------NTGDISEVEEKIN----- 2861
Query: 2777 SNDSQDGMKQSSGSIAESGPISWAGGRAWAYDGGAWGKEKVRAGPNLRRRWRTWKLDSVH 2836
W +G +K + + W + +
Sbjct: 2862 --------------------------SEWLPEGTVLPMKK-----KIIHYFLKWAYEDIR 2890
Query: 2837 ELLKRQYQLRPVAIELFSVNGSNDLLVFHKNERDEVFKNLLAQNLPRNSMLDTTISGASK 2896
++LKR+Y LR VA+E+FS +G N+L+V+ RDE ++ + L N TI G +
Sbjct: 2891 DVLKRRYLLRQVALEIFSTDGRNNLVVY----RDEPTRDEVYHTLVNNVSSHNTIGGDA- 2945
Query: 2897 QEGNEGGR--------------------LFKILARS--FSKRWQNGEISNFQYLMHLNTL 2934
+G GG+ F + R + +WQ G+ISNFQYLMHLNTL
Sbjct: 2946 -QGITGGQTGNDDNDDHHGGGGGRGVRDRFTSIWRKSPLTLKWQQGQISNFQYLMHLNTL 3004
Query: 2935 AGRGYNDLTQYPVFPWILADYESEELDLSKPETFRCLEKPMGALHPPREESFKTRYENWD 2994
AGR YNDLTQYPVFPW+L+DYESEELD+ P+ +R L KPMGAL R + F+ R+ENWD
Sbjct: 3005 AGRSYNDLTQYPVFPWVLSDYESEELDIDDPKVYRDLSKPMGALEESRAQKFRERFENWD 3064
Query: 2995 DSD-------IPRFHYGSHYSSAGIVLFYLIRLPPFSWENMKLQGGEFDHADRLFSSLLD 3047
D + +P+FHYG+HYSSA IVL+YLIRL PF+ +KLQGG +D DRLFSS+ +
Sbjct: 3065 DQEPNEHGHKVPKFHYGTHYSSAAIVLYYLIRLEPFTQHFLKLQGGRWDQPDRLFSSITE 3124
Query: 3048 TWLSASQGNTADVKELIPEFFYLPEFLENQFNFDLGMTQSGEKVDHVQLPPWAKGSAREF 3107
W S+SQG+T V ELIPEF+YL EFL N F+ G Q GE +D + LPPWAKGS +EF
Sbjct: 3125 AWASSSQGSTGVVMELIPEFYYLDEFLVNNNKFNFGTKQGGEPIDDIILPPWAKGSPQEF 3184
Query: 3108 IRKHREALESQYVSENLHHWIDLIFGYKQRGKAAVEATNVFYHLTYEGAVNIDSVTDSAM 3167
I+ HR+ALES YVSE+LH WIDLIFGY+Q+GKAA ++ NVFY+LTYEGAVNID+++D
Sbjct: 3185 IKLHRKALESDYVSEHLHEWIDLIFGYRQQGKAADDSLNVFYYLTYEGAVNIDAISDPVE 3244
Query: 3168 KAAILAQINHFGQTPRQLFPKPHPKRKWVPRPAVTLVPYSNHTIVPQEIRMMGSRVSQIL 3227
KAA +AQIN+FGQTP+QLF KPHPKR + +P+ + I+ +G V QI
Sbjct: 3245 KAATIAQINNFGQTPKQLFDKPHPKRN----ATLMGLPFYAKALTGNFIKDIGEPVGQIR 3300
Query: 3228 LYQNTPFIAIKNRVLRPPTYDKYVAWGFPDRSLRLMSYDQDKVLSTHENLHDDGPVTCAG 3287
L + N+VL PP + KY+ WG PD S+R + D+ KVL H DGP+TC
Sbjct: 3301 LINDRATCVGFNKVLLPPNHSKYMLWGLPDGSIRYNTGDKIKVLEDHH----DGPLTCLT 3356
Query: 3288 FSRDGQILVTGGEDGVVAVWRFIAPMNNSSPLQLQRALCAHTQAVTCLAVSQSYSLVVSA 3347
+ DG+I V+GG D ++ V+ N L + L HT ++TC++ S+ YS++VS
Sbjct: 3357 ATEDGRICVSGGSDSLICVY-------NLKRFSLAKRLSGHTGSITCVSASRPYSIIVSG 3409
Query: 3348 SKDRTIIFWDLTSLEYVRQLPELPTPATSLHINDMSGEVVTAVGLILTVWSINGDCLAAV 3407
S DRT I WDL L YVR L P + + I+D +GE+V G ++V+++NG+ L
Sbjct: 3410 SDDRTCIIWDLNRLCYVRSLDAHEGPISCIGIHDTTGEIVVCSGTTISVYTVNGELLINY 3469
Query: 3408 NTSHAYSDLILSITSPQVPEWTEAGWYITGHQSGMIRLWCMQ 3449
TS +D I + PEW +TGH+ G +++W ++
Sbjct: 3470 KTSQIANDQITCCIWSKGPEWLGENVLLTGHRDGKVKVWGLE 3511
Score = 100 bits (248), Expect = 4e-19, Method: Compositional matrix adjust.
Identities = 104/479 (21%), Positives = 200/479 (41%), Gaps = 99/479 (20%)
Query: 2109 ILDLIA----EVLADTLTEQVKGMALVEAAIEAVPTFAGLDTMLVFQGLCLGRMINFXXX 2164
+LDL+ +++ + + K ++++E +E PT A + +++ L ++
Sbjct: 2125 VLDLVVKFLCQIMLSAMRKTSKAISIIEMVLEGAPTTATDEEFILYHSRILLDLM----- 2179
Query: 2165 XXXXXXXXHAKKLDKNRWAPNLDTLSWLLVDRMFMGAFSDPGGAI---KVLEFLLAMLQL 2221
+ D R NL LS +LVDR+ + I ++ F++ +L+
Sbjct: 2180 YVVETNITKTEFFDNERVHSNLIKLSSMLVDRVNLDQLVKNNKIIIAKRIFLFIVKILEK 2239
Query: 2222 ANADGRVEEAVPXXXXXXXXXXXXXXQLEPYVQALLKNTNRMIMYCLLPSSPSDGFGEXX 2281
AD RV L+ VQ+L K+ NR+I+Y +
Sbjct: 2240 LEAD-RV-------------------GLQKTVQSLYKSLNRIILYLI------------- 2266
Query: 2282 XXXXXXXXXXXXXXXXXXXXHTAXXXXXXXXXXXQEIDKATVLQLILANKKLVFCASNVD 2341
HT + D + V I+ +++++F +N+D
Sbjct: 2267 -------------------NHTT------------DTDLSFVANHIINHQRIIFSENNLD 2295
Query: 2342 AELLCALCWNVTPLLWDPEPSTRNLAVDVWRALVTYRSSA----LEDILIWRGTQGA--- 2394
++ + A C+ + L+ + + ++ +WR L++ ++S+ L +L + + G+
Sbjct: 2296 SDFMNAFCYPLYKLVISDQHEHVDNSIKLWRLLLSLKTSSYIESLATVLQLKVSSGSNQR 2355
Query: 2395 -LNVDVLHNGFNLLL-TVGSKAFYE-----WIEDNYEKVRKVLEQRAAVVWKEYVQGASR 2447
+ L GF LL T G+ AF WI DN + + +V E+ + +
Sbjct: 2356 QSEIIDLKPGFELLRNTSGNGAFNNDEFKLWINDNIQTITQVFEENPKKQHLSFKNNEKK 2415
Query: 2448 FPGVRIKP-LEGRRKREMTRRSRDISKIDHSHREQVAKSRSGLAQ--VRESI--AAELRM 2502
P L+ RR ++++ R K D SH+E+ +K + AQ VR +++
Sbjct: 2416 HSSEHTLPSLKSRRTERLSKKQRQDRK-DQSHQEEKSKHITKKAQYFVRSESDRRKKIKQ 2474
Query: 2503 LRQDKYSWILHSESEWAEQIQQLVHERGLWPMTAANGKPNWQLCATEGPFRMRKKLERQ 2561
L DK + + +W Q+ ER +W + + W+L +TEGP+RMRKK+E+
Sbjct: 2475 LESDKQKF---NAIQWENMRAQITRERAVWGPSEPHPLDKWKLDSTEGPYRMRKKMEKN 2530
Score = 77.0 bits (188), Expect = 4e-12, Method: Compositional matrix adjust.
Identities = 85/431 (19%), Positives = 170/431 (39%), Gaps = 79/431 (18%)
Query: 806 NRNLLHECLMSQNFKRLLRCSGLVCEEFGEKIAELLFDLALERVHSPSQNSQGLPILLQK 865
NR + + + F L +G++ EF + + + +FD+ E +++
Sbjct: 881 NRENFEQQIGYKTFSSCLIMTGVLGTEFSKSVVDFIFDMVTENLNA-------------- 926
Query: 866 EEAGHEGFRLPGIQGTFVVDSNQALRQEEVNNASAIEVLLFCLLQF-TMTLQLRVLLRLK 924
S+Q Q +NN + V+L + +L+++ R+
Sbjct: 927 --------------------SDQISNQMIINNVESFNVILDIIPHIENKDFRLQIISRIN 966
Query: 925 AIASASPRNQDVLSAVGCVGLLLEAIRSMSPNSSSILT-CSLQIVEVLGSFRLSTSEIRT 983
+A NQ+ LS + +L S N++ L L +++ +G+ LS SE+R
Sbjct: 967 KMAEYGRYNQEALSKLSIPDWILSRFPSNLSNANDPLQPLLLSLIQTVGANCLSGSELRQ 1026
Query: 984 LGRYIWQNRDGSGGQIGKNILETVKRMWSIDFVPESLSLSSFIEFRMSRVGHACIRVPLA 1043
+ + + ++ IL ++ + S + EF +S++ IRVP+
Sbjct: 1027 FVKLL---QPEHSPEVLLKILSSMAK---------SPPTPPYFEFNLSKIPFGYIRVPIT 1074
Query: 1044 NRTWPPATGYSFACWIRFENLRS-----------HALTASEHNSTGRKLDSSGPTIRIFS 1092
R WPP GY+ W+ + + + S +++ +++ I +
Sbjct: 1075 ERAWPPTNGYTIMFWLYIDKFPTVNNNNNNNNSSNNSNNSNNSNNNNNNNNNNDQIDLVH 1134
Query: 1093 VCTAEEKSSTCVELFMDDTGGLKLVTSPTSFLSFKGVHLEECRWYHLVVVHNKPNALAGL 1152
+ + ++KSS + L + + ++ S + E +WYH+ +VH + L G
Sbjct: 1135 IYSDDKKSSLYIYL-KNGIITVNIINSSKYVIEIPSYKFVEGKWYHIGIVHAR-RLLGG- 1191
Query: 1153 FQSSFAYLYLNGRLCHTGKLGYSATPIGKPLQVT--------IGTTSSEAELCSMSWRLG 1204
+ +L G L Y+AT P Q+T IG ++ WR+G
Sbjct: 1192 ---------TDFKLFVDGFLKYTATKAQYPAQITSGSMLICDIGVSNQNRFPTDSIWRIG 1242
Query: 1205 SCYLYEEREGS 1215
+ YL E+ G+
Sbjct: 1243 TFYLLEDSLGA 1253
Query: CNT0034087
Subject: sp|Q86JF2|LVSB_DICDI BEACH domain-containing protein lvsBOS=Homo sapiens GN=WDFY4 PE=1 SV=3
Score = 488 bits (1257), Expect = e-137, Method: Compositional matrix adjust.
Identities = 284/752 (37%), Positives = 407/752 (54%), Gaps = 67/752 (8%)
Query: 2835 VHELLKRQYQLRPVAIELFSVNGSNDLLVFHKNERDEVFKNLLAQNLPRNSMLDTTISGA 2894
+ EL + ++ L+ +A+E+F NG + LVF+ N+R + FK+ + ++ G
Sbjct: 2468 MRELRQARFLLQDIALEIFFHNGYSKFLVFYNNDRSKAFKSFCS--------FQPSLKGK 2519
Query: 2895 SKQEGNEGGRLFKILARSFSKRWQNGEISNFQYLMHLNTLAGRGYNDLTQYPVFPWILAD 2954
+ E R + R ++WQ +ISNF+YLM+LNT AGR ND QYPVFPW+LAD
Sbjct: 2520 ATSEDTLSLRRYPGSDRIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLAD 2579
Query: 2955 YESEELDLSKPETFRCLEKPMGALHPPREESFKTRYENWDDSD---IPRFHYGSHYSSAG 3011
Y SE L+L+ P+ FR L KPMGA R+ F R++ + ++ + HY +HYSSA
Sbjct: 2580 YTSETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHYSSAI 2639
Query: 3012 IVLFYLIRLPPFSWENMKLQGGEFDHADRLFSSLLDTWLSASQGNTADVKELIPEFFYLP 3071
IV YL+R+PPF+ LQGG FD ADR+F S+ TW SAS+ N +DV+EL PEFFYLP
Sbjct: 2640 IVASYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLP 2699
Query: 3072 EFLENQFNFDLGMTQSGEKVDHVQLPPWAKGSAREFIRKHREALESQYVSENLHHWIDLI 3131
EFL N + G Q G + VQLPPWA G R+FI HR+ALES +VS NLHHWIDLI
Sbjct: 2700 EFLTNCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLI 2759
Query: 3132 FGYKQRGKAAVEATNVFYHLTYEGAVNIDSVTDSAMKAAILAQINHFGQTPRQLFPKPHP 3191
FGYKQ+G AAV+A N+F+ Y +++ S+TD +K+ IL +++FGQ P+QLF KPHP
Sbjct: 2760 FGYKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHP 2819
Query: 3192 KRKWVPRP--------AVTL------VPYSNHTIVPQEIRM-------MGSR-----VSQ 3225
R +P V+L YS ++ P ++ + +GS +
Sbjct: 2820 ARTAAGKPLPGKDVSTPVSLPGHPQPFFYSLQSLRPSQVTVKDMYLFSLGSESPKGAIGH 2879
Query: 3226 ILLYQNTPFIAIKNRVLRPPTYDKYVAWGFPDRSLRLMSYDQDKVLSTHENLHDDGPVTC 3285
I+ + T +N+VL PP +++ +WGF D S L SY DKVL T ENL G C
Sbjct: 2880 IVSTEKTILAVERNKVLLPPLWNRTFSWGFDDFSCCLGSYGSDKVLMTFENLAAWGRCLC 2939
Query: 3286 AGFSRDGQILVTGGEDGVVAVWRFIAPMNNSSPLQLQRALCAHTQAVTCLAVSQSYSLVV 3345
A +VT G VV VW L+L++AL HTQAVTCLA S ++SL+V
Sbjct: 2940 A-VCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLV 2998
Query: 3346 SASKDRTIIFWDLTSLEYVRQLPELPTPATSLHINDMSGEVVTAVGLILTVWSINGDCLA 3405
S S+D T I WDL L +V +LP +++ I+D+SG +V+ G L++W++NG LA
Sbjct: 2999 SGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCAGAHLSLWNVNGQPLA 3058
Query: 3406 AVNTSHAYSDLILSITSPQVPEWTEAGWYITGHQSGMIRLWCMQFDSHSSSNRMTLLRTK 3465
++ T+ I + P W + ITG Q GM+R+W +T+
Sbjct: 3059 SITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVW----------------KTE 3102
Query: 3466 CDPLTTPGKAGNKARTSWFTLPASSGIKRMNSGVEVTEDSTKFCITGGTPEYQLTLIKVL 3525
++ PG+ + + P+ G K + E +TG +
Sbjct: 3103 DVKMSVPGRPAGEEPPA--QPPSPRGHKWEKNLALSRELDVSIALTGKPSKT-------- 3152
Query: 3526 TWHKEPVTALCLGNDLKQLCSGDSGGHVVSWT 3557
VTAL + + +L GD G + W+
Sbjct: 3153 ---SPAVTALAVSRNHTKLLVGDERGRIFCWS 3181
Query: CNT0034087
Subject: sp|Q7LKZ7|BPH1_SCHPO Beige protein homolog 1 OS=SchizosaccharomycesOS=Dictyostelium discoideum GN=lvsB PE=3 SV=1
Score = 483 bits (1242), Expect = e-135, Method: Compositional matrix adjust.
Identities = 274/674 (40%), Positives = 378/674 (56%), Gaps = 77/674 (11%)
Query: 2821 PNLRRRWRTWKLDSVHELLKRQYQLRPVAIELFSVNG---SNDLLVFHK-NERDEVFKNL 2876
P R + TW D + E+ KR++ L+ AIE+F +G L F+K ++RD V+ +
Sbjct: 3419 PPQRGKHITWSYDDIIEIHKRRHVLKNNAIEIFLGSGVPHKTYLFAFNKPSDRDIVYDLI 3478
Query: 2877 LAQNLPRNSMLDTTISGASKQEGNEGGRLFKILARSFSKRWQNGEISNFQYLMHLNTLAG 2936
+++ LP + A++ GN IL S +K+WQ+G ISNF+YLMHLNTLAG
Sbjct: 3479 MSKPLPNR------VDYAAEVHGN-------ILKMSITKKWQSGLISNFEYLMHLNTLAG 3525
Query: 2937 RGYNDLTQYPVFPWILADYESEELDLSKPETFRCLEKPMGALHPPREESFKTRYENWDDS 2996
R +NDLTQYP+FP+IL DYESE LDL P TFR KPMGA P R E F +Y + +
Sbjct: 3526 RSFNDLTQYPIFPFILRDYESEVLDLENPNTFRDFTKPMGAQDPKRLEKFIEKYNDLLEM 3585
Query: 2997 DIPRFHYGSHYSSAGIVLFYLIRLPPFSWENMKLQGGEFDHADRLFSSLLDTWLSASQGN 3056
+ +HYGSHYS+ G VL +L+RL PF+ + QGG FD DR F S+ +W +S +
Sbjct: 3586 NEKPYHYGSHYSNIGSVLHFLVRLQPFTSYFIDFQGGRFDVPDRAFHSIAQSWNLSSSIS 3645
Query: 3057 TADVKELIPEFFYLPEFLENQFNFDLGMTQSGEKVDHVQLPPWAKGSAREFIRKHREALE 3116
+DVKELIPEFFYL +FL N F +G+ Q+G KVD V LPPWA R FI+KH EALE
Sbjct: 3646 NSDVKELIPEFFYLSDFLVNSNKFFMGIKQNGVKVDDVILPPWAHNDPRLFIKKHNEALE 3705
Query: 3117 SQYVSENLHHWIDLIFGYKQRGKAAVEATNVFYHLTYEGAVNIDSVTDSAMKAAILAQIN 3176
+YVSENLHHWIDL+FGYKQ+G+AAV+A N+F+ LTYEGAV+IDS+ D + A +AQI+
Sbjct: 3706 CKYVSENLHHWIDLLFGYKQQGEAAVKAHNMFFPLTYEGAVDIDSIEDQLNRDAAVAQIH 3765
Query: 3177 HFGQTPRQLFPKPHPKRKWVPRPAVTLVPYSNHTIVPQEIRMMGSRVSQILLYQ------ 3230
+GQTP+Q+F KPHPK+ W +T I R++ +++Q
Sbjct: 3766 SYGQTPKQIFTKPHPKKNWSKTIRLT----------QDSIFTKPERLTSYIMFQYRSPIG 3815
Query: 3231 -------NTPFIAIKNRVLRPPTYDKYVAWGFPDRSLRLMSYDQDKVLSTHENLHDDGPV 3283
++P R+L P +K ++WG D++LR+ S D KVLS E L+DD +
Sbjct: 3816 SITIANDSSPIHLTPQRILFFPDNNKSISWGHWDQNLRVNSIDTGKVLSIIEVLNDD--I 3873
Query: 3284 TCAGFSRDGQILVTGGEDGVVAVWR-------FIAPMNNSSPLQLQRALCAHTQAVTCLA 3336
C +++G++ VTGG G V VW+ + L L L HT ++ C+
Sbjct: 3874 ICGDITKNGRLFVTGGTAGTVKVWKRCNNDGTIMTRKERGDNLSLWSTLYGHTNSILCVT 3933
Query: 3337 VSQSYSLVVSASKDRTIIFWDLTSLEYVRQLPELPTPATSLHINDMSGEVVTAVGLI--- 3393
VSQ YS++VS SKD I WDL L Y+ L P T + ++ G + T I
Sbjct: 3934 VSQEYSIIVSGSKDSNCIIWDLNRLTYINSLQH-DHPVTCVQVSPTFGYIATFETNIYNK 3992
Query: 3394 ---------------------LTVWSINGDCLAAVNTSHAYSDLILSITSPQVPEWTEAG 3432
L +WSING LA N + + ++ ++ Q
Sbjct: 3993 QNNNSGGGGSKNDNSINGSGCLRLWSINGTLLAKQNFVNDRVNCMIFTSTIQ---GVNTN 4049
Query: 3433 WYITGHQSGMIRLW 3446
ITG +SG I LW
Sbjct: 4050 LLITGMESGTIILW 4063