Query: CNT0005101
Subject: sp|Q12019|MDN1_YEAST Midasin OS=Saccharomyces cerevisiae (strain ATCC

SV=2

 Score = 1556 bits (4030), Expect = 0.0,   Method: Compositional matrix adjust.
Identities = 874/2088 (41%), Positives = 1241/2088 (59%), Gaps = 185/2088 (8%)

Query: 508 AVDIFAAFSASAENRLTIMRELAKMWAVSDSVAEAFYPPNKPVIQDLGTDLTIGRVTLH- 566
A+D F + + R + + + ++W ++ + KP I ++ GR L
Sbjct: 567 ALDCFCSMISKKNLRKQLTQVIGRVWELTGDRINYYVELYKPSIIITQESVSTGRAKLKS 626

Query: 567 -------------RHQRVLRHQKK----------LFVEIRSSLHLLERIACSVKCNEPVL 603
+H R Q + +F +SL L+E+I+ S++ NEP+L
Sbjct: 627 LEKSDSIQISNGKKHTRFTTEQSQQDSGVTKHGNVFAHTMNSLRLMEKISISIQFNEPIL 686

Query: 604 LVGETGTGKTTLVQTLAMRLGQKLTVLNLSQQSDVADLLGGFKPMDAQFVCIPLYKDFEN 663
LVGETGTGKT++VQ +A +L QKL VLNL+QQSD +DL+GGFKP++ + +C+PL F++
Sbjct: 687 LVGETGTGKTSVVQYIADQLNQKLVVLNLNQQSDSSDLIGGFKPVEMRLLCLPLKNRFDS 746

Query: 664 LFSKTFSVKDNGEFLARLQHHLSDKNWKMLMTGFKKGVDFFRKSA--------------- 708
+F KTFS +N +FL ++ KNWK + K +
Sbjct: 747 MFKKTFSESNNTDFLEKIDKAFISKNWKQFIALLNKAIKLVENKVLKDDQTTTNNTKENN 806

Query: 709 ------EIXXXXXXXXXXXXLDETVLKAWEDFSVKLDTSRGQIGAS-SGMLFQFVEGAFV 761
+ V + W S + Q S + F FVEG+ V
Sbjct: 807 NNNNNNNNNNNNNNNNKKRTIRSEVKEKWIKLSNDIKKLTIQFEKSKNNFAFSFVEGSLV 866

Query: 762 TALRNGDWILLDEVNLAPPETLQRVIGVLEDVNGSLCLAERGDASYIPRHPNFRLFACMN 821
+R G W+LLDE+NLA ETL+ + G+ + GS+ L E+G+ + RHPNF++FACMN
Sbjct: 867 NCIRKGYWVLLDEMNLATSETLESLSGLFD--GGSITLTEKGEVEPVERHPNFKVFACMN 924

Query: 822 PATDAGKRDLPYSLRSRFTEYFXXXXXXXXXXTLFITQSLDDSCSSGDLVDKIVSFYKAA 881
P TD GK+DLP +R+RFTEY+ L + L + + + D IV FY
Sbjct: 925 PPTDIGKKDLPPGIRNRFTEYYVDDLDNRGDLCLVVKTVLSNLVPNPPIED-IVEFYLKT 983

Query: 882 KKESEERLQDGANQKPQYSLRSLYRAIEYTNKAKRKFGFQKAIYDGFSMFFLTLLDVPSA 941
K++++ ++ DG+NQKP +SLR+L RA+ YT + FGFQ+A+++G SM FLT L+ S
Sbjct: 984 KQDAQNKMLDGSNQKPIFSLRTLSRALNYTKHVTKSFGFQRALFEGISMSFLTQLNKSSY 1043

Query: 942 KLMNQMILSKVLGGKIP------------------------PQVPFDEYLMVRGSTISGD 977
+M Q+I + G++ V +++ + G+
Sbjct: 1044 PMMEQLIKQYIKKGEVKLYNQPLNRPPPTSTTNNNNNNAEESYVKIEQFWIECGNE-KPI 1102

Query: 978 FLENYILTKSVREHLRNLARAVLIKRYPVLLQGPTSSGKTSLVQYLAAITGHEFVRINNH 1037
+YILT S++ +L N+AR ++ +++P+LLQGPTSSGKTS+V+YLA TGH F+RINNH
Sbjct: 1103 IPTHYILTPSIKSNLSNIARVLVSRKHPILLQGPTSSGKTSMVEYLAIRTGHRFIRINNH 1162

Query: 1038 EHTDLQEYLGSYVTDASGKLVFHEGVLVKAVRNGYWIVLDELNLAPSDVLEALNRLLDDN 1097
EHTDLQEYLG Y++D GKLVF EG+LV+AVR GYW+VLDELNLAPS+VLEALNRLLDDN
Sbjct: 1163 EHTDLQEYLGQYISDDKGKLVFQEGILVEAVRKGYWVVLDELNLAPSEVLEALNRLLDDN 1222

Query: 1098 RELFVPELRETIPAHPDFMLFATQNPPTLYGGRKMLSRAFRNRFVEIHVDEIPEDELSTI 1157
RELF+PE +E + HP FMLFATQNPP LYGGRK+LSRAFRNRF+E+HVD+IPEDEL I
Sbjct: 1223 RELFIPETQEVVRPHPHFMLFATQNPPGLYGGRKVLSRAFRNRFLELHVDDIPEDELEEI 1282

Query: 1158 LDKRCKIPESYAKKMVEVMKELELHRQ-SSKVFAGKHGFITPRDLFRWADRFRTFGNSYE 1216
L KRC +P SY KK+V +MKEL+L+RQ S++VFAGKHG IT RDLFRWA+R + SYE
Sbjct: 1283 LCKRCALPPSYCKKLVLIMKELQLNRQGSNQVFAGKHGAITFRDLFRWAERQPS---SYE 1339

Query: 1217 DLARDGYYLLAERLRDEGEKKVVQAVLEKHLRVKLVKDNLYH-----------QKLGVGD 1265
+L GY LLAERLR + EK +++ V+EKHL++KL +++Y Q L D
Sbjct: 1340 ELGIAGYQLLAERLRKDEEKLIIKQVIEKHLKIKLDIESIYSCDDKPEFLKLLQLLSEND 1399

Query: 1266 NVFSSGKHAWASESLGDIIWTKSMRRLYFLVERCYRLREPILLVGETGGGKTTICQLLSA 1325
+ S H L I+WT+SM+RL+ LV +C +EPILLVGETG KTTICQL S
Sbjct: 1400 SELSKSNH------LEKIVWTRSMKRLFSLVGKCLEHKEPILLVGETGCSKTTICQLYSI 1453

Query: 1326 VLGLKLHILNCHQYTETSDFLGGFYPIRERSRLISEFKFLIEQLMMLKAFVDFPGDISIS 1385
+ KLHILNCHQ+TET+DF+GG P+R R +++S+ L++Q + ++
Sbjct: 1454 LNKQKLHILNCHQHTETADFIGGLRPVRGRDQVLSKLYSLVKQYFNQLSQLNL------- 1506

Query: 1386 SDIGHASQTLDQLDVIVNSYQQGITPWADVTRQDLDT--FVRMKLDLAQLHQKWQTIFMW 1443
+ + +D+L + + + W V+ L T ++ +++ + + + ++F W
Sbjct: 1507 YKLEQENNNIDELPIKEIMERLIVESWKQVSNSSLLTEQLKQLAIEIDKTYSSYCSLFNW 1566

Query: 1444 QDGPLVQAMKDGDLFLVDEISLADDSVLERLNSVLEPERKLALAEKGGSSLEIITAHPNF 1503
DGPLV+AMK GD FL+DEISLA+D+VLERLNSVLEP R L LAEKGG +E + H F
Sbjct: 1567 VDGPLVEAMKQGDYFLIDEISLAEDAVLERLNSVLEPSRLLVLAEKGGVEIEELRGHKEF 1626

Query: 1504 FLLATMNPGGDYGKKELSPALRNRFTEIWVPCVSDLDELRSIALQRFSNPKILWIVDPML 1563
+LATMNPGGD+GKKELSPA+RNRFTEIWVP +S +L I +RF++P++ ML
Sbjct: 1627 RILATMNPGGDFGKKELSPAMRNRFTEIWVPAISSHQDLLQIIEERFTSPQLKGKGSLML 1686

Query: 1564 NFWEWFNQLQTG-RALTVRDLLSWVAFINVT--EKSLQPDYAFLHGAFLVLLDGLSLGTG 1620
NF E+ +Q R +++RD+LSW++F+N+ ++ L P+ +++HGA LVLLDG +G+
Sbjct: 1687 NFIEYLLMIQKNKRVISLRDILSWISFMNLCMDKQLLSPNESYIHGACLVLLDGFGMGSN 1746

Query: 1621 ISKEDAG-RLRENCLSFLVEQLKLADLCLVVSELSRMENYSWGDLGTTADSSCSNNMQLD 1679
S E G +LRE CL L++Q++ D L + + E S ++ SS +N ++ +
Sbjct: 1747 SSSESEGLKLREACLIRLIDQIESQDEKLKL----QTELLSTSSSSSSLSSSIANIIKEE 1802

Query: 1680 NHFGIHPFYIEKGDQSCEIKGFEFLAPTTCKNAFRVLRAMQLAKPVLLEGSPGVGKTSLI 1739
N FGIHPFYI + + F APTT KNA RVLR MQL + +L+EGSPGVGKTSLI
Sbjct: 1803 NRFGIHPFYIPVRESNVPKIQFSLSAPTTSKNAQRVLRGMQLPRAILVEGSPGVGKTSLI 1862

Query: 1740 VALGKFSGHPVVRINLSEQTDIMDLLGSDLPVESSEGIKFAWSDGILLQALKQGSWVLLD 1799
A+ SG+ +VRINLSEQTDIMDLLGSDLPVE G +F W DG+ L+AL+ GSWVLLD
Sbjct: 1863 TAIANASGNQIVRINLSEQTDIMDLLGSDLPVEGGTGGQFEWRDGVFLEALRNGSWVLLD 1922

Query: 1800 ELNLAPQSVLEGLNAILDHRAEVFIPELGVTFKCPSSFRVFACQNPSSQGGGRKGLPRSF 1859
ELNLA Q+VLEGLN+ LDHR+EV+IPELG TF C +FRVFACQNP QGGGRKGLP+SF
Sbjct: 1923 ELNLASQTVLEGLNSCLDHRSEVYIPELGKTFACHPNFRVFACQNPLHQGGGRKGLPKSF 1982

Query: 1860 LNRFTKVYVDELVEDDYLFICSSLYPSIQRPILSKLILFNKRLHEDIMLNHKFAQDGSPW 1919
LNRFT+V++D+L + D LFI +++YP+I + ++I FN ++ ++ M+ HKFA+ G+PW
Sbjct: 1983 LNRFTQVFIDQLNQQDLLFISTAMYPTIPSKTIERMIEFNHQMFKESMIEHKFARKGAPW 2042

Query: 1920 EFNLRDVIRSCEIIEGAPEKL-KPDCFLNIVYVQRMRTAADRREVLRLYEQVFQVK---- 1974
EFNLRD R C++I P + P F++++Y+QRMRT DR VL ++++VF
Sbjct: 2043 EFNLRDTFRWCDLIVKDPTSISNPARFIDLIYLQRMRTLQDREHVLTIFKRVFTTSGDEN 2102

Query: 1975 -------PYINPY---PRVQLNHRYLVVGNTSIRR------NHFQSSKISN-SQLKILPG 2017
P I Y P ++ YL +G++ + R + F SS + N S +++L
Sbjct: 2103 DQSIDMMPTICNYDKQPHYSISPEYLQIGSSILPRVQNGGASSFDSSVLDNSSNIQLLQR 2162

Query: 2018 IRQSLEAVAHCVQRQWLCILVGPSSSGKTSLIRLLAHSTGNVLNELSLSSATDISELLGC 2077
+ LE + C++ W+ IL+GP+S+ KTS IRLLA TGN L E S++S+ D +E+LG
Sbjct: 2163 LLNPLENIMKCIEMNWMSILIGPTSTSKTSSIRLLAQLTGNTLYEFSMNSSVDTTEILGG 2222

Query: 2078 FEQYNAFR-------NFRSVVGQVECYVNEYCSLQLESSMEAFISERRDMITGW------ 2124
FEQ + R + S++ V ++ Y + ++ M+ IS +D+ W
Sbjct: 2223 FEQIDLVRYQKRIISSVSSLITIVSSHIMTYFNSNDDNLMKTCISSIQDIHQVWNLFKKQ 2282

Query: 2125 --LAVLSSMDCGPSSTSASTYMEDWKCNRSSLCLLVEIIEHLRVDLEKNKLPVSWSC--- 2179
G + S + L LL I++ L KL + ++
Sbjct: 2283 TQQTQQQIQQDGATIGSGGVGL----ITIEQLDLLSTIVDALE------KLSIQFNLDNN 2332

Query: 2180 -EDLNRTLKTILKLQEDQ--QKRTVAAKFEWVTGLLIKALENGEWIVLDNANLCNPTVLD 2236
E LNR ++Q + +K +V FEW+ GLLIKALE G WI++DN N CNPTVLD
Sbjct: 2333 QEHLNRIQDVRQQIQRIKSIEKESVTGCFEWIDGLLIKALETGAWILIDNVNFCNPTVLD 2392

Query: 2237 RINSLVEPCGSITVNECGIVDGKPLVVHPHPNFRMFLTVKPSHGDVSRAMRNRGVEIFMM 2296
R+N L+E G + +NE G+VDG+ VV PHPNFR+FLT+ G++SRAMRNRG+EI+M
Sbjct: 2393 RLNPLLEQDGVLMLNERGMVDGQVKVVKPHPNFRIFLTMDDKKGEISRAMRNRGIEIYMA 2452

Query: 2297 QPYWPLDQESDYYFEELELKDVKRFLVLSDIPGEKLVEAMAKAH--IYARDEGLGLNVHI 2354
L + F D ++ L IP E L M H I+ + N
Sbjct: 2453 ADQLSLMETPSNNF------DNQQLLTALGIPLESLTRTMIDFHNQIFTQLSSTIEN-PC 2505

Query: 2355 TYLELARWVQLFLQLLMNGNQPLWSLQISWEHTYLSSLGEIEGEYIIAHARTSYLSAVEF 2414
T +L W +L L L G L S++ S E Y+ + ++ + S +
Sbjct: 2506 TLSQLLYWGKLILDQLQRGFSLLNSIRNSMEQIYIRPRRHLTQRQLVTNIFNSIFN---- 2561

Query: 2415 SEFDSSLGCSLC----LPGGWPRPLRIRDLVYHSREVGVKQNCMYLEF 2458
+S++ LC + G +P ++ +D V S +K N + E+
Sbjct: 2562 ---ESAIKSILCEDQTVLGIYPHFIKGKDYVTDSISTTMKMNYQFFEY 2606



Score = 264 bits (674), Expect = 2e-68, Method: Compositional matrix adjust.
Identities = 134/316 (42%), Positives = 205/316 (64%), Gaps = 16/316 (5%)

Query: 4888 NEDIYQLSKLSVSDELRKAKNLEEASSDMKDN---AAALWRRYELLTTRLSQELAEQLRL 4944
+E+ + KL+ D R + LE+ + N LW++YE LT LSQ+L EQLRL
Sbjct: 5586 DEESVEEKKLTREDLDRMRQELEQYKIENSSNPEIGTELWKKYEQLTNDLSQDLCEQLRL 5645

Query: 4945 VMEPTLASKLQGDYKTGKRINMKKVIPYIASHYRKDKIWLRRTRPNKRDYQVVIAVDDSR 5004
++EPTLA+KLQGDYK+GKRINMKKVIPYIAS ++KDKIWLRRT+PNKR YQV++A+DD+
Sbjct: 5646 ILEPTLATKLQGDYKSGKRINMKKVIPYIASQFKKDKIWLRRTKPNKRQYQVLLAIDDTE 5705

Query: 5005 SMSESCCGDVAIEALVTVCRAMSQLEVGNLAVASYGKEGNIRLLHDFDQSFTGEAGIKMI 5064
SM+ G A+EA+ + RAMS+LEVG L + +G++ ++L+H FDQ F+ + G ++I
Sbjct: 5706 SMAAYHSGGFALEAMTMISRAMSRLEVGQLGIVRFGED--VQLVHSFDQVFSDQTGPEII 5763

Query: 5065 SNLTFKQENTIKDEPVVDLLKYLNNMLDTAVANARLPSGQNPLQQLVLIIADG-RFIEKE 5123
+ F+Q T +++ +L+ L N + SG+ P QLV I++DG + E
Sbjct: 5764 TQFKFQQTKT-------NMVNFLSKTLQIMDMNKQSSSGE-PAMQLVFIVSDGWSLRDPE 5815

Query: 5124 NLKRCVRDVLSRKRMVAFLLLDSP--QESIMDLQEVSFQGGNMKISKYLDSFPFPYYIIL 5181
K+ +R+ + + F+++D+P SI+D + +SF G ++ + Y+ FPF YY+IL
Sbjct: 5816 TTKKYLREASIKNVFIVFIVIDNPVNNNSILDFESISFNNGKIQRTNYMSEFPFMYYVIL 5875

Query: 5182 KNIEALPRTLADLLRQ 5197
+++ +P L+D LRQ
Sbjct: 5876 RSLNNIPSILSDTLRQ 5891



Score = 135 bits (341), Expect = 1e-29, Method: Compositional matrix adjust.
Identities = 140/567 (24%), Positives = 262/567 (46%), Gaps = 68/567 (11%)

Query: 3524 KDSNASMMAKMVKLLTALQKRLLSLLNEWEDHPGLQKILGVIEMLLAIPSSTPLAKALSG 3583
+DSN S + + + L + +KR+ LL E+ + L ++ +I+ L+ P++ PLAK L+G
Sbjct: 4031 RDSNISEIGIIREPLISFRKRVFELLVEYPEQANLTLMVKLIDRLMTYPATDPLAKILTG 4090

Query: 3584 LQFLLNRIRILQENGSK-FSLSDQLEPIILLASLWKKIEFDSWPALLDEVQDQYEINGGK 3642
L+ LL + + SK S+ + L I L W+K+E +SWP++ + + E+ K
Sbjct: 4091 LELLLRKSLEWESFASKAVSIQNHLNEISSLIVRWRKLEIESWPSIFQSQEKEAEVKALK 4150

Query: 3643 LWFPLYSVLQHRQSD-DIATYNQS-TIQSLEEFIQTSSIGEFRKRLELLFAFHGQISTGI 3700
WF LY ++ S ++ N S +L++++ +SS+G+F R+ELL +F+ Q+++ I
Sbjct: 4151 SWFILYDLINDEPSSPELEDENLSKNFHTLQQYLYSSSLGDFLTRIELLKSFYKQLNSTI 4210

Query: 3701 SLGIYS--SPFQMENLKILYNVFGYYVQFLPIALEHVQANRKNIETELKELLKLCRWEHS 3758
L S + ++ + I+YN+F Y+ F+ + + + K IE + E ++L RW+ +
Sbjct: 4211 KLIGTSKNTNYKQKLSDIIYNIFKYFENFISRFEDRLAKSIKPIEDKALEFIRLSRWDDN 4270

Query: 3759 ESYLSMENSKK----TQQKLRKLIQKYTDLLQQPVMLILNLEATQRGIKSKSIQE--LKV 3812
E K+ + + L K+ KY ++L QP+ I + I + +
Sbjct: 4271 RLLTQYERLKQHIEVSHRNLAKVTIKYKNVLAQPLHDIFTQIENELDIPPLVLHSGAATI 4330

Query: 3813 LGDFPDKHGEELNAATDLTEFSDKNRSVWYPDWRKKVAFALKTL-QLGKTPEFNIPFLSS 3871
L D K+ + + +N + W + K++ + K E P L
Sbjct: 4331 LEDKLKKNQKLNKKQIQKKSLAIENFNDWLSFSPSNYSIDRKSIDSISKPIEIESPLLKK 4390

Query: 3872 PSPCLVYLEHWREVRSTLE-------HVCRTVTECADLWK------DVSKNLG------- 3911
L +E+ + ++ L +C+ +D WK D+ +L
Sbjct: 4391 ----LFQIENEKLAQNKLSLLSKRMIQICKENLLESDSWKVVRDGVDIINDLSIEIIDRL 4446

Query: 3912 ---------KRRALSELLKLLES----CGLSRHKSIFFEDQLKSNQSSWLLQPSYDVQHL 3958
KR+ LK L S GLS H + + ++QL Q S+L ++V+HL
Sbjct: 4447 KELSSDEKIKRQEKEFALKELMSKFHEMGLSYHINRYPQEQL---QISYL----FNVRHL 4499

Query: 3959 LPM---QGRLPYQNVDLAASSQLQSLIHEVSDVEWSAANRYYFKSIASVQLLRQICLNFH 4015
+ QG LP + A + + L A++YY++ ++ V LRQ+ + ++
Sbjct: 4500 PTISDNQGYLPTSFSKITADNGAKLL---------DQADQYYYRIVSRVHRLRQLSIEYN 4550

Query: 4016 KDFTLEQVNRSVSFLDHLIIIQQEQRN 4042
D + + V R +++H + I QRN
Sbjct: 4551 SDLSSKHVQRINGYVEHFLSIIINQRN 4577



Score = 115 bits (289), Expect = 1e-23, Method: Compositional matrix adjust.
Identities = 63/191 (32%), Positives = 99/191 (51%), Gaps = 34/191 (17%)

Query: 349 LVLTLSLKKSYEMVLLAVSQKWPVLLYGPAGVGKTALISKLARDSGN-QVLSIHMDDQID 407
LV T ++ ++ + +AV P+L+ G G GKT +I +L+R +GN ++ IH+ DQ D
Sbjct: 275 LVYTNTVSQNLNSLAIAVGLGKPILIEGVTGSGKTTMIEELSRITGNDNIIRIHLGDQTD 334

Query: 408 GKTLIGSYVCMERPGEFRWQPGSLTQAAMNGFWVVFEGIDKAPSDVQSILLPLLEGAS-- 465
K L+G+Y+ + PGEF+WQ G+LTQA G W++ E ID AP +V S+L+PLLE +
Sbjct: 335 SKVLLGTYITSDTPGEFKWQAGALTQAVQEGRWILIEDIDLAPIEVLSVLIPLLENRTLF 394

Query: 466 -------------------------------GNSLGVLWRRVMIGHPSNEDLQSIVKAWY 494
N L LW RV+I S +++ ++ +
Sbjct: 395 IPGRGEVIEASNGFQLFATQTLFGSHSRDQNANILSHLWTRVVIEALSPTEMKQVLLTLF 454

Query: 495 PELEPVAGKLI 505
P+L + K I
Sbjct: 455 PQLTVMISKFI 465



Score = 108 bits (271), Expect = 2e-21, Method: Compositional matrix adjust.
Identities = 98/353 (27%), Positives = 168/353 (47%), Gaps = 34/353 (9%)

Query: 494 YPELEPVAGKLIG-AAVDIFAAFSASAENRLTIMRELAKMWAVSDSVAEAFYPPNKPVIQ 552
+ E +P + + +G A + A E +L I + + K + + + +KP
Sbjct: 1330 WAERQPSSYEELGIAGYQLLAERLRKDEEKLIIKQVIEKHLKIKLDIESIYSCDDKPEFL 1389

Query: 553 DLGTDLTIGRVTLHRHQRVLRHQKKLFVEIRSSLHLLERIACSVKCNEPVLLVGETGTGK 612
L L+ L + H +K+ V RS L + ++ EP+LLVGETG K
Sbjct: 1390 KLLQLLSENDSELSKS----NHLEKI-VWTRSMKRLFSLVGKCLEHKEPILLVGETGCSK 1444

Query: 613 TTLVQTLAMRLGQKLTVLNLSQQSDVADLLGGFKPMDAQFVCIPLYKDFENLFSKTFS-V 671
TT+ Q ++ QKL +LN Q ++ AD +GG +P+ + + + SK +S V
Sbjct: 1445 TTICQLYSILNKQKLHILNCHQHTETADFIGGLRPVRGR----------DQVLSKLYSLV 1494

Query: 672 KDNGEFLARLQ-HHLSDKNWKMLMTGFKKGVDFFRKSAEIXXXXXXXXXXXXLDETVLKA 730
K L++L + L +N + K+ ++ I L E +
Sbjct: 1495 KQYFNQLSQLNLYKLEQENNNIDELPIKEIMERL-----IVESWKQVSNSSLLTEQL--- 1546

Query: 731 WEDFSVKLDTSRGQIGASSGMLFQFVEGAFVTALRNGDWILLDEVNLAPPETLQRVIGVL 790
+ ++++D + +S LF +V+G V A++ GD+ L+DE++LA L+R+ VL
Sbjct: 1547 -KQLAIEIDKTY----SSYCSLFNWVDGPLVEAMKQGDYFLIDEISLAEDAVLERLNSVL 1601

Query: 791 EDVNGSLCLAERG--DASYIPRHPNFRLFACMNPATDAGKRDLPYSLRSRFTE 841
E + L LAE+G + + H FR+ A MNP D GK++L ++R+RFTE
Sbjct: 1602 EP-SRLLVLAEKGGVEIEELRGHKEFRILATMNPGGDFGKKELSPAMRNRFTE 1653



Score = 105 bits (263), Expect = 1e-20, Method: Compositional matrix adjust.
Identities = 61/153 (39%), Positives = 100/153 (65%), Gaps = 7/153 (4%)

Query: 979 LENYILTKSVREHLRNLARAVLIKRYPVLLQGPTSSGKTSLVQYLAAITGHE-FVRINNH 1037
++ + T +V ++L +LA AV + + P+L++G T SGKT++++ L+ ITG++ +RI+
Sbjct: 272 VQKLVYTNTVSQNLNSLAIAVGLGK-PILIEGVTGSGKTTMIEELSRITGNDNIIRIHLG 330

Query: 1038 EHTDLQEYLGSYVT-DASGKLVFHEGVLVKAVRNGYWIVLDELNLAPSDVLEALNRLLDD 1096
+ TD + LG+Y+T D G+ + G L +AV+ G WI++++++LAP +VL L LL +
Sbjct: 331 DQTDSKVLLGTYITSDTPGEFKWQAGALTQAVQEGRWILIEDIDLAPIEVLSVLIPLL-E 389

Query: 1097 NRELFVPELRETIPAHPDFMLFATQNPPTLYGG 1129
NR LF+P E I A F LFATQ TL+G
Sbjct: 390 NRTLFIPGRGEVIEASNGFQLFATQ---TLFGS 419



Score = 94.7 bits (234), Expect = 3e-17, Method: Compositional matrix adjust.
Identities = 54/142 (38%), Positives = 85/142 (59%), Gaps = 12/142 (8%)

Query: 1707 TTCKNAFRVLRAMQLAKPVLLEGSPGVGKTSLIVALGKFSGHP-VVRINLSEQTDIMDLL 1765
T +N + A+ L KP+L+EG G GKT++I L + +G+ ++RI+L +QTD LL
Sbjct: 280 TVSQNLNSLAIAVGLGKPILIEGVTGSGKTTMIEELSRITGNDNIIRIHLGDQTDSKVLL 339

Query: 1766 G----SDLPVESSEGIKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDHRAE 1821
G SD P E F W G L QA+++G W+L+++++LAP VL L +L++R
Sbjct: 340 GTYITSDTPGE------FKWQAGALTQAVQEGRWILIEDIDLAPIEVLSVLIPLLENRT- 392

Query: 1822 VFIPELGVTFKCPSSFRVFACQ 1843
+FIP G + + F++FA Q
Sbjct: 393 LFIPGRGEVIEASNGFQLFATQ 414



Score = 71.2 bits (173), Expect = 4e-10, Method: Compositional matrix adjust.
Identities = 42/126 (33%), Positives = 73/126 (57%), Gaps = 9/126 (7%)

Query: 345 CGN--PLV-----LTLSLKKSYEMVL-LAVSQKWPVLLYGPAGVGKTALISKLARDSGNQ 396
CGN P++ LT S+K + + + VS+K P+LL GP GKT+++ LA +G++
Sbjct: 1096 CGNEKPIIPTHYILTPSIKSNLSNIARVLVSRKHPILLQGPTSSGKTSMVEYLAIRTGHR 1155

Query: 397 VLSIHMDDQIDGKTLIGSYVCMERPGEFRWQPGSLTQAAMNGFWVVFEGIDKAPSDVQSI 456
+ I+ + D + +G Y+ ++ G+ +Q G L +A G+WVV + ++ APS+V
Sbjct: 1156 FIRINNHEHTDLQEYLGQYISDDK-GKLVFQEGILVEAVRKGYWVVLDELNLAPSEVLEA 1214

Query: 457 LLPLLE 462
L LL+
Sbjct: 1215 LNRLLD 1220



Score = 66.2 bits (160), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 35/99 (35%), Positives = 58/99 (58%), Gaps = 2/99 (2%)

Query: 357 KSYEMVLLAVSQKWPVLLYGPAGVGKTALISKLARDSGNQVLSIHMDDQIDGKTLIGSYV 416
K+ + VL + +L+ G GVGKT+LI+ +A SGNQ++ I++ +Q D L+GS +
Sbjct: 1833 KNAQRVLRGMQLPRAILVEGSPGVGKTSLITAIANASGNQIVRINLSEQTDIMDLLGSDL 1892

Query: 417 CME--RPGEFRWQPGSLTQAAMNGFWVVFEGIDKAPSDV 453
+E G+F W+ G +A NG WV+ + ++ A V
Sbjct: 1893 PVEGGTGGQFEWRDGVFLEALRNGSWVLLDELNLASQTV 1931



Score = 50.4 bits (119), Expect = 6e-04, Method: Compositional matrix adjust.
Identities = 49/164 (29%), Positives = 73/164 (44%), Gaps = 18/164 (10%)

Query: 4309 SICDEL--HKTIFYAVSMMTHVLANVFASLYSEGFGTPTEDQIDDNSHDTSK-----DAK 4361
SI D L HKT + ++ VF LYS+GF P + D + + D +
Sbjct: 4895 SIVDSLSYHKT----CCKLEYISTGVFIQLYSKGFCKPADGGDDGEGGEGGRSNFEDDVE 4950

Query: 4362 GTGMGEGVGLKDVSDQITDEDQLLGASEK---PSEEQDVSDEVPSKNDKGIEMEQDFAA- 4417
GTGMGEG G KDVSDQ+ D+ Q+ + + +E + ++ D+G +M+ DF
Sbjct: 4951 GTGMGEGKGKKDVSDQLEDQGQIEDTNTQKKEEKDEDEDEEKEEKDEDEGFDMQDDFEGE 5010

Query: 4418 --DTFXXXXXXXXXXXXXXXXXQLDSAMGE-TGADSEIVDEKLW 4458
D + D MG+ + +VDEKLW
Sbjct: 5011 MHDIKKDENKDEDKKDDPNNEKENDKEMGDLEKPEDNVVDEKLW 5054

Query: CNT0005101
Subject: sp|O94248|MDN1_SCHPO Midasin OS=Schizosaccharomyces pombe (strain 972

204508 / S288c) GN=MDN1 PE=1 SV=1

 Score = 1423 bits (3683), Expect = 0.0,   Method: Compositional matrix adjust.
Identities = 845/2078 (40%), Positives = 1171/2078 (56%), Gaps = 248/2078 (11%)

Query: 366 VSQKWPVLLYGPAGVGKTALISKLARDSG--NQVLSIHMDDQIDGKTLIGSYVCMERPGE 423
+ P++L G AG GKT LI++L++ G + ++ IH+ +Q D K LIG+Y ++PG
Sbjct: 305 IQNSTPIMLIGKAGSGKTFLINELSKYMGCHDSIVKIHLGEQTDAKLLIGTYTSGDKPGT 364

Query: 424 FRWQPGSLTQAAMNGFWVVFEGIDKAPSDVQSILLPLLE--------------GASG--- 466
F W+ G L A G WV+ E IDKAP+DV SILL LLE A+G
Sbjct: 365 FEWRAGVLATAVKEGRWVLIEDIDKAPTDVLSILLSLLEKRELTIPSRGETVKAANGFQL 424

Query: 467 ---------------------NSLGV-LWRRVMIGHPSNEDLQSIVKAWYPELEPVAGKL 504
N +G+ +W + + PS EDL I+ +P L + KL
Sbjct: 425 ISTVRINEDHQKDSSNKIYNLNMIGMRIWNVIELEEPSEEDLTHILAQKFPILTNLIPKL 484

Query: 505 IGAAVDI--------FAAFSASAENRLTIMRELAKMW---------------------AV 535
I + ++ F + + A R+ +R+L K+ +V
Sbjct: 485 IDSYKNVKSIYMNTKFISLNKGAHTRVVSVRDLIKLCERLDILFKNNGINKPDQLIQSSV 544

Query: 536 SDSV----AEAF------YPPNKPVIQDLGTDLTIG--RVTLHRHQRV------------ 571
DS+ A+ F + +P+IQ +G L I R++L Q V
Sbjct: 545 YDSIFSEAADCFAGAIGEFKALEPIIQAIGESLDIASSRISLFLTQHVPTLENLDDSIKI 604

Query: 572 ---------LRHQKK-----LFVEIRSSLHLLERIACSVKCNEPVLLVGETGTGKTTLVQ 617
L QKK LF SL L+E+I+ ++ EPVLLVGETGTGKTT+VQ
Sbjct: 605 GRAVLLKEKLNIQKKSMNSTLFAFTNHSLRLMEQISVCIQMTEPVLLVGETGTGKTTVVQ 664

Query: 618 TLAMRLGQKLTVLNLSQQSDVADLLGGFKPMDAQFVCIPLYKDFENLFSKTFSVKDNGEF 677
LA L +KLTV+N+SQQ++ DLLGG+KP++++ V +P+ ++FE LF+ TFS+K N +F
Sbjct: 665 QLAKMLAKKLTVINVSQQTETGDLLGGYKPVNSKTVAVPIQENFETLFNATFSLKKNEKF 724

Query: 678 LARLQHHLSDKNWKMLMT----GFKKGVDFFRKSAEIXXXXXXXXXXXXLD----ETVLK 729
L + WK ++ +K + + L+ + +L
Sbjct: 725 HKMLHRCFNKNQWKNVVKLWNEAYKMAQSILKITNTENENENAKKKKRRLNTHEKKLLLD 784

Query: 730 AWEDFSVKLDTSRGQIGA-SSGMLFQFVEGAFVTALRNGDWILLDEVNLAPPETLQRVIG 788
W DF+ + Q + + +F FVEG+ V +R G+W+LLDEVNLA +TL+ +
Sbjct: 785 KWADFNDSVKKFEAQSSSIENSFVFNFVEGSLVKTIRAGEWLLLDEVNLATADTLESISD 844

Query: 789 VLEDVNG-SLCLAERGDASYIPRHPNFRLFACMNPATDAGKRDLPYSLRSRFTEYFXXXX 847
+L + + S+ L+E+GDA I HP+FR+FACMNPATD GKRDLP +RSRFTE +
Sbjct: 845 LLTEPDSRSILLSEKGDAEPIKAHPDFRIFACMNPATDVGKRDLPMGIRSRFTEIYVHSP 904

Query: 848 XXXXXXTLFITQSLDDSCSSGD--LVDKIVSFYKAAKKESEER-LQDGANQKPQYSLRSL 904
L I S D + + I Y AKK S+ + DG+NQKP +S+R+L
Sbjct: 905 ERDITDLLSIIDKYIGKYSVSDEWVGNDIAELYLEAKKLSDNNTIVDGSNQKPHFSIRTL 964

Query: 905 YRAIEYTNKAKRKFGFQKAIYDGFSMFFLTLLDVPSAKLMNQMILSKVLG---------G 955
R + Y +G ++++YDGF M FLTLLD S ++ +I LG
Sbjct: 965 TRTLLYVTDIIHIYGLRRSLYDGFCMSFLTLLDQKSEAILKPVIEKFTLGRLKNVKSIMS 1024

Query: 956 KIPPQ-----VPFDEYLMVRG-STISGDFLENYILTKSVREHLRNLARAVLIKRYPVLLQ 1009
+ PP V F Y M +G +TI +YI+T V +++ NL RA KR+PVL+Q
Sbjct: 1025 QTPPSPGPDYVQFKHYWMKKGPNTIQEQ--AHYIITPFVEKNMMNLVRATSGKRFPVLIQ 1082

Query: 1010 GPTSSGKTSLVQYLAAITGHEFVRINNHEHTDLQEYLGSYVTDASGKLVFHEGVLVKAVR 1069
GPTSSGKTS+++YLA ITGH+FVRINNHEHTDLQEYLG+YVTD +GKL F EGVLV+A+R
Sbjct: 1083 GPTSSGKTSMIKYLADITGHKFVRINNHEHTDLQEYLGTYVTDDTGKLSFKEGVLVEALR 1142

Query: 1070 NGYWIVLDELNLAPSDVLEALNRLLDDNRELFVPELRETIPAHPDFMLFATQNPPTLYGG 1129
GYWIVLDELNLAP+DVLEALNRLLDDNRELF+PE +E + HPDF+LFATQNPP +YGG
Sbjct: 1143 KGYWIVLDELNLAPTDVLEALNRLLDDNRELFIPETQEVVHPHPDFLLFATQNPPGIYGG 1202

Query: 1130 RKMLSRAFRNRFVEIHVDEIPEDELSTILDKRCKIPESYAKKMVEVMKELELHRQSSKVF 1189
RK+LSRAFRNRF+E+H D+IP+DEL IL +RC+I SYAKK+VEV ++L + R +S++F
Sbjct: 1203 RKILSRAFRNRFLELHFDDIPQDELEIILRERCQIAPSYAKKIVEVYRQLSIERSASRLF 1262

Query: 1190 AGKHGFITPRDLFRWADRFRTFGNSYEDLARDGYYLLAERLRDEGEKKVVQAVLEKHLRV 1249
K+ F T RDLFRWA R YE LA GY LLAER R EK V+ LEK ++V
Sbjct: 1263 EQKNSFATLRDLFRWALRDAV---GYEQLAASGYMLLAERCRTPQEKVTVKKTLEKVMKV 1319

Query: 1250 KLVKDNLYHQKLGVGDNVFSSGKHAWASESLGDIIWTKSMRRLYFLVERCYRLREPILLV 1309
KL D Y + + E++G + WTK MRRL LV C + +EP+LLV
Sbjct: 1320 KLDMDQYY------------ASLEDKSLEAIGSVTWTKGMRRLSVLVSSCLKNKEPVLLV 1367

Query: 1310 GETGGGKTTICQLLSAVLGLKLHILNCHQYTETSDFLGGFYPIRERSRLISEFKFLIEQL 1369
GETG GKTTICQLL+ +G +L LN HQ TET D LG P+R RS + ++K +
Sbjct: 1368 GETGCGKTTICQLLAQFMGRELITLNAHQNTETGDILGAQRPVRNRSEI--QYKL----I 1421

Query: 1370 MMLKAFVDFPGDISISSDIGHASQTLDQLDVIVNSYQQGITPWADVTRQDLDTFVRMKLD 1429
LK ++ D + D+ Q + D + I DV +L+
Sbjct: 1422 KSLKTALNIANDQDV--DLKELLQLYSKSD------NKNIA--EDV-----------QLE 1460

Query: 1430 LAQLHQKWQTIFMWQDGPLVQAMKDGDLFLVDEISLADDSVLERLNSVLEPERKLALAEK 1489
+ +L +F W DGPL+QAM+ G+ FL+DEISLADDSVLERLNSVLEPER L LAE+
Sbjct: 1461 IQKLRDSLNVLFEWSDGPLIQAMRTGNFFLLDEISLADDSVLERLNSVLEPERSLLLAEQ 1520

Query: 1490 GGSSLEIITAHPNFFLLATMNPGGDYGKKELSPALRNRFTEIWVPCVSDLDELRSIALQR 1549
GSS ++TA NF ATMNPGGDYGKKELSPALRNRFTEIWVP + D +++ I R
Sbjct: 1521 -GSSDSLVTASENFQFFATMNPGGDYGKKELSPALRNRFTEIWVPSMEDFNDVNMIVSSR 1579

Query: 1550 FSNPKILWIVDPMLNFWEWF-NQLQTGRA----LTVRDLLSWVAFIN-VTEKSLQPDYAF 1603
+ + +P++ F EWF +L G A +++RD+L+WV FIN V K A
Sbjct: 1580 LLE-DLKDLANPIVKFSEWFGKKLGGGNATSGVISLRDILAWVEFINKVFPKIQNKSTAL 1638

Query: 1604 LHGAFLVLLDGLSLGTGI----SKEDAGRLRENCLSFLVEQLKLADLCLVVSELSRMENY 1659
+ GA +V +D L ++ D LR C+ ++L LC EL ++E
Sbjct: 1639 IQGASMVFIDALGTNNTAYLAENENDLKSLRTECI------IQLLKLCGDDLELQQIET- 1691

Query: 1660 SWGDLGTTADSSCSNNMQLDNHFGIHPFYIEKGDQSCEIKGFEFLAPTTCKNAFRVLRAM 1719
++ T D +Q+ F I F + F APTT N RV+RAM
Sbjct: 1692 --NEIIVTQDE-----LQV-GMFKIPRF------PDAQSSSFNLTAPTTASNLVRVVRAM 1737

Query: 1720 QLAKPVLLEGSPGVGKTSLIVALGKFSGHPVVRINLSEQTDIMDLLGSDLPVESSEGIKF 1779
Q+ KP+LLEGSPGVGKTSLI AL +G+ + RINLSEQTD++DL G+D P E S +F
Sbjct: 1738 QVHKPILLEGSPGVGKTSLITALANITGNKLTRINLSEQTDLVDLFGADAPGERSG--EF 1795

Query: 1780 AWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDHRAEVFIPELGVTFKCPSSFRV 1839
W D L+A+K+G WVLLDE+NLA QSVLEGLNA LDHR E +IPEL ++F C +F V
Sbjct: 1796 LWHDAPFLRAMKKGEWVLLDEMNLASQSVLEGLNACLDHRGEAYIPELDISFSCHPNFLV 1855

Query: 1840 FACQNPSSQGGGRKGLPRSFLNRFTKVYVDELVEDDYLFICSSLYPSIQRPILSKLILFN 1899
FA QNP QGGGRKGLP+SF+NRF+ V++D L DD L I LYPSI+ I++K+I
Sbjct: 1856 FAAQNPQYQGGGRKGLPKSFVNRFSVVFIDMLTSDDLLLIAKHLYPSIEPDIIAKMIKLM 1915

Query: 1900 KRLHEDIMLNHKFAQDGSPWEFNLRDVIRSCEIIE--GAPEKLKPDCFLNIVYVQRMRTA 1957
L + + + GSPWEFNLRD +R +++ E + F++I+ QR RT
Sbjct: 1916 STLEDQVCKRKLWGNSGSPWEFNLRDTLRWLKLLNQYSICEDVDVFDFVDIIVKQRFRTI 1975

Query: 1958 ADRREVLRLYEQVFQVKPYINPYPRVQLNHRYLVVGNTSIRRNHFQSSKISNSQLKILPG 2017
+D+ + L E +F + +L Y+ + N RN I+ + +
Sbjct: 1976 SDKNKAQLLIEDIF--GKFSTKENFFKLTEDYVQINNEVALRNPHYRYPITQNLFPLECN 2033

Query: 2018 IRQSLEAVAHCVQRQWLCILVGPSSSGKTSLIRLLAHSTGNVLNELSLSSATDISELLGC 2077
+ E+V + W +LVGPS+SGKT IR LA G ++ S++S D ++LG
Sbjct: 2034 V-AVYESVLKAINNNWPLVLVGPSNSGKTETIRFLASILGPRVDVFSMNSDIDSMDILGG 2092

Query: 2078 FEQYNAFRNFRSVVGQVECYVNEYCSLQLESSMEAFISERRDMITGWLAVLSSMDCGPSS 2137
+EQ + R + ++ V E S+ ++ S A A++ ++
Sbjct: 2093 YEQVDLTRQISYITEELTNIVREIISMNMKLSPNA------------TAIMEGLNLLKYL 2140

Query: 2138 TSASTYMEDWKCNRSSLCLLVEIIEHLRVDLEKNKLPVSWSCEDLNRTLKTILKLQEDQQ 2197
+ E ++ R+ N+ L +T+ ++ +
Sbjct: 2141 LNNIVTPEKFQDFRNRF----------------NRFFSHLEGHPLLKTMSMNIEKMTEII 2184

Query: 2198 KRTVAAKFEWVTGLLIKALENGEWIVLDNANLCNPTVLDRINSLVEPCGSITVNECGIVD 2257
+ + KFEW G+L+KA+E G W++LDNANLC+P+VLDR+NSL+E GS+ +NEC D
Sbjct: 2185 TKEASVKFEWFDGMLVKAVEKGHWLILDNANLCSPSVLDRLNSLLEIDGSLLINECSQED 2244

Query: 2258 GKPLVVHPHPNFRMFLTVKPSHGDVSRAMRNRGVEIFM 2295
G+P V+ PHPNFR+FLT+ P +G++SRAMRNRGVEI++
Sbjct: 2245 GQPRVLKPHPNFRLFLTMDPKYGELSRAMRNRGVEIYI 2282



Score = 334 bits (857), Expect = 1e-89, Method: Compositional matrix adjust.
Identities = 348/1315 (26%), Positives = 581/1315 (44%), Gaps = 200/1315 (15%)

Query: 356 KKSYEMVLLAVSQKWPVLLYGPAGVGKTALISKLARDSGNQVLSIHMDDQIDGKTLIGSY 415
K +V +++PVL+ GP GKT++I LA +G++ + I+ + D + +G+Y
Sbjct: 1063 KNMMNLVRATSGKRFPVLIQGPTSSGKTSMIKYLADITGHKFVRINNHEHTDLQEYLGTY 1122

Query: 416 VCMERPGEFRWQPGSLTQAAMNGFWVVFEGIDKAPSDVQSILLPLLEG------------ 463
V + G+ ++ G L +A G+W+V + ++ AP+DV L LL+
Sbjct: 1123 VT-DDTGKLSFKEGVLVEALRKGYWIVLDELNLAPTDVLEALNRLLDDNRELFIPETQEV 1181

Query: 464 ----------ASGNSLGVLWRRVMIGH--------------PSNEDLQSIVKAWYPELEP 499
A+ N G+ R ++ P +E L+ I++
Sbjct: 1182 VHPHPDFLLFATQNPPGIYGGRKILSRAFRNRFLELHFDDIPQDE-LEIILRERCQIAPS 1240

Query: 500 VAGKLIGAAVDIFAAFSAS----AENRLTIMRELAKMWAVSDSV-------------AEA 542
A K++ + SAS +N +R+L + WA+ D+V AE
Sbjct: 1241 YAKKIVEVYRQLSIERSASRLFEQKNSFATLRDLFR-WALRDAVGYEQLAASGYMLLAER 1299

Query: 543 FYPPNKPVIQDLGTDLTIGRVTLHRHQRVLRHQKKLFVEIRSSL------HLLERIACSV 596
P + V T + +V L Q + K I S L ++ +
Sbjct: 1300 CRTPQEKVTVK-KTLEKVMKVKLDMDQYYASLEDKSLEAIGSVTWTKGMRRLSVLVSSCL 1358

Query: 597 KCNEPVLLVGETGTGKTTLVQTLAMRLGQKLTVLNLSQQSDVADLLGGFKPM----DAQF 652
K EPVLLVGETG GKTT+ Q LA +G++L LN Q ++ D+LG +P+ + Q+
Sbjct: 1359 KNKEPVLLVGETGCGKTTICQLLAQFMGRELITLNAHQNTETGDILGAQRPVRNRSEIQY 1418

Query: 653 VCIPLYKDFENLFSKTFSVKDNGEFLARLQHHLSDKNWKMLMTGFKKGVDFFRKSAEIXX 712
I K N+ D L L S + K + + + R S
Sbjct: 1419 KLIKSLKTALNI------ANDQDVDLKELLQLYSKSDNKNIAEDVQLEIQKLRDSL---- 1468

Query: 713 XXXXXXXXXXLDETVLKAWEDFSVKLDTSRGQIGASSGMLFQFVEGAFVTALRNGDWILL 772
VL W D G + A+R G++ LL
Sbjct: 1469 -------------NVLFEWSD------------------------GPLIQAMRTGNFFLL 1491

Query: 773 DEVNLAPPETLQRVIGVLEDVNGSLCLAERGDA-SYIPRHPNFRLFACMNPATDAGKRDL 831
DE++LA L+R+ VLE SL LAE+G + S + NF+ FA MNP D GK++L
Sbjct: 1492 DEISLADDSVLERLNSVLEP-ERSLLLAEQGSSDSLVTASENFQFFATMNPGGDYGKKEL 1550

Query: 832 PYSLRSRFTEYFXXXXXXXXXXTLFITQSLDDSCSSGDLVDKIVSFYKAAKKESEERLQD 891
+LR+RFTE + + ++ L + DL + IV F + K +L
Sbjct: 1551 SPALRNRFTEIWVPSMEDFNDVNMIVSSRLLEDLK--DLANPIVKFSEWFGK----KLGG 1604

Query: 892 GANQKPQYSLRSLYRAIEYTNKAKRKFGFQK-AIYDGFSMFFLTLL-------------D 937
G SLR + +E+ NK K + A+ G SM F+ L D
Sbjct: 1605 GNATSGVISLRDILAWVEFINKVFPKIQNKSTALIQGASMVFIDALGTNNTAYLAENEND 1664

Query: 938 VPSAKLMNQMILSKVLGGKIP-PQVPFDEYLMVRGSTISGDFL---------ENYILTK- 986
+ S + + L K+ G + Q+ +E ++ + G F ++ LT
Sbjct: 1665 LKSLRTECIIQLLKLCGDDLELQQIETNEIIVTQDELQVGMFKIPRFPDAQSSSFNLTAP 1724

Query: 987 SVREHLRNLARAVLIKRYPVLLQGPTSSGKTSLVQYLAAITGHEFVRINNHEHTDLQEYL 1046
+ +L + RA+ + + P+LL+G GKTSL+ LA ITG++ RIN E TDL +
Sbjct: 1725 TTASNLVRVVRAMQVHK-PILLEGSPGVGKTSLITALANITGNKLTRINLSEQTDLVDLF 1783

Query: 1047 GSYVT-DASGKLVFHEGVLVKAVRNGYWIVLDELNLAPSDVLEALNRLLDDNRELFVPEL 1105
G+ + SG+ ++H+ ++A++ G W++LDE+NLA VLE LN LD E ++PEL
Sbjct: 1784 GADAPGERSGEFLWHDAPFLRAMKKGEWVLLDEMNLASQSVLEGLNACLDHRGEAYIPEL 1843

Query: 1106 RETIPAHPDFMLFATQNPPTLYGGRKMLSRAFRNRFVEIHVDEIPEDELSTILDK-RCKI 1164
+ HP+F++FA QNP GGRK L ++F NRF + +D + D+L I I
Sbjct: 1844 DISFSCHPNFLVFAAQNPQYQGGGRKGLPKSFVNRFSVVFIDMLTSDDLLLIAKHLYPSI 1903

Query: 1165 PESYAKKMVEVMKELELHRQSSKVF--AGKHGFITPRDLFRWADRFRTFGNSYEDLARDG 1222
KM+++M LE K++ +G RD RW + ED+
Sbjct: 1904 EPDIIAKMIKLMSTLEDQVCKRKLWGNSGSPWEFNLRDTLRWLKLLNQYSIC-EDVDVFD 1962

Query: 1223 YY--LLAERLRDEGEKKVVQAVLEKHLRVKLVKDNLY---HQKLGVGDNVFSSGKHAWAS 1277
+ ++ +R R +K Q ++E K+N + + + + V H +
Sbjct: 1963 FVDIIVKQRFRTISDKNKAQLLIEDIFGKFSTKENFFKLTEDYVQINNEVALRNPH-YRY 2021

Query: 1278 ESLGDIIWTKSMRRLYFLVERCYRLREPILLVGETGGGKTTICQLLSAVLGLKLHILNCH 1337
++ + +Y V + P++LVG + GKT + L+++LG ++ + + +
Sbjct: 2022 PITQNLFPLECNVAVYESVLKAINNNWPLVLVGPSNSGKTETIRFLASILGPRVDVFSMN 2081

Query: 1338 QYTETSDFLGGFYPIRERSRLISEFKFLIEQLMMLKAFVDFPGDISISSDIG-HASQTLD 1396
++ D LGG+ E+ L + ++ E+L + + IS++ + +A+ ++
Sbjct: 2082 SDIDSMDILGGY----EQVDLTRQISYITEELTNIVREI-----ISMNMKLSPNATAIME 2132

Query: 1397 QLDVIVNSYQQGITP--WADVTRQDLDTFVR----------MKLDLAQLHQ----KWQTI 1440
L+++ +TP + D R + F M +++ ++ + +
Sbjct: 2133 GLNLLKYLLNNIVTPEKFQDF-RNRFNRFFSHLEGHPLLKTMSMNIEKMTEIITKEASVK 2191

Query: 1441 FMWQDGPLVQAMKDGDLFLVDEISLADDSVLERLNSVLEPERKLALAE--KGGSSLEIIT 1498
F W DG LV+A++ G ++D +L SVL+RLNS+LE + L + E + ++
Sbjct: 2192 FEWFDGMLVKAVEKGHWLILDNANLCSPSVLDRLNSLLEIDGSLLINECSQEDGQPRVLK 2251

Query: 1499 AHPNFFLLATMNPGGDYGKKELSPALRNRFTEIWVPCVSDLDEL--RSIALQRFS 1551
HPNF L TM+P YG ELS A+RNR EI++ DEL RS A R +
Sbjct: 2252 PHPNFRLFLTMDPK--YG--ELSRAMRNRGVEIYI------DELHSRSTAFDRLT 2296



Score = 330 bits (847), Expect = 1e-88, Method: Compositional matrix adjust.
Identities = 314/1202 (26%), Positives = 550/1202 (45%), Gaps = 189/1202 (15%)

Query: 982 YILTKSVREHLRNLARAVLIKRYPVLLQGPTSSGKTSLVQYLAAITG-HE-FVRINNHEH 1039
++ T LR L R + P++L G SGKT L+ L+ G H+ V+I+ E
Sbjct: 288 FVPTHKTVSSLRQLGRKIQ-NSTPIMLIGKAGSGKTFLINELSKYMGCHDSIVKIHLGEQ 346

Query: 1040 TDLQEYLGSYVT-DASGKLVFHEGVLVKAVRNGYWIVLDELNLAPSDVLEALNRLLDDNR 1098
TD + +G+Y + D G + GVL AV+ G W+++++++ AP+DVL L LL + R
Sbjct: 347 TDAKLLIGTYTSGDKPGTFEWRAGVLATAVKEGRWVLIEDIDKAPTDVLSILLSLL-EKR 405

Query: 1099 ELFVPELRETIPAHPDFMLFAT--------QNPPTLYGGRKMLSRAFRNRFVEIHVDEIP 1150
EL +P ET+ A F L +T ++ M+ N I ++E
Sbjct: 406 ELTIPSRGETVKAANGFQLISTVRINEDHQKDSSNKIYNLNMIGMRIWNV---IELEEPS 462

Query: 1151 EDELSTILDKRCKIPESYAKKMVEVMKELELHRQSSKVFAGKHG----FITPRDLFRWAD 1206
E++L+ IL ++ I + K+++ K ++ ++K + G ++ RDL + +
Sbjct: 463 EEDLTHILAQKFPILTNLIPKLIDSYKNVKSIYMNTKFISLNKGAHTRVVSVRDLIKLCE 522

Query: 1207 R----FRTFG-NSYEDLARDGYY--LLAERLR----DEGEKK----VVQAV--------- 1242
R F+ G N + L + Y + +E GE K ++QA+
Sbjct: 523 RLDILFKNNGINKPDQLIQSSVYDSIFSEAADCFAGAIGEFKALEPIIQAIGESLDIASS 582

Query: 1243 -----LEKHL--------RVKLVKDNLYHQKLGVGDNVFSSGKHAWASESLGDIIWTKSM 1289
L +H+ +K+ + L +KL + +S A+ + SL
Sbjct: 583 RISLFLTQHVPTLENLDDSIKIGRAVLLKEKLNIQKKSMNSTLFAFTNHSL--------- 633

Query: 1290 RRLYFLVERCYRLREPILLVGETGGGKTTICQLLSAVLGLKLHILNCHQYTETSDFLGGF 1349
RL + C ++ EP+LLVGETG GKTT+ Q L+ +L KL ++N Q TET D LGG+
Sbjct: 634 -RLMEQISVCIQMTEPVLLVGETGTGKTTVVQQLAKMLAKKLTVINVSQQTETGDLLGGY 692

Query: 1350 YPIRERSRLI---SEFKFLIEQLMMLKAFVDF-------------PGDISISSDIGHASQ 1393
P+ ++ + F+ L LK F + + ++ +Q
Sbjct: 693 KPVNSKTVAVPIQENFETLFNATFSLKKNEKFHKMLHRCFNKNQWKNVVKLWNEAYKMAQ 752

Query: 1394 TLDQLDVIVNSYQQG---------------ITPWADVTRQDLDTFVRMKLDLAQLHQKWQ 1438
++ ++ N + + WAD D+ + + + + +
Sbjct: 753 SILKITNTENENENAKKKKRRLNTHEKKLLLDKWADFN----DSVKKFEAQSSSIENSF- 807

Query: 1439 TIFMWQDGPLVQAMKDGDLFLVDEISLADDSVLERLNSVL-EPE-RKLALAEKGGSSLEI 1496
+F + +G LV+ ++ G+ L+DE++LA LE ++ +L EP+ R + L+EKG + E
Sbjct: 808 -VFNFVEGSLVKTIRAGEWLLLDEVNLATADTLESISDLLTEPDSRSILLSEKGDA--EP 864

Query: 1497 ITAHPNFFLLATMNPGGDYGKKELSPALRNRFTEIWVPCVS-DLDELRSIALQRFSNPKI 1555
I AHP+F + A MNP D GK++L +R+RFTEI+V D+ +L SI + +
Sbjct: 865 IKAHPDFRIFACMNPATDVGKRDLPMGIRSRFTEIYVHSPERDITDLLSIIDKYIGKYSV 924

Query: 1556 L--WIVDPMLNFWEWFNQLQTGRAL----------TVRDLLSWVAFINVTEKSLQPDYAF 1603
W+ + + + +L + ++R L + ++ D
Sbjct: 925 SDEWVGNDIAELYLEAKKLSDNNTIVDGSNQKPHFSIRTLTRTLLYVT--------DIIH 976

Query: 1604 LHGAFLVLLDGLSLGTGISKEDAGRLRENCLSF--LVEQLKLADLCLVVSE--LSRMENY 1659
++G L DG C+SF L++Q A L V+ + L R++N
Sbjct: 977 IYGLRRSLYDGF-----------------CMSFLTLLDQKSEAILKPVIEKFTLGRLKNV 1019

Query: 1660 SWGDLGTTADSSCSNNMQLDNHFGIHPFYIEKGDQSCEIKGFEFLAPTTCKNAFRVLRAM 1719
+ T S + +Q + ++++KG + + + + P KN ++RA
Sbjct: 1020 K-SIMSQTPPSPGPDYVQFKH------YWMKKGPNTIQEQAHYIITPFVEKNMMNLVRAT 1072

Query: 1720 QLAK-PVLLEGSPGVGKTSLIVALGKFSGHPVVRINLSEQTDIMDLLGSDLPVESSEGIK 1778
+ PVL++G GKTS+I L +GH VRIN E TD+ + LG+ + ++ K
Sbjct: 1073 SGKRFPVLIQGPTSSGKTSMIKYLADITGHKFVRINNHEHTDLQEYLGTYVTDDTG---K 1129

Query: 1779 FAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDHRAEVFIPELGVTFKCPSSFR 1838
++ +G+L++AL++G W++LDELNLAP VLE LN +LD E+FIPE F
Sbjct: 1130 LSFKEGVLVEALRKGYWIVLDELNLAPTDVLEALNRLLDDNRELFIPETQEVVHPHPDFL 1189

Query: 1839 VFACQNPSSQGGGRKGLPRSFLNRFTKVYVDELVEDDYLFICS---SLYPSIQRPILSKL 1895
+FA QNP GGRK L R+F NRF +++ D++ +D+ I + PS + K+
Sbjct: 1190 LFATQNPPGIYGGRKILSRAFRNRFLELHFDDIPQDELEIILRERCQIAPSYAK----KI 1245

Query: 1896 ILFNKRLHEDIMLNHKFAQDGSPWEFNLRDVIRSCEIIEGAPEKLKPDCFLNIVYVQRMR 1955
+ ++L + + F Q S LRD+ R E+L ++ + +R R
Sbjct: 1246 VEVYRQLSIERSASRLFEQKNSFA--TLRDLFRWALRDAVGYEQLAASGYM--LLAERCR 1301

Query: 1956 TAADRREVLRLYEQVFQVKPYINPYPRVQLNHRYLVVGNTSIRRNHFQSSKISNSQLKIL 2015
T ++ V + E+V +VK ++ Y + +G+ + +
Sbjct: 1302 TPQEKVTVKKTLEKVMKVKLDMDQYYASLEDKSLEAIGSVTWTK---------------- 1345

Query: 2016 PGIRQSLEAVAHCVQRQWLCILVGPSSSGKTSLIRLLAHSTGNVLNELSLSSATDISELL 2075
G+R+ V+ C++ + +LVG + GKT++ +LLA G L L+ T+ ++L
Sbjct: 1346 -GMRRLSVLVSSCLKNKEPVLLVGETGCGKTTICQLLAQFMGRELITLNAHQNTETGDIL 1404

Query: 2076 GC 2077
G
Sbjct: 1405 GA 1406



Score = 285 bits (729), Expect = 7e-75, Method: Compositional matrix adjust.
Identities = 260/936 (27%), Positives = 431/936 (46%), Gaps = 108/936 (11%)

Query: 4318 IFYA-VSMMTHVLANVFASLYSEGFGTPT--EDQIDDNSHDTSKDAKGTGMGEGVGLKDV 4374
I+Y S ++L+ + SL GF +P +++DD + +GTG+G+G G ++
Sbjct: 4019 IYYTNTSRGMYILSTILHSLAKNGFCSPQPPSEEVDDKNL-----QEGTGLGDGEGAQNN 4073

Query: 4375 SDQI-TDEDQLLGASEKPSEEQDVSDEVPSKNDKGIEMEQDFAAD--TFXXXXXXXXXXX 4431
+ + DED A + E+QD + D +EME D A +
Sbjct: 4074 NKDVEQDEDLTEDAQNENKEQQDKDERDDENEDDAVEMEGDMAGELEDLSNGEENDDEDT 4133

Query: 4432 XXXXXXQLDSAMGETGADSEIVDEKLWN---------KDADENANNTKEKYESGPSVTD- 4481
+ D +D+K+W+ KD D+N + ++ + + D
Sbjct: 4134 DSEEEELDEEIDDLNEDDPNAIDDKMWDDKASDNSKEKDTDQNLDGKNQEEDVQAAENDE 4193

Query: 4482 -----KDASSRELRAKEXXXXXXXXEPGQLNQDESNEQNDEIGSQD--DLGNTEXXXXXX 4534
K+ + A E + +++ EQ DE+ ++ DL
Sbjct: 4194 QQRDNKEGGDEDPNAPEDGDEEIENDENAEEENDVGEQEDEVKDEEGEDLEANVPEIETL 4253

Query: 4535 XXKEDAFADPSGLKLDETNPMKEDL--DMDEQEGADPMEEAHPEEHDEFTENGD--GKEE 4590
ED D + DE M + + D++++E + EE E E D G EE
Sbjct: 4254 DLPEDMNLDSEHEESDEDVDMSDGMPDDLNKEEVGNEDEEVKQESGIESDNENDEPGPEE 4313

Query: 4591 DSNPADENLEEAESGQVD----GNSERDDLGKGNEEKADMDLEAPRKDVLGPGNSDFISD 4646
D+ + L+E E + D + ++D G EE+A D E ++D N + +
Sbjct: 4314 DAGETETALDEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEENKEKGGE 4373

Query: 4647 HVPNAESATQPKDDMQAADSRNMAPETKWSNSSDIHNNLAPISGLPSNDTSEMEMMVADS 4706
+ K D + D + S + G + DT E + +
Sbjct: 4374 QNTEGLDGVEEKADTEDIDQEAAVQQDSGSKGA----------GADATDTQEQDDVGGSG 4423

Query: 4707 SMDGKLTNDQPKTQLPQQDSSSIQKTQANPYRNVGDALEEWKERARVSSDLQEDNTEAPE 4766
+ DQ ++S ++ + +GD+++E+ R + + Q N E E
Sbjct: 4424 TTQNTYEEDQEDVTKNNEES---REEATAALKQLGDSMKEYHRRRQDIKEAQT-NGEEDE 4479

Query: 4767 NVE--DENADEYGYVSEFEKGT-AQALGPATFDQIDKNITQNEPDVDGVMAQKEHLTKEN 4823
N+E +E DE+ +V T QALG AT DQ+ +D MA + +
Sbjct: 4480 NLEKNNERPDEFEHVEGANTETDTQALGSATQDQLQT--------IDEDMA----IDDDR 4527

Query: 4824 EKQNSETDPIKSSALNLKKRIEEQMQISDSEVSPKEISPEVQSQGDGDPGS------VSE 4877
E+Q + + A + K I+E+ +SD + + + +V S+ G G
Sbjct: 4528 EEQEVDQKELVEDADDEKMDIDEEEMLSD--IDAHDANNDVDSKKSGFIGKRKSEEDFEN 4585

Query: 4878 SLVSIKRSYLNEDIYQLSKL---------SVSDELRKAKNLEEASSDMKDNAAALWRRYE 4928
L + S ED ++ L S L ++LEE+ LW + E
Sbjct: 4586 ELSNEHFSADQEDDSEIQSLIENIEDNPPDASASLTPERSLEESRE--------LWHKSE 4637

Query: 4929 LLTTRLSQELAEQLRLVMEPTLASKLQGDYKTGKRINMKKVIPYIASHYRKDKIWLRRTR 4988
+ T L L EQLRL++EPTLA+KL+GDYKTGKR+NMK++IPYIAS +RKDKIWLRRT+
Sbjct: 4638 ISTADLVSRLGEQLRLILEPTLATKLKGDYKTGKRLNMKRIIPYIASQFRKDKIWLRRTK 4697

Query: 4989 PNKRDYQVVIAVDDSRSMSESCCGDVAIEALVTVCRAMSQLEVGNLAVASYGKEGNIRLL 5048
P+KR YQ++IA+DDS+SMSES C +A ++L V + ++QLE G L++ +G+ NI+ +
Sbjct: 4698 PSKRQYQIMIALDDSKSMSESKCVKLAFDSLCLVSKTLTQLEAGGLSIVKFGE--NIKEV 4755

Query: 5049 HDFDQSFTGEAGIKMISNLTFKQENTIKDEPVVDLLKYLNNMLDTAVANARLPSGQNPLQ 5108
H FDQ F+ E+G + F++ T V L+ + + A A N
Sbjct: 4756 HSFDQQFSNESGARAFQWFGFQETKT----DVKKLVAESTKIFERARAMV-----HNDQW 4806

Query: 5109 QLVLIIADGRFIEKENLKRCVRDVLSRKRMVAFLLLD--SPQESIMDLQEVSF---QGGN 5163
QL ++I+DG + E +++ VR K M+ F+++D + ESI+D+ +V++ Q GN
Sbjct: 4807 QLEIVISDGICEDHETIQKLVRRARENKIMLVFVIIDGITSNESILDMSQVNYIPDQYGN 4866

Query: 5164 --MKISKYLDSFPFPYYIILKNIEALPRTLADLLRQ 5197
+KI+KYLD+FPF +Y+++ +I LP L+ +LRQ
Sbjct: 4867 PQLKITKYLDTFPFEFYVVVHDISELPEMLSLILRQ 4902



Score = 139 bits (349), Expect = 1e-30, Method: Compositional matrix adjust.
Identities = 159/640 (24%), Positives = 283/640 (44%), Gaps = 96/640 (15%)

Query: 1717 RAMQLAKPVLLEGSPGVGKTSLIVALGKFSG--HPVVRINLSEQTDIMDLLGSDLPVESS 1774
R +Q + P++L G G GKT LI L K+ G +V+I+L EQTD L+G+ +
Sbjct: 303 RKIQNSTPIMLIGKAGSGKTFLINELSKYMGCHDSIVKIHLGEQTDAKLLIGT-----YT 357

Query: 1775 EGIK---FAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDHRAEVFIPELGVTF 1831
G K F W G+L A+K+G WVL+++++ AP VL L ++L+ R E+ IP G T
Sbjct: 358 SGDKPGTFEWRAGVLATAVKEGRWVLIEDIDKAPTDVLSILLSLLEKR-ELTIPSRGETV 416

Query: 1832 KCPSSFRVFACQ--NPSSQGGGRK---GLPRSFLNRFTKVYVDELVEDDYLFICSSLYPS 1886
K + F++ + N Q L + + + ++E E+D I + +P
Sbjct: 417 KAANGFQLISTVRINEDHQKDSSNKIYNLNMIGMRIWNVIELEEPSEEDLTHILAQKFP- 475

Query: 1887 IQRPILSKLILFNKRLHEDIMLNHKFA---QDGSPWEFNLRDVIRSCEIIE--------G 1935
I ++ KLI K + + I +N KF + ++RD+I+ CE ++
Sbjct: 476 ILTNLIPKLIDSYKNV-KSIYMNTKFISLNKGAHTRVVSVRDLIKLCERLDILFKNNGIN 534

Query: 1936 APEKL------------KPDCFLNIV--------YVQRMRTAAD---RREVLRLYEQVFQ 1972
P++L DCF + +Q + + D R L L + V
Sbjct: 535 KPDQLIQSSVYDSIFSEAADCFAGAIGEFKALEPIIQAIGESLDIASSRISLFLTQHVPT 594

Query: 1973 VKPYINPYPRVQLNHRYLVVGNTSIRRNHFQSS--KISNSQLKILPGIRQSLEAVAHCVQ 2030
++ N +++ L+ +I++ S+ +N L+++ E ++ C+Q
Sbjct: 595 LE---NLDDSIKIGRAVLLKEKLNIQKKSMNSTLFAFTNHSLRLM-------EQISVCIQ 644

Query: 2031 RQWLCILVGPSSSGKTSLIRLLAHSTGNVLNELSLSSATDISELLGCFEQYNAFRNFRSV 2090
+LVG + +GKT++++ LA L +++S T+ +LLG ++ N+ +
Sbjct: 645 MTEPVLLVGETGTGKTTVVQQLAKMLAKKLTVINVSQQTETGDLLGGYKPVNSKTVAVPI 704

Query: 2091 VGQVECYVNEYCSLQLESSMEAFI------SERRDMITGWLAVLSSMDCGPSSTSASTYM 2144
E N SL+ + ++ ++++ W T+
Sbjct: 705 QENFETLFNATFSLKKNEKFHKMLHRCFNKNQWKNVVKLWNEAYKMAQSILKITNTENEN 764

Query: 2145 EDWKCNRSSLCLLVEIIEHLRVDLEKNKLPVSWSCEDLNRTLKTILKLQEDQQKRTVAAK 2204
E+ K + L H EK L W+ D N ++K K + +
Sbjct: 765 ENAKKKKRRLNT------H-----EKKLLLDKWA--DFNDSVK---KFEAQSSSIENSFV 808

Query: 2205 FEWVTGLLIKALENGEWIVLDNANLCNPTVLDRINSLV-EP-CGSITVNECGIVDGKPLV 2262
F +V G L+K + GEW++LD NL L+ I+ L+ EP SI ++E G D +P
Sbjct: 809 FNFVEGSLVKTIRAGEWLLLDEVNLATADTLESISDLLTEPDSRSILLSEKG--DAEP-- 864

Query: 2263 VHPHPNFRMFLTVKPSHG----DVSRAMRNRGVEIFMMQP 2298
+ HP+FR+F + P+ D+ +R+R EI++ P
Sbjct: 865 IKAHPDFRIFACMNPATDVGKRDLPMGIRSRFTEIYVHSP 904



Score = 107 bits (266), Expect = 5e-21, Method: Compositional matrix adjust.
Identities = 73/262 (27%), Positives = 134/262 (51%), Gaps = 12/262 (4%)

Query: 3537 LLTALQKRLLSLLNEWEDHPGLQKILGVIEMLLAIPSSTPLAKALSGLQFLLNRIRILQE 3596
++ + K +L LL +W +H L+++ V + L P TPLA+ L ++ + + ++
Sbjct: 3297 IIETVLKSVLKLLKQWPEHATLKELYRVSQEFLNYPIKTPLARQLQKIEQIYTYLAEWEK 3356

Query: 3597 NGS-KFSLSDQLEPIILLASLWKKIEFDSWPALLDEVQDQYEINGGKLWFPLYS--VLQH 3653
S + SL++ ++ I L W+K+E +W L + + + GK WF LY V+ +
Sbjct: 3357 YASSEVSLNNTVKLITDLIVSWRKLELRTWKGLFNSEDAKTRKSIGKWWFYLYESIVISN 3416

Query: 3654 RQSDDIATYNQST--IQSLEEFIQTSSIGEFRKRLELLFAFHGQISTGISLGIYSSPFQM 3711
S+ T +T + SL F S++GEF RL+L+ AF+ I +G+ SS
Sbjct: 3417 FVSEKKETAPNATLLVSSLNLFFSKSTLGEFNARLDLVKAFYKHIQL---IGLRSSKIA- 3472

Query: 3712 ENLKILYNVFGYYVQFLPIALEHVQANRKNIETELKELLKLCRWEHSESYLSMENSKKTQ 3771
+L+N +Y QF P+ E + +K++E E+ +++ L W+ ++S+K+
Sbjct: 3473 ---GLLHNTIKFYYQFKPLIDERITNGKKSLEKEIDDIILLASWKDVNVDALKQSSRKSH 3529

Query: 3772 QKLRKLIQKYTDLLQQPVMLIL 3793
L K+++KY DLL I+
Sbjct: 3530 NNLYKIVRKYRDLLNGDAKTII 3551



Score = 65.9 bits (159), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 40/134 (29%), Positives = 69/134 (51%), Gaps = 23/134 (17%)

Query: 1747 GHPVVR---INLSEQTDIMDLLGSDLPVESSEGIKFAWSDGILLQALKQGSWVLLDELNL 1803
GHP+++ +N+ + T+I + +KF W DG+L++A+++G W++LD NL
Sbjct: 2166 GHPLLKTMSMNIEKMTEI---------ITKEASVKFEWFDGMLVKAVEKGHWLILDNANL 2216

Query: 1804 APQSVLEGLNAILDHRAEVFIPELGV------TFKCPSSFRVFACQNPSSQGGGRKGLPR 1857
SVL+ LN++L+ + I E K +FR+F +P L R
Sbjct: 2217 CSPSVLDRLNSLLEIDGSLLINECSQEDGQPRVLKPHPNFRLFLTMDPK-----YGELSR 2271

Query: 1858 SFLNRFTKVYVDEL 1871
+ NR ++Y+DEL
Sbjct: 2272 AMRNRGVEIYIDEL 2285

Query: CNT0005101
Subject: sp|Q8T5T1|MDN1_GIAIN Midasin OS=Giardia intestinalis GN=MDN1 PE=3

/ ATCC 24843) GN=mdn1 PE=1 SV=1

 Score = 1397 bits (3617), Expect = 0.0,   Method: Compositional matrix adjust.
Identities = 834/2073 (40%), Positives = 1183/2073 (57%), Gaps = 222/2073 (10%)

Query: 349 LVLTLSLKKSYEMVLLAVSQKWPVLLYGPAGVGKTALISKLARDSGNQVLSIHMDDQIDG 408
LVLT S +++ + + QK P+LL GP G+GK LI+++A G Q++ IH+ D D
Sbjct: 132 LVLTKSTQENLNRITPYLVQKRPILLAGPEGIGKKFLITQIAAKLGQQIIRIHLSDSTDP 191

Query: 409 KTLIGSYVCMERPGEFRWQPGSLTQAAMNGFWVVFEGIDKAPSDVQSILLPLLEG----- 463
K LIG+Y +PGEF WQPG LTQA + G W++F I+ APS+V S+LLPLLE
Sbjct: 192 KMLIGTYTS-PKPGEFEWQPGVLTQAVITGKWILFTNIEHAPSEVLSVLLPLLEKRQLVI 250

Query: 464 -ASGNSLGV--------------------LWRRVMIGHPSNEDLQSIVKAWYPELEPVAG 502
+ G ++ LW+ + + + +E ++ +V YP L +
Sbjct: 251 PSRGETIYAKGSFQMFATSSMKTKILGQRLWQILDLTYQPDECVE-VVSTLYPVLSIICP 309

Query: 503 KLIGAAVDIFAAFSA-----------------------------------------SAEN 521
L DIF FS S E
Sbjct: 310 TLYSVYKDIFDLFSQRSFLATSKIYRRLCLRDFYKFIKRVAFLYHKFMIPSDHVVISQEL 369

Query: 522 RLTIMRELAKMWA------------VSDSVAEAFYPPNK--------PVIQDLGTDLTIG 561
+ + +E M+ V + E PP K PV Q+L ++ IG
Sbjct: 370 QDAVFKEAIDMFGAFIPSRDGFDLVVRNVAIELNIPPEKALQLRYSIPVFQNLEHNINIG 429

Query: 562 RVTLHRHQRVLRHQKKLFVEIRSSLHLLERIACSVKCNEPVLLVGETGTGKTTLVQTLAM 621
R +L + + + SSL LLE++A V+ NEP+LLVGETGTGKTT +Q LA
Sbjct: 430 RCSLKKLSTIRSCSTNSYAFTSSSLGLLEQLAAGVQTNEPLLLVGETGTGKTTTIQLLAG 489

Query: 622 RLGQKLTVLNLSQQSDVADLLGGFKPMDAQFVCIPLYKDFENLFSKTFSVKDNGEFLARL 681
LGQK+TV+N+SQQ++ +D+LGG+KP++A + +PL++ F ++F +TFS K N +F++
Sbjct: 490 LLGQKVTVINMSQQTESSDMLGGYKPINASTLGLPLHERFIDIFEQTFSSKKNAKFISMA 549

Query: 682 QHHLSDKNWKMLMTGFKKGVDFFRK--SAEIXXXXXXXXXXXXLDETVLK-AWEDFSVKL 738
WK + +K+ + + ++ L+ W F ++
Sbjct: 550 STSARRFRWKTCLKIWKEACKLSKTVLDGQQPLPNPQKRQKRLSNQVELRNQWAKFEKEV 609

Query: 739 -DTSRGQIGASSGMLFQFVEGAFVTALRNGDWILLDEVNLAPPETLQRVIGVLEDVNGSL 797
D + G S+G +F FVEGA V A+R+G W+LLDE+NLA ETL+ + +L +
Sbjct: 610 EDFEKVLTGGSNGFMFSFVEGALVKAVRSGHWVLLDEINLASLETLEPIGQLLSSYESGI 669

Query: 798 CLAERGDASYIPRHPNFRLFACMNPATDAGKRDLPYSLRSRFTEYFXXXXXXXXXXTLFI 857
L+ERGD + I H NFRLF CMNP+TD GKR+L S RSRFTE + L I
Sbjct: 670 LLSERGDITPITPHKNFRLFGCMNPSTDVGKRELEPSFRSRFTEIYVHSPDQNLDDLLSI 729

Query: 858 TQSLDDSCSSGD--LVDKIVSFYKAAKKES-EERLQDGANQKPQYSLRSLYRAIEYTNKA 914
Q S G+ ++ ++ Y+ AK S + L DGA Q+P Y++R+L R + Y +
Sbjct: 730 IQKYIGSLCIGNEHVIREVAELYQVAKSLSLDGSLVDGAGQRPHYTVRTLSRTLSYVTEI 789

Query: 915 KRKFGFQKAIYDGFSMFFLTLLDVPSAKLMNQMILSKVLGG----------KIPPQVP-- 962
+G ++++Y+GF M FLTLLD S L+ ++ LG K P+VP
Sbjct: 790 APIYGLRRSLYEGFCMSFLTLLDHTSESLLYNHVVRFTLGELNRDQQNAILKQIPKVPDH 849

Query: 963 -----FDEYLMVRGSTISGDFLENYILTKSVREHLRNLARAVLIKRYPVLLQGPTSSGKT 1017
F Y + RGS + E+YI+T V+++L N+ARA + +P+L+QGPTSSGKT
Sbjct: 850 SSYIAFCHYWLRRGS-FPVEEQEHYIITPFVQKNLLNIARACSTRMFPILIQGPTSSGKT 908

Query: 1018 SLVQYLAAITGHEFVRINNHEHTDLQEYLGSYVTDASGKLVFHEGVLVKAVRNGYWIVLD 1077
S+++Y+A TGH+FVRINNHEHTDLQEY+G+YVTD +G L F EGVLV+A+RNGYWIVLD
Sbjct: 909 SMIEYVAKKTGHKFVRINNHEHTDLQEYIGTYVTDDNGSLSFREGVLVEALRNGYWIVLD 968

Query: 1078 ELNLAPSDVLEALNRLLDDNRELFVPELRETIPAHPDFMLFATQNPPTLYGGRKMLSRAF 1137
ELNLAP+DVLEALNRLLDDNRELF+PE + + HP+FMLFATQNPP +Y GRK LSRAF
Sbjct: 969 ELNLAPTDVLEALNRLLDDNRELFIPETQVLVKPHPEFMLFATQNPPGVYAGRKHLSRAF 1028

Query: 1138 RNRFVEIHVDEIPEDELSTILDKRCKIPESYAKKMVEVMKELELHRQSSKVFAGKHGFIT 1197
RNRF+EIH D+IPE+EL TIL KRCKI SYA K+V+V +EL L RQ++++F K+ F T
Sbjct: 1029 RNRFLEIHFDDIPENELETILHKRCKIAPSYAAKIVQVFRELSLRRQTTRIFEQKNSFAT 1088

Query: 1198 PRDLFRWADRFRTFGNSYEDLARDGYYLLAERLRDEGEKKVVQAVLEKHLRVKLVKDNLY 1257
RDLFRWA FR Y+ LA +GY LLAER RD+ +K VQ V+EK ++VK+ D +Y
Sbjct: 1089 LRDLFRWA--FRE-AVGYQQLAENGYMLLAERARDQKDKLAVQEVIEKVMKVKIDTDGIY 1145

Query: 1258 HQKLGVGDNVFSSGKHAWASESLGDIIWTKSMRRLYFLVERCYRLREPILLVGETGGGKT 1317
+ D++ + L ++WT+ M RL+ LV RC +EP+LLVG+TG GKT
Sbjct: 1146 NL-----DSMEIFQDMSLKEGPLSKVVWTRPMIRLFCLVWRCLLAKEPVLLVGDTGCGKT 1200

Query: 1318 TICQLLSAVLGLKLHILNCHQYTETSDFLGGFYPIRERSRLISEFKFLIEQLMMLKAFVD 1377
T+CQ+L+ L +LHI+N HQ TE D +G P+R RS +
Sbjct: 1201 TVCQILAECLHKELHIINAHQDTENGDIIGAQRPVRNRSAV------------------- 1241

Query: 1378 FPGDISISSDIG---HASQTLDQLDVIVNSYQQGITPWADVTRQDLDTFVRMKLDLAQLH 1434
+ S+ S + + ++LD +D ++ +++ + + +L + ++
Sbjct: 1242 ---NYSLHSQLCEKFNVQESLDSIDDLIEKFEKLSSSEKN---DNLSNLIERQI------ 1289

Query: 1435 QKWQTIFMWQDGPLVQAMKDGDLFLVDEISLADDSVLERLNSVLEPERKLALAEKGGSSL 1494
K++++F W DG LV AMK GD FL+DEISLADDSVLERLNSVLE R L L E +++
Sbjct: 1290 IKYRSLFEWHDGALVTAMKQGDFFLLDEISLADDSVLERLNSVLELSRTLTLVEHSNAAV 1349

Query: 1495 EIITAHPNFFLLATMNPGGDYGKKELSPALRNRFTEIWVPCVSDLDELRSIALQRFSNPK 1554
+TA F ATMNPGGDYGKKELSPALRNRFTEIWVP + D +++ I + N K
Sbjct: 1350 S-LTAKDGFAFFATMNPGGDYGKKELSPALRNRFTEIWVPPMVDTEDILKIVEGKLHNNK 1408

Query: 1555 ILWIVDPMLNFWEWF-NQLQTGRALTVRDLLSWVAFINVTEKSLQPDYAFLHGAFLVLLD 1613
I + P++ + +W N+ +++RD+LS V FIN E L + + +V +D
Sbjct: 1409 I-ELARPLVEYAKWHANEYLYTDVISIRDVLSAVEFINACE-ILDLNLVLFNAVSMVFID 1466

Query: 1614 GLSLGTGISKEDAGRLRENCLSFLVEQLKLADLCLV-VSELSRMENYSWGDLGTTADSSC 1672
L T S L N S E+ + C ++EL+ G+ +S
Sbjct: 1467 ALGSFTTFS------LSNNLASLHAERQR----CFAKLNELA----------GSNIMASK 1506

Query: 1673 SNNMQL---DNHFGIHPFYIEKGDQSCEIKGFEFLAPTTCKNAFRVLRAMQLAKPVLLEG 1729
S ++ + D+ F I F I GD + TT NA +VLRA+Q+ KP+LLEG
Sbjct: 1507 SADISIKFSDSSFFIGDFGIPLGDSVESDSTYSLHTDTTLMNASKVLRALQVLKPILLEG 1566

Query: 1730 SPGVGKTSLIVALGKFSGHPVVRINLSEQTDIMDLLGSDLPVESSEGIKFAWSDGILLQA 1789
SPGVGKTSLI AL + +GH +VRINLS+QTD+MDL GSD+PVE EG +FAW D L A
Sbjct: 1567 SPGVGKTSLITALARETGHQLVRINLSDQTDLMDLFGSDVPVEGGEGGQFAWRDAPFLAA 1626

Query: 1790 LKQGSWVLLDELNLAPQSVLEGLNAILDHRAEVFIPELGVTFKCPSSFRVFACQNPSSQG 1849
++ G WVLLDELNLA QSVLEGLNA LDHR E +IPEL FK +FRVFA QNP QG
Sbjct: 1627 MRNGHWVLLDELNLASQSVLEGLNACLDHRNEAYIPELDKVFKAHPNFRVFAAQNPQHQG 1686

Query: 1850 GGRKGLPRSFLNRFTKVYVDELVEDDYLFICSSLYPSIQRPILSKLILFNKRLHEDIMLN 1909
GGRKGLPRSF+NRF+ VYV+ L E D + I + Y + K+I F RL ++I +
Sbjct: 1687 GGRKGLPRSFINRFSVVYVEALKEKDMIEIAACNYHQVNEDWRLKIIKFMFRLQDNIEKD 1746

Query: 1910 HKFAQDGSPWEFNLRDVIRSCEIIEGAPEK--LKPDCFLNIVYVQRMRTAADRREVLRLY 1967
F GSPWEFNLRD +R +++ AP+ + P +L ++ + RMRT DR L+
Sbjct: 1747 ISFGSFGSPWEFNLRDTLRWLQLLNDAPKYTCVSPADYLEVMVLHRMRTVEDRVRTCELF 1806

Query: 1968 EQVFQVKPYINPYPRV---QLNHRYLVVGNTSIRRNHFQSSKISNSQLKILPGIRQSLEA 2024
++VF I+ PR L+ + VG++ + R+ + + +SQ IL LE+
Sbjct: 1807 KEVFD----IDYEPRTIGFSLSSQCFKVGHSLLVRDVERQKTLLDSQ-NILQSQLPVLES 1861

Query: 2025 VAHCVQRQWLCILVGPSSSGKTSLIRLLAHSTGNVLNELSLSSATDISELLGCFEQYNAF 2084
V C+ ++W CILVG +++GKT ++RLLA G + E++++S TD +L+G +EQ +
Sbjct: 1862 VITCINKKWPCILVGDTATGKTCILRLLAAIAGAKIKEMAVNSDTDTMDLIGEYEQIDIS 1921

Query: 2085 RNFRSVVGQVECYVNEYCSLQLESSMEAFISERRDMITGWLAVLSSMDCGPSSTSASTYM 2144
R + E F + ++ + + + ++ +
Sbjct: 1922 RK----------------------ASELFTDLSQQLLNIVIKYRNFDNIFRETSLYTLTT 1959

Query: 2145 EDWKCNRSSLCLLVEIIEHLRVDLEKNKLPVSWSCEDLNRTLKTILKLQEDQQKRTVAAK 2204
+K + + LL ++++ L D K + S D++ + +L + + A +
Sbjct: 1960 TSFKTHSQAFTLLQKVVDQL--DQLKIHETLVHSLGDIHEKARKLLA----EFSASPAGR 2013

Query: 2205 FEWVTGLLIKALENGEWIVLDNANLCNPTVLDRINSLVEPCGSITVNECGIVDGKPLVVH 2264
FEW G L+KA+E G W VLDNANLC+P VLDR+NSL+E G + VNE DG P +
Sbjct: 2014 FEWFDGYLLKAVEEGHWFVLDNANLCSPAVLDRLNSLLEHKGVLIVNEKTTEDGHPKTIK 2073

Query: 2265 PHPNFRMFLTVKPSHGDVSRAMRNRGVEIFMMQ 2297
PHPNFR+FLTV P +G++SRAMRNRGVEIF+++
Sbjct: 2074 PHPNFRLFLTVNPVYGELSRAMRNRGVEIFLLK 2106



Score = 319 bits (818), Expect = 3e-85, Method: Compositional matrix adjust.
Identities = 269/899 (29%), Positives = 451/899 (50%), Gaps = 99/899 (11%)

Query: 4329 LANVFASLYSEGFGTPTEDQIDDNSHDTSKDAKGTGMGEGVGLKDVSDQITDEDQLLGAS 4388
++ +F + + GF +P D + ++ + GTG+G GVG +D+++ + ++D L
Sbjct: 3880 ISTLFFMVANNGFCSP--DLPQEGKSNSGELESGTGLGSGVGAEDITNTLNEDDDL---- 3933

Query: 4389 EKPSEEQDVSDEVPSKNDKGIEMEQDFAADTFXXXXXXXXXXXXXXXXXQLDSAMGETGA 4448
E+ + E+D +++ + E+E D T LD + +
Sbjct: 3934 EELANEEDTANQSDLDESEARELESDMNGVTKDSVVSENENSDSEEENQDLDEEVNDIPE 3993

Query: 4449 D-SEIVDEKLWNKDADENANNTKEKYESGPSVTDKDASSRELRAKEXXXXXXXXEPGQLN 4507
D S ++EKLW++ +E+ T++K + ++ +L +KE + Q
Sbjct: 3994 DLSNSLNEKLWDEPNEEDLLETEQKSNEQSAANNES----DLVSKEDDNKALEDKDRQEK 4049

Query: 4508 QDESNEQNDEIGSQDDLGN--TEXXXXXXXXKEDAFADPSGLKLDET------NPMKEDL 4559
+DE E +D++G D++ E ED P LKLDE + ED+
Sbjct: 4050 EDEE-EMSDDVGIDDEIQPDIQENNSQPPPENEDHLDLPEDLKLDEKEGDVSKDSDLEDM 4108

Query: 4560 DMDEQEGADPMEEAHPEEHDEFTENGDGKEEDSNPADENLEEAESGQVDGNSERDDLGKG 4619
DM E AD +E E DE ++ + E++N DE++++ + + + E+ + G
Sbjct: 4109 DM---EAADENKEEADAEKDEPMQDFEDPLEENNTLDEDIQQDDFSDLAEDDEKMN-EDG 4164

Query: 4620 NEEKADMDLEAPRKDVLGPGNSDFISDHVPNAESA-TQPKDDMQA------ADSRNMAPE 4672
EE + E+ V + + VP ++ PK D ++ AD N
Sbjct: 4165 FEENVQENEESTEDGV--KSDEELEQGEVPEDQAIDNHPKMDAKSTFASAEADEENTDKG 4222

Query: 4673 TKWSNSSDIHNNLAPISGLPSNDTSEMEMMVADSSMDGKLTNDQPKTQLPQQDSSSIQKT 4732
N + A SG+ N T++ E A+ G+ T+ PK + + D
Sbjct: 4223 IVGENEELGEEDGAAESGVRGNGTADGEFSSAEQVQKGEDTS-TPKEAMSEADRQ----- 4276

Query: 4733 QANPYRNVGDALEEWKERARVSSDLQEDNTEAPENVEDENADEYGYVSEFEKGTAQALGP 4792
Y+++GD L EW++ R+ ED TE+ D++ E+ +V E E+ QALG
Sbjct: 4277 ----YQSLGDHLREWQQANRIHE--WEDLTESQSQAFDDS--EFMHVKEDEEEDLQALGN 4328

Query: 4793 ATFDQIDKNITQNEPDVDGVMAQKEHLTKENEKQNSETDPIKSSALNLKKRIEEQMQISD 4852
A DQI K+I D D Q E D + K++++ ISD
Sbjct: 4329 AEKDQI-KSI-----DRDESANQNPDSMNSTNIAEDEADEVGD------KQLQDGQDISD 4376

Query: 4853 SEVSPKEISPEVQSQGDGDPGSVSESLVSIKRSYLNEDIYQLSK-LSVSDELR----KAK 4907
+ + ++ P + GS+++S E +++LS+ + DEL K
Sbjct: 4377 IKQTGEDTLP-------TEFGSINQS----------EKVFELSEDEDIEDELPDYNVKIT 4419

Query: 4908 NLEEASSDMKDNAAALWRRYELLTTRLSQELAEQLRLVMEPTLASKLQGDYKTGKRINMK 4967
NL A D A LW ++E T +LS EL EQLRL++EPTLA+K+QGD++TGKR+NMK
Sbjct: 4420 NLPAAMP--IDEARDLWNKHEDSTKQLSIELCEQLRLILEPTLATKMQGDFRTGKRLNMK 4477

Query: 4968 KVIPYIASHYRKDKIWLRRTRPNKRDYQVVIAVDDSRSMSESCCGDVAIEALVTVCRAMS 5027
++IPYIAS ++KDKIW+RR +P+KR YQV+I++DDS+SMSES +A+E L V +A+S
Sbjct: 4478 RIIPYIASQFKKDKIWMRRVKPSKRTYQVMISIDDSKSMSESGSTVLALETLALVTKALS 4537

Query: 5028 QLEVGNLAVASYGKEGNIRLLHDFDQSFTGEAGIKMISNLTFKQENTIKDEPVVDLLKYL 5087
LEVG +AV +G++ LLH FD+ F+ E+G++M S+ TF+Q NT + D
Sbjct: 4538 LLEVGQIAVMKFGEQP--ELLHPFDKQFSSESGVQMFSHFTFEQSNT-NVLALADASMKC 4594

Query: 5088 NNMLDTAVANARLPSGQNPLQQLVLIIADGRFIEKENLKRCVRDVLSRKRMVAFLLLDS- 5146
N +TA + + ++QL +II+DG + +++++ +R K M+ F++LD+
Sbjct: 4595 FNYANTASHH----RSNSDIRQLEIIISDGICEDHDSIRKLLRRAQEEKVMIVFVILDNV 4650

Query: 5147 ---PQESIMDLQEVSF---QGGNM--KISKYLDSFPFPYYIILKNIEALPRTLADLLRQ 5197
+ SI+D+++V + + G M KI Y+D F F YY++++NIE LP+ L+ LRQ
Sbjct: 4651 NTQKKSSILDIKKVYYDTKEDGTMDLKIQPYIDEFAFDYYLVVRNIEELPQLLSSALRQ 4709



Score = 89.0 bits (219), Expect = 2e-15, Method: Compositional matrix adjust.
Identities = 71/274 (25%), Positives = 144/274 (52%), Gaps = 21/274 (7%)

Query: 3525 DSNASMMAKMVKLLTALQKRLLSLLNEWEDHPGLQKILGVIEMLLAIPSSTPLAKALSGL 3584
D N S ++ L+ ++ R +SL+ W ++ L+ + I+ +L + +P+A+ LS L
Sbjct: 3130 DPNPSKAIEVRDLIKIVESRAISLIKNWPENFVLRGLKDAIDAILNLSPFSPIAEYLSKL 3189

Query: 3585 QFLLNRIRILQENGSK-FSLSDQLEPIILLASLWKKIEFDSWPALLDEVQDQYEINGGKL 3643
+ + + + ++ S+ +SL+++++ I W+K E +W LL ++Y+++ ++
Sbjct: 3190 ERVFHLLSEWEKLASREYSLANEMDLIKKKIIDWRKFELSNWNNLLK--LEEYKLSE-RV 3246

Query: 3644 WFPLYSVLQHRQSDDIATYNQSTIQSLEE-------FIQTSSIGEFRKRLELLFAF-HGQ 3695
+ LYS+LQ ++ T Q+L E FI ++GEF+ L+ L +F
Sbjct: 3247 YPRLYSILQFIILKPFFENSKFTKQNLCESASIIVQFITDLTVGEFQLCLKCLLSFSQHA 3306

Query: 3696 ISTGISLGIYSSPFQMENLKILYNVFGYYVQFLPIALEHVQANRKNIETELKELLKLCRW 3755
S I GI + +L N++ Y+ QFL E + ++++E +KE + L W
Sbjct: 3307 ASLRICHGIDA---------MLLNIYHYFEQFLSKVSEAIHTQKQSLENSIKERILLMSW 3357

Query: 3756 EHSESYLSMENSKKTQQKLRKLIQKYTDLLQQPV 3789
+ + Y E++KK+ +L K++ +Y ++L+QPV
Sbjct: 3358 KDTNVYALKESAKKSHAELFKVLHRYREVLRQPV 3391



Score = 72.8 bits (177), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 56/164 (34%), Positives = 80/164 (48%), Gaps = 29/164 (17%)

Query: 1039 HTDLQEYLGSYVTDASGKLVFHEGVLVKAVRNGYWIVLDELNLAPSDVLEALNRLLDDNR 1098
H ++ L + +G+ + +G L+KAV G+W VLD NL VL+ LN LL+
Sbjct: 1996 HEKARKLLAEFSASPAGRFEWFDGYLLKAVEEGHWFVLDNANLCSPAVLDRLNSLLEHKG 2055

Query: 1099 ELFVPELR------ETIPAHPDFMLFATQNPPTLYGGRKMLSRAFRNRFVEIHVDEIPED 1152
L V E +TI HP+F LF T NP +YG LSRA RNR VEI + ++
Sbjct: 2056 VLIVNEKTTEDGHPKTIKPHPNFRLFLTVNP--VYGE---LSRAMRNRGVEIF---LLKE 2107

Query: 1153 ELSTILDKRCKIPE---------------SYAKKMVEVMKELEL 1181
L+ I K+ + E SY K + E M ++E+
Sbjct: 2108 ALTEIDKKQMSLLEPAPISSAVDTLASNISYIKYVFETMGKIEI 2151



Score = 56.2 bits (134), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 38/105 (36%), Positives = 57/105 (54%), Gaps = 11/105 (10%)

Query: 2205 FEWVTGLLIKALENGEWIVLDNANLCNPTVLDRINSLVEPCGS-ITVNECGIVDGKPLVV 2263
F +V G L+KA+ +G W++LD NL + L+ I L+ S I ++E G D P+
Sbjct: 625 FSFVEGALVKAVRSGHWVLLDEINLASLETLEPIGQLLSSYESGILLSERG--DITPIT- 681

Query: 2264 HPHPNFRMFLTVKPSHGDVSR-----AMRNRGVEIFMMQPYWPLD 2303
PH NFR+F + PS DV + + R+R EI++ P LD
Sbjct: 682 -PHKNFRLFGCMNPS-TDVGKRELEPSFRSRFTEIYVHSPDQNLD 724

Query: CNT0005101
Subject: sp|Q9NU22|MDN1_HUMAN Midasin OS=Homo sapiens GN=MDN1 PE=1 SV=2

SV=1

 Score =  924 bits (2387), Expect = 0.0,   Method: Compositional matrix adjust.
Identities = 642/1895 (33%), Positives = 994/1895 (52%), Gaps = 255/1895 (13%)

Query: 558 LTIGRVTLHRHQRVLRHQKKLFVEIRSSLHLLERIACSVKCNEPVLLVGETGTGKTTLVQ 617
L GRV+L ++ + LLE I+ +++ NEP+LLVG TG GKTT +Q
Sbjct: 308 LVCGRVSLPFYESPDERSLDDICRTNHTTRLLEIISSAIRNNEPLLLVGPTGIGKTTCLQ 367

Query: 618 TLAMRLGQKLTVLNLSQQSDVADLLGGFKPMDAQFVCIPLYKDFENLFSKTFSVKDNGEF 677
+A LG+KL V+N+S Q+D ADLLGG+ P + LY SV+ N F
Sbjct: 368 VIARALGKKLHVVNMSSQTDAADLLGGYVPATLDRILRNLYDAITGSLGLYISVRKNQIF 427

Query: 678 LARLQHHLSDK-------NWKMLMTGFKK-----------------GVDFFRKSAEIXXX 713
+ L ++K N + ++G ++ V +K A
Sbjct: 428 VTELHKSYAEKDIAKFLANCETALSGMRQVLRKEVGEVVEQGSTEQRVSHDKKYARRGTY 487

Query: 714 XXXXXXXXXLDETVLKAWEDFSV---KLDTSRGQIGASSGMLFQFVEGAFVTALRNGDWI 770
L +T+ +A E + +++T + M F++ EG V AL GDWI
Sbjct: 488 ENSLYFLQSLGDTLEQATELHKILCHEVETKK------PTMAFKYQEGLLVQALVKGDWI 541

Query: 771 LLDEVNLAPPETLQRVIGVLEDVNGSLCLAERGDASYIPRHPNFRLFACMNPATDAGKRD 830
L+DE+NLA + L + ++ + + + ++G ++ ++P+FR+FA MNP +D GK+D
Sbjct: 542 LIDEINLASYDLLDVISQLVNPEHNEIAIPDKG---FVAKNPHFRVFAAMNPGSDVGKKD 598

Query: 831 LPYSLRSRFTEYFXXXXXXXXXXTLFITQS---LDDSC---SSGDLVDKIVSFYKAAKKE 884
LP ++R FTE + +T+S +DD+ G + + + K
Sbjct: 599 LPPTIRRCFTE-INVSEMSDDVDIVALTKSYLRMDDAMIEDRQGLDPNVVYQLFTVLKAR 657

Query: 885 SEERLQDGANQK-PQYSLRSLYRAIEYTNKAKRKFGFQKAIYDGFSMFFLTLLDVPSAKL 943
++ L A K P +SLRSL RA+ + ++ + G ++++Y+GF + F ++L+ S +
Sbjct: 658 AKTDLVTAAEAKSPCFSLRSLCRALSFAHRFRAAAGLRRSMYEGFMLAFGSMLNEKSRQA 717

Query: 944 MNQMILSKVLGGK----IPPQV--PFDE--YLMVRGSTISGD--------------FLE- 980
++ +IL K+L G + P + PF++ M+ +T + FLE
Sbjct: 718 VHALILDKLLNGNKEYLLNPFIIQPFNKPCTAMIFQATTKDEAVTVEYQEPQAAHGFLEE 777

Query: 981 --------NYILTKSVREHLRNLARAVLIKRYPVLLQGPTSSGKTSLVQYLAAITGHEFV 1032
+Y+LTKS R ++ ++RA+ + P+LL+G TSSGKTSL++++A G
Sbjct: 778 EKSRARSTDYVLTKSTRSYMTTISRAI-AAQLPILLEGTTSSGKTSLIKHIAKQFGCPIT 836

Query: 1033 RINNHEHTDLQEYLGSYVTDA-SGKLVFHEGVLVKAVRNGYWIVLDELNLAPSDVLEALN 1091
RINNHEHTDL EY GSY D +G+LVF +G LV ++ G+W++LDELN+A S++LEALN
Sbjct: 837 RINNHEHTDLSEYFGSYQPDPLTGQLVFKDGPLVTGMKQGHWVILDELNMASSEILEALN 896

Query: 1092 RLLDDNRELFVPELRETIPAHPDFMLFATQNPPTLYGGRKMLSRAFRNRFVEIHVDEIPE 1151
RLLDDNREL VP+ +E + P F+LFATQNP Y GRKMLS AF+NRF+ I +I
Sbjct: 897 RLLDDNRELLVPDTQEIVRPAPGFLLFATQNPSGSYAGRKMLSEAFQNRFIMIEFADIST 956

Query: 1152 DELSTILDKRCK---IPESYAKKMVEVMKELEL---HRQSSKVFAGKHGFITPRDLFRWA 1205
+EL IL R + Y +K++ ++ +++ HR ++ V + IT RDLFR A
Sbjct: 957 EELKEILINRSTSRHLAPQYCEKLITTIQAIKMQLSHRNNNAVMT--NALITLRDLFRVA 1014

Query: 1206 DRF-RTFGNSYEDLARDGYYLLAERLRDEGEKKVVQAVLEKHLRVKLVKDNLYHQKLGVG 1264
DR RT +LA + L+ ER RD +K++V ++ K+L +K + Q+ +
Sbjct: 1015 DRLPRTL----TELAMGIFELIGERQRDPADKQLVAEIIAKNLGLKTFSVSAAEQEYAIR 1070

Query: 1265 --------DNVFSSGKHAWASESL---GDIIWTKSMRRLYFLVERCYRLREPILLVGETG 1313
+ +G + S L DI+WT SM RL+ L+ E LLVG +G
Sbjct: 1071 VRPIQSMIEKALKAGADSPKSAFLLKFQDIVWTPSMIRLFALLFTSVSNGESPLLVGVSG 1130

Query: 1314 GGKTTICQLLSAVLGLKLHILNCHQYTETSDFLGGFYPIRERSRLISEFKFLIEQLMMLK 1373
GKTT +L++A++ +L +N H++TE++DF+G P+R R + + L E
Sbjct: 1131 AGKTTSVELIAAIMAQQLVQVNLHKHTESADFIGSLRPLRSRESMHAHLSVLKEY----- 1185

Query: 1374 AFVDFPGDISISSDIGHASQTLDQLDVIVNSYQQGITPWADVTRQDLDTFVRMKLDLAQL 1433
+ T +D V +A++ R L+T + KL
Sbjct: 1186 ------------------AATTTNVDKAV---------YAEIKR--LETTLGTKL----- 1211

Query: 1434 HQKWQTIFMWQDGPLVQAMKDGDLFLVDEISLADDSVLERLNSVLEPERKLALAEKGGSS 1493
F W+DGP++ MK G + L+DE+SLAD+SVLERLNSVLE R+L +AE
Sbjct: 1212 -------FEWEDGPILNCMKRGHILLLDEVSLADESVLERLNSVLETSRELTVAENPNMP 1264

Query: 1494 LEIITAHPNFFLLATMNPGGDYGKKELSPALRNRFTEIWVPCVSDLDELRSI-------- 1545
+I AH F L+ATMNP GDYGKKELSPA+R+R TE W+P + D++E+R I
Sbjct: 1265 RPVI-AHTGFKLIATMNPAGDYGKKELSPAMRSRLTEFWMPHIRDINEVRMILTRKLQKT 1323

Query: 1546 ALQRFSNPKILWIVDPMLNFWEWFNQL-QTGR-----ALTVRDLLSWVAFIN--VTEKSL 1597
A+ R + + L +V + +F+ +++ Q+GR L++RD+L+ +I T++
Sbjct: 1324 AIYRLGHQQGLDVVSLLADFFAEMDRITQSGRLGDVFTLSIRDILAVCDYITEVQTKEGT 1383

Query: 1598 QPDYAFLHGAFLVLLDGLSLGTGISKEDAGR-LRENCLSFLVEQLKLADLC-------LV 1649
+ + L +LDGL + T + A R ++ + +L ++ A+L L
Sbjct: 1384 ELGQMLIDAVTLSILDGLPVRTQLGNMPACREVKHEMVLYLANRILSANLTDIDLIQDLT 1443

Query: 1650 VS------ELSRMENYSWGDLGTTADSSCSNNMQLDNHFGIHPFYIEKGDQSCEIKGFEF 1703
VS EL+ ++ + L T N H + K + F
Sbjct: 1444 VSISKDTNELTFLQASTQTVLATIPPGPQYN----------HAKALRK------MTSFRL 1487

Query: 1704 LAPTTCKNAFRVLRAMQLAKPVLLEGSPGVGKTSLIVALGKFSGHPVVRINLSEQTDIMD 1763
APTT KNA R+ +A++ +P+LLEG PGVGK++L+ A+ + G+ +VRINLSEQTD+ D
Sbjct: 1488 DAPTTIKNACRIAKALRFQRPILLEGDPGVGKSALVSAIAEICGYSLVRINLSEQTDLSD 1547

Query: 1764 LLGSDLPVESSEGIKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDHRAEVF 1823
LLGSDLP E+ F W DG+LL+A+K+G+++LLDELNLA Q+VLEGLN++LDHR +F
Sbjct: 1548 LLGSDLPAENG----FRWVDGVLLKAVKEGAFILLDELNLANQTVLEGLNSLLDHRRSLF 1603

Query: 1824 IPELGVTFKCPSSFRVFACQNPSSQGGGRKGLPRSFLNRFTKVYVDELVEDDYLFICSSL 1883
IPEL ++ K P + R+F QNP SQG GRKGLP+SF+NRF VYVD L DY +I S+L
Sbjct: 1604 IPELMLSVKSPDTLRIFGTQNPRSQGSGRKGLPQSFINRFLNVYVDVLKSQDYDWILSNL 1663

Query: 1884 YPSIQRPILSKLILFNKRLHEDIMLNHKFAQDGSPWEFNLRDVIRSCEIIEGAPEKLK-- 1941
+ I +L ++ K+L + KF G PWE N+RD++R C+++ P +
Sbjct: 1664 FTDIPTYVLDYILGSTKQLRAGLE-ELKFGISGGPWELNVRDMMRLCDMLTTTPGLAQGI 1722

Query: 1942 ----PDCFLNIVYVQRMRTAADRREV---------LRLYEQVFQVKPYINPYPRVQLNHR 1988
+ +I++ R RTA D V L + Q + + P +
Sbjct: 1723 TLAHAKHYAHILFGYRFRTADDDAYVQNVLFSPHSLDSVAEATQSHHWYSLRPLWNVTED 1782

Query: 1989 YLVVGNTSIRR-----NHFQSSKISNSQLK-ILPGIRQSLEAVAHCVQRQWLCILVGPSS 2042
+ +G+ +I R +K+S + L +LEA+A V + CILVG
Sbjct: 1783 VVKIGSLAIPRIDPVFRDVLGTKLSYAHTSCFLTAQLVALEALAVAVTQNLSCILVGSPE 1842

Query: 2043 SGKTSLIRLLAHSTGNVLNELSLSSATDISELLGCFEQYNAFRNFRSVVGQVECYVNEYC 2102
SGK+S++R LA L +S S+ATD+S+L+G +EQ + + +SV+ + +V+
Sbjct: 1843 SGKSSILRTLADVVRQPLVHISASTATDVSDLIGAYEQVDVLYDLKSVIRDLCLFVH--- 1899

Query: 2103 SLQLESSMEAF-ISERRDMITGWLAVLSSMDCGPSSTSASTYMEDWKCNRSSLCLLVEII 2161
SL +++S A SE +T L + G S S + ME + LL+E +
Sbjct: 1900 SLPIKASYSAISFSEFLKDLTASLD--REIGDGLGSKSRAISMESI-VSEVVQKLLLEFM 1956

Query: 2162 EHLRVDLEKNKLPV---SWSC------------EDLNRTLKTILKLQED--------QQK 2198
DL+ L S C E + + TI +L + QQ
Sbjct: 1957 AKFSPDLDSGGLAAKNFSLFCSEILTQDTTPVDERFSPHMPTIPELCKSMASLYLSTQQS 2016

Query: 2199 RTVAAKFEWVTGLLIKALENGEWIVLDNANLCNPTVLDRINSLVEPCGSITVNECGIVDG 2258
+T +F W LI+ALE G W+ L NAN C P+VLDR+NSL+E G + + E G+ +
Sbjct: 2017 QT--GRFVWRDSELIRALERGYWVELTNANFCMPSVLDRLNSLLERGGGLEILEQGLEET 2074

Query: 2259 KPLVVHPHPNFRMFLTVKPSHGDVSRAMRNRGVEI 2293
+ + V HPNFR+F++ P+ D+SRA+RNR +E+
Sbjct: 2075 RSIKV--HPNFRLFISYAPT-SDISRALRNRSLEL 2106



Score = 211 bits (537), Expect = 2e-52, Method: Compositional matrix adjust.
Identities = 257/1020 (25%), Positives = 443/1020 (43%), Gaps = 174/1020 (17%)

Query: 4237 EGRSELSPCDENHSELEAGFSGAFERTLKHIMDAFQKLGPLNNTCALSEWSSDNITSWKV 4296
EG S D ++ A + F TL+ I+ CA S + K+
Sbjct: 3941 EGLSVEIIVDNAKKQVSAYMTAFFTSTLQPILQ-----------CATRHVVSLPVLPQKL 3989

Query: 4297 LFESYVMNLQLDSICDELHKTIFYAVSMMTHVLANVFASLYSEGFGTPTEDQIDDNSHDT 4356
L + + + ++ D L K I +S +L F +DD+ +T
Sbjct: 3990 LCQIETLKGDMQALADVLAKFIGPLISGAIALLRTGFHC------------HVDDDQKET 4037

Query: 4357 SKDAKGTGMGEGVGL-----KDVSDQITDEDQLLGASEKPSEEQDVSDEVPSKNDKGIEM 4411
D + K+ + ++ ++D + +++ +EQ D +D+ IEM
Sbjct: 4038 DNDNQSGLGLGDGTGDQNVSKEAAKELCEDDLMGNQNDRDQQEQQEKD----GDDEAIEM 4093

Query: 4412 EQDFAADTFXXXXXXXXXXXXXXXXXQ-LDSAMGETGADSEIVDEKLWNKDADENANNTK 4470
+ DF + + L+ MG+ E +DE+ +N+D D +
Sbjct: 4094 QNDFGGMSESLHHDIEEEDSNGSDEEEVLEKEMGD--EQGEAIDERNYNEDDDSAEEYSD 4151

Query: 4471 EKYESGPSVTDKDASSRELRAKEXXXXXXXXEPGQLNQDESNEQNDEIGSQDDLGNTEXX 4530
E+ ++ + D + EL A+E E + ++ EQ D GS D+
Sbjct: 4152 EQKKNTNNNND----TMELAAQEKDQDSINSELSDPSGEQHEEQADATGSTDE------- 4200

Query: 4531 XXXXXXKEDAFADPSGLKLDETN-PMKEDLDMDEQEGADPMEEAHPEEHDEFTENGDGKE 4589
+ED + D LD+ N + DL + E +G D EE + + +
Sbjct: 4201 ----QAQEDDYND-----LDDKNLSGQSDLSVPEADGEDETVNEELEEEQQQMSDLSNPD 4251

Query: 4590 EDSNPADENLEEAESGQVDGNSERDDLGKGNEEKADMDLEAPRKDVLGPGNSDFISDHVP 4649
+D+ +E+ ++ + D N+E D E +A +D I D+
Sbjct: 4252 QDACAIEED-DDRDLPSSDENAEEHD-----EHEAPVD----------------IDDNEA 4289

Query: 4650 NAESATQPKDDMQAADSRNMAPETKWSNSSDIHNNLAPISGLPSNDTSEMEMMVADSSMD 4709
+ E +T +D D+ N++ + + +N + DT + + DS+ D
Sbjct: 4290 SDEQSTYNDNDRD--DAINISAQQQATNDEEEMQK----------DTEYDQENITDSNPD 4337

Query: 4710 GKL--TNDQPKT-----QLPQQ------DSSSIQKTQA-----------NPYRNVGDALE 4745
TNDQ +T Q Q+ ++ S + +Q NP ++ +
Sbjct: 4338 ANEVGTNDQKQTHEDNDQFRQENIEDQWEAESTENSQGEGAESADLKEGNPDMSLEEFQR 4397

Query: 4746 EWKERARVSS-DLQEDNTEAPENVEDENADEYGYVSEFEKGTAQALGPATFDQIDKNITQ 4804
WKER + + ++D P+++ ++ + + + G ALG + +N+T
Sbjct: 4398 IWKERLNIHDRESEKDEAAEPQDMPLQSNKTVEF-DDSKSGRDGALGLT--ESKHRNLTN 4454

Query: 4805 NEPDVDGVMAQKEHLTKENEKQNSETDPIKSSALNLKKRIEEQMQISDSEVSPKEISPEV 4864
E D NE++N E + SS E Q S + ++PE+
Sbjct: 4455 QEFD------------NPNEERNVEHN---SSC--------ETSQSSHDRPPAEHLNPEI 4491

Query: 4865 QSQGDGDPGSVSESLVSIKRSYLNEDIYQL--SKLSVSDELRKAKNLEEASSDMKDNAAA 4922
+G+ + + S+ S++ E L + V EL + EE +D AAA
Sbjct: 4492 SDEGE-ESSTASDKQEQAVLSHMRESSKDLLNPEGEVYQELAVSLASEETKRAPEDVAAA 4550

Query: 4923 LWRRYELLTTRLSQ------ELAEQLRLVMEPTLASKLQGDYKTGKRINMKKVIPYIASH 4976
R LL + Q LAE+LR+++EPT+ S L+GD++TGK++N++++IP+IAS
Sbjct: 4551 SARGNHLLLDLIKQTSAAAFSLAERLRIILEPTVTSDLKGDFRTGKKLNLRRIIPFIASE 4610

Query: 4977 YRKDKIWLRRTRPNKRDYQVVIAVDDSRSMSESCCGDVAIEALVTVCRAMSQLEVGNLAV 5036
++KDKIWLRRT+P+KR YQV++AVDDS SM+ A++A+ + A LEVG L+V
Sbjct: 4611 FQKDKIWLRRTKPSKRVYQVLLAVDDSSSMAP--IAKYALQAITLLFNACKFLEVGQLSV 4668

Query: 5037 ASYGKEGNIRLLHDFDQSFTGEAGIKMISNLTFKQENTIKDEPVVDLLKYLNNMLDTAVA 5096
S+G++ LL + + I + TF Q T V D + ++ LD+
Sbjct: 4669 FSFGQK--FELLLPITDQYNDASLAYAIGSFTFAQNET----RVSDAISIASDYLDS--- 4719

Query: 5097 NARLPSGQNPLQQLVLIIADGRFIEKENLKRCVRDVLSRKRMVAFLLLDSPQESIMDLQE 5156
R G + QL+L+I+DGR EK + R +R + R ++ ++LD+ ++SIMD++
Sbjct: 4720 -VRFFKGSDSALQLLLMISDGRLKEKGGVAREIRKCMGRGQLPVLIVLDTDKKSIMDIKS 4778

Query: 5157 VSF----QGGNMK-ISKYLDSFPFPYYIILKNIEALPRTLADLLRQVVGVLGNWSESLKV 5211
VSF G ++ S YLD FPF Y +L++IE LP TL V V+ W ES+ V
Sbjct: 4779 VSFITDSSGKRVRQTSMYLDDFPFQCYALLRHIEDLPETL-------VAVIKRWIESVSV 4831



Score = 103 bits (257), Expect = 5e-20, Method: Compositional matrix adjust.
Identities = 102/400 (25%), Positives = 178/400 (44%), Gaps = 63/400 (15%)

Query: 996 ARAVLIKRYPVLLQGPTSSGKTSLVQYLAAITGHEF-VRINNHEHTDLQEYLGSYV-TDA 1053
A +++ VLL GP++SG+T+L+ +LA+ G + + ++ D ++ +GSYV T+
Sbjct: 17 AESIVSSGQAVLLCGPSASGRTALLSHLASKLGAKPPIPLHLTTAQDTRDLIGSYVMTNK 76

Query: 1054 SGKLVFHEGVLVKAVRNGYWIVLDELNLAPSDVLEALNRLLDDNRELFVPELRETIPAHP 1113
G F G L A ++G WI ++E+ D L L+ +++ R L V + I HP
Sbjct: 77 PGDFRFILGPLAYAAQSGRWISIEEITTISQDSLLLLSSVVN-TRTLSVGSYQ--ISVHP 133

Query: 1114 DFMLFA-TQNPPTLYGGRKMLSRAFRNRFVEIHVDEIPEDELSTILDKRCKIPESYAKKM 1172
DF + A T P L LS ++ F + + + + L +L K C + +
Sbjct: 134 DFRIHAKTSADPAL------LSTIVKSMFYPLVLPPLG-NHLFQVLTKHCN------RGI 180

Query: 1173 VEVMKELELHRQSSKVFAGKHGFITPRDLFRWADR----FRTFG---------------- 1212
++ + + ++ ++ AG+ I+ D+ +WA R + G
Sbjct: 181 CTILAHIHVQFETHRLTAGR---ISASDMVKWARRIDLDLKNGGAVLNKAVQEASAGTAA 237

Query: 1213 ---------NSYEDLARDGYYLLAERLRDEGEKKVV------------QAVLEKHLRVKL 1251
N+ + ++ + R E ++ + +L L++K+
Sbjct: 238 TTLVSWLDDNTRMVMIKNAWEAFVLRYSKEQTRRAFLDILRLSLNIHEELMLSTLLKIKV 297

Query: 1252 VKDNLYHQKLGVGDNVFSSGKHAWASESLGDIIWTKSMRRLYFLVERCYRLREPILLVGE 1311
+ Y QK V V + SL DI T RL ++ R EP+LLVG
Sbjct: 298 DIRHDYTQKRLVCGRVSLPFYESPDERSLDDICRTNHTTRLLEIISSAIRNNEPLLLVGP 357

Query: 1312 TGGGKTTICQLLSAVLGLKLHILNCHQYTETSDFLGGFYP 1351
TG GKTT Q+++ LG KLH++N T+ +D LGG+ P
Sbjct: 358 TGIGKTTCLQVIARALGKKLHVVNMSSQTDAADLLGGYVP 397



Score = 72.4 bits (176), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 60/268 (22%), Positives = 117/268 (43%), Gaps = 18/268 (6%)

Query: 3537 LLTALQKRLLSLLNEWEDHPGLQKILGVIEMLLAIPS-STPLAKALSGLQFLLNRIRILQ 3595
LL + R LL EW D+ L I+ V + L+ +P PL L+G + L+ +
Sbjct: 3309 LLRKIIVRTQHLLTEWPDNVQLLDIMHVCDKLMELPVLEAPLVMFLTGAEVLVRHLETWD 3368

Query: 3596 ENGS---KFSLSDQL-------EPIILLASLWKKIEFDSWPALLDEVQDQYEINGGKLWF 3645
+ K+ + + + +I L W+++E SW V Q+ N ++
Sbjct: 3369 KGAPAVYKYVTNPNVPVPESLTKSLIHLMVTWRRVELMSWNGFFSRVHTQFS-NVSLTYW 3427

Query: 3646 P---LYSVLQHRQSDDIATYNQSTIQSLEEFIQTSSIGEFRKRLELLFAFHGQISTGISL 3702
P + S+ R ++ + EF+ S++GEF RL+LL+ +S L
Sbjct: 3428 PELLIASLTYQRSVTQGEPSTEAYYAQMREFLYESNVGEFPVRLKLLYTLSALLSNIEEL 3487

Query: 3703 G---IYSSPFQMENLKILYNVFGYYVQFLPIALEHVQANRKNIETELKELLKLCRWEHSE 3759
+ SSP + +L+++ V+F + + I+ ++ +++ W
Sbjct: 3488 AEPELVSSPHKTMTSAVLFSIASEAVEFAKYMNKEFEEEAAQIKKRFEDQIRIFEWNERS 3547

Query: 3760 SYLSMENSKKTQQKLRKLIQKYTDLLQQ 3787
SY S ++ + + K+I++YT++LQ
Sbjct: 3548 SYTSWLTAQNSHRLCTKIIREYTEVLQH 3575



Score = 66.6 bits (161), Expect = 8e-09, Method: Compositional matrix adjust.
Identities = 36/88 (40%), Positives = 49/88 (55%), Gaps = 1/88 (1%)

Query: 366 VSQKWPVLLYGPAGVGKTALISKLARDSGNQV-LSIHMDDQIDGKTLIGSYVCMERPGEF 424
VS VLL GP+ G+TAL+S LA G + + +H+ D + LIGSYV +PG+F
Sbjct: 21 VSSGQAVLLCGPSASGRTALLSHLASKLGAKPPIPLHLTTAQDTRDLIGSYVMTNKPGDF 80

Query: 425 RWQPGSLTQAAMNGFWVVFEGIDKAPSD 452
R+ G L AA +G W+ E I D
Sbjct: 81 RFILGPLAYAAQSGRWISIEEITTISQD 108



Score = 57.0 bits (136), Expect = 8e-06, Method: Compositional matrix adjust.
Identities = 35/98 (35%), Positives = 52/98 (53%), Gaps = 10/98 (10%)

Query: 1054 SGKLVFHEGVLVKAVRNGYWIVLDELNLAPSDVLEALNRLLDDNRELFVPE--LRET--I 1109
+G+ V+ + L++A+ GYW+ L N VL+ LN LL+ L + E L ET I
Sbjct: 2018 TGRFVWRDSELIRALERGYWVELTNANFCMPSVLDRLNSLLERGGGLEILEQGLEETRSI 2077

Query: 1110 PAHPDFMLFATQNPPTLYGGRKMLSRAFRNRFVEIHVD 1147
HP+F LF + Y +SRA RNR +E+ +D
Sbjct: 2078 KVHPNFRLFIS------YAPTSDISRALRNRSLELSID 2109



Score = 54.3 bits (129), Expect = 4e-05, Method: Compositional matrix adjust.
Identities = 32/113 (28%), Positives = 54/113 (47%)

Query: 350 VLTLSLKKSYEMVLLAVSQKWPVLLYGPAGVGKTALISKLARDSGNQVLSIHMDDQIDGK 409
VLT S + + A++ + P+LL G GKT+LI +A+ G + I+ + D
Sbjct: 788 VLTKSTRSYMTTISRAIAAQLPILLEGTTSSGKTSLIKHIAKQFGCPITRINNHEHTDLS 847

Query: 410 TLIGSYVCMERPGEFRWQPGSLTQAAMNGFWVVFEGIDKAPSDVQSILLPLLE 462
GSY G+ ++ G L G WV+ + ++ A S++ L LL+
Sbjct: 848 EYFGSYQPDPLTGQLVFKDGPLVTGMKQGHWVILDELNMASSEILEALNRLLD 900



Score = 53.5 bits (127), Expect = 9e-05, Method: Compositional matrix adjust.
Identities = 33/94 (35%), Positives = 52/94 (55%), Gaps = 6/94 (6%)

Query: 371 PVLLYGPAGVGKTALISKLARDSGNQVLSIHMDDQIDGKTLIGSYVCMERPGE--FRWQP 428
P+LL G GVGK+AL+S +A G ++ I++ +Q D L+GS + P E FRW
Sbjct: 1508 PILLEGDPGVGKSALVSAIAEICGYSLVRINLSEQTDLSDLLGS----DLPAENGFRWVD 1563

Query: 429 GSLTQAAMNGFWVVFEGIDKAPSDVQSILLPLLE 462
G L +A G +++ + ++ A V L LL+
Sbjct: 1564 GVLLKAVKEGAFILLDELNLANQTVLEGLNSLLD 1597



Score = 53.1 bits (126), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 32/96 (33%), Positives = 53/96 (55%), Gaps = 9/96 (9%)

Query: 2205 FEWVTGLLIKALENGEWIVLDNANLCNPTVLDRINSLVEPCGSITVNECGIVDGKPLVVH 2264
FEW G ++ ++ G ++LD +L + +VL+R+NS++E +TV E P V
Sbjct: 1212 FEWEDGPILNCMKRGHILLLDEVSLADESVLERLNSVLETSRELTVAEN---PNMPRPVI 1268

Query: 2265 PHPNFRMFLTVKPSHGD-----VSRAMRNRGVEIFM 2295
H F++ T+ P+ GD +S AMR+R E +M
Sbjct: 1269 AHTGFKLIATMNPA-GDYGKKELSPAMRSRLTEFWM 1303

Query: CNT0005101
Subject: sp|Q96H78|S2544_HUMAN Solute carrier family 25 member 44 OS=Homo

OS=Dictyostelium discoideum GN=mcfJ PE=2 SV=1

 Score =  108 bits (270), Expect = 7e-23,   Method: Compositional matrix adjust.
Identities = 92/363 (25%), Positives = 150/363 (41%), Gaps = 48/363 (13%)

Query: 5224 AQEIHLPAD--IDWEMLDKSKFFFLGAALFSGVSATLYPVVVLKTRQQIAQSQVSSIRTA 5281
+E+H + I W+ LD +++F L + ++P+ V++TR Q+ SQ ++ +
Sbjct: 10 TKEVHTKTNKRIQWDDLDPKRYYFYNFLLGGSIDLLMFPLDVIRTRLQVQGSQ--NVIQS 67

Query: 5282 F-----------SIVRHEGFRALYRGFGTSLMGTIPARALYMTALEVTKSNVGTATVRLG 5330
F ++R EG RALY+GF TS G + +RA+Y + E K ++
Sbjct: 68 FPQYNGTFDGFKKLIRLEGKRALYKGFLTSECGYLCSRAIYFGSYEFVKQGF----LKGR 123

Query: 5331 FPEPTXXXXXXXXXXXXXXXXXQLVWTPIDVVSQRLMVQXXXXXXXXXXXXXXEKLKIPN 5390
+ ++W P DV +Q + +Q +
Sbjct: 124 SDSDSDLLFVTTISGAISEALASVIWVPFDVATQSVQIQG-------------------S 164

Query: 5391 ASSCKYLGGIDAFRKILNTDGPRGLYRGFGISILTYAPSNAVWWASYSVAQ-RLIWSGIG 5449
S KY GG D F+KI G +GLY+GFG +I+ P + +WW +Y +++ +L I
Sbjct: 165 LSKPKYKGGSDVFKKIYGERGIKGLYKGFGATIIRNVPYSGIWWGTYEISKSKLTQFNIR 224

Query: 5450 VYLCKKDDETGENGVST----FRPDSKTXXXXXXXXXXXXXXXXXL---ITMPLDTIKTR 5502
L K+ + VS P + IT PLD KTR
Sbjct: 225 QKLGLKERSSHSLAVSAEIDKNNPSHEVENEDPIIHFISGFFAAVFATSITNPLDVAKTR 284

Query: 5503 LQVLDGEENGRRGPTIGQTVRNLVREGGWMACYRGLGPRWXXXXXXXXXXXXXYEFLKRL 5562
LQ EN + P +++ +R+ G A ++GL P YE +K+L
Sbjct: 285 LQTGVFPENEK--PNFYTIIKSTIRKEGIRALWKGLVPSLLTSTPYSMISIFLYEEVKKL 342

Query: 5563 SAK 5565
S K
Sbjct: 343 SLK 345