Query: CNT0005102
Subject: sp|Q9NU22|MDN1_HUMAN Midasin OS=Homo sapiens GN=MDN1 PE=1 SV=2

SV=2

 Score =  465 bits (1196), Expect = e-129,   Method: Compositional matrix adjust.
Identities = 273/752 (36%), Positives = 398/752 (52%), Gaps = 129/752 (17%)

Query: 9 CSLRSLTDIMDLLGSDLPVESSEGIKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGL 68
+L TDIMDLLGSDLPVE G +F W DG+ L+AL+ GSWVLLDELNLA Q+VLEGL
Sbjct: 1876 INLSEQTDIMDLLGSDLPVEGGTGGQFEWRDGVFLEALRNGSWVLLDELNLASQTVLEGL 1935

Query: 69 NAILDHRAEVFIPELGVTFKCPSSFRVFACQNPSSQGGGRKGLPRSFLNRFTKVYVDELV 128
N+ LDHR+EV+IPELG TF C +FRVFACQNP QGGGRKGLP+SFLNRFT+V++D+L
Sbjct: 1936 NSCLDHRSEVYIPELGKTFACHPNFRVFACQNPLHQGGGRKGLPKSFLNRFTQVFIDQLN 1995

Query: 129 EDDYLFICSSLYPSIQRPILSKLILFNKRLHEDIMLNHKFAQDGSPWEFNLRDVIRSCEI 188
+ D LFI +++YP+I + ++I FN ++ ++ M+ HKFA+ G+PWEFNLRD R C++
Sbjct: 1996 QQDLLFISTAMYPTIPSKTIERMIEFNHQMFKESMIEHKFARKGAPWEFNLRDTFRWCDL 2055

Query: 189 IEGAPEKL-KPDCFLNIVYVQRMRTAADRREVLRLYEQVF-------------------- 227
I P + P F++++Y+QRMRT DR VL ++++VF
Sbjct: 2056 IVKDPTSISNPARFIDLIYLQRMRTLQDREHVLTIFKRVFTTSGDENDQSIDMMPTICNY 2115

Query: 228 ------QVKPQL-----KILPGIRQS-------------------------LEAVAHCVQ 251
+ P+ ILP ++ LE + C++
Sbjct: 2116 DKQPHYSISPEYLQIGSSILPRVQNGGASSFDSSVLDNSSNIQLLQRLLNPLENIMKCIE 2175

Query: 252 RQWLCILVGPSSSGKTSLIRLLAHSTGNVLNELSLSSATDISELLGCFEQYNAFRNFRSV 311
W+ IL+GP+S+ KTS IRLLA TGN L E S++S+ D +E+LG FEQ + R + +
Sbjct: 2176 MNWMSILIGPTSTSKTSSIRLLAQLTGNTLYEFSMNSSVDTTEILGGFEQIDLVRYQKRI 2235

Query: 312 VDMITGWLAVLSSMDCGPSSTSASTYMED-----------WKCNRSS------------- 347
+ ++ + ++SS +++ M+ W +
Sbjct: 2236 ISSVSSLITIVSSHIMTYFNSNDDNLMKTCISSIQDIHQVWNLFKKQTQQTQQQIQQDGA 2295

Query: 348 -----------------LCLLVEIIEHLRV--DLEKNKLPVSWSCEDLNRTLKTILKLQE 388
L +V+ +E L + +L+ N+ E LNR ++Q
Sbjct: 2296 TIGSGGVGLITIEQLDLLSTIVDALEKLSIQFNLDNNQ-------EHLNRIQDVRQQIQR 2348

Query: 389 DQ--QKRTVAAKFEWVTGLLIKALENGEWIVLDNANLCNPTVLDRINSLVEPCGSITVNE 446
+ +K +V FEW+ GLLIKALE G WI++DN N CNPTVLDR+N L+E G + +NE
Sbjct: 2349 IKSIEKESVTGCFEWIDGLLIKALETGAWILIDNVNFCNPTVLDRLNPLLEQDGVLMLNE 2408

Query: 447 CGIVDGKPLVVHPHPNFRMFLTVKPSHGDVSRAMRNRGVEIFMMQPYWPLDQESDYYFEE 506
G+VDG+ VV PHPNFR+FLT+ G++SRAMRNRG+EI+M L + F
Sbjct: 2409 RGMVDGQVKVVKPHPNFRIFLTMDDKKGEISRAMRNRGIEIYMAADQLSLMETPSNNF-- 2466

Query: 507 LELKDVKRFLVLSDIPGEKLVEAMAKAH--IYARDEGLGLNVHITYLELARWVQLFLQLL 564
D ++ L IP E L M H I+ + N T +L W +L L L
Sbjct: 2467 ----DNQQLLTALGIPLESLTRTMIDFHNQIFTQLSSTIEN-PCTLSQLLYWGKLILDQL 2521

Query: 565 MNGNQPLWSLQISWEHTYLSSLGEIEGEYIIAHARTSYLSAVEFSEFDSSLGCSLC---- 620
G L S++ S E Y+ + ++ + S + +S++ LC
Sbjct: 2522 QRGFSLLNSIRNSMEQIYIRPRRHLTQRQLVTNIFNSIFN-------ESAIKSILCEDQT 2574

Query: 621 LPGGWPRPLRIRDLVYHSREVGVKQNCMYLEF 652
+ G +P ++ +D V S +K N + E+
Sbjct: 2575 VLGIYPHFIKGKDYVTDSISTTMKMNYQFFEY 2606



Score = 264 bits (675), Expect = 9e-69, Method: Compositional matrix adjust.
Identities = 134/316 (42%), Positives = 205/316 (64%), Gaps = 16/316 (5%)

Query: 3256 NEDIYQLSKLSVSDELRKAKNLEEASSDMKDN---AAALWRRYELLTTRLSQELAEQLRL 3312
+E+ + KL+ D R + LE+ + N LW++YE LT LSQ+L EQLRL
Sbjct: 5586 DEESVEEKKLTREDLDRMRQELEQYKIENSSNPEIGTELWKKYEQLTNDLSQDLCEQLRL 5645

Query: 3313 VMEPTLASKLQGDYKTGKRINMKKVIPYIASHYRKDKIWLRRTRPNKRDYQVVIAVDDSR 3372
++EPTLA+KLQGDYK+GKRINMKKVIPYIAS ++KDKIWLRRT+PNKR YQV++A+DD+
Sbjct: 5646 ILEPTLATKLQGDYKSGKRINMKKVIPYIASQFKKDKIWLRRTKPNKRQYQVLLAIDDTE 5705

Query: 3373 SMSESCCGDVAIEALVTVCRAMSQLEVGNLAVASYGKEGNIRLLHDFDQSFTGEAGIKMI 3432
SM+ G A+EA+ + RAMS+LEVG L + +G++ ++L+H FDQ F+ + G ++I
Sbjct: 5706 SMAAYHSGGFALEAMTMISRAMSRLEVGQLGIVRFGED--VQLVHSFDQVFSDQTGPEII 5763

Query: 3433 SNLTFKQENTIKDEPVVDLLKYLNNMLDTAVANARLPSGQNPLQQLVLIIADG-RFIEKE 3491
+ F+Q T +++ +L+ L N + SG+ P QLV I++DG + E
Sbjct: 5764 TQFKFQQTKT-------NMVNFLSKTLQIMDMNKQSSSGE-PAMQLVFIVSDGWSLRDPE 5815

Query: 3492 NLKRCVRDVLSRKRMVAFLLLDSP--QESIMDLQEVSFQGGNMKISKYLDSFPFPYYIIL 3549
K+ +R+ + + F+++D+P SI+D + +SF G ++ + Y+ FPF YY+IL
Sbjct: 5816 TTKKYLREASIKNVFIVFIVIDNPVNNNSILDFESISFNNGKIQRTNYMSEFPFMYYVIL 5875

Query: 3550 KNIEALPRTLADLLRQ 3565
+++ +P L+D LRQ
Sbjct: 5876 RSLNNIPSILSDTLRQ 5891



Score = 187 bits (474), Expect = 2e-45, Method: Compositional matrix adjust.
Identities = 232/991 (23%), Positives = 440/991 (44%), Gaps = 103/991 (10%)

Query: 1822 TYNFYKDSNASMMAKMVKLLTALQKRLLSLLNEWEDHPGLQKILGVIEMLLAIPSSTPLA 1881
TYN Y+DSN S + + + L + +KR+ LL E+ + L ++ +I+ L+ P++ PLA
Sbjct: 4026 TYNIYRDSNISEIGIIREPLISFRKRVFELLVEYPEQANLTLMVKLIDRLMTYPATDPLA 4085

Query: 1882 KALSGLQFLLNRIRILQENGSK-FSLSDQLEPIILLASLWKKIEFDSWPALLDEVQDQYE 1940
K L+GL+ LL + + SK S+ + L I L W+K+E +SWP++ + + E
Sbjct: 4086 KILTGLELLLRKSLEWESFASKAVSIQNHLNEISSLIVRWRKLEIESWPSIFQSQEKEAE 4145

Query: 1941 INGGKLWFPLYSVLQHRQSD-DIATYNQS-TIQSLEEFIQTSSIGEFRKRLELLFAFHGQ 1998
+ K WF LY ++ S ++ N S +L++++ +SS+G+F R+ELL +F+ Q
Sbjct: 4146 VKALKSWFILYDLINDEPSSPELEDENLSKNFHTLQQYLYSSSLGDFLTRIELLKSFYKQ 4205

Query: 1999 ISTGISLGIYS--SPFQMENLKILYNVFGYYVQFLPIALEHVQANRKNIETELKELLKLC 2056
+++ I L S + ++ + I+YN+F Y+ F+ + + + K IE + E ++L
Sbjct: 4206 LNSTIKLIGTSKNTNYKQKLSDIIYNIFKYFENFISRFEDRLAKSIKPIEDKALEFIRLS 4265

Query: 2057 RWEHSESYLSMENSKK----TQQKLRKLIQKYTDLLQQPVMLILNLEATQRGIKSKSIQE 2112
RW+ + E K+ + + L K+ KY ++L QP+ I + I +
Sbjct: 4266 RWDDNRLLTQYERLKQHIEVSHRNLAKVTIKYKNVLAQPLHDIFTQIENELDIPPLVLHS 4325

Query: 2113 --LKVLGDFPDKHGEELNAATDLTEFSDKNRSVWYPDWRKKVAFALKTL-QLGKTPEFNI 2169
+L D K+ + + +N + W + K++ + K E
Sbjct: 4326 GAATILEDKLKKNQKLNKKQIQKKSLAIENFNDWLSFSPSNYSIDRKSIDSISKPIEIES 4385

Query: 2170 PFLCFEDAQDVENTTQQDLASPSPCLVYL--------EHWREVRSTLEHVCRTVTECADL 2221
P L + E Q L+ S ++ + + W+ VR ++ + E D
Sbjct: 4386 PLLKKLFQIENEKLAQNKLSLLSKRMIQICKENLLESDSWKVVRDGVDIINDLSIEIIDR 4445

Query: 2222 WKDVSKNLGKRR-----ALSELLKLLESCGLSRHKSIFFEDQLKSNQSSWLLQPSYDVQH 2276
K++S + +R AL EL+ GLS H + + ++QL Q S+L ++V+H
Sbjct: 4446 LKELSSDEKIKRQEKEFALKELMSKFHEMGLSYHINRYPQEQL---QISYL----FNVRH 4498

Query: 2277 LLPM---QGRLPYQNVDLAASSQLQSLIHEVSDVEWSAANRYYFKSIASVQLLRQICLNF 2333
L + QG LP + A + + L A++YY++ ++ V LRQ+ + +
Sbjct: 4499 LPTISDNQGYLPTSFSKITADNGAKLL---------DQADQYYYRIVSRVHRLRQLSIEY 4549

Query: 2334 HKDFTLEQVNRSVSFLDHLIIIQQEQRNAVYHFSEHVKDLRKSVASLENLYSSSTTCDNG 2393
+ D + + V R +++H + I QRN + L N+ S G
Sbjct: 4550 NSDLSSKHVQRINGYVEHFLSIIINQRNNLIDSINSWNHLTLFTELFTNISGSG-----G 4604

Query: 2394 TDSKC--SVAPNQHATLKYMWQQKQLFDGLCSMLHEESLLLRTVESTHLSTCQHVKGSAN 2451
++S+ + N + K+ Q++ + + E LL R T V G
Sbjct: 4605 SNSEIDEQIFNNHNMLSKWFEIQRESINQFNQAIKEILLLCR-------KTTSAVSGGMI 4657

Query: 2452 RVLVFIEKFVPLFQKSKESLDDYLLGRNRVLTTVATSFYPPVITKQMEQLVFQNFQVIRE 2511
++ + + +S +S D + R L + + YP ++T L+ F +E
Sbjct: 4658 STIIPEICSIQIIIESIKSEIDKHQSKLRNLFSFLNNQYP-MMTWSTINLIISIFTKFKE 4716

Query: 2512 FEECLCAFQRQEVDR----RSVQEVLLNRFEDIMKKGKAMAEQFNNALEGRSELSPCD-E 2566
+E L ++ +S ++L+N + ++ K + E+ L G +E++ D E
Sbjct: 4717 IKEKLNQLLLSKLSNINYIKSPIQILINNIDSLINKFNSEYEE----LVG-NEINDNDIE 4771

Query: 2567 NHSELEAGFSGAFERTLKHIMDAFQKLGPLNNTC---------------ALSEWSSDN-- 2609
N + ++ F+ F + I+ + Q L +N + E++ ++
Sbjct: 4772 NQNNIKE-FTNQFGILIDQILISIQDLKIQSNQIIAYNKEQEELDQELEKVREYTIEDGS 4830

Query: 2610 ITSWKVLFESYVMNLQLDSICDELHKTIFYAGKLLNHSGNKIPSLCFQVETYFKHLYQLL 2669
I+ + V +L+L + ++ K ++ G + +L Y + + Q+
Sbjct: 4831 ISKLSEFIDHQVQSLRLSKLLEQFVK----LHNIIVDGGGSVSTLSI----YRQMIKQMG 4882

Query: 2670 DLVSGFS---DGLLHDFLDVHKKVSMMTHVLANVFASLYSEGFGTPTEDQIDDNSHDTSK 2726
L++ F + + D L HK + ++ VF LYS+GF P + D + +
Sbjct: 4883 PLLAQFMLIVNQSIVDSLSYHKTCCKLEYISTGVFIQLYSKGFCKPADGGDDGEGGEGGR 4942

Query: 2727 -----DAKGTGMGEGVGLKDVSDQITDEDQL 2752
D +GTGMGEG G KDVSDQ+ D+ Q+
Sbjct: 4943 SNFEDDVEGTGMGEGKGKKDVSDQLEDQGQI 4973



Score = 157 bits (396), Expect = 3e-36, Method: Compositional matrix adjust.
Identities = 143/520 (27%), Positives = 245/520 (47%), Gaps = 73/520 (14%)

Query: 15 TDIMDLLGSDLPVESSEGIKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDH 74
TD+ + LG + S + K + +GIL++A+++G WV+LDELNLAP VLE LN +LD
Sbjct: 1165 TDLQEYLGQYI---SDDKGKLVFQEGILVEAVRKGYWVVLDELNLAPSEVLEALNRLLDD 1221

Query: 75 RAEVFIPELGVTFKCPSSFRVFACQNPSSQGGGRKGLPRSFLNRFTKVYVDELVEDDY-L 133
E+FIPE + F +FA QNP GGRK L R+F NRF +++VD++ ED+
Sbjct: 1222 NRELFIPETQEVVRPHPHFMLFATQNPPGLYGGRKVLSRAFRNRFLELHVDDIPEDELEE 1281

Query: 134 FICS--SLYPSIQRPILSKLILFNKRLHEDIM-LNHKFAQDGSPWEFNLRDVIRSCEIIE 190
+C +L PS + KL+L K L + N FA G RD+ R E
Sbjct: 1282 ILCKRCALPPSYCK----KLVLIMKELQLNRQGSNQVFA--GKHGAITFRDLFRWAERQP 1335

Query: 191 GAPEKLKPDCFLNIVYVQRMRTAADRREVLRLYEQVFQV------------KPQ-LKILP 237
+ E+L + + +R+R ++ + ++ E+ ++ KP+ LK+L
Sbjct: 1336 SSYEELGIAGYQ--LLAERLRKDEEKLIIKQVIEKHLKIKLDIESIYSCDDKPEFLKLLQ 1393

Query: 238 ----------------------GIRQSLEAVAHCVQRQWLCILVGPSSSGKTSLIRLLAH 275
+++ V C++ + +LVG + KT++ +L +
Sbjct: 1394 LLSENDSELSKSNHLEKIVWTRSMKRLFSLVGKCLEHKEPILLVGETGCSKTTICQLYSI 1453

Query: 276 STGNVLNELSLSSATDISELLGCFEQYNAFRNFRS-VVDMITGWLAVLSSMDCGPSSTSA 334
L+ L+ T+ ++ +G S + ++ + LS ++
Sbjct: 1454 LNKQKLHILNCHQHTETADFIGGLRPVRGRDQVLSKLYSLVKQYFNQLSQLNL------- 1506

Query: 335 STYMEDWKCNRSSLCLLVEIIEHLRVDLEKNKLPVSWSCEDLNRTLKTILKLQEDQQKRT 394
Y + + N + EI+E L V+ K S E L + L ++ D+ +
Sbjct: 1507 --YKLEQENNNIDELPIKEIMERLIVESWKQVSNSSLLTEQLKQ-----LAIEIDKTYSS 1559

Query: 395 VAAKFEWVTGLLIKALENGEWIVLDNANLCNPTVLDRINSLVEPCGSITVNECGIVDGKP 454
+ F WV G L++A++ G++ ++D +L VL+R+NS++EP + + E G V+ +
Sbjct: 1560 YCSLFNWVDGPLVEAMKQGDYFLIDEISLAEDAVLERLNSVLEPSRLLVLAEKGGVEIEE 1619

Query: 455 LVVHPHPNFRMFLTVKPSHGD-----VSRAMRNRGVEIFM 489
L H FR+ T+ P GD +S AMRNR EI++
Sbjct: 1620 L--RGHKEFRILATMNPG-GDFGKKELSPAMRNRFTEIWV 1656



Score = 72.0 bits (175), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 39/102 (38%), Positives = 59/102 (57%), Gaps = 4/102 (3%)

Query: 28 ESSEGIKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDHRAEVFIPELGVT- 86
+S F++ +G L+ +++G WVLLDE+NLA LE L+ + D + + E G
Sbjct: 851 KSKNNFAFSFVEGSLVNCIRKGYWVLLDEMNLATSETLESLSGLFDG-GSITLTEKGEVE 909

Query: 87 -FKCPSSFRVFACQNPSSQGGGRKGLPRSFLNRFTKVYVDEL 127
+ +F+VFAC NP + G+K LP NRFT+ YVD+L
Sbjct: 910 PVERHPNFKVFACMNPPT-DIGKKDLPPGIRNRFTEYYVDDL 950



Score = 57.8 bits (138), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 34/89 (38%), Positives = 51/89 (57%), Gaps = 11/89 (12%)

Query: 15 TDIMDLLG----SDLPVESSEGIKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNA 70
TD LLG SD P E F W G L QA+++G W+L+++++LAP VL L
Sbjct: 333 TDSKVLLGTYITSDTPGE------FKWQAGALTQAVQEGRWILIEDIDLAPIEVLSVLIP 386

Query: 71 ILDHRAEVFIPELGVTFKCPSSFRVFACQ 99
+L++R +FIP G + + F++FA Q
Sbjct: 387 LLENRT-LFIPGRGEVIEASNGFQLFATQ 414



Score = 55.8 bits (133), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 68/300 (22%), Positives = 126/300 (42%), Gaps = 77/300 (25%)

Query: 243 LEAVAHCVQRQWLCILVGPSSSGKTSLIRLLAHSTGNVLNELSLSSATDISELLGCFEQY 302
+E ++ +Q +LVG + +GKTS+++ +A L L+L+ +D S
Sbjct: 672 MEKISISIQFNEPILLVGETGTGKTSVVQYIADQLNQKLVVLNLNQQSDSS--------- 722

Query: 303 NAFRNFRSVVDMITGWLAVLSSMDCGP-------------SSTSASTYME---------D 340
D+I G+ V + C P S ++ + ++E +
Sbjct: 723 ----------DLIGGFKPVEMRLLCLPLKNRFDSMFKKTFSESNNTDFLEKIDKAFISKN 772

Query: 341 WKCNRSSLCLLVEIIEH--LRVD-------------LEKNKLPVSWSCEDLNRTLKTI-- 383
WK + L ++++E+ L+ D N + + + RT+++
Sbjct: 773 WKQFIALLNKAIKLVENKVLKDDQTTTNNTKENNNNNNNNNNNNNNNNNNKKRTIRSEVK 832

Query: 384 ---LKLQEDQQKRTVAAK-------FEWVTGLLIKALENGEWIVLDNANLCNPTVLDRIN 433
+KL D +K T+ + F +V G L+ + G W++LD NL L+ ++
Sbjct: 833 EKWIKLSNDIKKLTIQFEKSKNNFAFSFVEGSLVNCIRKGYWVLLDEMNLATSETLESLS 892

Query: 434 SLVEPCGSITVNECGIVDGKPLVVHPHPNFRMFLTVKP----SHGDVSRAMRNRGVEIFM 489
L + GSIT+ E G V+ V HPNF++F + P D+ +RNR E ++
Sbjct: 893 GLFD-GGSITLTEKGEVEP----VERHPNFKVFACMNPPTDIGKKDLPPGIRNRFTEYYV 947

Query: CNT0005102
Subject: sp|Q12019|MDN1_YEAST Midasin OS=Saccharomyces cerevisiae (strain ATCC

/ ATCC 24843) GN=mdn1 PE=1 SV=1

 Score =  385 bits (990), Expect = e-105,   Method: Compositional matrix adjust.
Identities = 212/517 (41%), Positives = 300/517 (58%), Gaps = 46/517 (8%)

Query: 15 TDIMDLLGSDLPVESSEGIKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDH 74
TD+MDL GSD+PVE EG +FAW D L A++ G WVLLDELNLA QSVLEGLNA LDH
Sbjct: 1596 TDLMDLFGSDVPVEGGEGGQFAWRDAPFLAAMRNGHWVLLDELNLASQSVLEGLNACLDH 1655

Query: 75 RAEVFIPELGVTFKCPSSFRVFACQNPSSQGGGRKGLPRSFLNRFTKVYVDELVEDDYLF 134
R E +IPEL FK +FRVFA QNP QGGGRKGLPRSF+NRF+ VYV+ L E D +
Sbjct: 1656 RNEAYIPELDKVFKAHPNFRVFAAQNPQHQGGGRKGLPRSFINRFSVVYVEALKEKDMIE 1715

Query: 135 ICSSLYPSIQRPILSKLILFNKRLHEDIMLNHKFAQDGSPWEFNLRDVIRSCEIIEGAPE 194
I + Y + K+I F RL ++I + F GSPWEFNLRD +R +++ AP+
Sbjct: 1716 IAACNYHQVNEDWRLKIIKFMFRLQDNIEKDISFGSFGSPWEFNLRDTLRWLQLLNDAPK 1775

Query: 195 K--LKPDCFLNIVYVQRMRTAADRREVLRLYEQVFQVKPQLKIL---------------- 236
+ P +L ++ + RMRT DR L+++VF + + + +
Sbjct: 1776 YTCVSPADYLEVMVLHRMRTVEDRVRTCELFKEVFDIDYEPRTIGFSLSSQCFKVGHSLL 1835

Query: 237 -------------PGIRQS----LEAVAHCVQRQWLCILVGPSSSGKTSLIRLLAHSTGN 279
I QS LE+V C+ ++W CILVG +++GKT ++RLLA G
Sbjct: 1836 VRDVERQKTLLDSQNILQSQLPVLESVITCINKKWPCILVGDTATGKTCILRLLAAIAGA 1895

Query: 280 VLNELSLSSATDISELLGCFEQYNAFRN----FRSVVDMITGWLAVLSSMD-CGPSSTSA 334
+ E++++S TD +L+G +EQ + R F + + + + D ++
Sbjct: 1896 KIKEMAVNSDTDTMDLIGEYEQIDISRKASELFTDLSQQLLNIVIKYRNFDNIFRETSLY 1955

Query: 335 STYMEDWKCNRSSLCLLVEIIEHLRVDLEKNKLPVSWSCEDLNRTLKTILKLQEDQQKRT 394
+ +K + + LL ++++ L D K + S D++ + +L + +
Sbjct: 1956 TLTTTSFKTHSQAFTLLQKVVDQL--DQLKIHETLVHSLGDIHEKARKLLA----EFSAS 2009

Query: 395 VAAKFEWVTGLLIKALENGEWIVLDNANLCNPTVLDRINSLVEPCGSITVNECGIVDGKP 454
A +FEW G L+KA+E G W VLDNANLC+P VLDR+NSL+E G + VNE DG P
Sbjct: 2010 PAGRFEWFDGYLLKAVEEGHWFVLDNANLCSPAVLDRLNSLLEHKGVLIVNEKTTEDGHP 2069

Query: 455 LVVHPHPNFRMFLTVKPSHGDVSRAMRNRGVEIFMMQ 491
+ PHPNFR+FLTV P +G++SRAMRNRGVEIF+++
Sbjct: 2070 KTIKPHPNFRLFLTVNPVYGELSRAMRNRGVEIFLLK 2106



Score = 319 bits (818), Expect = 2e-85, Method: Compositional matrix adjust.
Identities = 273/922 (29%), Positives = 460/922 (49%), Gaps = 99/922 (10%)

Query: 2674 GFSDGLLHDFLDVHKKVSMMTHVLANVFASLYSEGFGTPTEDQIDDNSHDTSKDAKGTGM 2733
++ +L F++VH ++ +F + + GF +P D + ++ + GTG+
Sbjct: 3857 NLAESVLDYFINVHNSNLDSLSKISTLFFMVANNGFCSP--DLPQEGKSNSGELESGTGL 3914

Query: 2734 GEGVGLKDVSDQITDEDQLLGASEKPSEEQDVSDEVPSKNDKGIEMEQDFAADTFXXXXX 2793
G GVG +D+++ + ++D L E+ + E+D +++ + E+E D T
Sbjct: 3915 GSGVGAEDITNTLNEDDDL----EELANEEDTANQSDLDESEARELESDMNGVTKDSVVS 3970

Query: 2794 XXXXXXXXXXXXQLDSAMGETGAD-SEIVDEKLWNKDADENANNTKEKYESGPSVTDKDA 2852
LD + + D S ++EKLW++ +E+ T++K + ++
Sbjct: 3971 ENENSDSEEENQDLDEEVNDIPEDLSNSLNEKLWDEPNEEDLLETEQKSNEQSAANNES- 4029

Query: 2853 SSRELRAKEXXXXXXXXEPGQLNQDESNEQNDEIGSQDDLGN--TEXXXXXXXXKEDAFA 2910
+L +KE + Q +DE E +D++G D++ E ED
Sbjct: 4030 ---DLVSKEDDNKALEDKDRQEKEDEE-EMSDDVGIDDEIQPDIQENNSQPPPENEDHLD 4085

Query: 2911 DPSGLKLDET------NPMKEDLDMDEQEGADPMEEAHPEEHDEFTENGDGKEEDSNPAD 2964
P LKLDE + ED+DM E AD +E E DE ++ + E++N D
Sbjct: 4086 LPEDLKLDEKEGDVSKDSDLEDMDM---EAADENKEEADAEKDEPMQDFEDPLEENNTLD 4142

Query: 2965 ENLEEAESGQVDGNSERDDLGKGNEEKADMDLEAPRKDVLGPGNSDFISDHVPNAESA-T 3023
E++++ + + + E+ + G EE + E+ V + + VP ++
Sbjct: 4143 EDIQQDDFSDLAEDDEKMN-EDGFEENVQENEESTEDGV--KSDEELEQGEVPEDQAIDN 4199

Query: 3024 QPKDDMQA------ADSRNMAPETKWSNSSDIHNNLAPISGLPSNDTSEMEMMVADSSMD 3077
PK D ++ AD N N + A SG+ N T++ E A+
Sbjct: 4200 HPKMDAKSTFASAEADEENTDKGIVGENEELGEEDGAAESGVRGNGTADGEFSSAEQVQK 4259

Query: 3078 GKLTNDQPKTQLPQQDSSSIQKTQANPYRNVGDALEEWKERARVSSDLQEDNTEAPENVE 3137
G+ T+ PK + + D Y+++GD L EW++ R+ ED TE+
Sbjct: 4260 GEDTS-TPKEAMSEADRQ---------YQSLGDHLREWQQANRIHE--WEDLTESQSQAF 4307

Query: 3138 DENADEYGYVSEFEKGTAQALGPATFDQIDKNITQNEPDVDGVMAQKEHLTKENEKQNSE 3197
D++ E+ +V E E+ QALG A DQI K+I D D Q E
Sbjct: 4308 DDS--EFMHVKEDEEEDLQALGNAEKDQI-KSI-----DRDESANQNPDSMNSTNIAEDE 4359

Query: 3198 TDPIKSSALNLKKRIEEQMQISDSEVSPKEISPEVQSQGDGDPGSVSESLVSIKRSYLNE 3257
D + K++++ ISD + + ++ P + GS+++S E
Sbjct: 4360 ADEVGD------KQLQDGQDISDIKQTGEDTLP-------TEFGSINQS----------E 4396

Query: 3258 DIYQLSK-LSVSDELR----KAKNLEEASSDMKDNAAALWRRYELLTTRLSQELAEQLRL 3312
+++LS+ + DEL K NL A D A LW ++E T +LS EL EQLRL
Sbjct: 4397 KVFELSEDEDIEDELPDYNVKITNLPAAMP--IDEARDLWNKHEDSTKQLSIELCEQLRL 4454

Query: 3313 VMEPTLASKLQGDYKTGKRINMKKVIPYIASHYRKDKIWLRRTRPNKRDYQVVIAVDDSR 3372
++EPTLA+K+QGD++TGKR+NMK++IPYIAS ++KDKIW+RR +P+KR YQV+I++DDS+
Sbjct: 4455 ILEPTLATKMQGDFRTGKRLNMKRIIPYIASQFKKDKIWMRRVKPSKRTYQVMISIDDSK 4514

Query: 3373 SMSESCCGDVAIEALVTVCRAMSQLEVGNLAVASYGKEGNIRLLHDFDQSFTGEAGIKMI 3432
SMSES +A+E L V +A+S LEVG +AV +G++ LLH FD+ F+ E+G++M
Sbjct: 4515 SMSESGSTVLALETLALVTKALSLLEVGQIAVMKFGEQP--ELLHPFDKQFSSESGVQMF 4572

Query: 3433 SNLTFKQENTIKDEPVVDLLKYLNNMLDTAVANARLPSGQNPLQQLVLIIADGRFIEKEN 3492
S+ TF+Q NT + D N +TA + + ++QL +II+DG + ++
Sbjct: 4573 SHFTFEQSNT-NVLALADASMKCFNYANTASHH----RSNSDIRQLEIIISDGICEDHDS 4627

Query: 3493 LKRCVRDVLSRKRMVAFLLLDS----PQESIMDLQEVSF---QGGNM--KISKYLDSFPF 3543
+++ +R K M+ F++LD+ + SI+D+++V + + G M KI Y+D F F
Sbjct: 4628 IRKLLRRAQEEKVMIVFVILDNVNTQKKSSILDIKKVYYDTKEDGTMDLKIQPYIDEFAF 4687

Query: 3544 PYYIILKNIEALPRTLADLLRQ 3565
YY++++NIE LP+ L+ LRQ
Sbjct: 4688 DYYLVVRNIEELPQLLSSALRQ 4709



Score = 132 bits (333), Expect = 6e-29, Method: Compositional matrix adjust.
Identities = 136/511 (26%), Positives = 229/511 (44%), Gaps = 90/511 (17%)

Query: 15 TDIMDLLGSDLPVESSEGIKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDH 74
TD+ + +G+ + + + ++ +G+L++AL+ G W++LDELNLAP VLE LN +LD
Sbjct: 931 TDLQEYIGTYV---TDDNGSLSFREGVLVEALRNGYWIVLDELNLAPTDVLEALNRLLDD 987

Query: 75 RAEVFIPELGVTFKCPSSFRVFACQNPSSQGGGRKGLPRSFLNRFTKVYVDELVEDDYLF 134
E+FIPE V K F +FA QNP GRK L R+F NRF +++ D++ E++
Sbjct: 988 NRELFIPETQVLVKPHPEFMLFATQNPPGVYAGRKHLSRAFRNRFLEIHFDDIPENELET 1047

Query: 135 IC---SSLYPSIQRPILSKLILFNKRLHEDIMLNHK--FAQDGSPWEFNLRDVIRSCEII 189
I + PS I+ + R + K FA LRD+ R
Sbjct: 1048 ILHKRCKIAPSYAAKIVQVFRELSLRRQTTRIFEQKNSFA--------TLRDLFRWAFRE 1099

Query: 190 EGAPEKLKPDCFLNIVYVQRMRTAADRREVLRLYEQVFQVK------------------- 230
++L + ++ + +R R D+ V + E+V +VK
Sbjct: 1100 AVGYQQLAENGYM--LLAERARDQKDKLAVQEVIEKVMKVKIDTDGIYNLDSMEIFQDMS 1157

Query: 231 ----PQLKIL---PGIRQSLEAVAHCVQRQWLCILVGPSSSGKTSLIRLLAHSTGNVLNE 283
P K++ P IR V C+ + +LVG + GKT++ ++LA L+
Sbjct: 1158 LKEGPLSKVVWTRPMIRL-FCLVWRCLLAKEPVLLVGDTGCGKTTVCQILAECLHKELHI 1216

Query: 284 LSLSSATDISELLGCFEQYNAFRNFRSVVDMITGWLAVLSSMDCGPSSTSASTYMEDWKC 343
++ T+ +++G RN RS V+ L S C + S
Sbjct: 1217 INAHQDTENGDIIGA---QRPVRN-RSAVNY------SLHSQLCEKFNVQESL------- 1259

Query: 344 NRSSLCLLVEIIEHLRVDLEKNKLPVSWSCEDLNRTLKTILKLQEDQQKRTVAAKFEWVT 403
S+ L+E E L S + N L ++ ++Q + FEW
Sbjct: 1260 --DSIDDLIEKFEKL-------------SSSEKNDNLSNLI----ERQIIKYRSLFEWHD 1300

Query: 404 GLLIKALENGEWIVLDNANLCNPTVLDRINSLVEPCGSITVNECGIVDGKPLVVHPHPNF 463
G L+ A++ G++ +LD +L + +VL+R+NS++E ++T+ E + + F
Sbjct: 1301 GALVTAMKQGDFFLLDEISLADDSVLERLNSVLELSRTLTLVEHS---NAAVSLTAKDGF 1357

Query: 464 RMFLTVKPSHGD-----VSRAMRNRGVEIFM 489
F T+ P GD +S A+RNR EI++
Sbjct: 1358 AFFATMNPG-GDYGKKELSPALRNRFTEIWV 1387



Score = 98.6 bits (244), Expect = 1e-18, Method: Compositional matrix adjust.
Identities = 75/280 (26%), Positives = 148/280 (52%), Gaps = 21/280 (7%)

Query: 1822 TYNFYKDSNASMMAKMVKLLTALQKRLLSLLNEWEDHPGLQKILGVIEMLLAIPSSTPLA 1881
YNFY D N S ++ L+ ++ R +SL+ W ++ L+ + I+ +L + +P+A
Sbjct: 3124 VYNFYSDPNPSKAIEVRDLIKIVESRAISLIKNWPENFVLRGLKDAIDAILNLSPFSPIA 3183

Query: 1882 KALSGLQFLLNRIRILQENGSK-FSLSDQLEPIILLASLWKKIEFDSWPALLDEVQDQYE 1940
+ LS L+ + + + ++ S+ +SL+++++ I W+K E +W LL ++Y+
Sbjct: 3184 EYLSKLERVFHLLSEWEKLASREYSLANEMDLIKKKIIDWRKFELSNWNNLLK--LEEYK 3241

Query: 1941 INGGKLWFPLYSVLQHRQSDDIATYNQSTIQSLEE-------FIQTSSIGEFRKRLELLF 1993
++ +++ LYS+LQ ++ T Q+L E FI ++GEF+ L+ L
Sbjct: 3242 LSE-RVYPRLYSILQFIILKPFFENSKFTKQNLCESASIIVQFITDLTVGEFQLCLKCLL 3300

Query: 1994 AF-HGQISTGISLGIYSSPFQMENLKILYNVFGYYVQFLPIALEHVQANRKNIETELKEL 2052
+F S I GI + +L N++ Y+ QFL E + ++++E +KE
Sbjct: 3301 SFSQHAASLRICHGIDA---------MLLNIYHYFEQFLSKVSEAIHTQKQSLENSIKER 3351

Query: 2053 LKLCRWEHSESYLSMENSKKTQQKLRKLIQKYTDLLQQPV 2092
+ L W+ + Y E++KK+ +L K++ +Y ++L+QPV
Sbjct: 3352 ILLMSWKDTNVYALKESAKKSHAELFKVLHRYREVLRQPV 3391



Score = 79.3 bits (194), Expect = 8e-13, Method: Compositional matrix adjust.
Identities = 139/540 (25%), Positives = 230/540 (42%), Gaps = 96/540 (17%)

Query: 34 KFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDHRAEVFIPELGVTFKCPSSF 93
+F W G+L QA+ G W+L + AP VL L +L+ R ++ IP G T SF
Sbjct: 205 EFEWQPGVLTQAVITGKWILFTNIEHAPSEVLSVLLPLLEKR-QLVIPSRGETIYAKGSF 263

Query: 94 RVFACQNPSSQGGGRKGLPRSFLNRFTKVYVDELVEDDYLFICSSLYPSI---------- 143
++FA + ++ G+ R ++ D+ + + S+LYP +
Sbjct: 264 QMFATSSMKTKILGQ---------RLWQILDLTYQPDECVEVVSTLYPVLSIICPTLYSV 314

Query: 144 ---------QRPILS------KLIL--FNKRLHEDIMLNHKF--AQDGSPWEFNLRDVIR 184
QR L+ +L L F K + L HKF D L+D +
Sbjct: 315 YKDIFDLFSQRSFLATSKIYRRLCLRDFYKFIKRVAFLYHKFMIPSDHVVISQELQDAVF 374

Query: 185 SCEI-IEGA--PEKLKPDCFLNIVYVQRMRTAADRREVLRLYEQVFQ--------VKPQL 233
I + GA P + D + V ++ + ++ LR VFQ + L
Sbjct: 375 KEAIDMFGAFIPSRDGFDLVVRNVAIE-LNIPPEKALQLRYSIPVFQNLEHNINIGRCSL 433

Query: 234 KILPGIRQS--------------LEAVAHCVQRQWLCILVGPSSSGKTSLIRLLAHSTGN 279
K L IR LE +A VQ +LVG + +GKT+ I+LLA G
Sbjct: 434 KKLSTIRSCSTNSYAFTSSSLGLLEQLAAGVQTNEPLLLVGETGTGKTTTIQLLAGLLGQ 493

Query: 280 VLNELSLSSATDISELLGCFEQYNA----FRNFRSVVDMITGWLAVLSSMD-CGPSSTSA 334
+ +++S T+ S++LG ++ NA +D+ + + +STSA
Sbjct: 494 KVTVINMSQQTESSDMLGGYKPINASTLGLPLHERFIDIFEQTFSSKKNAKFISMASTSA 553

Query: 335 -----STYMEDWKCNRSSLCLLVEIIEHLRVDL---EKNKLPVSWSCEDLNRTLKTILKL 386
T ++ WK C L + + + L +K + +S E N+ K ++
Sbjct: 554 RRFRWKTCLKIWK----EACKLSKTVLDGQQPLPNPQKRQKRLSNQVELRNQWAKFEKEV 609

Query: 387 QEDQQKRTVAAK---FEWVTGLLIKALENGEWIVLDNANLCNPTVLDRINSLVEPCGS-I 442
++ ++ T + F +V G L+KA+ +G W++LD NL + L+ I L+ S I
Sbjct: 610 EDFEKVLTGGSNGFMFSFVEGALVKAVRSGHWVLLDEINLASLETLEPIGQLLSSYESGI 669

Query: 443 TVNECGIVDGKPLVVHPHPNFRMFLTVKPSHGDVSR-----AMRNRGVEIFMMQPYWPLD 497
++E G D P+ PH NFR+F + PS DV + + R+R EI++ P LD
Sbjct: 670 LLSERG--DITPIT--PHKNFRLFGCMNPS-TDVGKRELEPSFRSRFTEIYVHSPDQNLD 724



Score = 72.8 bits (177), Expect = 7e-11, Method: Compositional matrix adjust.
Identities = 40/98 (40%), Positives = 62/98 (63%), Gaps = 4/98 (4%)

Query: 30 SEGIKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAIL-DHRAEVFIPELG-VTF 87
S G F++ +G L++A++ G WVLLDE+NLA LE + +L + + + + E G +T
Sbjct: 620 SNGFMFSFVEGALVKAVRSGHWVLLDEINLASLETLEPIGQLLSSYESGILLSERGDITP 679

Query: 88 KCP-SSFRVFACQNPSSQGGGRKGLPRSFLNRFTKVYV 124
P +FR+F C NPS+ G R+ P SF +RFT++YV
Sbjct: 680 ITPHKNFRLFGCMNPSTDVGKRELEP-SFRSRFTEIYV 716



Score = 68.9 bits (167), Expect = 1e-09, Method: Compositional matrix adjust.
Identities = 40/100 (40%), Positives = 58/100 (58%), Gaps = 8/100 (8%)

Query: 35 FAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDHRAEVFIPE---LGVTFKCPS 91
F W DG L+ A+KQG + LLDE++LA SVLE LN++L+ + + E V+
Sbjct: 1296 FEWHDGALVTAMKQGDFFLLDEISLADDSVLERLNSVLELSRTLTLVEHSNAAVSLTAKD 1355

Query: 92 SFRVFACQNPSSQGG--GRKGLPRSFLNRFTKVYVDELVE 129
F FA NP GG G+K L + NRFT+++V +V+
Sbjct: 1356 GFAFFATMNP---GGDYGKKELSPALRNRFTEIWVPPMVD 1392

Query: CNT0005102
Subject: sp|Q8T5T1|MDN1_GIAIN Midasin OS=Giardia intestinalis GN=MDN1 PE=3

204508 / S288c) GN=MDN1 PE=1 SV=1

 Score =  372 bits (956), Expect = e-101,   Method: Compositional matrix adjust.
Identities = 205/517 (39%), Positives = 298/517 (57%), Gaps = 41/517 (7%)

Query: 9 CSLRSLTDIMDLLGSDLPVESSEGIKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGL 68
+L TD++DL G+D P E S +F W D L+A+K+G WVLLDE+NLA QSVLEGL
Sbjct: 1771 INLSEQTDLVDLFGADAPGERSG--EFLWHDAPFLRAMKKGEWVLLDEMNLASQSVLEGL 1828

Query: 69 NAILDHRAEVFIPELGVTFKCPSSFRVFACQNPSSQGGGRKGLPRSFLNRFTKVYVDELV 128
NA LDHR E +IPEL ++F C +F VFA QNP QGGGRKGLP+SF+NRF+ V++D L
Sbjct: 1829 NACLDHRGEAYIPELDISFSCHPNFLVFAAQNPQYQGGGRKGLPKSFVNRFSVVFIDMLT 1888

Query: 129 EDDYLFICSSLYPSIQRPILSKLILFNKRLHEDIMLNHKFAQDGSPWEFNLRDVIRSCEI 188
DD L I LYPSI+ I++K+I L + + + GSPWEFNLRD +R ++
Sbjct: 1889 SDDLLLIAKHLYPSIEPDIIAKMIKLMSTLEDQVCKRKLWGNSGSPWEFNLRDTLRWLKL 1948

Query: 189 IE--GAPEKLKPDCFLNIVYVQRMRTAADRREVLRLYEQVF-----------------QV 229
+ E + F++I+ QR RT +D+ + L E +F Q+
Sbjct: 1949 LNQYSICEDVDVFDFVDIIVKQRFRTISDKNKAQLLIEDIFGKFSTKENFFKLTEDYVQI 2008

Query: 230 KPQLKIL-PGIRQSL--------------EAVAHCVQRQWLCILVGPSSSGKTSLIRLLA 274
++ + P R + E+V + W +LVGPS+SGKT IR LA
Sbjct: 2009 NNEVALRNPHYRYPITQNLFPLECNVAVYESVLKAINNNWPLVLVGPSNSGKTETIRFLA 2068

Query: 275 HSTGNVLNELSLSSATDISELLGCFEQYNAFRNFRSVVDMITGWLAVLSSMDCGPSSTSA 334
G ++ S++S D ++LG +EQ + R + + +T + + SM+ S +A
Sbjct: 2069 SILGPRVDVFSMNSDIDSMDILGGYEQVDLTRQISYITEELTNIVREIISMNM-KLSPNA 2127

Query: 335 STYMEDWKCNRSSLCLLV--EIIEHLRVDLEKNKLPVSWSCEDLNRTLKTILKLQEDQQK 392
+ ME + L +V E + R N+ L +T+ ++ +
Sbjct: 2128 TAIMEGLNLLKYLLNNIVTPEKFQDFRNRF--NRFFSHLEGHPLLKTMSMNIEKMTEIIT 2185

Query: 393 RTVAAKFEWVTGLLIKALENGEWIVLDNANLCNPTVLDRINSLVEPCGSITVNECGIVDG 452
+ + KFEW G+L+KA+E G W++LDNANLC+P+VLDR+NSL+E GS+ +NEC DG
Sbjct: 2186 KEASVKFEWFDGMLVKAVEKGHWLILDNANLCSPSVLDRLNSLLEIDGSLLINECSQEDG 2245

Query: 453 KPLVVHPHPNFRMFLTVKPSHGDVSRAMRNRGVEIFM 489
+P V+ PHPNFR+FLT+ P +G++SRAMRNRGVEI++
Sbjct: 2246 QPRVLKPHPNFRLFLTMDPKYGELSRAMRNRGVEIYI 2282



Score = 281 bits (720), Expect = 4e-74, Method: Compositional matrix adjust.
Identities = 258/934 (27%), Positives = 429/934 (45%), Gaps = 107/934 (11%)

Query: 2687 HKKVSMMTHVLANVFASLYSEGFGTPT--EDQIDDNSHDTSKDAKGTGMGEGVGLKDVSD 2744
+ S ++L+ + SL GF +P +++DD + +GTG+G+G G ++ +
Sbjct: 4021 YTNTSRGMYILSTILHSLAKNGFCSPQPPSEEVDDKNL-----QEGTGLGDGEGAQNNNK 4075

Query: 2745 QI-TDEDQLLGASEKPSEEQDVSDEVPSKNDKGIEMEQDFAAD--TFXXXXXXXXXXXXX 2801
+ DED A + E+QD + D +EME D A +
Sbjct: 4076 DVEQDEDLTEDAQNENKEQQDKDERDDENEDDAVEMEGDMAGELEDLSNGEENDDEDTDS 4135

Query: 2802 XXXXQLDSAMGETGADSEIVDEKLWN---------KDADENANNTKEKYESGPSVTD--- 2849
+ D +D+K+W+ KD D+N + ++ + + D
Sbjct: 4136 EEEELDEEIDDLNEDDPNAIDDKMWDDKASDNSKEKDTDQNLDGKNQEEDVQAAENDEQQ 4195

Query: 2850 ---KDASSRELRAKEXXXXXXXXEPGQLNQDESNEQNDEIGSQD--DLGNTEXXXXXXXX 2904
K+ + A E + +++ EQ DE+ ++ DL
Sbjct: 4196 RDNKEGGDEDPNAPEDGDEEIENDENAEEENDVGEQEDEVKDEEGEDLEANVPEIETLDL 4255

Query: 2905 KEDAFADPSGLKLDETNPMKEDL--DMDEQEGADPMEEAHPEEHDEFTENGD--GKEEDS 2960
ED D + DE M + + D++++E + EE E E D G EED+
Sbjct: 4256 PEDMNLDSEHEESDEDVDMSDGMPDDLNKEEVGNEDEEVKQESGIESDNENDEPGPEEDA 4315

Query: 2961 NPADENLEEAESGQVD----GNSERDDLGKGNEEKADMDLEAPRKDVLGPGNSDFISDHV 3016
+ L+E E + D + ++D G EE+A D E ++D N + +
Sbjct: 4316 GETETALDEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEENKEKGGEQN 4375

Query: 3017 PNAESATQPKDDMQAADSRNMAPETKWSNSSDIHNNLAPISGLPSNDTSEMEMMVADSSM 3076
+ K D + D + S + G + DT E + + +
Sbjct: 4376 TEGLDGVEEKADTEDIDQEAAVQQDSGSKGA----------GADATDTQEQDDVGGSGTT 4425

Query: 3077 DGKLTNDQPKTQLPQQDSSSIQKTQANPYRNVGDALEEWKERARVSSDLQEDNTEAPENV 3136
DQ ++S ++ + +GD+++E+ R + + Q N E EN+
Sbjct: 4426 QNTYEEDQEDVTKNNEES---REEATAALKQLGDSMKEYHRRRQDIKEAQT-NGEEDENL 4481

Query: 3137 E--DENADEYGYVSEFEKGT-AQALGPATFDQIDKNITQNEPDVDGVMAQKEHLTKENEK 3193
E +E DE+ +V T QALG AT DQ+ +D MA + + E+
Sbjct: 4482 EKNNERPDEFEHVEGANTETDTQALGSATQDQLQT--------IDEDMA----IDDDREE 4529

Query: 3194 QNSETDPIKSSALNLKKRIEEQMQISDSEVSPKEISPEVQSQGDGDPGS------VSESL 3247
Q + + A + K I+E+ +SD + + + +V S+ G G L
Sbjct: 4530 QEVDQKELVEDADDEKMDIDEEEMLSD--IDAHDANNDVDSKKSGFIGKRKSEEDFENEL 4587

Query: 3248 VSIKRSYLNEDIYQLSKL---------SVSDELRKAKNLEEASSDMKDNAAALWRRYELL 3298
+ S ED ++ L S L ++LEE+ LW + E+
Sbjct: 4588 SNEHFSADQEDDSEIQSLIENIEDNPPDASASLTPERSLEESRE--------LWHKSEIS 4639

Query: 3299 TTRLSQELAEQLRLVMEPTLASKLQGDYKTGKRINMKKVIPYIASHYRKDKIWLRRTRPN 3358
T L L EQLRL++EPTLA+KL+GDYKTGKR+NMK++IPYIAS +RKDKIWLRRT+P+
Sbjct: 4640 TADLVSRLGEQLRLILEPTLATKLKGDYKTGKRLNMKRIIPYIASQFRKDKIWLRRTKPS 4699

Query: 3359 KRDYQVVIAVDDSRSMSESCCGDVAIEALVTVCRAMSQLEVGNLAVASYGKEGNIRLLHD 3418
KR YQ++IA+DDS+SMSES C +A ++L V + ++QLE G L++ +G+ NI+ +H
Sbjct: 4700 KRQYQIMIALDDSKSMSESKCVKLAFDSLCLVSKTLTQLEAGGLSIVKFGE--NIKEVHS 4757

Query: 3419 FDQSFTGEAGIKMISNLTFKQENTIKDEPVVDLLKYLNNMLDTAVANARLPSGQNPLQQL 3478
FDQ F+ E+G + F++ T V L+ + + A A N QL
Sbjct: 4758 FDQQFSNESGARAFQWFGFQETKT----DVKKLVAESTKIFERARAMV-----HNDQWQL 4808

Query: 3479 VLIIADGRFIEKENLKRCVRDVLSRKRMVAFLLLD--SPQESIMDLQEVSF---QGGN-- 3531
++I+DG + E +++ VR K M+ F+++D + ESI+D+ +V++ Q GN
Sbjct: 4809 EIVISDGICEDHETIQKLVRRARENKIMLVFVIIDGITSNESILDMSQVNYIPDQYGNPQ 4868

Query: 3532 MKISKYLDSFPFPYYIILKNIEALPRTLADLLRQ 3565
+KI+KYLD+FPF +Y+++ +I LP L+ +LRQ
Sbjct: 4869 LKITKYLDTFPFEFYVVVHDISELPEMLSLILRQ 4902



Score = 161 bits (408), Expect = 1e-37, Method: Compositional matrix adjust.
Identities = 144/501 (28%), Positives = 244/501 (48%), Gaps = 76/501 (15%)

Query: 15 TDIMDLLGSDLPVESSEGIKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDH 74
TD+ + LG+ + ++ K ++ +G+L++AL++G W++LDELNLAP VLE LN +LD
Sbjct: 1113 TDLQEYLGTYVTDDTG---KLSFKEGVLVEALRKGYWIVLDELNLAPTDVLEALNRLLDD 1169

Query: 75 RAEVFIPELGVTFKCPSSFRVFACQNPSSQGGGRKGLPRSFLNRFTKVYVDELVEDDYLF 134
E+FIPE F +FA QNP GGRK L R+F NRF +++ D++ +D+
Sbjct: 1170 NRELFIPETQEVVHPHPDFLLFATQNPPGIYGGRKILSRAFRNRFLELHFDDIPQDELEI 1229

Query: 135 ICSS---LYPSIQRPILSKLILFNKRLHEDIMLNHKFAQDGSPWEFNLRDVIRSCEIIEG 191
I + PS + K++ ++L + + F Q S LRD+ R
Sbjct: 1230 ILRERCQIAPSYAK----KIVEVYRQLSIERSASRLFEQKNSFA--TLRDLFRWALRDAV 1283

Query: 192 APEKLKPDCFLNIVYVQRMRTAADRREVLRLYEQVFQVKPQL---------KIL------ 236
E+L ++ + +R RT ++ V + E+V +VK + K L
Sbjct: 1284 GYEQLAASGYM--LLAERCRTPQEKVTVKKTLEKVMKVKLDMDQYYASLEDKSLEAIGSV 1341

Query: 237 ---PGIRQSLEAVAHCVQRQWLCILVGPSSSGKTSLIRLLAHSTGNVLNELSLSSATDIS 293
G+R+ V+ C++ + +LVG + GKT++ +LLA G L L+ T+
Sbjct: 1342 TWTKGMRRLSVLVSSCLKNKEPVLLVGETGCGKTTICQLLAQFMGRELITLNAHQNTETG 1401

Query: 294 ELLGCFEQYNAFRNFRSVVDMITGWLAVLSSMDCGPSSTSASTYMEDWKCNRSSLCLLVE 353
++LG A R R+ ++ +K + SL +
Sbjct: 1402 DILG------AQRPVRNRSEI-------------------------QYKLIK-SLKTALN 1429

Query: 354 IIEHLRVDLEKNKLPVSWSCEDLNRTLKTILKLQEDQQKRTVAAKFEWVTGLLIKALENG 413
I VDL+ +L +S D N+ + ++L+ + + ++ FEW G LI+A+ G
Sbjct: 1430 IANDQDVDLK--ELLQLYSKSD-NKNIAEDVQLEIQKLRDSLNVLFEWSDGPLIQAMRTG 1486

Query: 414 EWIVLDNANLCNPTVLDRINSLVEPCGSITVNECGIVDGKPLVVHPHPNFRMFLTVKPSH 473
+ +LD +L + +VL+R+NS++EP S+ + E G D +V NF+ F T+ P
Sbjct: 1487 NFFLLDEISLADDSVLERLNSVLEPERSLLLAEQGSSDS---LVTASENFQFFATMNPG- 1542

Query: 474 GD-----VSRAMRNRGVEIFM 489
GD +S A+RNR EI++
Sbjct: 1543 GDYGKKELSPALRNRFTEIWV 1563



Score = 112 bits (280), Expect = 9e-23, Method: Compositional matrix adjust.
Identities = 80/296 (27%), Positives = 146/296 (49%), Gaps = 12/296 (4%)

Query: 1806 CLEHEPKFVSYHKVAHTYNFYKDSNASMMAKMVKLLTALQKRLLSLLNEWEDHPGLQKIL 1865
L+ E + +V +FY D + K ++ + K +L LL +W +H L+++
Sbjct: 3263 TLDAETQSFKNTEVFGNIDFYHDFSIPEFQKAGDIIETVLKSVLKLLKQWPEHATLKELY 3322

Query: 1866 GVIEMLLAIPSSTPLAKALSGLQFLLNRIRILQENGS-KFSLSDQLEPIILLASLWKKIE 1924
V + L P TPLA+ L ++ + + ++ S + SL++ ++ I L W+K+E
Sbjct: 3323 RVSQEFLNYPIKTPLARQLQKIEQIYTYLAEWEKYASSEVSLNNTVKLITDLIVSWRKLE 3382

Query: 1925 FDSWPALLDEVQDQYEINGGKLWFPLYS--VLQHRQSDDIATYNQST--IQSLEEFIQTS 1980
+W L + + + GK WF LY V+ + S+ T +T + SL F S
Sbjct: 3383 LRTWKGLFNSEDAKTRKSIGKWWFYLYESIVISNFVSEKKETAPNATLLVSSLNLFFSKS 3442

Query: 1981 SIGEFRKRLELLFAFHGQISTGISLGIYSSPFQMENLKILYNVFGYYVQFLPIALEHVQA 2040
++GEF RL+L+ AF+ I +G+ SS +L+N +Y QF P+ E +
Sbjct: 3443 TLGEFNARLDLVKAFYKHIQL---IGLRSSKIA----GLLHNTIKFYYQFKPLIDERITN 3495

Query: 2041 NRKNIETELKELLKLCRWEHSESYLSMENSKKTQQKLRKLIQKYTDLLQQPVMLIL 2096
+K++E E+ +++ L W+ ++S+K+ L K+++KY DLL I+
Sbjct: 3496 GKKSLEKEIDDIILLASWKDVNVDALKQSSRKSHNNLYKIVRKYRDLLNGDAKTII 3551



Score = 95.9 bits (237), Expect = 8e-18, Method: Compositional matrix adjust.
Identities = 125/555 (22%), Positives = 232/555 (41%), Gaps = 112/555 (20%)

Query: 35 FAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDHRAEVFIPELGVTFKCPSSFR 94
F W G+L A+K+G WVL+++++ AP VL L ++L+ R E+ IP G T K + F+
Sbjct: 365 FEWRAGVLATAVKEGRWVLIEDIDKAPTDVLSILLSLLEKR-ELTIPSRGETVKAANGFQ 423

Query: 95 VFACQ--NPSSQGGGRK---GLPRSFLNRFTKVYVDELVEDDYLFICSSLYPSIQRPILS 149
+ + N Q L + + + ++E E+D I + +P I ++
Sbjct: 424 LISTVRINEDHQKDSSNKIYNLNMIGMRIWNVIELEEPSEEDLTHILAQKFP-ILTNLIP 482

Query: 150 KLILFNKRLHEDIMLNHKFA---QDGSPWEFNLRDVIRSCEIIE--------GAPEKL-- 196
KLI K + + I +N KF + ++RD+I+ CE ++ P++L
Sbjct: 483 KLIDSYKNV-KSIYMNTKFISLNKGAHTRVVSVRDLIKLCERLDILFKNNGINKPDQLIQ 541

Query: 197 ----------KPDCF---------------------------LNIVYVQRMRTAADRREV 219
DCF +++ Q + T + +
Sbjct: 542 SSVYDSIFSEAADCFAGAIGEFKALEPIIQAIGESLDIASSRISLFLTQHVPTLENLDDS 601

Query: 220 LRLYEQVFQVKPQLKILPGIRQS------------LEAVAHCVQRQWLCILVGPSSSGKT 267
+++ V +K +L I S +E ++ C+Q +LVG + +GKT
Sbjct: 602 IKIGRAVL-LKEKLNIQKKSMNSTLFAFTNHSLRLMEQISVCIQMTEPVLLVGETGTGKT 660

Query: 268 SLIRLLAHSTGNVLNELSLSSATDISELLGCFEQYNAF-------RNFRSVVDMITGWLA 320
++++ LA L +++S T+ +LLG ++ N+ NF ++ +
Sbjct: 661 TVVQQLAKMLAKKLTVINVSQQTETGDLLGGYKPVNSKTVAVPIQENFETLFNATFSLKK 720

Query: 321 -------VLSSMDCGPSSTSASTYMEDWKCNRSSLCLLVEIIEHLRVDLEKNKLPV---- 369
+ + + E +K +S L + E+ +K +L
Sbjct: 721 NEKFHKMLHRCFNKNQWKNVVKLWNEAYKMAQSILKITNTENENENAKKKKRRLNTHEKK 780

Query: 370 ----SWSCEDLNRTLKTILKLQEDQQKRTVAAKF--EWVTGLLIKALENGEWIVLDNANL 423
W+ D N ++K + Q ++ F +V G L+K + GEW++LD NL
Sbjct: 781 LLLDKWA--DFNDSVKKF-----EAQSSSIENSFVFNFVEGSLVKTIRAGEWLLLDEVNL 833

Query: 424 CNPTVLDRINSLV-EP-CGSITVNECGIVDGKPLVVHPHPNFRMFLTVKPSHG----DVS 477
L+ I+ L+ EP SI ++E G D +P + HP+FR+F + P+ D+
Sbjct: 834 ATADTLESISDLLTEPDSRSILLSEKG--DAEP--IKAHPDFRIFACMNPATDVGKRDLP 889

Query: 478 RAMRNRGVEIFMMQP 492
+R+R EI++ P
Sbjct: 890 MGIRSRFTEIYVHSP 904



Score = 88.2 bits (217), Expect = 2e-15, Method: Compositional matrix adjust.
Identities = 85/336 (25%), Positives = 144/336 (42%), Gaps = 84/336 (25%)

Query: 30 SEGIKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDHRAEVFIPELGVT--- 86
S + F WSDG L+QA++ G++ LLDE++LA SVLE LN++L+ + + E G +
Sbjct: 1467 SLNVLFEWSDGPLIQAMRTGNFFLLDEISLADDSVLERLNSVLEPERSLLLAEQGSSDSL 1526

Query: 87 FKCPSSFRVFACQNPSSQGG--GRKGLPRSFLNRFTKVYVDEL--VEDDYLFICSSLYPS 142
+F+ FA NP GG G+K L + NRFT+++V + D + + S L
Sbjct: 1527 VTASENFQFFATMNP---GGDYGKKELSPALRNRFTEIWVPSMEDFNDVNMIVSSRLLED 1583

Query: 143 IQ---RPILSKLILFNKRLHEDIMLNHKFAQDGSPWEFNLRDVI---------------R 184
++ PI+ F K+L + + +LRD++ +
Sbjct: 1584 LKDLANPIVKFSEWFGKKLG---------GGNATSGVISLRDILAWVEFINKVFPKIQNK 1634

Query: 185 SCEIIEGAP----------------------EKLKPDCFLNIVYVQRMRTAADRREVLRL 222
S +I+GA + L+ +C +Q ++ D E+ ++
Sbjct: 1635 STALIQGASMVFIDALGTNNTAYLAENENDLKSLRTECI-----IQLLKLCGDDLELQQI 1689

Query: 223 -YEQVFQVKPQLKI-------------------LPGIRQSLEAVAHCVQRQWLCILVGPS 262
++ + +L++ P +L V +Q +L G
Sbjct: 1690 ETNEIIVTQDELQVGMFKIPRFPDAQSSSFNLTAPTTASNLVRVVRAMQVHKPILLEGSP 1749

Query: 263 SSGKTSLIRLLAHSTGNVLNELSLSSATDISELLGC 298
GKTSLI LA+ TGN L ++LS TD+ +L G
Sbjct: 1750 GVGKTSLITALANITGNKLTRINLSEQTDLVDLFGA 1785



Score = 61.6 bits (148), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 34/101 (33%), Positives = 55/101 (54%), Gaps = 11/101 (10%)

Query: 33 IKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDHRAEVFIPELGV------T 86
+KF W DG+L++A+++G W++LD NL SVL+ LN++L+ + I E
Sbjct: 2190 VKFEWFDGMLVKAVEKGHWLILDNANLCSPSVLDRLNSLLEIDGSLLINECSQEDGQPRV 2249

Query: 87 FKCPSSFRVFACQNPSSQGGGRKGLPRSFLNRFTKVYVDEL 127
K +FR+F +P L R+ NR ++Y+DEL
Sbjct: 2250 LKPHPNFRLFLTMDPK-----YGELSRAMRNRGVEIYIDEL 2285

Query: CNT0005102
Subject: sp|Q54VX4|MCFJ_DICDI Mitochondrial substrate carrier family protein J

SV=1

 Score =  289 bits (740), Expect = 2e-76,   Method: Compositional matrix adjust.
Identities = 199/588 (33%), Positives = 298/588 (50%), Gaps = 117/588 (19%)

Query: 6 CGLCSLR----SLTDIMDLLGSDLPVESSEGIKFAWSDGILLQALKQGSWVLLDELNLAP 61
CG +R TD+ DLLGSDLP E+ F W DG+LL+A+K+G+++LLDELNLA
Sbjct: 1530 CGYSLVRINLSEQTDLSDLLGSDLPAENG----FRWVDGVLLKAVKEGAFILLDELNLAN 1585

Query: 62 QSVLEGLNAILDHRAEVFIPELGVTFKCPSSFRVFACQNPSSQGGGRKGLPRSFLNRFTK 121
Q+VLEGLN++LDHR +FIPEL ++ K P + R+F QNP SQG GRKGLP+SF+NRF
Sbjct: 1586 QTVLEGLNSLLDHRRSLFIPELMLSVKSPDTLRIFGTQNPRSQGSGRKGLPQSFINRFLN 1645

Query: 122 VYVDELVEDDYLFICSSLYPSIQRPILSKLILFNKRLHEDIMLNHKFAQDGSPWEFNLRD 181
VYVD L DY +I S+L+ I +L ++ K+L + KF G PWE N+RD
Sbjct: 1646 VYVDVLKSQDYDWILSNLFTDIPTYVLDYILGSTKQLRAGLE-ELKFGISGGPWELNVRD 1704

Query: 182 VIRSCEIIEGAPEKLK------PDCFLNIVYVQRMRTAADR------------------- 216
++R C+++ P + + +I++ R RTA D
Sbjct: 1705 MMRLCDMLTTTPGLAQGITLAHAKHYAHILFGYRFRTADDDAYVQNVLFSPHSLDSVAEA 1764

Query: 217 ---------REVLRLYEQVFQ--------VKPQLKILPGIRQS--------------LEA 245
R + + E V + + P + + G + S LEA
Sbjct: 1765 TQSHHWYSLRPLWNVTEDVVKIGSLAIPRIDPVFRDVLGTKLSYAHTSCFLTAQLVALEA 1824

Query: 246 VAHCVQRQWLCILVGPSSSGKTSLIRLLAHSTGNVLNELSLSSATDISELLGCFEQYNAF 305
+A V + CILVG SGK+S++R LA L +S S+ATD+S+L+G +EQ +
Sbjct: 1825 LAVAVTQNLSCILVGSPESGKSSILRTLADVVRQPLVHISASTATDVSDLIGAYEQVDVL 1884

Query: 306 RNFRSVVDMITGWLAVLSSMDCGPSSTSASTYMEDWKC-----------------NRSSL 348
+ +SV+ + ++ L + S+ S S +++D + S+
Sbjct: 1885 YDLKSVIRDLCLFVHSL-PIKASYSAISFSEFLKDLTASLDREIGDGLGSKSRAISMESI 1943

Query: 349 C------LLVEIIEHLRVDLEKNKLPV---SWSC------------EDLNRTLKTILKLQ 387
LL+E + DL+ L S C E + + TI +L
Sbjct: 1944 VSEVVQKLLLEFMAKFSPDLDSGGLAAKNFSLFCSEILTQDTTPVDERFSPHMPTIPELC 2003

Query: 388 ED--------QQKRTVAAKFEWVTGLLIKALENGEWIVLDNANLCNPTVLDRINSLVEPC 439
+ QQ +T +F W LI+ALE G W+ L NAN C P+VLDR+NSL+E
Sbjct: 2004 KSMASLYLSTQQSQT--GRFVWRDSELIRALERGYWVELTNANFCMPSVLDRLNSLLERG 2061

Query: 440 GSITVNECGIVDGKPLVVHPHPNFRMFLTVKPSHGDVSRAMRNRGVEI 487
G + + E G+ + + + V HPNFR+F++ P+ D+SRA+RNR +E+
Sbjct: 2062 GGLEILEQGLEETRSIKV--HPNFRLFISYAPT-SDISRALRNRSLEL 2106



Score = 208 bits (529), Expect = 9e-52, Method: Compositional matrix adjust.
Identities = 242/935 (25%), Positives = 415/935 (44%), Gaps = 154/935 (16%)

Query: 2693 MTHVLANVFASLYSEGFG---TPTEDQIDDNSHDTSKDAKGTGMGEGVGL-----KDVSD 2744
+ VLA L S T +DD+ +T D + K+ +
Sbjct: 4003 LADVLAKFIGPLISGAIALLRTGFHCHVDDDQKETDNDNQSGLGLGDGTGDQNVSKEAAK 4062

Query: 2745 QITDEDQLLGASEKPSEEQDVSDEVPSKNDKGIEMEQDFAADTFXXXXXXXXXXXXXXXX 2804
++ ++D + +++ +EQ D +D+ IEM+ DF +
Sbjct: 4063 ELCEDDLMGNQNDRDQQEQQEKD----GDDEAIEMQNDFGGMSESLHHDIEEEDSNGSDE 4118

Query: 2805 XQ-LDSAMGETGADSEIVDEKLWNKDADENANNTKEKYESGPSVTDKDASSRELRAKEXX 2863
+ L+ MG+ E +DE+ +N+D D + E+ ++ + D + EL A+E
Sbjct: 4119 EEVLEKEMGD--EQGEAIDERNYNEDDDSAEEYSDEQKKNTNNNND----TMELAAQEKD 4172

Query: 2864 XXXXXXEPGQLNQDESNEQNDEIGSQDDLGNTEXXXXXXXXKEDAFADPSGLKLDETN-P 2922
E + ++ EQ D GS D+ +ED + D LD+ N
Sbjct: 4173 QDSINSELSDPSGEQHEEQADATGSTDE-----------QAQEDDYND-----LDDKNLS 4216

Query: 2923 MKEDLDMDEQEGADPMEEAHPEEHDEFTENGDGKEEDSNPADENLEEAESGQVDGNSERD 2982
+ DL + E +G D EE + + ++D+ +E+ ++ + D N+E
Sbjct: 4217 GQSDLSVPEADGEDETVNEELEEEQQQMSDLSNPDQDACAIEED-DDRDLPSSDENAEEH 4275

Query: 2983 DLGKGNEEKADMDLEAPRKDVLGPGNSDFISDHVPNAESATQPKDDMQAADSRNMAPETK 3042
D E +A +D I D+ + E +T +D D+ N++ + +
Sbjct: 4276 D-----EHEAPVD----------------IDDNEASDEQSTYNDNDRD--DAINISAQQQ 4312

Query: 3043 WSNSSDIHNNLAPISGLPSNDTSEMEMMVADSSMDGKL--TNDQPKT-----QLPQQ--- 3092
+N + DT + + DS+ D TNDQ +T Q Q+
Sbjct: 4313 ATNDEEEMQK----------DTEYDQENITDSNPDANEVGTNDQKQTHEDNDQFRQENIE 4362

Query: 3093 ---DSSSIQKTQA-----------NPYRNVGDALEEWKERARV-SSDLQEDNTEAPENVE 3137
++ S + +Q NP ++ + WKER + + ++D P+++
Sbjct: 4363 DQWEAESTENSQGEGAESADLKEGNPDMSLEEFQRIWKERLNIHDRESEKDEAAEPQDMP 4422

Query: 3138 DENADEYGYVSEFEKGTAQALGPATFDQIDKNITQNEPDVDGVMAQKEHLTKENEKQNSE 3197
++ + + + G ALG + +N+T E D NE++N E
Sbjct: 4423 LQSNKTVEF-DDSKSGRDGALGLT--ESKHRNLTNQEFD------------NPNEERNVE 4467

Query: 3198 TDPIKSSALNLKKRIEEQMQISDSEVSPKEISPEVQSQGDGDPGSVSESLVSIKRSYLNE 3257
+ SS E Q S + ++PE+ +G+ + + S+ S++ E
Sbjct: 4468 HN---SSC--------ETSQSSHDRPPAEHLNPEISDEGE-ESSTASDKQEQAVLSHMRE 4515

Query: 3258 DIYQL--SKLSVSDELRKAKNLEEASSDMKDNAAALWRRYELLTTRLSQ------ELAEQ 3309
L + V EL + EE +D AAA R LL + Q LAE+
Sbjct: 4516 SSKDLLNPEGEVYQELAVSLASEETKRAPEDVAAASARGNHLLLDLIKQTSAAAFSLAER 4575

Query: 3310 LRLVMEPTLASKLQGDYKTGKRINMKKVIPYIASHYRKDKIWLRRTRPNKRDYQVVIAVD 3369
LR+++EPT+ S L+GD++TGK++N++++IP+IAS ++KDKIWLRRT+P+KR YQV++AVD
Sbjct: 4576 LRIILEPTVTSDLKGDFRTGKKLNLRRIIPFIASEFQKDKIWLRRTKPSKRVYQVLLAVD 4635

Query: 3370 DSRSMSESCCGDVAIEALVTVCRAMSQLEVGNLAVASYGKEGNIRLLHDFDQSFTGEAGI 3429
DS SM+ A++A+ + A LEVG L+V S+G++ LL + +
Sbjct: 4636 DSSSMAP--IAKYALQAITLLFNACKFLEVGQLSVFSFGQK--FELLLPITDQYNDASLA 4691

Query: 3430 KMISNLTFKQENTIKDEPVVDLLKYLNNMLDTAVANARLPSGQNPLQQLVLIIADGRFIE 3489
I + TF Q T V D + ++ LD+ R G + QL+L+I+DGR E
Sbjct: 4692 YAIGSFTFAQNET----RVSDAISIASDYLDS----VRFFKGSDSALQLLLMISDGRLKE 4743

Query: 3490 KENLKRCVRDVLSRKRMVAFLLLDSPQESIMDLQEVSF----QGGNMK-ISKYLDSFPFP 3544
K + R +R + R ++ ++LD+ ++SIMD++ VSF G ++ S YLD FPF
Sbjct: 4744 KGGVAREIRKCMGRGQLPVLIVLDTDKKSIMDIKSVSFITDSSGKRVRQTSMYLDDFPFQ 4803

Query: 3545 YYIILKNIEALPRTLADLLRQVVGVLGNWSESLKV 3579
Y +L++IE LP TL V V+ W ES+ V
Sbjct: 4804 CYALLRHIEDLPETL-------VAVIKRWIESVSV 4831



Score = 110 bits (274), Expect = 4e-22, Method: Compositional matrix adjust.
Identities = 131/538 (24%), Positives = 212/538 (39%), Gaps = 141/538 (26%)

Query: 15 TDIMDLLGSDLPVESSEGIKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDH 74
TD+ + GS P + G + + DG L+ +KQG WV+LDELN+A +LE LN +LD
Sbjct: 844 TDLSEYFGSYQP-DPLTG-QLVFKDGPLVTGMKQGHWVILDELNMASSEILEALNRLLDD 901

Query: 75 RAEVFIPELGVTFKCPSSFRVFACQNPSSQGGGRKGLPRSFLNRFTKVYVDELVEDDYLF 134
E+ +P+ + F +FA QNPS GRK L +F NRF + ++ ++
Sbjct: 902 NRELLVPDTQEIVRPAPGFLLFATQNPSGSYAGRKMLSEAFQNRFIMIEFADISTEELKE 961

Query: 135 I--------------CSSLYPSIQRPILSKLILFNKRLHEDIMLNHKFAQDGSPWEFNLR 180
I C L +IQ + + R + +M N LR
Sbjct: 962 ILINRSTSRHLAPQYCEKLITTIQAIKMQ----LSHRNNNAVMTNAL---------ITLR 1008

Query: 181 DVIRSCEIIEGAPEKLKPDCFLNIVYVQRMRTAADRREVLRLY----------------E 224
D+ R + + +L F I +R R AD++ V + E
Sbjct: 1009 DLFRVADRLPRTLTELAMGIFELI--GERQRDPADKQLVAEIIAKNLGLKTFSVSAAEQE 1066

Query: 225 QVFQVKPQLKILPGIRQSLEAVAHCVQRQWLC---------------------------- 256
+V+P I I ++L+A A + +L
Sbjct: 1067 YAIRVRP---IQSMIEKALKAGADSPKSAFLLKFQDIVWTPSMIRLFALLFTSVSNGESP 1123

Query: 257 ILVGPSSSGKTSLIRLLAHSTGNVLNELSLSSATDISELLGCFEQYNAFRNFRSVVDMIT 316
+LVG S +GKT+ + L+A L +++L T+ ++ +G + R RS M
Sbjct: 1124 LLVGVSGAGKTTSVELIAAIMAQQLVQVNLHKHTESADFIG------SLRPLRSRESM-H 1176

Query: 317 GWLAVLSSMDCGPSSTSASTYMEDWKCNRSSLCLLVEIIEHLRVDLEKNKLPVSWSCEDL 376
L+VL ++ + Y E + L
Sbjct: 1177 AHLSVLKEYAATTTNVDKAVYAE---------------------------------IKRL 1203

Query: 377 NRTLKTILKLQEDQQKRTVAAKFEWVTGLLIKALENGEWIVLDNANLCNPTVLDRINSLV 436
TL T L FEW G ++ ++ G ++LD +L + +VL+R+NS++
Sbjct: 1204 ETTLGTKL--------------FEWEDGPILNCMKRGHILLLDEVSLADESVLERLNSVL 1249

Query: 437 EPCGSITVNECGIVDGKPLVVHPHPNFRMFLTVKPSHGD-----VSRAMRNRGVEIFM 489
E +TV E P V H F++ T+ P+ GD +S AMR+R E +M
Sbjct: 1250 ETSRELTVAEN---PNMPRPVIAHTGFKLIATMNPA-GDYGKKELSPAMRSRLTEFWM 1303



Score = 76.6 bits (187), Expect = 5e-12, Method: Compositional matrix adjust.
Identities = 67/263 (25%), Positives = 127/263 (48%), Gaps = 45/263 (17%)

Query: 243 LEAVAHCVQRQWLCILVGPSSSGKTSLIRLLAHSTGNVLNELSLSSATDISELLGCFEQY 302
LE ++ ++ +LVGP+ GKT+ ++++A + G L+ +++SS TD ++LLG +
Sbjct: 339 LEIISSAIRNNEPLLLVGPTGIGKTTCLQVIARALGKKLHVVNMSSQTDAADLLGGYVPA 398

Query: 303 NAFRNFRSVVDMITGWLAV----------LSSMDCGPSSTSASTYMEDWKCNRSSLCLLV 352
R R++ D ITG L + ++ + + + ++ + + S + ++
Sbjct: 399 TLDRILRNLYDAITGSLGLYISVRKNQIFVTELHKSYAEKDIAKFLANCETALSGMRQVL 458

Query: 353 -----EIIE-------------HLRVDLEKNKLPVSWSCEDLNRTLKTILKLQE------ 388
E++E + R +N L + + L TL+ +L +
Sbjct: 459 RKEVGEVVEQGSTEQRVSHDKKYARRGTYENSL---YFLQSLGDTLEQATELHKILCHEV 515

Query: 389 DQQKRTVAAKFEWVTGLLIKALENGEWIVLDNANLCNPTVLDRINSLVEPCGSITVNECG 448
+ +K T+A F++ GLL++AL G+WI++D NL + +LD I+ LV P NE
Sbjct: 516 ETKKPTMA--FKYQEGLLVQALVKGDWILIDEINLASYDLLDVISQLVNP----EHNEIA 569

Query: 449 IVDGKPLVVHPHPNFRMFLTVKP 471
I D + +PH FR+F + P
Sbjct: 570 IPDKGFVAKNPH--FRVFAAMNP 590



Score = 72.0 bits (175), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 38/99 (38%), Positives = 62/99 (62%), Gaps = 3/99 (3%)

Query: 33 IKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILD-HRAEVFIPELGVTFKCPS 91
+ F + +G+L+QAL +G W+L+DE+NLA +L+ ++ +++ E+ IP+ G K P
Sbjct: 522 MAFKYQEGLLVQALVKGDWILIDEINLASYDLLDVISQLVNPEHNEIAIPDKGFVAKNP- 580

Query: 92 SFRVFACQNPSSQGGGRKGLPRSFLNRFTKVYVDELVED 130
FRVFA NP S G+K LP + FT++ V E+ +D
Sbjct: 581 HFRVFAAMNPGSD-VGKKDLPPTIRRCFTEINVSEMSDD 618



Score = 72.0 bits (175), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 60/268 (22%), Positives = 117/268 (43%), Gaps = 18/268 (6%)

Query: 1840 LLTALQKRLLSLLNEWEDHPGLQKILGVIEMLLAIPS-STPLAKALSGLQFLLNRIRILQ 1898
LL + R LL EW D+ L I+ V + L+ +P PL L+G + L+ +
Sbjct: 3309 LLRKIIVRTQHLLTEWPDNVQLLDIMHVCDKLMELPVLEAPLVMFLTGAEVLVRHLETWD 3368

Query: 1899 ENGS---KFSLSDQL-------EPIILLASLWKKIEFDSWPALLDEVQDQYEINGGKLWF 1948
+ K+ + + + +I L W+++E SW V Q+ N ++
Sbjct: 3369 KGAPAVYKYVTNPNVPVPESLTKSLIHLMVTWRRVELMSWNGFFSRVHTQFS-NVSLTYW 3427

Query: 1949 P---LYSVLQHRQSDDIATYNQSTIQSLEEFIQTSSIGEFRKRLELLFAFHGQISTGISL 2005
P + S+ R ++ + EF+ S++GEF RL+LL+ +S L
Sbjct: 3428 PELLIASLTYQRSVTQGEPSTEAYYAQMREFLYESNVGEFPVRLKLLYTLSALLSNIEEL 3487

Query: 2006 G---IYSSPFQMENLKILYNVFGYYVQFLPIALEHVQANRKNIETELKELLKLCRWEHSE 2062
+ SSP + +L+++ V+F + + I+ ++ +++ W
Sbjct: 3488 AEPELVSSPHKTMTSAVLFSIASEAVEFAKYMNKEFEEEAAQIKKRFEDQIRIFEWNERS 3547

Query: 2063 SYLSMENSKKTQQKLRKLIQKYTDLLQQ 2090
SY S ++ + + K+I++YT++LQ
Sbjct: 3548 SYTSWLTAQNSHRLCTKIIREYTEVLQH 3575



Score = 49.7 bits (117), Expect = 8e-04, Method: Compositional matrix adjust.
Identities = 32/105 (30%), Positives = 54/105 (51%), Gaps = 10/105 (9%)

Query: 25 LPVESSEGIKFAWSDGILLQALKQGSWVLLDELNLAPQSVLEGLNAILDHRAEVFIPELG 84
L + S+ +F W D L++AL++G WV L N SVL+ LN++L+ + I E G
Sbjct: 2011 LSTQQSQTGRFVWRDSELIRALERGYWVELTNANFCMPSVLDRLNSLLERGGGLEILEQG 2070

Query: 85 V----TFKCPSSFRVFACQNPSSQGGGRKGLPRSFLNRFTKVYVD 125
+ + K +FR+F P+S + R+ NR ++ +D
Sbjct: 2071 LEETRSIKVHPNFRLFISYAPTSD------ISRALRNRSLELSID 2109

Query: CNT0005102
Subject: sp|Q96H78|S2544_HUMAN Solute carrier family 25 member 44 OS=Homo

OS=Dictyostelium discoideum GN=mcfJ PE=2 SV=1

 Score =  108 bits (270), Expect = 5e-23,   Method: Compositional matrix adjust.
Identities = 92/363 (25%), Positives = 150/363 (41%), Gaps = 48/363 (13%)

Query: 3592 AQEIHLPAD--IDWEMLDKSKFFFLGAALFSGVSATLYPVVVLKTRQQIAQSQVSSIRTA 3649
+E+H + I W+ LD +++F L + ++P+ V++TR Q+ SQ ++ +
Sbjct: 10 TKEVHTKTNKRIQWDDLDPKRYYFYNFLLGGSIDLLMFPLDVIRTRLQVQGSQ--NVIQS 67

Query: 3650 F-----------SIVRHEGFRALYRGFGTSLMGTIPARALYMTALEVTKSNVGTATVRLG 3698
F ++R EG RALY+GF TS G + +RA+Y + E K ++
Sbjct: 68 FPQYNGTFDGFKKLIRLEGKRALYKGFLTSECGYLCSRAIYFGSYEFVKQGF----LKGR 123

Query: 3699 FPEPTXXXXXXXXXXXXXXXXXQLVWTPIDVVSQRLMVQXXXXXXXXXXXXXXEKLKIPN 3758
+ ++W P DV +Q + +Q +
Sbjct: 124 SDSDSDLLFVTTISGAISEALASVIWVPFDVATQSVQIQG-------------------S 164

Query: 3759 ASSCKYLGGIDAFRKILNTDGPRGLYRGFGISILTYAPSNAVWWASYSVAQ-RLIWSGIG 3817
S KY GG D F+KI G +GLY+GFG +I+ P + +WW +Y +++ +L I
Sbjct: 165 LSKPKYKGGSDVFKKIYGERGIKGLYKGFGATIIRNVPYSGIWWGTYEISKSKLTQFNIR 224

Query: 3818 VYLCKKDDETGENGVST----FRPDSKTXXXXXXXXXXXXXXXXXL---ITMPLDTIKTR 3870
L K+ + VS P + IT PLD KTR
Sbjct: 225 QKLGLKERSSHSLAVSAEIDKNNPSHEVENEDPIIHFISGFFAAVFATSITNPLDVAKTR 284

Query: 3871 LQVLDGEENGRRGPTIGQTVRNLVREGGWMACYRGLGPRWXXXXXXXXXXXXXYEFLKRL 3930
LQ EN + P +++ +R+ G A ++GL P YE +K+L
Sbjct: 285 LQTGVFPENEK--PNFYTIIKSTIRKEGIRALWKGLVPSLLTSTPYSMISIFLYEEVKKL 342

Query: 3931 SAK 3933
S K
Sbjct: 343 SLK 345