Query: CNT0000583
Subject: sp|Q8H0T4|UPL2_ARATH E3 ubiquitin-protein ligase UPL2 OS=Arabidopsisthaliana GN=UPL1 PE=1 SV=3
Score = 2845 bits (7374), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1580/2902 (54%), Positives = 1905/2902 (65%), Gaps = 139/2902 (4%)
Query: 1 MKLKRKRALEVPPKIRCFIDRVTSVPLEKIEEPLKAFVWEFDKGDFHHWVDLFNHFDSFF 60
MKL+R+RA EVP KI+ FI+ VTSVPLE I EPL F WEFDKGDFHHWVDLFN+FD+FF
Sbjct: 1 MKLRRRRASEVPSKIKSFINSVTSVPLELIHEPLACFRWEFDKGDFHHWVDLFNYFDTFF 60
Query: 61 EKYVKPRKDLQIXXXXXXXXXXXXRESXXXXXXXXXXXXDNCTNKHFYSSYEQHLSALLA 120
EK+V+ RKDL I +++ +NCTNKHFYSSYEQHLS LLA
Sbjct: 61 EKHVQVRKDLHIEENFEESDPPFPKDAVLQVLRVIRVVLENCTNKHFYSSYEQHLSLLLA 120
Query: 121 STDPDVVEASLDTLATFLKKTVGKYSIRDASLNSKLYALAQGWGGKEEGLGLIASAVPNG 180
STD DVVEA L TLA FLK+ +GKYSIRDASLNSKL++LAQGWGGKEEGLGL + A N
Sbjct: 121 STDADVVEACLQTLAAFLKRQIGKYSIRDASLNSKLFSLAQGWGGKEEGLGLTSCAAENS 180
Query: 181 CDPIACELGRTLHFEFYAVNESESDIKVTEPLVQGLQIIHLSDVNKCVETDLELLHKLVT 240
CD ++ +LGRTLHFEFY +ES S+ L GLQ+IH+ DV+ C E+DLELL+KLV
Sbjct: 181 CDQVSLQLGRTLHFEFYPSDESPSE------LPGGLQVIHVPDVSICAESDLELLNKLVI 234
Query: 241 EYKVPXXXXXXXXXXXXXXXXXGSLSSRQQYTCIRLYAFIVLIQASADADDLVSFFNVEP 300
++ VP SL++RQQ+TCIRLYAF+VL+QAS D +++VSFFN EP
Sbjct: 235 DHNVPPSLRFALLTRMRFARAFSSLATRQQFTCIRLYAFVVLVQASGDTENVVSFFNGEP 294
Query: 301 GFINELVSLLSYEDAVLEKIRILCLHSLAALCQDRSRQQSVQTAVTSGGHRGILSSLMQK 360
F+NELV+L+SYED V EKIRILCL SL AL QDR+RQ +V TAVTSGGHRG+LS LMQK
Sbjct: 295 EFVNELVTLVSYEDTVPEKIRILCLLSLVALSQDRTRQPTVLTAVTSGGHRGLLSGLMQK 354
Query: 361 AIDSVTSNTSKWSVHFAEAXXXXXXXXXXXXXGCSAMREAGFIPTLLPLLKDTNPQHLHL 420
AIDSV TSKWS+ FAEA GCSAMREAG IPTL+PL+KDT+PQHLHL
Sbjct: 355 AIDSVVCITSKWSLAFAEALLSLVTVLVSSSSGCSAMREAGLIPTLVPLIKDTDPQHLHL 414
Query: 421 VEKAVRILEAFMDYSNPAAALFRDLGGLDDTISRLKIEVSNVENSGKQPDDNXXXXXXXX 480
V AV ILEAFMDYSNPAAALFRDLGGLDDTI RLK+EVS E+ K+ +
Sbjct: 415 VSAAVHILEAFMDYSNPAAALFRDLGGLDDTIFRLKLEVSRTEDDVKEKN---------- 464
Query: 481 XXXXXXXTGPDDTQPLYSELLISYHRRLLMKALLRAISLGTYAPGNTARIYGSEENVLPH 540
GPD Q YSE LISYHRRLL+KALLRAISLGTYAPGNT +YGSEE++LP
Sbjct: 465 --CSSDSNGPDTEQLPYSEALISYHRRLLLKALLRAISLGTYAPGNT-NLYGSEESLLPE 521
Query: 541 CLCIIFRRAKDFGGGVFSLAATVMSDLIQKDPTCFPVLDAAGLPSAFLDAIMVDVLNSAE 600
CLCIIFRRAKDFGGGVFSLAATVMSDLI KDPTCF LD+AGL S FLDAI +V+ SAE
Sbjct: 522 CLCIIFRRAKDFGGGVFSLAATVMSDLIHKDPTCFNALDSAGLTSTFLDAISDEVICSAE 581
Query: 601 AITCIPQCLDALCLNSNGLQAVKDRNSLRCFVKVFTSRTYLRALAGDTPASLSSGLDELM 660
AITCIPQCLDALCLN++GLQAVKDRN+LRCFVK+FTS +YLRAL GDTP SLSSGLDEL+
Sbjct: 582 AITCIPQCLDALCLNNSGLQAVKDRNALRCFVKIFTSPSYLRALTGDTPGSLSSGLDELL 641
Query: 661 RHASSLRGPGVEMLVEILEAISKIGSAVXXXXXXXXX--XXXXXVPMEMDGEDKNLILPN 718
RH SSLR GV+M +EIL ++ IGS + VPME+D ++K+L + +
Sbjct: 642 RHQSSLRTYGVDMFIEILNSMLIIGSGMEATTSKSADVPTSAAPVPMEIDVDEKSLAVSD 701
Query: 719 NKESSNANDTEQITEPSHDVPIVNVESFLPDCVNNIARLLETILQNADTCRIFVEKKGIE 778
EPS D N+E FLPDCV N+ARL ET+LQNA+ C +FVEKKGI+
Sbjct: 702 E------------AEPSSDTSPANIELFLPDCVCNVARLFETVLQNAEVCSLFVEKKGID 749
Query: 779 AILQLVTLPLMPPSVSVGQSISVAFKNFSPQHYVSLARAVCSFLREHLKSINELLDLVGG 838
A+LQL +LPLMP S S+GQS SVAFKNFSPQH LAR VCS+LREHLK LL + G
Sbjct: 750 AVLQLFSLPLMPLSTSLGQSFSVAFKNFSPQHSAGLARIVCSYLREHLKKTKILLVSIEG 809
Query: 839 TQLALVESAKQTKVLKYLASLEAVLTLSVFLLKGSTTVVSELSTLDADVLKDLGKTYKEV 898
TQL +ESA QTK+L+ L+ LE +L+LS FLLKGS +V+SELS DADVLK+LG TYK+
Sbjct: 810 TQLLKLESAIQTKILRSLSCLEGMLSLSNFLLKGSASVISELSAADADVLKELGITYKQT 869
Query: 899 IWQISLCNDSKAEGKKNADQEPEVAQVPPSTAVERESDDDS-NIQTVRYTNPVFARNGSH 957
IWQ++LCND+K + KK+ D+ + + S+ ERESD+DS N VRYTNPV R+ S
Sbjct: 870 IWQMALCNDTKEDEKKSVDRGSDNSVSASSSTAERESDEDSSNALAVRYTNPVSIRSSSS 929
Query: 958 SL-WSGEREFLSVVRAGESMHRRSRHGLSRIRGGRTGRHLEALNIDXXXXXXXXXXXXXQ 1016
W G+REFLS+VR+GE +H R+RH ++R+RGGRT RHLE+ N D
Sbjct: 930 QSIWGGDREFLSIVRSGEGIHGRTRHAIARMRGGRTRRHLESFNFDSEIPADLPVTSSSH 989
Query: 1017 DLKKKSPDVLVLEILNKLASTLRSFFTALVKGFTSPNRRRADSGSLSSASKTLGAVLATN 1076
+LKKKS +VL+ EILNKL TLR FFTALVKGFTS NRRR D SLSSASKTLG LA
Sbjct: 990 ELKKKSTEVLIAEILNKLNCTLRFFFTALVKGFTSANRRRIDGASLSSASKTLGTALAKV 1049
Query: 1077 FFEALSFSGHSTYAGLEMSLSVKCRYLGKVVDDMAALTFDSRRRSCYTAMVNNFYVHGTF 1136
F EAL+F G+ AG E SLSVKCRYLGKVVDD+ L+FD+RRR C+TAMVN+FYVHGTF
Sbjct: 1050 FLEALNFDGYGAAAGHEKSLSVKCRYLGKVVDDITFLSFDTRRRVCFTAMVNSFYVHGTF 1109
Query: 1137 KELLTTFEATSQLLWTLPCSLPSSDIDVGKKGEGGKLSHNTWLLDTLQSYCRLLEYFVNS 1196
KELLTTFEATSQLLWT+P S+P+S + K GE SH+ WL+DTLQ+YCR L+YFVNS
Sbjct: 1110 KELLTTFEATSQLLWTVPFSIPASSTENEKPGERNIWSHSKWLVDTLQNYCRALDYFVNS 1169
Query: 1197 SLLLSPTSASQAELLVQPVAVGLSIGLFPVPRDPEVFVCMLQSQVLDVILLVWNHPMFCS 1256
+ LLSPT SQ +LLVQP +VGLSIGLFPVPR+PE FV LQSQVLDVIL +WNHPMF
Sbjct: 1170 TYLLSPT--SQTQLLVQPASVGLSIGLFPVPREPETFVRNLQSQVLDVILPIWNHPMFPD 1227
Query: 1257 CSPGFIASIISLVTHVYSGVGDVKRNRINIVGSTNQRFMPPPPDEATIATIVEMGFSXXX 1316
C+P F+AS+ SLVTH+YSGV D + NR + NQR +P DE+ + IVEMGFS
Sbjct: 1228 CNPNFVASVTSLVTHIYSGVVDARENRSGVTRGINQRALPLQLDESIVGMIVEMGFSRSR 1287
Query: 1317 XXXXXXXXXTNSVEMAMEWLFSHADDPVQEDDXXXXXXXXXXXXXXXXXXXXXXXKTIDV 1376
TNSVEMAM+WLF++ + PVQEDD K +DV
Sbjct: 1288 AEIALRRVGTNSVEMAMDWLFTNPEQPVQEDDELAQALALSLGNSSETPKLEDTEKPVDV 1347
Query: 1377 LTEEGHVKKPPVDDILAASVKLFQSSDSVPFQLTDLLVTLCSQSKGDDRPKVTSYLLQQL 1436
EE K+PPVD+++AASVKLFQS DS+ F L DL VTLC+++KG+DRPK+ SYL+QQL
Sbjct: 1348 PQEEAEPKEPPVDEVIAASVKLFQSDDSMAFPLMDLFVTLCNRNKGEDRPKIVSYLIQQL 1407
Query: 1437 KLCPLDFSQDNCXXXXXXXXXXXXXFEDGSTREIAAQNGIISTIIDILTNFKGRQELGKE 1496
KL LDFS+D ED +TREIAAQ+GI++ I ILT+F + E E
Sbjct: 1408 KLVQLDFSKDTGALTMIPHILALVLSEDDNTREIAAQDGIVTVAIGILTDFNLKSESETE 1467
Query: 1497 LPVPKCISALLLILDQMVQSRPKV--ENMEGTQTGSLPDSSGEQFSDTVLPKEKNSNGIE 1554
+ PKCISALLL+L M+Q++ K+ E +EG Q GSL S Q S L +S+ +
Sbjct: 1468 ILAPKCISALLLVLSMMLQAQTKLSSEYVEGNQGGSLVPSDSPQDSTAALKDALSSDVAK 1527
Query: 1555 KEPAMAFENILGKSTGFATIDESHKLLDIACDLIKQHVPAVVMQAVLQLCARLTKTHALA 1614
E A E I GKSTG+ T++E HK L IAC LIKQHVPA++MQAVLQLCARLTK+HALA
Sbjct: 1528 GESNQALELIFGKSTGYLTMEEGHKALLIACGLIKQHVPAMIMQAVLQLCARLTKSHALA 1587
Query: 1615 LQFLENGGLAALFNLPRTCLFPGYDSVVSAIVRHLLEDPQTLQTAMELEIRQTLSGNRHS 1674
+QFLENGGL++LFNLP+ C FPGYD+V S IVRHL+EDPQTLQ AME EIRQTLSG RH
Sbjct: 1588 IQFLENGGLSSLFNLPKKCCFPGYDTVASVIVRHLVEDPQTLQIAMETEIRQTLSGKRHI 1647
Query: 1675 GRVSPRSFLTSLAPVISRDPMVFMKAAAAVCQIETSGGRTXXXXXXXXXXXXXXXXXXXX 1734
GRV PR+FLT++APVISRDP+VFMKA A+ CQ+E+SGGR
Sbjct: 1648 GRVLPRTFLTTMAPVISRDPVVFMKAVASTCQLESSGGRDFVILSKEKEKPKVSGSEHGF 1707
Query: 1735 XXXXXXCVRIPEIKSHDGLGKFLKSHKKVPVNLTQVIDQLLEIVLKYPLVKGQEDSECDS 1794
+ I E K HD GK KSH++VP N QVIDQL+++VL +P VK QED E +
Sbjct: 1708 SLNEP--LGISENKLHDVSGKCSKSHRRVPANFIQVIDQLIDLVLSFPRVKRQEDGETNL 1765
Query: 1795 TFMDIDEPTMKVKGKSKVEE------AGILEPES----ERSTGLVKVTFVLKLLSDILLM 1844
M++DEPT KVKGKSKV E + + EPE E+S L +VTF+LKLLSDI+LM
Sbjct: 1766 ISMEVDEPTTKVKGKSKVGEPEKASSSRVGEPEKAEIPEKSEELARVTFILKLLSDIVLM 1825
Query: 1845 YGHAVGVILRRDSEMCQFRGSNQPS---GHSGIIHHVLHRLLPLSVDKSAGPDDWRGKLS 1901
Y H VILRRD+E+ Q RGSN P G+ G+I+HV+HRLLP+S++K GP++W+ KLS
Sbjct: 1826 YSHGTSVILRRDTEISQLRGSNLPDDSPGNGGLIYHVIHRLLPISLEKFVGPEEWKEKLS 1885
Query: 1902 EKASWFLVVLCGRSGEGRKRVTNELVKELMSFSHLESNSMKSSLLPDKRLFTFVDLVXXX 1961
EKASWFLVVLC RS EGRKR+ NEL + L F+ L +S KS LLPDKR+ F +LV
Sbjct: 1886 EKASWFLVVLCSRSNEGRKRIINELSRVLSVFASLGRSSSKSVLLPDKRVLAFANLVYSI 1945
Query: 1962 XXXXXXXXXXXX--XXXXXDIAKSMIDGGIILSLTSILQVVDLDHPDAPKIVNLILKGLE 2019
D+AKSM+DGG I LTSIL V+DLDHPDAPK+V LILK LE
Sbjct: 1946 LTKNSSSSSSNFPGCGCSPDVAKSMMDGGTIQCLTSILHVIDLDHPDAPKLVTLILKSLE 2005
Query: 2020 GLTRAANASEQIFKSDGTEKKRSAVLNDRSDDQITAPSAAEAVAHDQNAGSQEASRDAMD 2079
LTRAANA+EQ+ KS+ +K++ ++R D + + EA +QN S + DA
Sbjct: 2006 TLTRAANAAEQL-KSEVPNEKKNRDSDERHDSHGNS-TETEADELNQNNSSLQQVTDAAG 2063
Query: 2080 NAHNQG---TSQGDDRADNPDQSMEHDIRVEEGGTMAQNQTMELGMDFMREEMGEGGVLH 2136
N Q + +R + Q+M D+R+E T+ + MDFMREE+ EG
Sbjct: 2064 NGQEQAQVSSQSAGERGSSQTQAMPQDMRIEGDETILPE---PIQMDFMREEI-EG---- 2115
Query: 2137 NPDQIEMTFHVENRAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSLADTD 2196
DQIEM+FHVENRA SLA TD
Sbjct: 2116 --DQIEMSFHVENRA-------DDDVDDDMGDEGEDDEGDDEDADLVEDGAGVMSLAGTD 2166
Query: 2197 VEDHDDVGFGXXXXXXXXXXXXXXXXXNRVIEVRWREALDGLDHLQILGQP----GFI-D 2251
VED +D G G NRVIEVRWREALDGLDH QILG+ GFI D
Sbjct: 2167 VEDPEDTGLGDEYNDDMVDEDDDDFHENRVIEVRWREALDGLDHFQILGRSGGGNGFIDD 2226
Query: 2252 VAAEPFEGVNVDDLFRLQ---SFERRRQTGRSSFERSATEVNGFQHPLLVRPPPSGDFVS 2308
+ AEPFEGVNVDDLF L+ FERRRQTGRSS +RS +EV+GFQHPL RP +G+ S
Sbjct: 2227 ITAEPFEGVNVDDLFALRRPLGFERRRQTGRSSLDRSGSEVHGFQHPLFSRPSQTGNTAS 2286
Query: 2309 MWSSSGNSASRDSETLSSGNLDVAHFYMFDAPILPYDHVPSSLFGDRL-GGAAPPPLTDY 2367
+ +S+G S SR SE +G+ DVA FYMFD P+LP+D VP F RL GG APPPLTDY
Sbjct: 2287 VSASAG-SISRHSE---AGSYDVAQFYMFDTPVLPFDQVPVDPFSARLAGGGAPPPLTDY 2342
Query: 2368 S-VGMGSLHLPGRRVLGNGRWTDDGQPQGSXXXXXXXXXVEEQFLAQLCSVAPASSPVER 2426
S VGM S RR +G+ RWTD G PQ S +EE F++ L + AP ++ VER
Sbjct: 2343 SVVGMDS----SRRGVGDSRWTDIGHPQPSSLSASIAQLIEEHFISNLRASAPVNTVVER 2398
Query: 2427 QLQNSGEQENKSDALASHDGPILTAGIDSTSQQIDSQEQENGNGTRAQQINDGGLCEE-- 2484
+ + QE + G G D S+E+E N + E
Sbjct: 2399 ETNTTEIQEQLHPDVPPSVGSETVLG-DGNEGGQQSEERELLNNNENVNNPPDVMAESFA 2457
Query: 2485 --EINVDSG-GRDTAEELQANEPMSVQPVSLNIMPNGFD-CTVIEGNVTHDENVAQAFVN 2540
+ N+ S +DT E LQ E M QP+ LN PN D V EG+ + V V+
Sbjct: 2458 QGQANLASPVSQDTGESLQQLEVM--QPLPLNSTPNEIDRMEVGEGDGAPIDQVDHEAVH 2515
Query: 2541 SSINSDAAIQCESGADVPTSIHNVPIESMEFNGSSNADGQPPNIELGGSGFETPNPGDSH 2600
I G +SI NV + ++ P D
Sbjct: 2516 -------LISTAQGQPDTSSIQNVSVTAI------------------------APPVDDP 2544
Query: 2601 ASSIYASADVDMGGTDAEGNQSEQPTVFEDGRGEMLSTQNTEVAPDATQADQVSANNEAS 2660
S+ S DVDM AEGNQS QP+ + E+ S + TE + Q ++ S + A
Sbjct: 2545 DSNFQPSVDVDMSSDGAEGNQSVQPSPLDGDNNELSSMEATENVRNDEQVEEGSLDGRAP 2604
Query: 2661 GANTIDPTFLEALPEDLRAEVLXXXXXXXXXXXXXXXXXXEDIDPEFLAALPPDIQAEVL 2720
N IDPTFLEALPEDLRAEVL +DIDPEFLAALPPDIQ EVL
Sbjct: 2605 EVNAIDPTFLEALPEDLRAEVLASQQAQSVQPPTYEPPPVDDIDPEFLAALPPDIQTEVL 2664
Query: 2721 XXXXXXXXXXXXEGQPVDMDNASIIATFPAELREEVLLTXXXXXXXXXXXXXXXXXQILR 2780
+GQ VDMDNASIIAT PA+LREEVLLT Q+LR
Sbjct: 2665 AQQRAQRMVQQSQGQAVDMDNASIIATLPADLREEVLLTSSEAVLAALPSPLLAEAQMLR 2724
Query: 2781 DRAMSHYQAR-SLFGSSHRLNNRRNGLGFDRRPVMDRGVGVTIGRR--SALTDSLKVKEI 2837
DRAMSHYQAR S+FGSSHRLNNRRNGLG++R MDRGVGVTIG+R S+ D LKVKEI
Sbjct: 2725 DRAMSHYQARSSVFGSSHRLNNRRNGLGYNRLTGMDRGVGVTIGQRAVSSSADGLKVKEI 2784
Query: 2838 EGEPLLDGNALKALIRLLRLSQ 2859
EG+PL++ +ALK+LIRLLRL+Q
Sbjct: 2785 EGDPLVNADALKSLIRLLRLAQ 2806
Query: CNT0000583
Subject: sp|Q7Z6Z7|HUWE1_HUMAN E3 ubiquitin-protein ligase HUWE1 OS=Homothaliana GN=UPL2 PE=1 SV=3
Score = 2775 bits (7194), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1560/2917 (53%), Positives = 1889/2917 (64%), Gaps = 186/2917 (6%)
Query: 1 MKLKRKRALEVPPKIRCFIDRVTSVPLEKIEEPLKAFVWEFDKGDFHHWVDLFNHFDSFF 60
MKL+R+RA EVP KI FI+ VTSVPLE I+EPL +F WEFDKGDFHHWVDLF HFD+FF
Sbjct: 1 MKLRRRRASEVPTKISLFINSVTSVPLELIQEPLASFRWEFDKGDFHHWVDLFYHFDTFF 60
Query: 61 EKYVKPRKDLQIXXXXXXXXXXXXRESXXXXXXXXXXXXDNCTNKHFYSSYEQHLSALLA 120
EK+VK RKDL+I +++ +NCTNK FY+SYEQHLS LLA
Sbjct: 61 EKHVKVRKDLRIEEEFDESDPPFPKDAVLQVLRVIRLVLENCTNKQFYTSYEQHLSLLLA 120
Query: 121 STDPDVVEASLDTLATFLKKTVGKYSIRDASLNSKLYALAQGWGGKEEGLGLIASAVPNG 180
STD DVVEA L TLA FLK+ GKYSIRDASLN KL++LAQGWGGKEEGLGL + A +
Sbjct: 121 STDADVVEACLQTLAAFLKRPTGKYSIRDASLNLKLFSLAQGWGGKEEGLGLTSCATEHS 180
Query: 181 CDPIACELGRTLHFEFYAVNESESDIKVTEPLVQGLQIIHLSDVNKCVETDLELLHKLVT 240
CD + +LG TL FEFYA +ES S+ L GLQ+IH+ DV+ E+DLELL+KLV
Sbjct: 181 CDQLFLQLGCTLLFEFYASDESPSE------LPGGLQVIHVPDVSMRSESDLELLNKLVI 234
Query: 241 EYKVPXXXXXXXXXXXXXXXXXGSLSSRQQYTCIRLYAFIVLIQASADADDLVSFFNVEP 300
++ VP SL++RQQYTCIRLYAFIVL+QAS D +++VSFFN EP
Sbjct: 235 DHNVPPSLRFALLTRLRFARAFSSLATRQQYTCIRLYAFIVLVQASGDTENVVSFFNGEP 294
Query: 301 GFINELVSLLSYEDAVLEKIRILCLHSLAALCQDRSRQQSVQTAVTSGGHRGILSSLMQK 360
F+NELV+L+SYED V KIRILCL SL AL QDR+RQ +V TAVTSGGHRG+LS LMQK
Sbjct: 295 EFVNELVTLVSYEDTVPAKIRILCLQSLVALSQDRTRQPTVLTAVTSGGHRGLLSGLMQK 354
Query: 361 AIDSVTSNTSKWSVHFAEAXXXXXXXXXXXXXGCSAMREAGFIPTLLPLLKDTNPQHLHL 420
AIDSV NTSKWS+ FAEA GCSAMREAG IPTL+PL+KDT+PQHLHL
Sbjct: 355 AIDSVICNTSKWSLAFAEALLSLVTVLVSSSSGCSAMREAGLIPTLVPLIKDTDPQHLHL 414
Query: 421 VEKAVRILEAFMDYSNPAAALFRDLGGLDDTISRLKIEVSNVENSGKQPDDNXXXXXXXX 480
V AV ILE FMDYSNPAAALFRDLGGLDDTI RLK EVS E+ K+
Sbjct: 415 VSTAVHILEVFMDYSNPAAALFRDLGGLDDTIFRLKQEVSRTEDDVKE------------ 462
Query: 481 XXXXXXXTGP-DDTQPL-YSELLISYHRRLLMKALLRAISLGTYAPGNTARIYGSEENVL 538
GP DDT+ L YSE LISYHRRLL+KALLRAISLGTYAPGNT +YGSEE++L
Sbjct: 463 IVCCSGSNGPEDDTEQLPYSEALISYHRRLLLKALLRAISLGTYAPGNT-NLYGSEESLL 521
Query: 539 PHCLCIIFRRAKDFGGGVFSLAATVMSDLIQKDPTCFPVLDAAGLPSAFLDAIMVDVLNS 598
P CLCIIFRRAKDFGGGVFSLAATVMSDLI KDPTCF LD+AGL SAFLDAI +V+ S
Sbjct: 522 PECLCIIFRRAKDFGGGVFSLAATVMSDLIHKDPTCFNALDSAGLTSAFLDAISDEVICS 581
Query: 599 AEAITCIPQCLDALCLNSNGLQAVKDRNSLRCFVKVFTSRTYLRALAGDTPASLSSGLDE 658
AEAITCIPQCLDALCLN++GLQAVKDRN+LRCFVK+F+S +YL+AL DTP SLSSGLDE
Sbjct: 582 AEAITCIPQCLDALCLNNSGLQAVKDRNALRCFVKIFSSPSYLKALTSDTPGSLSSGLDE 641
Query: 659 LMRHASSLRGPGVEMLVEILEAISKIGSAVXXXXXXXXX--XXXXXVPMEMDGEDKNLIL 716
L+RH SSLR GV+M +EIL +I IGS + VPME+D ++K+L +
Sbjct: 642 LLRHQSSLRTYGVDMFIEILNSILIIGSGMEATTSKSADVPTDAAPVPMEIDVDEKSLAV 701
Query: 717 PNNKESSNANDTEQITEPSHDVPIVNVESFLPDCVNNIARLLETILQNADTCRIFVEKKG 776
+ EPS D N+E FLPDCV N+ARL ET+LQNA+ C +FVEKKG
Sbjct: 702 SDE------------AEPSSDTSPANIELFLPDCVCNVARLFETVLQNAEVCSLFVEKKG 749
Query: 777 IEAILQLVTLPLMPPSVSVGQSISVAFKNFSPQHYVSLARAVCSFLREHLKSINELLDLV 836
I+ +LQL +LPLMP S S+GQS SVAFKNFSPQH LAR +CS+LREHLK N LL +
Sbjct: 750 IDTVLQLFSLPLMPLSTSLGQSFSVAFKNFSPQHSAGLARILCSYLREHLKKTNNLLVSI 809
Query: 837 GGTQLALVESAKQTKVLKYLASLEAVLTLSVFLLKGSTTVVSELSTLDADVLKDLGKTYK 896
GTQL +ESA QTK+L+ L+ LE +L+LS FLLKGS +V+SELS +ADVLK+LG TYK
Sbjct: 810 EGTQLLKLESAVQTKILRSLSCLEGMLSLSNFLLKGSASVISELSAANADVLKELGITYK 869
Query: 897 EVIWQISLCNDSKAEGKKNADQEPEVAQVPPSTAVERESDDDS-NIQTVRYTNPVFARNG 955
+ IWQ++LCND+K + KK+ D+ + + S+ ERESD+DS N VRYTNPV R+
Sbjct: 870 QTIWQMALCNDTKEDEKKSVDRASDNSVSASSSTAERESDEDSSNALAVRYTNPVSIRSS 929
Query: 956 SHSL-WSGEREFLSVVRAGESMHRRSRHGLSRIRGGRTGRHLEALNIDXXXXXXXXXXXX 1014
S W G REFLSVVR+G +H +RH ++R+RGGRT RHLE+ N D
Sbjct: 930 SSQSIWGGHREFLSVVRSGRGVHGHTRHAIARMRGGRTRRHLESFNFDSEIPADLPVTSS 989
Query: 1015 XQDLKKKSPDVLVLEILNKLASTLRSFFTALVKGFTSPNRRRADSGSLSSASKTLGAVLA 1074
+LKKKS +VL+ EILNKL TLR FFT+LVKGFTS NRRR D SLSSASKTLG LA
Sbjct: 990 SHELKKKSTEVLIAEILNKLNCTLRFFFTSLVKGFTSANRRRIDGPSLSSASKTLGTALA 1049
Query: 1075 TNFFEALSFSGHSTYAGLEMSLSVKCRYLGKVVDDMAALTFDSRRRSCYTAMVNNFYVHG 1134
F EAL+F G+ AG + SLS+KCRYLGKVVDD+ LTFD+RRR C+TAMVN+FYVHG
Sbjct: 1050 KVFLEALNFQGYGAAAGPDTSLSLKCRYLGKVVDDITFLTFDTRRRVCFTAMVNSFYVHG 1109
Query: 1135 TFKELLTTFEATSQLLWTLPCSLPSSDIDVGKKGEGGKLSHNTWLLDTLQSYCRLLEYFV 1194
TFKELLTTFEATSQLLW +P S+ +S + K GE SH+ WL+DTLQ+YCR L+YFV
Sbjct: 1110 TFKELLTTFEATSQLLWKVPFSIRASSTENEKSGERNLWSHSKWLVDTLQNYCRALDYFV 1169
Query: 1195 NSSLLLSPTSASQAELLVQPVAVGLSIGLFPVPRDPEVFVCMLQSQVLDVILLVWNHPMF 1254
NS+ LLSPT SQ +LLVQP +V LSIGLFPVPR+PE FV LQSQVL+VIL +WNHPMF
Sbjct: 1170 NSTYLLSPT--SQTQLLVQPASVDLSIGLFPVPREPETFVRNLQSQVLEVILPIWNHPMF 1227
Query: 1255 CSCSPGFIASIISLVTHVYSGVGDVKRNRINIVGSTNQRFMPPPPDEATIATIVEMGFSX 1314
C+P F+AS+ SLVTH+YSGV D + NR TNQR +P PDEA + IVEMGFS
Sbjct: 1228 PDCNPNFVASVTSLVTHIYSGVVDTRENRSGATQGTNQRALPLQPDEAIVGMIVEMGFSR 1287
Query: 1315 XXXXXXXXXXXTNSVEMAMEWLFSHADDPVQEDDXXXXXXXXXXXXXXXXXXXXXXXKTI 1374
TNSVEMAM+WLF++ +DPVQEDD K +
Sbjct: 1288 SRAEDALRRVGTNSVEMAMDWLFTNPEDPVQEDDELAQALALSLGNSSETPKLEDTEKPV 1347
Query: 1375 DVLTEEGHVKKPPVDDILAASVKLFQSSDSVPFQLTDLLVTLCSQSKGDDRPKVTSYLLQ 1434
DV EE K+PPVD+++AASVKLFQS DS+ F L DL VTLC+++KG+DRPK+ YL+Q
Sbjct: 1348 DVPQEEAEPKEPPVDEVIAASVKLFQSDDSIAFPLVDLFVTLCNRNKGEDRPKIVFYLIQ 1407
Query: 1435 QLKLCPLDFSQDNCXXXXXXXXXXXXXFEDGSTREIAAQNGIISTIIDILTNFKGRQELG 1494
QLKL LDFS+D ED +TREIAAQ+GI++ I ILT+F + E
Sbjct: 1408 QLKLVQLDFSKDTGALTMIPHILALVLSEDDNTREIAAQDGIVAVAIGILTDFNLKSESE 1467
Query: 1495 KELPVPKCISALLLILDQMVQSRPKV--ENMEGTQTGSLPDSSGEQFSDTVLPKEKNSNG 1552
++ PKCISALLL+L M+Q++ ++ E +EG Q GSL S Q S L +S+
Sbjct: 1468 TDILAPKCISALLLVLSMMLQAQTRLSSEYVEGNQGGSLVLSDSPQDSTAALKDALSSDV 1527
Query: 1553 IEKEPAMAFENILGKSTGFATIDESHKLLDIACDLIKQHVPAVVMQAVLQLCARLTKTHA 1612
+ E A E++ GKSTG+ T++ES K+L IAC LIKQ VPA++MQAVLQLCARLTK+HA
Sbjct: 1528 AKGESNQALESMFGKSTGYLTMEESSKVLLIACGLIKQRVPAMIMQAVLQLCARLTKSHA 1587
Query: 1613 LALQFLENGGLAALFNLPRTCLFPGYDSVVSAIVRHLLEDPQTLQTAMELEIRQTLSGNR 1672
LA+QFLENGGL++LFNLP+ C FPGYD+V S IVRHL+EDPQTLQ AME EIRQTLSG R
Sbjct: 1588 LAIQFLENGGLSSLFNLPKKCFFPGYDTVASVIVRHLVEDPQTLQIAMETEIRQTLSGKR 1647
Query: 1673 HSGRVSPRSFLTSLAPVISRDPMVFMKAAAAVCQIETSGGRTXXXXXXXXXXXXXXXXXX 1732
H GRV PR+FLT++APVISRDP+VFMKA A+ CQ+E+SGG
Sbjct: 1648 HIGRVLPRTFLTTMAPVISRDPVVFMKAVASTCQLESSGG--TDFVILTKEKEKPKVSGS 1705
Query: 1733 XXXXXXXXCVRIPEIKSHDGLGKFLKSHKKVPVNLTQVIDQLLEIVLKYPLVKGQEDSEC 1792
+ I E K HDG GK KSH++VP N QVIDQL++IVL +P +K QE
Sbjct: 1706 EHGFSLNEPLGISENKLHDGSGKCSKSHRRVPTNFIQVIDQLIDIVLSFPGLKRQEGEAA 1765
Query: 1793 DSTFMDIDEPTMKVKGKSKVEEAGILEPESERSTGLVKVTFVLKLLSDILLMYGHAVGVI 1852
+ MD+DEPT KVKGKSKV E E SE+S L +VTF+LKLLSDI+LMY H VI
Sbjct: 1766 NLISMDVDEPTTKVKGKSKVGEPEKAELGSEKSEELARVTFILKLLSDIVLMYLHGTSVI 1825
Query: 1853 LRRDSEMCQFRGSNQPS---GHSGIIHHVLHRLLPLSVDKSAGPDDWRGKLSEKASWFLV 1909
LRRD+E+ Q RGSN P G+ G+I+HV+HRLLP+S++K GP++W+ KLSEKASWFLV
Sbjct: 1826 LRRDTEISQLRGSNLPDDSPGNGGLIYHVIHRLLPISLEKFVGPEEWKEKLSEKASWFLV 1885
Query: 1910 VLCGRSGEGRKRVTNELVKELMSFSHLESNSMKSSLLPDKRLFTFVDLVXXXXXXXXXXX 1969
VLC RS EGRKR+ NEL + L F+ L +S +S LLPDKR+ F +LV
Sbjct: 1886 VLCSRSNEGRKRIINELTRVLSVFASLGRSSSQSVLLPDKRVLAFANLVYSILTKNSSSS 1945
Query: 1970 XXXXXXXXXDIAKSMIDGGIILSLTSILQVVDLDHPDAPKIVNLILKGLEGLTRAANASE 2029
D+AKSMIDGG I LTSIL V+DLDHPDAPK+V LILK LE LTRAANA+E
Sbjct: 1946 NFPGCGCSPDVAKSMIDGGTIQCLTSILNVIDLDHPDAPKLVTLILKSLETLTRAANAAE 2005
Query: 2030 QIFKSDGTEKKRSAVLNDRSDDQITAPSAAEAVAHDQNAGSQEASRDAMDNAHNQG--TS 2087
Q+ KS+ ++++ ++R D T+ S E +QN S + DA+DN Q +S
Sbjct: 2006 QL-KSEVPNEQKNTDSDERHDSHGTSTS-TEVDELNQNNSSLQQVTDAVDNGQEQPQVSS 2063
Query: 2088 QGD-DRADNPDQSMEHDIRVEEGGTMAQNQTMELGMDFMREEMGEGGVLHNPDQIEMTFH 2146
Q + +R + Q+M ++R+E T+ + MDF REE+ EG DQIEM+FH
Sbjct: 2064 QSEGERGSSLTQAMLQEMRIEGDETILPE---PIQMDFFREEI-EG------DQIEMSFH 2113
Query: 2147 VENRAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSLADTDVEDHDDVGFG 2206
VE+RA S+A TDVED +D G G
Sbjct: 2114 VEDRA-------DDDVDDDMDDEGEDDEGDDEDADSVEDGAGVMSIAGTDVEDPEDTGLG 2166
Query: 2207 XXXXXXXXXXXXXXXX------------------------------XNRVIEVRWREALD 2236
RVIEVRWREALD
Sbjct: 2167 DEYNDDMVDEDEEDEDEYNDDMVDEDEDDEDEYNDDMVDEDEDDFHETRVIEVRWREALD 2226
Query: 2237 GLDHLQILGQP----GFI-DVAAEPFEGVNVDDLFRLQ---SFERRRQTGRSSFERSATE 2288
GLDH QI+G+ GFI D+ AEPFEGVNVDDLF L+ FERRRQTGRSSF+RS +E
Sbjct: 2227 GLDHFQIVGRSGGGNGFIDDITAEPFEGVNVDDLFALRRSLGFERRRQTGRSSFDRSGSE 2286
Query: 2289 VNGFQHPLLVRPPPSGDFVSMWSSSGNSASRDSETLSSGNLDVAHFYMFDAPILPYDHVP 2348
V+GFQHPL RP +G+ S+ +S+G S SR SE +G+ DVA FYMFD+P+LP+D VP
Sbjct: 2287 VHGFQHPLFSRPSQTGNTASVSASAG-SISRHSE---AGSYDVAQFYMFDSPVLPFDQVP 2342
Query: 2349 SSLFGDRL-GGAAPPPLTDYS-VGMGSLHLPGRRVLGNGRWTDDGQPQGSXXXXXXXXXV 2406
F DRL GG APPPLTDYS VGM S RR +G+ RWTD G PQ S +
Sbjct: 2343 VDPFSDRLGGGGAPPPLTDYSVVGMDS----SRRGVGDSRWTDVGHPQPSSLSASIAQLI 2398
Query: 2407 EEQFLAQLCSVAPASSPVERQLQNSGEQENKSDALASHDGPILTAGIDSTSQQIDSQEQE 2466
EE F+ L + AP + VER+ + QE + P + + S E
Sbjct: 2399 EEHFITNLRASAPVDTVVERETNTTEVQEQQQ--------PDVPPSVGS--------ETV 2442
Query: 2467 NGNGTRAQQINDGGLCEEEINVDSGGRDTAEELQANEPMSVQPVSLNIMPNGFD-CTVIE 2525
G+G N+GG EE E L NE M P+ LN PN D V E
Sbjct: 2443 LGDG------NEGGEQSEE----------HELLNNNEVM--HPLPLNSTPNEIDRMEVGE 2484
Query: 2526 GNVTHDENVAQAFVNSSINSDAAIQCESGADVPTSIHNVPIESMEFNGSSNADGQPPNIE 2585
G E V + V+ I G + I NV + ++
Sbjct: 2485 GGGAPIEQVDREAVH-------LISSAQGQSDTSGIQNVSVTAI---------------- 2521
Query: 2586 LGGSGFETPNPGDSHASSIYASADVDMGGTDAEGNQSEQPTVFEDGRGEMLSTQNTEVAP 2645
P P D S+ S DVDM AEGNQS QP+ + E+ S + T+
Sbjct: 2522 --------PPPVDDPDSNFQPSVDVDMSSDGAEGNQSVQPSPLDGDNNELSSMEATQDVR 2573
Query: 2646 DATQADQVSANNEASGANTIDPTFLEALPEDLRAEVLXXXXXXXXXXXXXXXXXXEDIDP 2705
+ Q D+ S + A N IDPTFLEALPEDLRAEVL +DIDP
Sbjct: 2574 NDEQVDEGSLDGRAPEVNAIDPTFLEALPEDLRAEVLASQQAQSVQPPTYEPPSVDDIDP 2633
Query: 2706 EFLAALPPDIQAEVLXXXXXXXXXXXXEGQPVDMDNASIIATFPAELREEVLLTXXXXXX 2765
EFLAALPP+IQ EVL +GQPVDMDNASIIAT PA+LREEVLLT
Sbjct: 2634 EFLAALPPEIQREVLAQQRAQRMLQQSQGQPVDMDNASIIATLPADLREEVLLTSSEAVL 2693
Query: 2766 XXXXXXXXXXXQILRDRAMSHYQARS-LFGSSHRLNNRRNGLGFDRRPVMDRGVGVTIGR 2824
Q+LRDRAM HYQARS +FGSSHRLNNRRNGLG+ R M+RGVGVTIG+
Sbjct: 2694 AALPPPLLAEAQMLRDRAMRHYQARSRVFGSSHRLNNRRNGLGY-RLTGMERGVGVTIGQ 2752
Query: 2825 R--SALTDSLKVKEIEGEPLLDGNALKALIRLLRLSQ 2859
R S+ D LKVKEIEG+PL++ +ALK+LIRLLRL+Q
Sbjct: 2753 RDVSSSADGLKVKEIEGDPLVNADALKSLIRLLRLAQ 2789
Query: CNT0000583
Subject: sp|Q7TMY8|HUWE1_MOUSE E3 ubiquitin-protein ligase HUWE1 OS=Mussapiens GN=HUWE1 PE=1 SV=3
Score = 193 bits (490), Expect = 2e-47, Method: Compositional matrix adjust.
Identities = 236/973 (24%), Positives = 392/973 (40%), Gaps = 96/973 (9%)
Query: 5 RKRALEVPPKIRCFIDRVTSVPLEKIEEPLKAF-VWEFDKGDFHHWVDLFNHFDSFFEKY 63
+K E P R ID++ E++ L+ W K + +HWVDL + FD
Sbjct: 9 KKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADA 68
Query: 64 VKPRKDLQIXXXXXXXXXXXXRESXXXXXXXXXXXXDNCTNKHFYSSYEQHLSALLASTD 123
+ +++ + + ++H YSS E HL+ LLAS+D
Sbjct: 69 GQTVENMSWMLVCDRPEREQLKMLLLAVLNFTALLIEYSFSRHLYSSIE-HLTTLLASSD 127
Query: 124 PDVVEASLDTLATFLKKTVGKYSIRDAS-----LNSKLYALAQGWGGKEEGLGLIASAVP 178
VV A L+ L F K++ Y R S L ++L LA+ WGGKE G GL
Sbjct: 128 MQVVLAVLNLLYVFSKRS--NYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLAEC--- 182
Query: 179 NGCDPIAC----ELGRTLHFEFYAVNESESDIKVTEPLVQGLQIIHLSDVNKCVETDLEL 234
C + TLHFEFYA +E I+ L IH+ ++K E+ E+
Sbjct: 183 --CRDLHMMKYPPSATTLHFEFYADPGAEVKIE-KRTTSNTLHYIHIEQLDKISESPSEI 239
Query: 235 LHKLVTEYKVPXXXXXXXXXXXXXXXXXGSLSSRQQYTCIRLYAFIVLIQASADADDLVS 294
+ L Y +P + R Q RL+A +L+ ++A + S
Sbjct: 240 MESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANS 299
Query: 295 -FFNVEPGFINELVSLLSYEDAVLEKIRILCLHSLAALCQ-DRS-RQQSVQTAVTSGGHR 351
+N G I ELV +L D L +I+ L +L ++ +R+ + S+ + +
Sbjct: 300 ILYN---GLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYH 356
Query: 352 GILSSLMQKAIDS-VTSNTSKWSVHFAEAXXXXXXXXXXXXXGCSAMREAGFIPTLLPLL 410
G L L++ I + + + + FA A G A+ G + LL ++
Sbjct: 357 GFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVI 416
Query: 411 K---DTNPQHLHLVEKAVRILEAFMDYSNPAAALFRDLGGLDDTISRLKIEVSNVENSGK 467
K D Q + V +AVR+++ +N A F+ GL I RL+ EV
Sbjct: 417 KFLGDEQDQ-ITFVTRAVRVVDLI---TNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECP 472
Query: 468 QPDDNXXXXXXXXXXXXXXXTGPDDTQPLYSELLISYHRRLLMKALLRAISLGTYAPGNT 527
T D Q + R L+K++L + P +
Sbjct: 473 FVIKPKIQRPNTTQEGEEMETDMDGVQCI-------PQRAALLKSMLNFLKKAIQDPAFS 525
Query: 528 ARIYGSEENVLPHCLCIIFRRAKDFGGGVFSLAATVMSDLIQKDPTCFPVLDAAGLPSAF 587
I + LP L I A+ +G +F LA V++ + ++P+ L GL
Sbjct: 526 DGIRHVMDGSLPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVM 585
Query: 588 LDAIMV-DVLNSAEAITCIPQCLDALCLNSNGLQAVKDRNSLRCFVKVFTSRTYLRALA- 645
L A+++ DV + E + +P ALCLN+ GLQ+ KV S YL A+
Sbjct: 586 LHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRR 645
Query: 646 -------GDTPASLSSGLDELMRHASSLRGPGVEMLVEILEAISKIG---SAVXXXXXXX 695
GDT ++L S +DELMRH +L+ ++++LE I +G +
Sbjct: 646 RRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQ 705
Query: 696 XXXXXXXVPMEMDGEDKNLILPNN------KESSNANDTEQI-TEPSHDVPIVNVESFLP 748
P + + + N T+Q TEP+ V V E +P
Sbjct: 706 KADGTATAPPPRSNHAAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQV--VGTEERIP 763
Query: 749 ----DCVNNIARLLETILQNA---DTCRIFVEKKGIEAILQLVTLPLMP---PSVSVGQS 798
D + N+ + +E+IL N D C+ FV +KG+ ++ ++ LP +P P+ + Q+
Sbjct: 764 IPLMDYILNVMKFVESILSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQA 823
Query: 799 ISVAFKN-FSPQHYVSLARAVCSFLREHLKSINEL---LDLVGGT----QLALVE----- 845
++ K+ + H + + L L S+ L ++ GG+ +LA
Sbjct: 824 VAGVCKSILTLSHEPKVLQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADA 883
Query: 846 --SAKQTKVLKYLASLEAVLTLSVFLLKGSTTVVSELST------LDADVLKDLGKTYKE 897
SA+ T +L L + A + + V + + + +S L VL L + Y
Sbjct: 884 TLSAQATPLLHALTAAHAYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCS 943
Query: 898 VIWQ----ISLCN 906
++W+ +SLC
Sbjct: 944 LVWESTVLLSLCT 956
Score = 64.7 bits (156), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 40/128 (31%), Positives = 62/128 (48%), Gaps = 10/128 (7%)
Query: 1596 VMQAVLQLCARLTKTHALALQFLENGGLAALFNLPRTCLFPGYDSVVSAIVRHLLEDPQT 1655
+ A L+LC RLT+ H A+ F E + NL ++ F G+ +V+ ++RH++EDP T
Sbjct: 1774 TLHATLRLCLRLTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCT 1833
Query: 1656 LQTAMELEIRQTLS---GNRHSGRVSP-------RSFLTSLAPVISRDPMVFMKAAAAVC 1705
L+ ME +R + G+ SG VS L L P R+P +F + A
Sbjct: 1834 LRHTMEKVVRSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCI 1893
Query: 1706 QIETSGGR 1713
+I R
Sbjct: 1894 RIALPAPR 1901
Score = 51.2 bits (121), Expect = 2e-04, Method: Compositional matrix adjust.
Identities = 35/107 (32%), Positives = 44/107 (41%), Gaps = 14/107 (13%)
Query: 2665 IDPTFLEALPEDLRAEVLXXXXXXXXXXXXXXXXXXE-----------DIDPEFLAALPP 2713
+DP+FL ALP+D+R EVL ++ PEFLAALPP
Sbjct: 2968 VDPSFLAALPDDIRREVLQNQLGIRPPTRTAPSTNSSAPAVVGNPGVTEVSPEFLAALPP 3027
Query: 2714 DIQAEVLXXXXXXXXX---XXXEGQPVDMDNASIIATFPAELREEVL 2757
IQ EVL MD + I T P++LR VL
Sbjct: 3028 AIQEEVLAQQRAEQQRRELAQNASSDTPMDPVTFIQTLPSDLRRSVL 3074
Query: CNT0000583
Subject: sp|O13834|PTR1_SCHPO E3 ubiquitin-protein ligase ptr1musculus GN=Huwe1 PE=1 SV=5
Score = 192 bits (487), Expect = 4e-47, Method: Compositional matrix adjust.
Identities = 228/971 (23%), Positives = 391/971 (40%), Gaps = 92/971 (9%)
Query: 5 RKRALEVPPKIRCFIDRVTSVPLEKIEEPLKAF-VWEFDKGDFHHWVDLFNHFDSFFEKY 63
+K E P R ID++ E++ L+ W K + +HWVDL + FD
Sbjct: 9 KKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADA 68
Query: 64 VKPRKDLQIXXXXXXXXXXXXRESXXXXXXXXXXXXDNCTNKHFYSSYEQHLSALLASTD 123
+ +++ + + ++H YSS E HL+ LLAS+D
Sbjct: 69 GQTVENMSWMLVCDRPEKEQLKMLLLAVLNFTALLIEYSFSRHLYSSIE-HLTTLLASSD 127
Query: 124 PDVVEASLDTLATFLKKTVGKYSIRDAS-----LNSKLYALAQGWGGKEEGLGLIASAVP 178
VV A L+ L F K++ Y R S L ++L LA+ WGGKE G GL
Sbjct: 128 MQVVLAVLNLLYVFSKRS--NYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLAEC--- 182
Query: 179 NGCDPIAC----ELGRTLHFEFYAVNESESDIKVTEPLVQGLQIIHLSDVNKCVETDLEL 234
C + TLHFEFYA +E I+ L IH+ ++K E+ E+
Sbjct: 183 --CRDLQMLKYPPSATTLHFEFYADPGAEVKIE-KRTTSNTLHYIHIEQLDKISESPSEI 239
Query: 235 LHKLVTEYKVPXXXXXXXXXXXXXXXXXGSLSSRQQYTCIRLYAFIVLIQASADADDLVS 294
+ L Y +P + R Q RL+A +L+ ++A + S
Sbjct: 240 MESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANS 299
Query: 295 -FFNVEPGFINELVSLLSYEDAVLEKIRILCLHSLAALCQ-DRS-RQQSVQTAVTSGGHR 351
+N G I ELV +L D L +I+ L +L ++ +R+ + S+ + +
Sbjct: 300 ILYN---GLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYH 356
Query: 352 GILSSLMQKAIDS-VTSNTSKWSVHFAEAXXXXXXXXXXXXXGCSAMREAGFIPTLLPLL 410
G L L++ I + + + + FA A G A+ G + LL ++
Sbjct: 357 GFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVI 416
Query: 411 K---DTNPQHLHLVEKAVRILEAFMDYSNPAAALFRDLGGLDDTISRLKIEVSNVENSGK 467
K D Q + V +AVR+++ +N A F+ GL I RL+ EV
Sbjct: 417 KFLGDEQDQ-ITFVTRAVRVVDLI---TNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECP 472
Query: 468 QPDDNXXXXXXXXXXXXXXXTGPDDTQPLYSELLISYHRRLLMKALLRAISLGTYAPGNT 527
T D Q + R L+K++L + P +
Sbjct: 473 FVIKPKIQRPSTTQEGEEMETDMDGVQCI-------PQRAALLKSMLNFLKKAIQDPAFS 525
Query: 528 ARIYGSEENVLPHCLCIIFRRAKDFGGGVFSLAATVMSDLIQKDPTCFPVLDAAGLPSAF 587
I + LP L I A+ +G +F LA V++ + ++P+ L GL
Sbjct: 526 DGIRHVMDGSLPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVM 585
Query: 588 LDAIMV-DVLNSAEAITCIPQCLDALCLNSNGLQAVKDRNSLRCFVKVFTSRTYLRALA- 645
L A+++ DV + E + +P ALCLN+ GLQ+ KV S YL A+
Sbjct: 586 LHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRR 645
Query: 646 -------GDTPASLSSGLDELMRHASSLRGPGVEMLVEILEAISKIG---SAVXXXXXXX 695
GDT ++L S +DELMRH +L+ ++++LE I +G +
Sbjct: 646 RRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQ 705
Query: 696 XXXXXXXVPMEMDGEDKNLILPNNK-----ESSNANDTEQITEPSHDVPIVNVESFLP-- 748
P ++ ++ + ++ Q E + +V E +P
Sbjct: 706 KADGTATAPPPRSNHAAEEASSEDEEEEEVQAMQSFNSAQQNETEPNQQVVGTEERIPIP 765
Query: 749 --DCVNNIARLLETILQNA---DTCRIFVEKKGIEAILQLVTLPLMP---PSVSVGQSIS 800
D + N+ + +E+IL N D C+ FV +KG+ ++ ++ LP +P P+ + Q+++
Sbjct: 766 LMDYILNVMKFVESILSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVA 825
Query: 801 VAFKN-FSPQHYVSLARA---VCSFLREHLKSINELLDLVGGT----QLALVE------- 845
K+ + H + + + L+ ++ ++ GG+ +LA
Sbjct: 826 GVCKSILTLSHEPKVLQEGLLQLDLILSSLEPLHRPIESPGGSVLLRELACAGNVADATL 885
Query: 846 SAKQTKVLKYLASLEAVLTLSVFLLKGSTTVVSELST------LDADVLKDLGKTYKEVI 899
SA+ T +L L + A + + V + + + +S L VL L + Y ++
Sbjct: 886 SAQATPLLHALTAAHAYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLV 945
Query: 900 WQ----ISLCN 906
W+ +SLC
Sbjct: 946 WESTVLLSLCT 956
Score = 65.1 bits (157), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 40/128 (31%), Positives = 62/128 (48%), Gaps = 10/128 (7%)
Query: 1596 VMQAVLQLCARLTKTHALALQFLENGGLAALFNLPRTCLFPGYDSVVSAIVRHLLEDPQT 1655
+ A L+LC RLT+ H A+ F E + NL ++ F G+ +V+ ++RH++EDP T
Sbjct: 1774 TLHATLRLCLRLTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCT 1833
Query: 1656 LQTAMELEIRQTLS---GNRHSGRVSP-------RSFLTSLAPVISRDPMVFMKAAAAVC 1705
L+ ME +R + G+ SG VS L L P R+P +F + A
Sbjct: 1834 LRHTMEKVVRSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCI 1893
Query: 1706 QIETSGGR 1713
+I R
Sbjct: 1894 RIALPAPR 1901
Query: CNT0000583
Subject: sp|Q03280|TOM1_YEAST E3 ubiquitin-protein ligase TOM1OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843)
GN=ptr1 PE=1 SV=1
Score = 147 bits (370), Expect = 2e-33, Method: Compositional matrix adjust.
Identities = 158/695 (22%), Positives = 295/695 (42%), Gaps = 58/695 (8%)
Query: 12 PPKIRCFI-----DRVTS-VPLEKIEEPLKAFVWEFDKGDFHHWVDLFNHFDSFFEKYVK 65
PP++ FI + VTS + L + + W + +GD + WV + N FD+ E+ V+
Sbjct: 16 PPRVAEFIRQAQNEEVTSDLGLVSLCSEFRKNDWPYPRGDLYSWVPVLNRFDAILERIVE 75
Query: 66 PR--KDLQIXXXXXXXXXXXXRESXXXXXXXXXXXXDNCTNKHFYSSYEQHLSALLASTD 123
KD E +C N+ Y+S +L LL S+
Sbjct: 76 HYSLKDKVQTKPFDSDTLSILLE----ILSFSAHLLSHCANRSIYNS-TVYLEYLLNSSV 130
Query: 124 PDVVEASLDTLATFLKK-TVGKYSIRDASLNS-KLY---------ALAQGWGGKEEGLGL 172
+V++++L L ++K T+ K + SL+ +L+ A+ G+ E L L
Sbjct: 131 LEVIDSTLALLLHIVQKATISKRGKQLFSLSQDRLFRFLMFLPQDAMKTGFSQNYETL-L 189
Query: 173 IASAVPNGCDPIACELGRTLHFEFYAVNESESDIKVTEPLVQGLQIIHLSDVNKCVETDL 232
++ +P C +L +Y + S+ ++P +G I+ L NK + +
Sbjct: 190 FSNEIPQEW----C----SLELSYYKSSPSKDFSSASQPNSEGFSILKLP-YNKVLGKPI 240
Query: 233 E-LLHKLVTEYKVPXXXXXXXXXXXXXXXXXGSLSSRQQYTCIRLYAFIVLIQASADADD 291
E LL K + + ++P ++ R+ I L A L+ A + A
Sbjct: 241 EELLVKTLHDNQIPEQYSFDLLVSLMLRQNLYDINRRRLMIRIGLLALSNLVYAHSQAVQ 300
Query: 292 LVSFFNVEPGFINELVSLLSYEDAVLEKIRILCLHSLAALCQDRSRQQSVQTAVTSGGHR 351
F +P L +L+S + + + + +C A +S SV ++
Sbjct: 301 -TRFLIADPEITTHLANLVSPDVDLPQNFKAVCFECFKAFFFKKSMIPSVLASLNVSVSY 359
Query: 352 GILSSLMQKAIDSVTSNTSKWSVHFAEAXXXXXXXXXXXXXGCSAMREAGFIPTLLPLLK 411
G++ +L++ ++ + + + ++ G + AG L L
Sbjct: 360 GLMMNLVRDFSKNLENPNFYYEREYVDSFYDFLQFMTSSPLGGNMACSAGLTSLLGYHLS 419
Query: 412 DTNPQHLHLVEKAVRILEAFMDYSNPAAALFRDLGGLDDTISRLKIEVSNVENSGKQPDD 471
PQ ++V +++ +L+ +D + A F + GLD + R++ E+ +G Q
Sbjct: 420 VKTPQATYVVARSIVMLDHLIDGYSMAFPDFSESKGLDMLVDRVQYELE----AGLQ--- 472
Query: 472 NXXXXXXXXXXXXXXXTGPDDTQ-PLYSELLISYHRRLLMKALLRAISLGTYAPGNTARI 530
+G + + L + ISY R L+K LL+ + + G+ +
Sbjct: 473 -------------DIKSGKGNPEIVLNMDYAISYDRYFLLKNLLKFVLHLIQSGGSVVEL 519
Query: 531 YGSEENVLPHCLCIIFRRAKDFGGGVFSLAATVMSDLIQKDPTCFPVLDAAGLPSAFLDA 590
++ L L + + +G +F+ +MS I +PTC+ ++ L AFLDA
Sbjct: 520 RNLIDSSLISSLAFLLEHHEVYGSNLFASTTNIMSTFIHNEPTCYGIIHEKKLSHAFLDA 579
Query: 591 IMVDVLNSAEAITCIPQCLDALCLNSNGLQAVKDRNSLRCFVKVFTSRTYLRAL-AGDTP 649
+ +LNS++AIT IP A+CLNS G ++N + +FTS + ++L + D
Sbjct: 580 VNRKILNSSDAITSIPLAFGAICLNSQGFDLFLEKNPIPQLFSIFTSLNHCKSLISSDNA 639
Query: 650 ASLSSGLDELMRHASSLRGPGVEMLVEILEAISKI 684
A L + +DELMRH SL+ P V+M+ + + +S +
Sbjct: 640 AILGTYIDELMRHQPSLKDPIVKMIFKACDQVSAL 674