Query: CNT0006736
Subject: sp|P50851|LRBA_HUMAN Lipopolysaccharide-responsive and beige-like

OS=Dictyostelium discoideum GN=lvsC PE=3 SV=2

 Score =  610 bits (1572), Expect = e-175,   Method: Compositional matrix adjust.
Identities = 327/730 (44%), Positives = 445/730 (60%), Gaps = 39/730 (5%)

Query: 2492 RRWNIVKIKSVHWTRYLLRYTAIEIFFNDSVAPIFFNFASQKDAKDVGTLIVATRNDSMF 2551
+RW IK VH RYLLR +AIEIF D FNF + K + R S
Sbjct: 1769 KRWPNEMIKDVHLRRYLLRGSAIEIFMRDKTN-YLFNFKKNERNKVYNKINSVKREFSKE 1827

Query: 2552 PKGSNRDKNGAISFVDRRVALEMAETARESWKRREMTNFEYLMILNTLAGRSYNDLTQYP 2611
P S D M + A W+ R ++NF+YLM LNT+AGR+YNDLTQYP
Sbjct: 1828 PTLSPSD---------------MLKKATSEWQARRISNFDYLMTLNTIAGRTYNDLTQYP 1872

Query: 2612 VFPWVLADYSSEILDFNKSSTFRDLSKPVGALDLKRFEVFEDRYRNFCDPDIPSFYYGSH 2671
VFPWV+ADY+S +LD NK+ TFRDLSKP+GAL+ KR E+F+DRY +F DP IP FYYGSH
Sbjct: 1873 VFPWVIADYTSPVLDLNKAETFRDLSKPIGALNEKRLEIFKDRYESFDDPVIPKFYYGSH 1932

Query: 2672 YSSMGIVLFYLLRLEPFTALHRNLQGGKFDHADRLFQSIEATYRNCLSNTSDVKELIPEF 2731
YSS GIVLFYL+RLEPFT NLQGG+FDH DR+F SI + N L++++DVKELIPEF
Sbjct: 1933 YSSAGIVLFYLIRLEPFTTQFLNLQGGRFDHPDRMFDSIALAWDNSLTSSTDVKELIPEF 1992

Query: 2732 FYMPEFLVNSNSYHLGVKQDGGPIGDICLPPWAKGSPEEFINRNREALESEYVSSNLHHW 2791
+YMPEFL N N + G+KQ+G I D+ LPPWA SP +FI NREALES+YVSS+LH W
Sbjct: 1993 YYMPEFLTNHNHINFGIKQNGIGIEDVLLPPWA-SSPSDFIRINREALESDYVSSHLHEW 2051

Query: 2792 IDLVFGYKQRGKPAVEAANIFYYLTYEGAVELETMEDDLQRSAIEDQIANFGQTPIQIFR 2851
IDL+FG KQRGK A E N+FYYLTYEG+V+++++ED+ R A E QI NFGQTP Q+F
Sbjct: 2052 IDLIFGIKQRGKQAKEVFNVFYYLTYEGSVDIDSIEDETTRRATESQINNFGQTPTQLFS 2111

Query: 2852 KKHPRRGPPIPIAHPLYFAPGSINLXXXXXXXXXXXXAVLYVGILDSNIV---LVNQGLT 2908
KKH + P+ +H + N ++YV I + N + LV +T
Sbjct: 2112 KKHHIQRDPLNESH-ISILKTPPNQLQAYFLKITNKNPIVYVYIPEPNPIMSYLVADKVT 2170

Query: 2909 MSVKMWLTTQLQSGGNFTFSGSQDPF-FGIGSDILSSRKIGSPLAEYIELGAQCFAIMQT 2967
+ K TT + + T + PF F + + R+IG P A + + CFAI T
Sbjct: 2171 VIDKSRTTTNHKWFPS-TPNDKISPFTFELDPSSTTKRRIGLPFANDVTISPNCFAI--T 2227

Query: 2968 PSENFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGRILATGSYDTTVMV 3027
++ISC +W+NSF++ ++ +++QS+ +HKD V+C+++ SDG+ L TGS DTTVMV
Sbjct: 2228 SDGRYVISCAHWDNSFKLSFVDSAKLIQSVVKHKDTVTCLSLASDGQTLITGSKDTTVMV 2287

Query: 3028 WAVSRVRGSEKRVKTTQAELPRKDYVIVETPFHILCGHDDIITCLFVSVELDIVISGSKD 3087
W ++ T ++ P+ + + P HIL GHDD ITC+ V+V LDI ISGSKD
Sbjct: 2288 WRIA---------TTNKSGAPKFN----DVPDHILYGHDDEITCVDVNVGLDISISGSKD 2334

Query: 3088 GTCVFHTLREGRYVRSLRHPSGSALSKLVASRHGRIVXXXXXXXXXXXXXINGKHIATSE 3147
GTC+ H L+ G YVRS+ P S +S + S G IV ING + T +
Sbjct: 2335 GTCIIHNLKHGEYVRSIYLPRQSPISLIAISNQGYIVIYSQADLMIYLYSINGGLLKTVD 2394

Query: 3148 SNGRLNCVQLSGCGEFLACAGDQGQIIVRSMNSLEVVKRYNGIGKIITSLTVTPEECFL- 3206
++ RL+ + +S E+L G++G +++R++ +L+ G I SL + ++ L
Sbjct: 2395 THERLHSIIISKDSEYLITGGERGVVVIRTLFNLKPTNHKLVFGTPIHSLAMASDQKHLM 2454

Query: 3207 AGTKDGSLLV 3216
G +DG LL+
Sbjct: 2455 VGLEDGRLLI 2464



Score = 275 bits (702), Expect = 3e-72, Method: Compositional matrix adjust.
Identities = 214/819 (26%), Positives = 384/819 (46%), Gaps = 81/819 (9%)

Query: 823 LLVGMRAMLLTDQVHYQDLFRDGECFLHVVSLLNGNLDEANGEKLVLNVLQTLTCLLARN 882
+L G+R ++ + Q+LF+ F+ +V+L+N + + L +VL+T+ L+A N
Sbjct: 1 MLDGIR-QIIKNNPKKQNLFKKFRVFIKIVNLVNADDKKERLSVLCHSVLRTVILLMANN 59

Query: 883 DASKAAFRALVGKGYQTLQSLLLEFCQWRPSEGLLNALLDMLVDGKFDIKASPVIKNEDV 942
K FR +G Y T++ L+++ + SE +N L DM+VDG+FDI+ VI+N D
Sbjct: 60 PKIKKHFRNHIG--YDTIKDLIIK-SEGIVSETTMNILFDMIVDGEFDIEYKYVIQNPDS 116

Query: 943 IILYLSILQKSSDSSRHYGLNVFQQLLRDSISNRASCVRAGMLNFLLDWFSQEDMDSVIL 1002
+L ++L+ +H L+ F ++ +N++ C ++ LL+ + V
Sbjct: 117 CLLIFNLLKYFPTKLQHEILDRFTVMVEKCTTNQSVCCNCHLIYNLLEAIYKGQPMEVTT 176

Query: 1003 KIAQLIQVTGGHSISGKDIRKIFALLRSKKIGTQQKYCSLLLTSILSMLNEK--GPTAFF 1060
KI +LI+ G HS++ ++++K+F LL+S++ S LLT++ ++ N + GP +F
Sbjct: 177 KILKLIERLGIHSVTVRELKKLFGLLKSEQGDYLPPTTSALLTTLQNISNSRNPGPQVYF 236

Query: 1061 DLNGSDSGVKITTPVQWPLNKGFSFSCWLRVESF----------PRNGTMGLFSFLTENG 1110
D +G DS + + T +WP KGFSF W+R+ESF PR LFSFL+++G
Sbjct: 237 DFDGKDSCIILPTFDKWPFPKGFSFCTWVRIESFVDPTGTPEYKPR-----LFSFLSDSG 291

Query: 1111 RGCLAALAKDKLIYESIN--QKRQCVSLHVNLVRKKWHFLCLTHSIGRAFSGGSQLRCYV 1168
G +L ++N Q + V ++W+F+ + +SI +++R Y+
Sbjct: 292 CGIEVLFIYQQLQVLTVNNHQSKAVFQSPPTFVEREWYFVSVVYSIN--LISSNEIRIYI 349

Query: 1169 DGNLASSEKCRYPKISELLTSCTIGTKINLPPYEEENAVYSIKESSPFLGQIGPIYMFND 1228
+G ++ + L IG E E P GQ+G +F++
Sbjct: 350 NGQQSAKSSIKLNISGTLWNHFKIGNNSKKMSGERE---------CPLYGQMGAFNIFDE 400

Query: 1229 VITSEQVLGIYSLGPSYMYSFLDNEIASSYDNPLPSGILDAKDGLASKIIFGLNAQASDG 1288
++ Q+ IY+LGP++ SF D E ++ + S L S + N +A DG
Sbjct: 401 SLSPSQIQAIYTLGPNFNTSFQDVEGSTKSAHTFES-------SLTSHLFLNYNCRALDG 453

Query: 1289 RTLFNVSPLLDHALDKNSFEATVMLGTQLCSRRLLQQIIYCVGGVSVFFPLFSQSDRYEN 1348
+ +P D DKN ++AT ++ C R ++ IIYC+GG+ V FPL Q N
Sbjct: 454 DLCLDNTP--DIGGDKN-YDAT-LVSINPCVSRDIKDIIYCLGGIKVLFPLIQQI----N 505

Query: 1349 VESGKLEHTLLTPITKE------------------------RLTAEVIELIASVLDENSA 1384
L L+T +LT +V+ L +L E+ A
Sbjct: 506 NPISPLSLELITNENNNNNNNNLSLSSQQQTLEQLQQSINIKLTNQVLALFKFMLKESEA 565

Query: 1385 NQHQMHXXXXXXXXXXXXQSVPPVQLNLETLSALKHMFNVVASCGLSELLVKDAISSVFL 1444
NQ +M Q + P L + + M N ++ LV++ S++ L
Sbjct: 566 NQEEMLRCQGFSVMGYLLQQISPEYLTIGCTNIFIDMSNQIS----DPTLVEEVYSNLML 621

Query: 1445 NPLIWVYTVYKVQRELYMFLIQQFDNDPRLLKSLCRLPRVIDIIRQFYWGNAKSRSAIGS 1504
N IW+ T Y++QR L + + Q + + + ++DI+ FYW + A +
Sbjct: 622 NFCIWIKTKYELQRNLLVIIKQIVFEKYDQVSDIITVQLILDIMNDFYWYDDSKNEAHRN 681

Query: 1505 KPLLHPITKQVIGERPSKEEIRKIRLLLLSLGEMSVRQNIAASDIKALVAFFETSQDMAC 1564
H K ++ +RPS IR++R +L + + +R ++DI+A++ F +D
Sbjct: 682 H---HFFNKDILSKRPSISNIRELRQILFEVLRILLRHQ-KSTDIQAIIKFLIYCKDYQQ 737

Query: 1565 IEDVLHMVIRAVSQKSLLASFLEQVNLIGGCHIFVNLLQ 1603
+ +++ V+ F +++ +GG +F+ LL+
Sbjct: 738 LIEMMEFVLGLNGNGHNCQQFFDEIMGLGGTDVFLTLLK 776



Score = 71.2 bits (173), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 41/128 (32%), Positives = 71/128 (55%), Gaps = 7/128 (5%)

Query: 2158 EAKYIKTCKSERRRQLHE--LHTRLDENSSTESSHNKAFEDEIQSSLSTILASDDSRRAV 2215
E K + + +R+++L + L+T E S ++ KA ++++ S + + RRA+
Sbjct: 1490 EEKSLYSWLEKRKKKLTKVVLNTDEKEAESFNAAERKA-DNDLNSIHVKLWMPECERRAL 1548

Query: 2216 YQLAHDEEQQNVAEKWMHLFRTLIDERGPWSANPFPNSAVRHWKLDKTEDAWRRRLKLRQ 2275
+ E + +W + R+L +ERGPW ++ HWKLDKTE++ R R+KL++
Sbjct: 1549 HLYKARELRNQTTVQWRKILRSLTNERGPWGTT----ESIVHWKLDKTENSSRMRIKLKR 1604

Query: 2276 NYHFDERL 2283
NY FDE L
Sbjct: 1605 NYKFDEHL 1612

Query: CNT0006736
Subject: sp|Q9ESE1|LRBA_MOUSE Lipopolysaccharide-responsive and beige-like

anchor protein OS=Homo sapiens GN=LRBA PE=1 SV=4

 Score =  513 bits (1321), Expect = e-145,   Method: Compositional matrix adjust.
Identities = 294/750 (39%), Positives = 417/750 (55%), Gaps = 54/750 (7%)

Query: 2491 HRRWNIVKIKSVHWTRYLLRYTAIEIFFNDSVAPIFFNFASQKDAKDVGTLIVATRNDSM 2550
H +W +I+S+ RYLL+ TA+EIF + VA + FNF K V + +
Sbjct: 2130 HGKWLFTEIRSIFSRRYLLQNTALEIFMANRVA-VMFNFPDPATVKKVVNYLPRVGVGTS 2188

Query: 2551 FPKGSNRDKNGAISFVDRRVALEMAETARESWKRREMTNFEYLMILNTLAGRSYNDLTQY 2610
F R IS R L A + W+ RE++NFEYLM LNT+AGRSYNDL QY
Sbjct: 2189 FGLPQTR----RISLASPR-QLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQY 2243

Query: 2611 PVFPWVLADYSSEILDFNKSSTFRDLSKPVGALDLKRFEVFEDRYRNFCDPDIPSFYYGS 2670
PVFPWV+ +Y SE LD + FRDLSKP+GAL+ KR F +RY ++ D +P F+YG+
Sbjct: 2244 PVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFHYGT 2303

Query: 2671 HYSSMGIVLFYLLRLEPFTALHRNLQGGKFDHADRLFQSIEATYRNCLSNTSDVKELIPE 2730
HYS+ VL +LLR+EPFT NLQGGKFDHADR F SI +RN +TSD+KELIPE
Sbjct: 2304 HYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKELIPE 2363

Query: 2731 FFYMPEFLVNSNSYHLGVKQDGGPIGDICLPPWAKGSPEEFINRNREALESEYVSSNLHH 2790
F+Y+PE VN N+Y+LGV DG + D+ LPPWAK S EEF++ NR ALESE+VS LH
Sbjct: 2364 FYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTS-EEFVHINRLALESEFVSCQLHQ 2422

Query: 2791 WIDLVFGYKQRGKPAVEAANIFYYLTYEGAVELETMEDDLQRSAIEDQIANFGQTPIQIF 2850
WIDL+FGYKQ+G AV A N+FYYLTYEGAV L ++ D + R A+E QI +FGQTP Q+
Sbjct: 2423 WIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLL 2482

Query: 2851 RKKHPRRGPPIPIAHPLYFAPGS-----INLXXXXXXXXXXXXAVLYVGILDSNIVLVNQ 2905
+ HP RG + ++ PL F + + L A G+ ++ V
Sbjct: 2483 IEPHPPRGSAMQVS-PLMFTDKAQQDVIMVLKFPSNSPVTHVAANTQPGLATPAVITVTA 2541

Query: 2906 GLTMSVKMWLTTQLQSGG----NFTFSGSQDPFFGIGSDILSSRKIGSPLAEYIELGAQC 2961
+V W G + DP + + R+I L + I++ +QC
Sbjct: 2542 NRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTG-MHRRQITDLLDQSIQVHSQC 2600

Query: 2962 FAIMQTPSENFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVA-----VTSDGRIL 3016
F I T +++ CG W+ SF+V S + GR++Q + H DVV+C+A + + IL
Sbjct: 2601 FVI--TSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYIL 2658

Query: 3017 ATGSYDTTVMVW-------AVSRVRGSEKRVKTTQAELPRKDYVIVETPFHILCGHDDII 3069
+GS D T+++W + GSE P IL GHD +
Sbjct: 2659 -SGSRDATLLLWYWNGKCSGIGDNPGSE-----------------TAAPRAILTGHDYEV 2700

Query: 3070 TCLFVSVELDIVISGSKDGTCVFHTLREGRYVRSLRHPSGSALSKLV-ASRHGRIVXXXX 3128
TC V EL +V+SGS++G C+ H++ G +R+L P KL+ ASR G V
Sbjct: 2701 TCAAVCAELGLVLSGSQEGPCLIHSMN-GDLLRTLEGPENCLKPKLIQASREGHCV-IFY 2758

Query: 3129 XXXXXXXXXINGKHIATSESNGRLNCVQLSGCGEFLACAGDQGQIIVRSMNSLEVVKRYN 3188
+NGK AT E++ + +QLS G++L GD+G ++VR ++ L+ + Y
Sbjct: 2759 ENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYP 2818

Query: 3189 GIGKIITSLTVTPEE-CFLAGTKDGSLLVY 3217
G I ++ ++ ++ C ++G GS++++
Sbjct: 2819 GCDAGIRAMALSYDQRCIISGMASGSIVLF 2848



Score = 181 bits (459), Expect = 9e-44, Method: Compositional matrix adjust.
Identities = 218/942 (23%), Positives = 417/942 (44%), Gaps = 124/942 (13%)

Query: 916 LLNALLDMLVDGKFDIKASPVIKNEDVIILYLSILQKSSDSSRHYGLNVFQQLLRDSISN 975
++ + ++LV G+FD++ + +I+ + I + +L+K + + ++F +L+ SI N
Sbjct: 65 IVETVFNLLVGGQFDLEMNFIIQEGESINCMVDLLEKCDITCQAEVWSMFTAILKKSIRN 124

Query: 976 RASCVRAGMLNFLLDWFSQEDMDSVILKI-AQLIQVTGGHSISGKDIRKIFALLRSKKIG 1034
C G++ +L E +D++I + ++ V ++++ ++++ F+ L+ K G
Sbjct: 125 LQVCTEVGLVEKVLGKI--EKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDK-G 181

Query: 1035 TQQKYCSLLLTSILSMLNEKGPTAFFDLNG-SDSGVKITTPVQWPLNKGFSFSCWLRVES 1093
+ LL+ + M + GP AFF+ G S + + + +WP GF+F WLR++
Sbjct: 182 RWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMD- 240

Query: 1094 FPRNG------TMGLFSFLTENGRGCLAALAKDKLIYESINQK----RQCVSLHVNLVRK 1143
P N L+ F T G G A LI SI K + CV + +
Sbjct: 241 -PVNNINVDKDKPYLYCFRTSKGLGYSAHFVGGCLIVTSIKSKGKGFQHCVKF--DFKPQ 297

Query: 1144 KWHFLCLTHSIGRAFSGGSQLRCYVDGNLAS-SEKCRYPKISELLTSCTIGTKINLPPYE 1202
KW+ + + H R S+LRCYV+G LAS E + S+ C +G+ E
Sbjct: 298 KWYMVTIVHIYNRW--KNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSS------E 349

Query: 1203 EENAVYSIKESSPFLGQIGPIYMFNDVITSEQVLGIYSLGPSYMYSF---LDNEIASSYD 1259
+A + F GQ+ +Y+F++ + + Q+ IY LG Y +F ++++ +
Sbjct: 350 TADA------NRVFCGQMTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEH 403

Query: 1260 NPLPSGILDAKDGLASKIIFGLNAQASDGRTLFNVSPLLDHALDKNSFEATVMLGTQLCS 1319
+ L + D K L+S I F N +A+D + SP + ++ +S A ++ +
Sbjct: 404 HKLL--LYDGK--LSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVL 459

Query: 1320 RRLLQQIIYCVGGVSVFFPLFSQSDRYENVESGKLEHTLLTPITKERLTAEVIELIASVL 1379
+Q ++ +GGV V FPLF+Q D Y S +++ T+ + L A ++EL+ + +
Sbjct: 460 THSIQSAMHSIGGVQVLFPLFAQLD-YRQYLSDEIDLTICS-----TLLAFIMELLKNSI 513

Query: 1380 DENSANQHQMHXXXXXXXXXXXXQSVPPVQLNLETLSALKHMFNVVASCGLSELLVKDAI 1439
A Q QM + ++ L +++ L+K
Sbjct: 514 ----AMQEQMLACKGFLVIGYSLEKSSKSHVSRAVLELCLAFSKYLSNLQNGMPLLKQLC 569

Query: 1440 SSVFLNPLIWVYTVYKVQRELYMFLIQQFDNDPRLLKSLCRLPRVIDI---IRQFYWG-N 1495
V LNP IW++T KVQ LY +L +F + ++ R+ V+ I ++ +YW N
Sbjct: 570 DHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVN 629

Query: 1496 AKSRSAIGSKPLLHPITKQVIGERPSKEEIRKIRLLLLSLGEMSVRQN--IAASDIKALV 1553
+ RS I K L G RP+++E+ +R LL + V ++ + +++A++
Sbjct: 630 PQDRSGITPKGL--------DGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAIL 681

Query: 1554 AFFETSQDMACIEDVLHMVIRAVSQ--KSLLASFLEQVNLIGGCHIFVNLLQREFEPXXX 1611
+ T + + DVL +++ +S+ S++ +F +Q N G + LL
Sbjct: 682 NYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAF-DQRN---GLRVIYKLLA-------- 729

Query: 1612 XXXXXXXXXXXXXPSEKKGPKFFNL-AVGRSRSASESQRKISLRM-QPIFFAMSDRLFRF 1669
S+ +G + L A+G +RK + + +F +++RL
Sbjct: 730 --------------SKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLM-- 773

Query: 1670 SLTDNLCA-----TLFDVLLGGASPKQVLQKHSHVDKHRSKASSSHFFLPQILVLIFRFL 1724
L NL LF++L+ + + ++H D SS PQIL +I L
Sbjct: 774 -LQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPD------SSVKIQNPQILKVIATLL 826

Query: 1725 SG---CGDA-SARLKIMTXXXXXXXSNPSNIEALMEYA-WNAWLTASMRLDVLKIYKVES 1779
C ++ R ++ ++ N +L++ + W W+ L +
Sbjct: 827 RNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWM--------LSLCYFNP 878

Query: 1780 RIQSDTEINEQNLVRNLFCVVLCHYTLSVKGGWQHLEETVNV 1821
+ + +I E +V +F ++L H GGW+ +T+++
Sbjct: 879 KNSDEQKITE--MVYAIFRILLYHAVKYEWGGWRVWVDTLSI 918

Query: CNT0006736
Subject: sp|Q9W4E2|NBEA_DROME Neurobeachin OS=Drosophila melanogaster GN=rg

anchor protein OS=Mus musculus GN=Lrba PE=1 SV=1

 Score =  511 bits (1316), Expect = e-144,   Method: Compositional matrix adjust.
Identities = 296/746 (39%), Positives = 414/746 (55%), Gaps = 46/746 (6%)

Query: 2491 HRRWNIVKIKSVHWTRYLLRYTAIEIFFNDSVAPIFFNFASQKDAKDVGTLIVATRNDSM 2550
H +W +I+S+ RYLL+ TA+EIF + VA + FNF K V + +
Sbjct: 2123 HGKWLFTEIRSIFSRRYLLQNTALEIFMANRVA-VMFNFPDPATVKKVVNYLPRVGVGTS 2181

Query: 2551 FPKGSNRDKNGAISFVDRRVALEMAETARESWKRREMTNFEYLMILNTLAGRSYNDLTQY 2610
F R IS R L A + W+ RE++NFEYLM LNT+AGRSYNDL QY
Sbjct: 2182 FGLPQTR----RISLATPR-QLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQY 2236

Query: 2611 PVFPWVLADYSSEILDFNKSSTFRDLSKPVGALDLKRFEVFEDRYRNFCDPDIPSFYYGS 2670
PVFPWV+ +Y SE LD S FRDLSKP+GAL+ KR F +R+ ++ D +P F+YG+
Sbjct: 2237 PVFPWVITNYESEELDLTLPSNFRDLSKPIGALNPKRAAFFAERFESWEDDQVPKFHYGT 2296

Query: 2671 HYSSMGIVLFYLLRLEPFTALHRNLQGGKFDHADRLFQSIEATYRNCLSNTSDVKELIPE 2730
HYS+ VL +LLR+EPFT NLQGGKFDHADR F S+ +RN +TSD+KELIPE
Sbjct: 2297 HYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSVSRAWRNSQRDTSDIKELIPE 2356

Query: 2731 FFYMPEFLVNSNSYHLGVKQDGGPIGDICLPPWAKGSPEEFINRNREALESEYVSSNLHH 2790
F+Y+PE VN N+Y+LGV DG + D+ LPPWAK S EEF+ NR ALESE+VS LH
Sbjct: 2357 FYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTS-EEFVRINRLALESEFVSCQLHQ 2415

Query: 2791 WIDLVFGYKQRGKPAVEAANIFYYLTYEGAVELETMEDDLQRSAIEDQIANFGQTPIQIF 2850
WIDL+FGYKQ+G AV A N+FYYLTYEGAV L ++ D + R A+E QI +FGQTP Q+
Sbjct: 2416 WIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLL 2475

Query: 2851 RKKHPRRGPPIPIAHPLYFAPGS-----INLXXXXXXXXXXXXAVLYVGILDSNIVLVNQ 2905
+ HP RG + A PL F + + L A G+ ++ V
Sbjct: 2476 IEPHPPRGSAMQ-ASPLMFTDQAQQDVIMVLKFPSNSPVTHVAANTQPGLAMPAVITVTA 2534

Query: 2906 GLTMSVKMWLTTQLQSGG----NFTFSGSQDPFFGIGSDILSSRKIGSPLAEYIELGAQC 2961
+V W G + DP G+ R++ L + I++ +QC
Sbjct: 2535 NRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIACGTGT-HRRQVTDLLDQSIQVHSQC 2593

Query: 2962 FAIMQTPSENFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVA-----VTSDGRIL 3016
F I T +++ CG W+ SF+V S + G+++Q + H DVV+C+A + + IL
Sbjct: 2594 FVI--TSDNRYILVCGFWDKSFRVYSTDTGKLIQVVFGHWDVVTCLARSESYIGGNCYIL 2651

Query: 3017 ATGSYDTTVMVW---AVSRVRGSEKRVKTTQAELPRKDYVIVETPFHILCGHDDIITCLF 3073
+GS D T+++W S G +T TP IL GHD ITC
Sbjct: 2652 -SGSRDATLLLWYWNGKSSGIGDNPGGETA-------------TPRAILTGHDYEITCAA 2697

Query: 3074 VSVELDIVISGSKDGTCVFHTLREGRYVRSLRHPSGSALSKLV-ASRHGRIVXXXXXXXX 3132
V EL +V+SGS++G C+ H++ G +R+L P KL+ ASR G V
Sbjct: 2698 VCAELGLVLSGSQEGPCLIHSMN-GDLLRTLEGPENCLKPKLIQASREGHCV-IFYENGC 2755

Query: 3133 XXXXXINGKHIATSESNGRLNCVQLSGCGEFLACAGDQGQIIVRSMNSLEVVKRYNGIGK 3192
+NGK AT E++ + +QLS G++L GD G +IVR ++ L+ + Y G
Sbjct: 2756 FCTFSVNGKLQATVETDDHIRAIQLSRDGQYLLTGGDNGVVIVRQVSDLKQLFAYPGCDA 2815

Query: 3193 IITSLTVT-PEECFLAGTKDGSLLVY 3217
I ++ ++ + C ++G GS++++
Sbjct: 2816 GIRAMALSFDQRCIISGMASGSIVLF 2841



Score = 186 bits (471), Expect = 3e-45, Method: Compositional matrix adjust.
Identities = 216/939 (23%), Positives = 419/939 (44%), Gaps = 118/939 (12%)

Query: 916 LLNALLDMLVDGKFDIKASPVIKNEDVIILYLSILQKSSDSSRHYGLNVFQQLLRDSISN 975
++ + ++LV G+FD++ + +I+ + I+ + +L+K + + ++F +L+ SI N
Sbjct: 65 IVETVFNLLVGGQFDLEMNFIIQEGESIMCMVELLEKCDVTCQAEVWSMFTAILKKSIRN 124

Query: 976 RASCVRAGMLNFLLDWFSQEDMDSVILKI-AQLIQVTGGHSISGKDIRKIFALLRSKKIG 1034
C G++ +L E +DS+I + ++ V ++++ ++++ F+ L+ K G
Sbjct: 125 LQVCTEVGLVEKVLGKI--EKVDSMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDK-G 181

Query: 1035 TQQKYCSLLLTSILSMLNEKGPTAFFDLNG-SDSGVKITTPVQWPLNKGFSFSCWLRVES 1093
+ LL+ + M + GP AFF+ G S + + + +WP GF+F WLR++
Sbjct: 182 QWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIARWPYQNGFTFHTWLRMD- 240

Query: 1094 FPRNG------TMGLFSFLTENGRGCLAALAKDKLIYESINQK----RQCVSLHVNLVRK 1143
P N L+ F T G G A LI SI K + CV + +
Sbjct: 241 -PVNNINVDKDKPYLYCFRTSKGLGYSAHFVGGCLIITSIKSKGKGFQHCVKF--DFKPQ 297

Query: 1144 KWHFLCLTHSIGRAFSGGSQLRCYVDGNLAS-SEKCRYPKISELLTSCTIGTKINLPPYE 1202
KW+ + + H R S+LRCYV+G LAS E + S+ C +G+
Sbjct: 298 KWYMVTIVHIYNRW--KNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSS----ETA 351

Query: 1203 EENAVYSIKESSPFLGQIGPIYMFNDVITSEQVLGIYSLGPSYMYSF---LDNEIASSYD 1259
+ N V F GQ+ +Y+F+D + + Q+ IY LG Y +F ++++ +
Sbjct: 352 DANRV--------FCGQMTAVYLFSDALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEH 403

Query: 1260 NPLPSGILDAKDGLASKIIFGLNAQASDGRTLFNVSPLLDHALDKNSFEATVMLGTQLCS 1319
+ L + D K L+S I F N +A+D + SP + ++ +S A ++ +
Sbjct: 404 HKLL--LYDGK--LSSAIAFMYNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVL 459

Query: 1320 RRLLQQIIYCVGGVSVFFPLFSQSDRYENVESGKLEHTLLTPITKERLTAEVIELIASVL 1379
+Q ++ +GGV V FPLF+Q D Y+ S +++ T+ T L A ++EL+ + +
Sbjct: 460 THSIQSAMHSIGGVQVLFPLFAQLD-YKQYLSDEVDLTICT-----TLLAFIMELLKNSI 513

Query: 1380 DENSANQHQMHXXXXXXXXXXXXQSVPPVQLNLETLSALKHMFNVVASCGLSELLVKDAI 1439
A Q QM + ++ L +++ L+K
Sbjct: 514 ----AMQEQMLACKGFLVIGYSLEKSSKSHVSRAVLELCLAFSKYLSNLQNGMPLLKQLC 569

Query: 1440 SSVFLNPLIWVYTVYKVQRELYMFLIQQFDNDPRLLKSLCRLPRVIDI---IRQFYWG-N 1495
+ LNP +W++T KVQ LY +L +F + ++ R+ V+ I ++ +YW N
Sbjct: 570 DHILLNPAVWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVN 629

Query: 1496 AKSRSAIGSKPLLHPITKQVIGERPSKEEIRKIRLLLLSLGEMSVRQN--IAASDIKALV 1553
+ RS I K L G RP+++EI +R LL + V ++ + +++A++
Sbjct: 630 PQDRSGITPKGL--------DGPRPNQKEILSLRAFLLMFIKQLVMKDSGVKEDELQAIL 681

Query: 1554 AFFETSQDMACIEDVLHMVIRAVSQ--KSLLASFLEQVNLIGGCHIFVNLLQREFEPXXX 1611
+ T + + DVL +++ +++ S++ +F +Q N G + LL
Sbjct: 682 NYLLTMHEDDNLMDVLQLLVALMAEHPNSMIPAF-DQRN---GLRVIYKLLA-------- 729

Query: 1612 XXXXXXXXXXXXXPSEKKGPKFFNL-AVGRSRSASESQRKISLRM-QPIFFAMSDRLFRF 1669
S+ +G + L A+G +RK + + +F +++RL
Sbjct: 730 --------------SKSEGIRVQALKALGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQ 775

Query: 1670 S--LTDNLCATLFDVLLGGASPKQVLQKHSHVDKHRSKASSSHFFLPQILVLIFRFLSG- 1726
+ +T + LF++L+ + + ++H D S+ PQIL +I L
Sbjct: 776 TNLITMTMYNVLFEILIEQICTQVIHKQHPDPD------STVKIQNPQILKVIATLLRNS 829

Query: 1727 --CGDA-SARLKIMTXXXXXXXSNPSNIEALMEYA-WNAWLTASMRLDVLKIYKVESRIQ 1782
C ++ R ++ ++ N +L++ + W W+ L + +
Sbjct: 830 PQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWM--------LSLCYFNPKNS 881

Query: 1783 SDTEINEQNLVRNLFCVVLCHYTLSVKGGWQHLEETVNV 1821
+ +I E +V +F ++L H GGW+ +T+++
Sbjct: 882 DEQKITE--MVYAIFRILLYHAVKYEWGGWRVWVDTLSI 918

Query: CNT0006736
Subject: sp|Q6ZS30|NBEL1_HUMAN Neurobeachin-like protein 1 OS=Homo sapiens

PE=1 SV=3

 Score =  489 bits (1260), Expect = e-137,   Method: Compositional matrix adjust.
Identities = 295/771 (38%), Positives = 423/771 (54%), Gaps = 80/771 (10%)

Query: 2491 HRRWNIVKIKSVHWTRYLLRYTAIEIFFNDSVAPIFFNFASQKDAKDVGTL--------- 2541
H +W +++++ RYLL+ A+EIF + I F F Q K V
Sbjct: 2835 HGKWYFSEVRAIFSRRYLLQNVALEIFLASRTS-ILFAFPDQHTVKKVIKALPRVGVGIK 2893

Query: 2542 --IVATRNDSMF-PKGSNRDKNGAISFVDRRVALEMAETARESWKRREMTNFEYLMILNT 2598
I TR SM P+ R+ N + W+RRE++NFEYLM LNT
Sbjct: 2894 YGIPQTRRASMMSPRQLMRNSN-----------------MTQKWQRREISNFEYLMFLNT 2936

Query: 2599 LAGRSYNDLTQYPVFPWVLADYSSEILDFNKSSTFRDLSKPVGALDLKRFEVFEDRYRNF 2658
+AGR+YNDL QYP+FPWVL +Y S+ LD + S +RDLSKP+GAL+ R FE+RY ++
Sbjct: 2937 IAGRTYNDLNQYPIFPWVLTNYESKDLDLSLPSNYRDLSKPIGALNPSRRAYFEERYESW 2996

Query: 2659 CDPDIPSFYYGSHYSSMGIVLFYLLRLEPFTALHRNLQGGKFDHADRLFQSIEATYRNCL 2718
IP F+YG+HYS+ L +L+R+EPFT + LQGGKFD+ DRLF S+ +++NC
Sbjct: 2997 DSDTIPPFHYGTHYSTAAFTLNWLVRVEPFTTMFLALQGGKFDYPDRLFSSVSLSWKNCQ 3056

Query: 2719 SNTSDVKELIPEFFYMPEFLVNSNSYHLGVKQDGGPIGDICLPPWAKGSPEEFINRNREA 2778
+TSDVKELIPE++++PE NS+ Y LG ++DG + DI LPPWAK SPEEF+ NR A
Sbjct: 3057 RDTSDVKELIPEWYFLPEMFYNSSGYRLGHREDGALVDDIELPPWAK-SPEEFVRINRMA 3115

Query: 2779 LESEYVSSNLHHWIDLVFGYKQRGKPAVEAANIFYYLTYEGAVELETMEDDLQRSAIEDQ 2838
LESE+VS LH WIDL+FGYKQRG A+ A N+FYYLTYEG+V+L+ + D + R A+E+Q
Sbjct: 3116 LESEFVSCQLHQWIDLIFGYKQRGPEAIRATNVFYYLTYEGSVDLDGVLDPVMREAVENQ 3175

Query: 2839 IANFGQTPIQIFRKKHPRRGPPIPIAHPLYFAPGSINLXXX----XXXXXXXXXAVLYVG 2894
I NFGQTP Q+ + HP R + ++ P+ F+ +L A Y
Sbjct: 3176 IRNFGQTPSQLLMEPHPPRSSAMHLS-PMMFSAMPEDLCQMLKFYQNSPVIHISANTYPQ 3234

Query: 2895 ILDSNIVLVNQGLTMSVKMW---LTTQLQS----------GGNFTFSGSQDPFFGI---- 2937
+ ++V V G +V W T +QS G N + DP +
Sbjct: 3235 LSLPSVVTVTAGHQFAVNRWNCNYTASVQSPSYAESPQSPGSNQPL--TIDPVLAVHGTN 3292

Query: 2938 -GSDILSSRKIGSPLAEYIELGAQCFAIMQTPSENFLISCGNWENSFQVISLNDGRMVQS 2996
S+ S R +G ++ +++ + CF + T FLI+CG W+NSF+V + ++VQ
Sbjct: 3293 NNSNAASRRHLGDNFSQMLKIRSNCF--VTTVDSRFLIACGFWDNSFRVFATETAKIVQI 3350

Query: 2997 IRQHKDVVSCVA-----VTSDGRILATGSYDTTVMVWAVSRVRGSEKRVKTTQAELPRKD 3051
+ H VV+C+A +TSD I A+GS D TV++W + TQ+ + D
Sbjct: 3351 VFGHFGVVTCMARSECNITSDCYI-ASGSADCTVLLWHWN---------ARTQSIVGEGD 3400

Query: 3052 YVIVETPFHILCGHDDIITCLFVSVELDIVISGSKDGTCVFHTLREGRYVRSLRHPSGSA 3111
V TP L GH+ +T + +S EL +V+SGS +G + HT G +RSL P+
Sbjct: 3401 ---VPTPRATLTGHEQAVTSVVISAELGLVVSGSSNGPVLIHTTF-GDLLRSLDPPAEFH 3456

Query: 3112 LSKLVA-SRHGRIVXXXXXXXXXXXXXINGKHIATSESNGRLNCVQLSGCGEFLACAGDQ 3170
+L+ SR G IV INGK + N L C+ LS GE+L AGD+
Sbjct: 3457 SPELITMSREGFIV-INYDKGNVAAYTINGKKLRHETHNDNLQCMLLSRDGEYLMTAGDR 3515

Query: 3171 GQIIVRSMNSLEVVKRYNGIGKIITSLTVTPEECF-LAGTKDGSLLVYSIE 3220
G + V +L + + I SL +T ++ + LAG GS++V+ I+
Sbjct: 3516 GIVEVWRTFNLAPLYAFPACNAGIRSLALTHDQKYLLAGLSTGSIIVFHID 3566



Score = 94.4 bits (233), Expect = 2e-17, Method: Compositional matrix adjust.
Identities = 82/337 (24%), Positives = 161/337 (47%), Gaps = 30/337 (8%)

Query: 1260 NPLPSGILDAKDGLASKIIFGLNAQASDGRTLFNVSPLLDHALDKNSFEATVMLGTQLCS 1319
N L + + D K L++ I+F N A+DG+ SP + + ++ A ++ +
Sbjct: 393 NQLKAVLYDGK--LSNAIVFMYNPVATDGQLCLQSSPKGNVSYFVHTPHALMLQDVKAVV 450

Query: 1320 RRLLQQIIYCVGGVSVFFPLFSQSDRYENVESGKLEHTLLTPITKE-RLTAEVIELIASV 1378
+ + +GG+ V FPLFSQ D + H L I ++ L ++++ I +
Sbjct: 451 THSIHCTLNSIGGIQVLFPLFSQLD---------MAHEGLGDIKRDPTLCSKLLGFICEL 501

Query: 1379 LDENSANQHQMHXXXXXXXXXXXXQSVPPVQLNLETLSALKHMFNVVASC--GLSELLVK 1436
++ + Q M Q L LE L + ++ + +C S+LL+K
Sbjct: 502 VETSQTVQQHMIQNRGFLVISFMLQRSSREHLTLEVLGSFLNLTKYLVTCLSANSDLLLK 561

Query: 1437 DAISSVFLNPLIWVYTVYKVQRELYMFLIQQFDNDPRLLKSLCRLPRVIDII---RQFYW 1493
+ V NP +W+YT VQ LY +L +F +D ++ ++ R+ V+ + + +YW
Sbjct: 562 QLLDHVLFNPALWIYTPANVQARLYSYLATEFLSDTQIYSNVRRVSTVLQTVHTLKYYYW 621

Query: 1494 -GNAKSRSAIGSKPLLHPITKQVIGERPSKEEIRKIR-LLLLSLGEMSVRQN-IAASDIK 1550
N +++S I I K + G RP++++I IR +LL L ++ + N + +++
Sbjct: 622 VVNPRAKSGI--------IPKGLDGPRPAQKDILAIRAYILLFLKQLIMIGNGVKEDELQ 673

Query: 1551 ALVAFFETSQDMACIEDVLHMVIRAVSQ--KSLLASF 1585
+++ + T + + DVL M+I +S+ S++ +F
Sbjct: 674 SILNYLTTMHEDENLHDVLQMLISLMSEHPSSMVPAF 710



Score = 76.3 bits (186), Expect = 5e-12, Method: Compositional matrix adjust.
Identities = 53/191 (27%), Positives = 86/191 (45%), Gaps = 30/191 (15%)

Query: 1075 VQWPLNKGFSFSCWLRVESFPRNGT------MGLFSFLTENGRGCLAALAKDKLIYESIN 1128
+WP GF+F+ W R++ P N L+ F T G G A + L+ S+
Sbjct: 7 AKWPYENGFTFTTWFRLD--PINSVNIEREKPYLYCFKTSKGVGYTAHFVGNCLVLTSMK 64

Query: 1129 QK----RQCVSLHVNLVRKKWHFLCLTHSIGRAFSGGSQLRCYVDGNLASS-EKCRYPKI 1183
K + CV +KW+ + + + R S+++C V+G LASS E +
Sbjct: 65 VKGKGFQHCVKYEFQ--PRKWYMIAIVYIYNRWTK--SEIKCLVNGQLASSTEMAWFVST 120

Query: 1184 SELLTSCTIGTKINLPPYEEENAVYSIKESSPFLGQIGPIYMFNDVITSEQVLGIYSLGP 1243
++ C IG A + E F GQ+ IY+F++ +T++Q+ ++ LGP
Sbjct: 121 NDPFDKCYIG------------ATPELDEERVFCGQMSAIYLFSEALTTQQICAMHRLGP 168

Query: 1244 SYMYSF-LDNE 1253
Y F DNE
Sbjct: 169 GYKSQFRFDNE 179

Query: CNT0006736
Subject: sp|Q6ZQA0|NBEL2_MOUSE Neurobeachin-like protein 2 OS=Mus musculus

GN=NBEAL1 PE=2 SV=3

 Score =  466 bits (1200), Expect = e-130,   Method: Compositional matrix adjust.
Identities = 284/778 (36%), Positives = 416/778 (53%), Gaps = 75/778 (9%)

Query: 2493 RWNIVKIKSVHWTRYLLRYTAIEIFFNDSVAPIFFNFASQKDAKDVGTLIVATRNDSMFP 2552
+W +I+ +H RY LR +A+EIF D + F NF + K L+ +S +
Sbjct: 1932 KWPHSQIREIHLRRYNLRRSALEIFHVDQ-SNYFLNFKKEVRNKIYSRLLSLHSPNSYYG 1990

Query: 2553 KGSNRDKNGAISFVDRRVALEMAETARESWKRREMTNFEYLMILNTLAGRSYNDLTQYPV 2612
S ++ L A + W RE++NF+YL+ +NT+AGR+YNDL QYPV
Sbjct: 1991 SRSPQE-------------LFKASGLTQKWVNREISNFDYLIQINTMAGRTYNDLAQYPV 2037

Query: 2613 FPWVLADYSSEILDFNKSSTFRDLSKPVGALDLKRFEVFEDRYRNFCDP--DIPSFYYGS 2670
FPW+L DY+SE LD N + FRDLSKP+G ++ K + ++Y NF DP I F+YG+
Sbjct: 2038 FPWILQDYTSEELDLNNPAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGT 2097

Query: 2671 HYSSMGIVLFYLLRLEPFTALHRNLQGGKFDHADRLFQSIEATYRNCLSNTSDVKELIPE 2730
HYS+ V+ YL+R+EPFT LH LQ G+FD ADR F SI AT++ + N DVKELIPE
Sbjct: 2098 HYSNSAGVMHYLIRVEPFTTLHIQLQSGRFDCADRQFHSIPATWQALMDNPYDVKELIPE 2157

Query: 2731 FFYMPEFLVNSNSYHLGVKQDGGP-IGDICLPPWAKGSPEEFINRNREALESEYVSSNLH 2789
FFY PEFL N N ++LG Q + D+ LP WAK S E+FI ++R+ALESEYVS++LH
Sbjct: 2158 FFYFPEFLENQNQFNLGRLQISKELVNDVILPKWAK-SAEDFIYKHRKALESEYVSAHLH 2216

Query: 2790 HWIDLVFGYKQRGKPAVEAANIFYYLTYEGAVELETMEDDLQRSAIEDQIANFGQTPIQI 2849
WIDL+FGYKQRG AVEA N+FYY +YEGAV+L+ + D+ +R A+E I NFGQTP Q+
Sbjct: 2217 EWIDLIFGYKQRGPAAVEALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQL 2276

Query: 2850 FRKKHPRR-GPPIPIAHPLYFAPGSINLXXXXXXXXXXXXAVLYVGI--LDSNI------ 2900
++ HP R + P ++NL + GI L + I
Sbjct: 2277 LKEPHPPRLSAEEAVQKPTKIDTSTLNLFQHLPELKSFFIEGISDGIPLLKATIPKNQYR 2336

Query: 2901 VLVNQG---LTMSVKM--------WLTTQLQSGGNFTFSGSQDPFFGIGSDILSSRKIGS 2949
++QG L +++ M WL FTF Q ++ + R I
Sbjct: 2337 SFMSQGSPELLITISMNYVIGTHGWLPYDRNISNYFTFIKDQTV-----TNPKTQRSING 2391

Query: 2950 PLAEYIELGAQCFAIMQTPSENFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAV 3009
A +E+ ++ F + + L S G W+NS QV+SL G+++ I +H D+V+C+A
Sbjct: 2392 SFAPGLEITSKLFVV--SHDAKLLFSAGYWDNSIQVMSLTKGKIISHIIRHMDIVTCLAT 2449

Query: 3010 TSDGRILATGSYDTTVMVWAVSRVRGSEKRVKTTQAELPRKDYVIVETPFHILCGHDDII 3069
G L +GS DTT M+W + T Q +P + PF IL GH + +
Sbjct: 2450 DYCGIHLISGSRDTTCMIWQI-----------TQQGGVPVG---LASKPFQILYGHTNEV 2495

Query: 3070 TCLFVSVELDIVISGSKDGTCVFHTLREGRYVRSLRHPSGSAL----SKLVASRHGRIVX 3125
+ +S ELD+ +SGS+DGT + HT+++G+Y+R+LR P S+L L S G IV
Sbjct: 2496 LSVGISTELDMAVSGSRDGTVIIHTIQKGQYMRTLRPPCESSLFLTIPNLAISWEGHIVV 2555

Query: 3126 XXXXXXXXXXX--------XINGKHIATSESNGRLNCVQLSGCGEFLACAGDQGQIIVRS 3177
INGK++ + +++ + + GE + QG + +R
Sbjct: 2556 YSSTEEKTTLKDKNALHLFSINGKYLGSQILKEQVSDICI--IGEHIVTGSIQGFLSIRD 2613

Query: 3178 MNSLEVVKRYNGIGKIITSLTVTPEEC-FLAGTKDGSLLVYSIENP-QLQKASLPRNL 3233
++SL + + I + VT E L G +DG L+V + P +++ L R
Sbjct: 2614 LHSLNLSINPLAMRLPIHCVCVTKEYSHILVGLEDGKLIVVGVGKPAEMRSGQLSRKF 2671



Score = 98.6 bits (244), Expect = 1e-18, Method: Compositional matrix adjust.
Identities = 180/845 (21%), Positives = 343/845 (40%), Gaps = 119/845 (14%)

Query: 810 KEREKSFAELSIDLLVGMRAML-LTDQVHYQDLFRDGECFLHVVSLL-NGNLDEANGEKL 867
++ E F L I +L + AML TD+ Q +F + CF H++ LL N + + + L
Sbjct: 316 RQWENRFIALQIKMLNTITAMLDCTDRPVLQAIFLNSNCFEHLIRLLQNCKVFQGQLDCL 375

Query: 868 VLNVLQTLTCLLARNDASKAAFRALVGKGYQTLQSLLLEFCQWRPSEGLLNALLDMLVDG 927
++ +Q LT ++ ++ A+K F+ +G Y + +L Q P LL L++M V+G
Sbjct: 376 AISTIQALTAVMNKSPAAKEVFKERIG--YTHMLEVLKSLGQ--PPLELLKELMNMAVEG 431

Query: 928 KFDIKASPVIKNEDVIILYLSILQK-SSDSSRHYGLNVFQQLLRDSISNRASCVRAGMLN 986
I N ++L + L + S + + + +++ + +R +CV A M
Sbjct: 432 DHTSVGILGISNVQPLLLLIQWLPELQSHDLQIFISDWLKRICCINRQSRTTCVNANMGI 491

Query: 987 FLLDWFSQEDMDSVILKIA--QLIQV---TGGHSISGKDIRKIFALLRSKKIGTQQKYCS 1041
+++ D+ S + + LI + G S+S ++IR++ LLR + + Y +
Sbjct: 492 RIIETL---DLHSSLHQTCAENLIAIHGSLGSQSVSSEEIRRLLRLLRVDESESVHPYVT 548

Query: 1042 LLLTSILSM---LNEKGPTAFFDLNGSDSGVKITTPVQWPLNKGFSFSCWLRVESFPRNG 1098
+ +IL+M L+ + +F+L+ S +G+ + +WP FSFS W ++
Sbjct: 549 PVTRAILTMARKLSLESALQYFNLSHSMAGISVPPIQKWP-GSAFSFSAWFCLDQ--DQL 605

Query: 1099 TMG----------LFSFLTENGRGCLAALAKDKLIYESINQKRQCVSLHV---NLVRKKW 1145
T+G L+SF T +G G A + ++ ++ KR+ ++ + + W
Sbjct: 606 TLGIANKGGKRKQLYSFFTGSGMGFEAFITHSGMLVVAVCTKREYATVMLPDHSFCDSLW 665

Query: 1146 HFLCLTHSIGRAFSGGSQLRCYVDGNLASSEKCRYPKISELLTSCTIGTKINLPPYEEEN 1205
H + + H G+ G S + Y +G S R+P ++E TSC IG+ +
Sbjct: 666 HNITVVHMPGKRPFGQSFVYIYDNGQQKVSAPLRFPAMNEPFTSCCIGSAGQRTTTPPPS 725

Query: 1206 AVYSIKESSPFLGQIGPIYM-FNDVITSEQVLGIYSLGPSYMYSFLDNEIASSYDNPLPS 1264
+ SSP I P F +++S S G + S L ++ S+
Sbjct: 726 QIPDPPFSSP----ITPHRTSFGGILSSA------SWGGTIEKSKLITKLISAGTQDSEW 775

Query: 1265 GILDAKDG-LASKIIFGLNAQASDGRTLFNVSP--------------------LLDHALD 1303
G + +G L S IIF Q + L+ P LL +
Sbjct: 776 GCPTSLEGQLGSVIIFYEPLQPPQVKALYLAGPNCLSPWKCQESDMADLPGNILLYYTAK 835

Query: 1304 KNSFEATVMLGTQLCSRRL---------LQQIIYCVGGVSVFFPLFSQSDRYE--NVESG 1352
+ L T RL ++ II C+GG++V FPL Q + +
Sbjct: 836 ACKNSICLDLSTNCLHGRLTGNKVVNWDIKDIINCIGGLNVLFPLLEQISHFSEGQIPEE 895

Query: 1353 KLEHTL---LTPIT----------------KERLTAEVIELIASVLDENSANQHQMHXXX 1393
K E T+ +TP+ + L A I ++ + + NQ +
Sbjct: 896 KNESTVPESVTPVEGDWLVWTSTKASESRLERNLVATFILIVKHFIQRHPINQGNLIHSH 955

Query: 1394 XXXXXXXXXQSVPPVQLNLETLSALKHMFNVVASCGLSELLVKDAISSVFLNPLIWVYTV 1453
Q VP +++ L A++ + V S + L++ + + IW
Sbjct: 956 GVATLGALLQKVPSTLMDVNVLMAVQLLIEQV-SLEKNMQLLQQMYQYLLFDFRIWNRGD 1014

Query: 1454 YKVQRELYMFLIQQFDNDPRLLKSLCRLPRVIDIIRQFYWGNAKSRSAIGSKPLLHPITK 1513
+ + +L + R+ + + ++D +R Y+GN + +
Sbjct: 1015 FPFRIGHIQYLSTIIKDSRRVFRKKYGVQFLLDTLR-IYYGNGCKYNEL----------- 1062

Query: 1514 QVIGERPSKEEIRKIRLLLLSLGEMSVRQNIAASDIKALVAFFETS---QDMACIEDVLH 1570
S ++IR IR L L + + + + +I++++ + + + + I DVL
Sbjct: 1063 -------SLDDIRTIRTSLYGLIKYFLCKGGSHEEIQSIMGYIAATNEEEQLFGILDVLF 1115

Query: 1571 MVIRA 1575
++R
Sbjct: 1116 SLLRT 1120