Query: CNT0007486
Subject: sp|Q6VNB8|WDFY3_MOUSE WD repeat and FYVE domain-containing protein 3OS=Homo sapiens GN=WDFY3 PE=1 SV=2
Score = 618 bits (1594), Expect = e-176, Method: Compositional matrix adjust.
Identities = 384/1007 (38%), Positives = 545/1007 (54%), Gaps = 114/1007 (11%)
Query: 2463 LELVREAMSTELRVVRQDKYGWVLHAESEWQTYLQQLVHERGIF-PMRKTSLTEDPEWQL 2521
+ +VR+ + T+ + ++ + + + EW +L+ ERG++ P + L + W L
Sbjct: 2315 IAVVRDLVDTQYKEYQERQQNALKYVTEEWCQIECELLRERGLWGPPIGSHLDK---WML 2371
Query: 2522 CPIEGPYRMRKKLERCKLKIDTIQNVLDGQFES---VEI---------ELSREKNENGFE 2569
EGP RMRKK+ R + + V + + E+ EI ++ ++K
Sbjct: 2372 EMTEGPCRMRKKMVRNDMFYNHYPYVPETEQETNVASEIPSKQPETPDDIPQKKPARYRR 2431
Query: 2570 ASDTDSESYFPLLDSGVKQIDDKYYDESFFKESDDIKDVASARSGWNDDRASSINEASLH 2629
A DS+ Y+ L SG I D I + + + + A +
Sbjct: 2432 AVSYDSKEYYMRLASGNPAI-----------VQDAIVESSEGEAAQQEPEHGEDTIAKVK 2480
Query: 2630 SALEFGVKSSAISVPMSESIHGRSDTGSPRQSSSVK--IEEGKGTEDKLDKELLDNGEYL 2687
++ +K S S P D G ++ I EG E++ E DN L
Sbjct: 2481 GLVKPPLKRSR-SAP---------DGGDEENQEQLQDQIAEGSSIEEE---EKTDNAT-L 2526
Query: 2688 IRPYLEPLEKIRFRYNCERVVGLDKHDGIFLIGELCLYVIENFYIDDTGCICEKECEDEL 2747
+R LE EKI+ Y C RV GLD +G+ L G+ YVI+ F + T +E D
Sbjct: 2527 LR-LLEEGEKIQHMYRCARVQGLDTSEGLLLFGKEHFYVIDGFTMTAT-----REIRD-- 2578
Query: 2748 SVIDQALGVKKDVNGGMDFQPKSTPSRGVTKAWVGGRAWAYNGGAWGKEKVCSSGNLPHA 2807
++ P + + + G R G ++ CS
Sbjct: 2579 ----------------IETLPPNMHEPIIPR---GARQ-----GPSQLKRTCS------- 2607
Query: 2808 WNMWKLSSVHEILKRDYQLRPVAIEIFSMDGCNDLLVFHKKEREEVFKNLVAMNLPRNSM 2867
++ + E+ KR Y L+P+A+E+FS DG N LL F K R +V++ +A+ +P +
Sbjct: 2608 --IFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAV-VPSLTD 2664
Query: 2868 LDTTISGSMKQESNE-GSRLFKIMA--KSFSKRWQNGEISNFQYLMHLNTLAGRGYSDLT 2924
++SG S E GS L + KS ++RW+ GEISNFQYLMHLNTLAGR Y+DL
Sbjct: 2665 SSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLM 2724
Query: 2925 QYPVFPWVLADYESENLDLSDPKTFRKLEKPMGCQTLEGEEEFKKRYESWDDP--EVPKF 2982
QYPVFPW+LADY+SE +DL++PKTFR L KPMG QT E ++KKRY+ W+DP E P +
Sbjct: 2725 QYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAY 2784
Query: 2983 HYGSHYSSAGIVLFYLLRLPPFSAENQKLQGGQFDHADRLFNSVRDTWLSAAGKGNTSDV 3042
HYG+HYSSA IV YL+R+ PF+ +LQGG FD ADR+F+SVR+ W SA+ K N +DV
Sbjct: 2785 HYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSAS-KHNMADV 2843
Query: 3043 KELIPEFFYMPEFLENRFNLDLGEKQSGEKVGDVVLPPWAKGSTREFIRKHREALESDFV 3102
KELIPEFFY+PEFL N N DLG KQ+G K+GDV+LPPWAKG REFIR HREALE D+V
Sbjct: 2844 KELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYV 2903
Query: 3103 SENLHHWIDLIFGYKQRGKAAEEAVNVFYHYTYEGSVDIDSVTDPSLKASILAQINHFGQ 3162
S +LH WIDLIFGYKQ+G AA EAVNVF+H YEG VDI ++ DP + + + IN+FGQ
Sbjct: 2904 SAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQ 2963
Query: 3163 TPKQLFLKPHVKRR-------------------SDRKFPPHPLKHNMHLVPHEIRKCSSS 3203
PKQLF KPH +R SD+ F H L P +++
Sbjct: 2964 IPKQLFKKPHPPKRVRSRLNGDNAGISVLPGSTSDKIFFHHLDNLRPSLTP--VKELKEP 3021
Query: 3204 ITQIVTFHDKVLVAGTNSLLKPITYTKYVSWGFPDRSLRFMSYDQDRLLSTHENLHGGNQ 3263
+ QIV +L N +L P T+ K +WG+ D S R +Y+ D+ ++ +E L Q
Sbjct: 3022 VGQIVCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCRLGTYESDKAMTVYECLSEWGQ 3081
Query: 3264 IQCASASHDGQILVTGADDGLVSVWRINKDGPRNLRRLQLEKALCAHTAKITCLHVSQPY 3323
I CA + ++++TG +V VW + + + + L++AL HT +TC S Y
Sbjct: 3082 ILCAICP-NPKLVITGGTSTVVCVWEMGTSKEK-AKTVTLKQALLGHTDTVTCATASLAY 3139
Query: 3324 MLIVSASDDCTVILWDLSSLVFVRQLPQFPAPISAIYVNDLTGEIVTAAGVLLAVWSING 3383
+IVS S D T I+WDL+ L F+ QL AP+SA+ +N+LTG+IV+ AG + VWSING
Sbjct: 3140 HIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINELTGDIVSCAGTYIHVWSING 3199
Query: 3384 DGLAVINTSQLPSDSILSVTSCTFSDWLDTNWYVTGHQSGAVKVWKM 3430
+ + +NT S I+ ++W N VTGH G V+ W+M
Sbjct: 3200 NPIVSVNTFTGRSQQIICCCMSEMNEWDTQNVIVTGHSDGVVRFWRM 3246
Score = 53.9 bits (128), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 33/122 (27%), Positives = 56/122 (45%), Gaps = 13/122 (10%)
Query: 1330 GRLHGDVYVCGQCVIG-------------DSIRPVGGMAVVLALVEASETRDMLHMALTL 1376
G L+G G +IG +++ VGG A +L LV + + L+ A+
Sbjct: 1374 GHLNGSARTIGAALIGYLGVRTFVPKPVATTLQYVGGAAAILGLVAMASDVEGLYAAVKA 1433
Query: 1377 LACALHQNPQNVKDMQTCRGYHLLSLFLHRRMSLFDMQSLEIFFQIAACEASFSEPKKLE 1436
L C + NP K+M+ +GY LL++ L ++ SL + L + F + S E +
Sbjct: 1434 LVCVVKSNPLASKEMERIKGYQLLAMLLKKKRSLLNSHILHLTFSLVGTVDSGHETSIIP 1493
Query: 1437 NT 1438
N+
Sbjct: 1494 NS 1495
Query: CNT0007486
Subject: sp|Q55DM1|LVSA_DICDI BEACH domain-containing protein lvsAOS=Mus musculus GN=Wdfy3 PE=1 SV=1
Score = 617 bits (1590), Expect = e-176, Method: Compositional matrix adjust.
Identities = 375/993 (37%), Positives = 532/993 (53%), Gaps = 103/993 (10%)
Query: 2463 LELVREAMSTELRVVRQDKYGWVLHAESEWQTYLQQLVHERGIF-PMRKTSLTEDPEWQL 2521
+ +VR+ + T+ + ++ + + + EW +L+ ERG++ P + L + W L
Sbjct: 2314 IAVVRDLVDTQYKEYQERQQNALKYVTEEWCQIECELLRERGLWGPPIGSHLDK---WML 2370
Query: 2522 CPIEGPYRMRKKLERCKLKIDTIQNVLDGQFESVEIELSREKNENGFEASDTDSESYFPL 2581
EGP RMRKK+ R + + V + E E S K A DS+ Y+
Sbjct: 2371 EMTEGPCRMRKKMVRNDMFYNHYPYVPE-----TEQEASVGKPARYRRAISYDSKEYYLR 2425
Query: 2582 LDSGVKQIDDKYYDESFFKESDDIKDVASARSGWNDDRASSINEASLHSALEFGVKSSAI 2641
L SG I ES + + H +
Sbjct: 2426 LASGNPAIVQDAIVES--------------------SEGEATQQEPEHGEDTIAKVKGLV 2465
Query: 2642 SVPMSESIHGRSDTGSPRQSSSVKIEEGKGTEDKLDKELLDNGEYLIRPYLEPLEKIRFR 2701
P+ S RS + + ++++ +++E + L+R LE EKI+
Sbjct: 2466 KPPLKRS---RSAPDGGDEETQEQLQDQIAESGSIEEEEKTDNATLLR-LLEEGEKIQHM 2521
Query: 2702 YNCERVVGLDKHDGIFLIGELCLYVIENFYIDDTGCICEKECEDELSVIDQALGVKKDVN 2761
Y C RV GLD +G+ L G+ YVI+ F + T +E D
Sbjct: 2522 YRCARVQGLDTSEGLLLFGKEHFYVIDGFTMTAT-----REIRD---------------- 2560
Query: 2762 GGMDFQPKSTPSRGVTKAWVGGRAWAYNGGAWGKEKVCSSGNLPHAWNMWKLSSVHEILK 2821
++ P + + + G R G ++ CS ++ + E+ K
Sbjct: 2561 --IETLPPNMHEPIIPR---GARQ-----GPSQLKRTCS---------IFAYEDIKEVHK 2601
Query: 2822 RDYQLRPVAIEIFSMDGCNDLLVFHKKEREEVFKNLVAMNLPRNSMLDTTISGSMKQESN 2881
R Y L+P+A+E+FS DG N LL F K R +V++ +A+ +P + ++SG S
Sbjct: 2602 RRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAV-VPSLTDSSESVSGQRPNTSV 2660
Query: 2882 E-GSRLFKIMA--KSFSKRWQNGEISNFQYLMHLNTLAGRGYSDLTQYPVFPWVLADYES 2938
E GS L + KS ++RW+ GEISNFQYLMHLNTLAGR Y+DL QYPVFPW+L+DY+S
Sbjct: 2661 EQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILSDYDS 2720
Query: 2939 ENLDLSDPKTFRKLEKPMGCQTLEGEEEFKKRYESWDDP--EVPKFHYGSHYSSAGIVLF 2996
E +DL++PKTFR L KPMG QT E ++KKRY+ W+DP E P +HYG+HYSSA IV
Sbjct: 2721 EEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVAS 2780
Query: 2997 YLLRLPPFSAENQKLQGGQFDHADRLFNSVRDTWLSAAGKGNTSDVKELIPEFFYMPEFL 3056
YL+R+ PF+ +LQGG FD ADR+F+SVR+ W SA+ K N +DVKELIPEFFY+PEFL
Sbjct: 2781 YLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSAS-KHNMADVKELIPEFFYLPEFL 2839
Query: 3057 ENRFNLDLGEKQSGEKVGDVVLPPWAKGSTREFIRKHREALESDFVSENLHHWIDLIFGY 3116
N N DLG KQ+G K+GDV+LPPWAKG REFIR HREALE D+VS +LH WIDLIFGY
Sbjct: 2840 FNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGY 2899
Query: 3117 KQRGKAAEEAVNVFYHYTYEGSVDIDSVTDPSLKASILAQINHFGQTPKQLFLKPHVKRR 3176
KQ+G AA EAVNVF+H YEG VDI ++ DP + + + IN+FGQ PKQLF KPH +R
Sbjct: 2900 KQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKR 2959
Query: 3177 -------------------SDRKFPPHPLKHNMHLVPHEIRKCSSSITQIVTFHDKVLVA 3217
SD+ F H L P +++ + QIV +L
Sbjct: 2960 VRSRLNGDNIGISVPPGATSDKIFFHHLDNLRPSLTP--VKELKEPVGQIVCTDKGILAV 3017
Query: 3218 GTNSLLKPITYTKYVSWGFPDRSLRFMSYDQDRLLSTHENLHGGNQIQCASASHDGQILV 3277
N +L P + K +WG+ D S R +Y+ D+ ++ +E L QI CA + ++++
Sbjct: 3018 EQNKVLIPPAWNKTFAWGYADLSCRLGTYESDKAVTVYECLSEWGQILCAVCP-NPKLVI 3076
Query: 3278 TGADDGLVSVWRINKDGPRNLRRLQLEKALCAHTAKITCLHVSQPYMLIVSASDDCTVIL 3337
TG +V VW + + + L L++AL HT +TC S Y +IVS S D T I+
Sbjct: 3077 TGGTSTVVCVWEMGTSKEK-AKPLTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCII 3135
Query: 3338 WDLSSLVFVRQLPQFPAPISAIYVNDLTGEIVTAAGVLLAVWSINGDGLAVINTSQLPSD 3397
WDL+ L F+ QL AP+SA+ +N+LTG+IV+ AG + VWSING+ + +NT S
Sbjct: 3136 WDLNKLSFLTQLRGHRAPVSALCINELTGDIVSCAGTYIHVWSINGNPIVSVNTFTGRSQ 3195
Query: 3398 SILSVTSCTFSDWLDTNWYVTGHQSGAVKVWKM 3430
I+ ++W N VTGH G V+ W+M
Sbjct: 3196 QIVCCCMSEMNEWDTQNVIVTGHSDGVVRFWRM 3228
Score = 53.5 bits (127), Expect = 5e-05, Method: Compositional matrix adjust.
Identities = 32/122 (26%), Positives = 56/122 (45%), Gaps = 13/122 (10%)
Query: 1330 GRLHGDVYVCGQCVIG-------------DSIRPVGGMAVVLALVEASETRDMLHMALTL 1376
G L+G G +IG +++ +GG A +L LV + + L+ A+
Sbjct: 1374 GHLNGPARTIGAALIGYLGVRTFVPKPVATTLQYIGGAAAILGLVAMASDVEGLYAAVKA 1433
Query: 1377 LACALHQNPQNVKDMQTCRGYHLLSLFLHRRMSLFDMQSLEIFFQIAACEASFSEPKKLE 1436
L C + NP K+M+ +GY LL++ L ++ SL + L + F + S E +
Sbjct: 1434 LVCVVKSNPLASKEMERIKGYQLLAMLLKKKRSLLNSHILHLTFSLVGTVDSGHETSIIP 1493
Query: 1437 NT 1438
N+
Sbjct: 1494 NS 1495
Query: CNT0007486
Subject: sp|Q6ZS81|WDFY4_HUMAN WD repeat- and FYVE domain-containing protein 4OS=Dictyostelium discoideum GN=lvsA PE=3 SV=2
Score = 607 bits (1564), Expect = e-173, Method: Compositional matrix adjust.
Identities = 340/844 (40%), Positives = 485/844 (57%), Gaps = 111/844 (13%)
Query: 2702 YNCERVVGLDKHDGIFLIGELCLYVIENFYIDD-TGCICEKECEDELSVIDQALGVKKDV 2760
YNC V G+DK +GI + + +Y+ + +Y D+ TG I E V++ +
Sbjct: 2816 YNCGSVDGMDKIEGILIFCPVYMYIFDGYYKDENTGDISE---------------VEEKI 2860
Query: 2761 NGGMDFQPKSTPSRGVTKAWVGGRAWAYNGGAWGKEKVCSSGNLPHAWNMWKLSSVHEIL 2820
N W G +K + H + W + ++L
Sbjct: 2861 NS----------------------EWLPEGTVLPMKK-----KIIHYFLKWAYEDIRDVL 2893
Query: 2821 KRDYQLRPVAIEIFSMDGCNDLLVFHKK-EREEVFKNLVAMNLPRNSMLDTTISGSMK-- 2877
KR Y LR VA+EIFS DG N+L+V+ + R+EV+ LV N TI G +
Sbjct: 2894 KRRYLLRQVALEIFSTDGRNNLVVYRDEPTRDEVYHTLV-----NNVSSHNTIGGDAQGI 2948
Query: 2878 -----------------QESNEGSRLFKIMAKS-FSKRWQNGEISNFQYLMHLNTLAGRG 2919
R I KS + +WQ G+ISNFQYLMHLNTLAGR
Sbjct: 2949 TGGQTGNDDNDDHHGGGGGRGVRDRFTSIWRKSPLTLKWQQGQISNFQYLMHLNTLAGRS 3008
Query: 2920 YSDLTQYPVFPWVLADYESENLDLSDPKTFRKLEKPMGCQTLEGEEEFKKRYESWDDPE- 2978
Y+DLTQYPVFPWVL+DYESE LD+ DPK +R L KPMG ++F++R+E+WDD E
Sbjct: 3009 YNDLTQYPVFPWVLSDYESEELDIDDPKVYRDLSKPMGALEESRAQKFRERFENWDDQEP 3068
Query: 2979 ------VPKFHYGSHYSSAGIVLFYLLRLPPFSAENQKLQGGQFDHADRLFNSVRDTWLS 3032
VPKFHYG+HYSSA IVL+YL+RL PF+ KLQGG++D DRLF+S+ + W S
Sbjct: 3069 NEHGHKVPKFHYGTHYSSAAIVLYYLIRLEPFTQHFLKLQGGRWDQPDRLFSSITEAWAS 3128
Query: 3033 AAGKGNTSDVKELIPEFFYMPEFLENRFNLDLGEKQSGEKVGDVVLPPWAKGSTREFIRK 3092
++ +G+T V ELIPEF+Y+ EFL N + G KQ GE + D++LPPWAKGS +EFI+
Sbjct: 3129 SS-QGSTGVVMELIPEFYYLDEFLVNNNKFNFGTKQGGEPIDDIILPPWAKGSPQEFIKL 3187
Query: 3093 HREALESDFVSENLHHWIDLIFGYKQRGKAAEEAVNVFYHYTYEGSVDIDSVTDPSLKAS 3152
HR+ALESD+VSE+LH WIDLIFGY+Q+GKAA++++NVFY+ TYEG+V+ID+++DP KA+
Sbjct: 3188 HRKALESDYVSEHLHEWIDLIFGYRQQGKAADDSLNVFYYLTYEGAVNIDAISDPVEKAA 3247
Query: 3153 ILAQINHFGQTPKQLFLKPHVKRRSDRKFPPHPLKHNMHLVPHEIRKCSSSITQIVTFHD 3212
+AQIN+FGQTPKQLF KPH KR + P K L + I+ + QI +D
Sbjct: 3248 TIAQINNFGQTPKQLFDKPHPKRNATLMGLPFYAK---ALTGNFIKDIGEPVGQIRLIND 3304
Query: 3213 KVLVAGTNSLLKPITYTKYVSWGFPDRSLRFMSYDQDRLLSTHENLHGGNQIQCASASHD 3272
+ G N +L P ++KY+ WG PD S+R+ + D+ ++L H H G + C +A+ D
Sbjct: 3305 RATCVGFNKVLLPPNHSKYMLWGLPDGSIRYNTGDKIKVLEDH---HDG-PLTCLTATED 3360
Query: 3273 GQILVTGADDGLVSVWRINKDGPRNLRRLQLEKALCAHTAKITCLHVSQPYMLIVSASDD 3332
G+I V+G D L+ V+ NL+R L K L HT ITC+ S+PY +IVS SDD
Sbjct: 3361 GRICVSGGSDSLICVY--------NLKRFSLAKRLSGHTGSITCVSASRPYSIIVSGSDD 3412
Query: 3333 CTVILWDLSSLVFVRQLPQFPAPISAIYVNDLTGEIVTAAGVLLAVWSINGDGLAVINTS 3392
T I+WDL+ L +VR L PIS I ++D TGEIV +G ++V+++NG+ L TS
Sbjct: 3413 RTCIIWDLNRLCYVRSLDAHEGPISCIGIHDTTGEIVVCSGTTISVYTVNGELLINYKTS 3472
Query: 3393 QLPSDSILSVTSCTFS---DWLDTNWYVTGHQSGAVKVW----KMVHCSDEGSSRSKSTN 3445
Q+ +D I T C +S +WL N +TGH+ G VKVW +++ ++ ++ + + N
Sbjct: 3473 QIANDQI---TCCIWSKGPEWLGENVLLTGHRDGKVKVWGLETRLLPDNNNSNNNNNNNN 3529
Query: 3446 SXXXXXXXXXXXXEYRLVLQKVL---------KFHKHPVTALHLTTDLKQLLSGDSGGHL 3496
+ +L + V+ + H +T++ LT D ++ +GD G +
Sbjct: 3530 NNNNNATQIPSTNNNKLKFKNVIILRATFSNSQSHSTAITSIFLTNDQQKFYTGDITGRV 3589
Query: 3497 ISWT 3500
W+
Sbjct: 3590 CMWS 3593
Score = 82.8 bits (203), Expect = 7e-14, Method: Compositional matrix adjust.
Identities = 102/462 (22%), Positives = 186/462 (40%), Gaps = 77/462 (16%)
Query: 661 SGGFKKHFDSKDAIISSPKLIESGSEKFPLFEIESTVAVAWDCLVSLLKKTETNQASFRS 720
+G +K DS D ++S +ES F+I D L L+ + N + RS
Sbjct: 702 TGNGEKEADSNDQALNSIIKVES-------FQI------LLDSLFILISENPDNISLIRS 748
Query: 721 TSGVTTVLPFLVSDIHRSGVLRVFSCLIIEDVTQAHPEELGALVEVLKSGMVTSVSGSQY 780
S +L FL R LR+ LI D + +E L++VL TSV+ Y
Sbjct: 749 FSIFNILLRFLPYSSVRGKSLRILQQLIKYD-PEPTQKEFDGLIKVL-----TSVNKENY 802
Query: 781 RLQNDAKCDILGSVWRILGVNSSAQRVFGEATGF----SLLLTTLHSFQNNEGHTDQSSL 836
+ K DIL + ++ ++ A+ F E GF S+ ++ SF N + +
Sbjct: 803 PM----KSDILNATRKLFNISKHARDSFREHGGFVSIISVFISLESSFSPNRKDSRNWDM 858
Query: 837 VIYVKVFTYLLRVVTAGVFDNAANRTKLHTIILSQTFYDLLCESGLLSVEWEKXXXXXXX 896
+++ + R T+ + N NR I +TF L +G+L E+ K
Sbjct: 859 E-KLELIESICRCTTSALCGNVINRENFEQQIGYKTFSSCLIMTGVLGTEFSKSVVD--- 914
Query: 897 XXXXXXXXXXXXXXXXXXXXDMSETGSSTFVLATPSGSFNP-----DKERVYNAGAVRVL 951
F+ + + N ++ + N + V+
Sbjct: 915 -----------------------------FIFDMVTENLNASDQISNQMIINNVESFNVI 945
Query: 952 IRSLLLFTPK-VQLEVLNIIDKLARAGPYNQENLTSVGCVELLL-EIIHPFXXXXXXXXX 1009
+ + K +L++++ I+K+A G YNQE L+ + + +L
Sbjct: 946 LDIIPHIENKDFRLQIISRINKMAEYGRYNQEALSKLSIPDWILSRFPSNLSNANDPLQP 1005
Query: 1010 XXXKIVEVLGAYRLSTSELRVLIRYILQMRLKSSGHILVSMMERLILMEDLAFESVPLAP 1069
+++ +GA LS SELR ++ ++ + S +L+ ++ + +S P P
Sbjct: 1006 LLLSLIQTVGANCLSGSELRQFVKL---LQPEHSPEVLLKILSSMA-------KSPPTPP 1055
Query: 1070 FVEMDMSRIGHASVQVSLGARSWPPAAGYSFVCWFQYRNFLT 1111
+ E ++S+I ++V + R+WPP GY+ + W F T
Sbjct: 1056 YFEFNLSKIPFGYIRVPITERAWPPTNGYTIMFWLYIDKFPT 1097
Score = 57.0 bits (136), Expect = 4e-06, Method: Compositional matrix adjust.
Identities = 74/419 (17%), Positives = 147/419 (35%), Gaps = 92/419 (21%)
Query: 1330 GRLHGDVYVCGQCVIGDSIRPVGGMAVVLALVEASETRDMLHMALTLLACALHQNPQNVK 1389
G L G V + + DSI+ +GGM + L L+E + + + L +L LL + +P N
Sbjct: 1410 GVLIGSVEAFRRNKVADSIKKIGGMPISLLLLEKANSEETLFDSLGLLVGLIQYHPTNTH 1469
Query: 1390 DMQTCRGYHLLSLFLHRRMS--LFDMQSLEIFFQIAACEASFSEPKKLENTHNISLPAAT 1447
+M GY LL+ L ++ S LF+ LE+ F + + S ++ +
Sbjct: 1470 EMSQINGYELLAWVLKKKASLGLFNSNILELLFDLIGINGNCS----------TTITSRA 1519
Query: 1448 IPEASIEDLNFSKFRDEFSSVGFHGDMDDFSAHKDSFSHISELENTDIPVETSNCIVLAN 1507
E ++ + N K+ ++ N
Sbjct: 1520 PQEGTVANWNACKY------------------------------------------IMMN 1537
Query: 1508 ADMVEHVLLDWTLWVKASISVQIALLGFLEHLVSMHWYRNHNLTVLRRINLVQHLLVTLQ 1567
D+ W + ++Q ++ L+ + R N+ LR++N++Q + L
Sbjct: 1538 WDI----------WRLTTPALQRHVINGYNSLIVNNIQRRFNIDSLRKVNVIQEIFDILS 1587
Query: 1568 RGDXXXXXXXXXXXXXXXXXXD-----GFLASELEHVVRFVIMTFDPPEPTP-------- 1614
+ G + ++ + F+I PTP
Sbjct: 1588 SSTNEEPLPESVASSVINVLYNILSYGGLIEDDIRQISAFLISHLHKDIPTPSSSSSSSS 1647
Query: 1615 -------RRQIIRETMGKH-------IIVRNMLLEMLIDLQVTIHSEELLEQWHKIVSSK 1660
R+ I R + I + N + + + ++E + + VSS
Sbjct: 1648 TSSTSSRRKSIHRSKLATMELSNTATIQLVNHVFYTFLKVVSNCQTQETAAIFRR-VSSY 1706
Query: 1661 LITYFLDEAVHPTSMRWVMTLLGVCLASSPTFALKFRTSGGYQGLARVLPSFYDSPDVY 1719
+F+DE + P ++ + + + + F G++ L +VLPS ++Y
Sbjct: 1707 WCFFFIDENLPPLTVSLALRVTCIFFLYKYDYCSTFIKKSGFKLLEKVLPSLSGHQEIY 1765
Score = 55.8 bits (133), Expect = 9e-06, Method: Compositional matrix adjust.
Identities = 27/86 (31%), Positives = 50/86 (58%)
Query: 497 NYKVKDLEAVQMLQDIFLKANSRELQAEVLNRMFKIFSGHLENYKLCQQLRTVPLLILNM 556
NY K+ A ++L+ FLK+N E + ++L+R+ ++S + N+ L Q T+ I
Sbjct: 494 NYISKNGNAFKVLERYFLKSNYEENRVKILDRILSVYSSNTVNFILLQHTSTLTKFIQEY 553
Query: 557 DGFPPSLQEIILKILEYAVTVVNCIP 582
+ L+ ++KI+ + VTV+NC+P
Sbjct: 554 ESLSNGLKYHVMKIVCFVVTVLNCVP 579
Query: CNT0007486
Subject: sp|Q7LKZ7|BPH1_SCHPO Beige protein homolog 1 OS=SchizosaccharomycesOS=Homo sapiens GN=WDFY4 PE=1 SV=3
Score = 499 bits (1285), Expect = e-140, Method: Compositional matrix adjust.
Identities = 286/729 (39%), Positives = 393/729 (53%), Gaps = 55/729 (7%)
Query: 2814 SSVHEILKRDYQLRPVAIEIFSMDGCNDLLVFHKKEREEVFKNLVAMNLPRNSMLDTTIS 2873
+ + E+ + + L+ +A+EIF +G + LVF+ +R + FK+ + ++
Sbjct: 2466 ADMRELRQARFLLQDIALEIFFHNGYSKFLVFYNNDRSKAFKSFCSFQ--------PSLK 2517
Query: 2874 GSMKQESNEGSRLFKIMAKSFSKRWQNGEISNFQYLMHLNTLAGRGYSDLTQYPVFPWVL 2933
G E R + + ++WQ +ISNF+YLM+LNT AGR +D QYPVFPWVL
Sbjct: 2518 GKATSEDTLSLRRYPGSDRIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVL 2577
Query: 2934 ADYESENLDLSDPKTFRKLEKPMGCQTLEGEEEFKKRYESWDDPE---VPKFHYGSHYSS 2990
ADY SE L+L++PK FR L KPMG QT E + +F +R++ + E + HY +HYSS
Sbjct: 2578 ADYTSETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHYSS 2637
Query: 2991 AGIVLFYLLRLPPFSAENQKLQGGQFDHADRLFNSVRDTWLSAAGKGNTSDVKELIPEFF 3050
A IV YL+R+PPF+ LQGG FD ADR+F+SV+ TW SA+ + N SDV+EL PEFF
Sbjct: 2638 AIIVASYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESAS-RENMSDVRELTPEFF 2696
Query: 3051 YMPEFLENRFNLDLGEKQSGEKVGDVVLPPWAKGSTREFIRKHREALESDFVSENLHHWI 3110
Y+PEFL N ++ G Q G +GDV LPPWA G R+FI HR+ALESDFVS NLHHWI
Sbjct: 2697 YLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWI 2756
Query: 3111 DLIFGYKQRGKAAEEAVNVFYHYTYEGSVDIDSVTDPSLKASILAQINHFGQTPKQLFLK 3170
DLIFGYKQ+G AA +AVN+F+ Y Y +D+ S+TDP +K++IL +++FGQ PKQLF K
Sbjct: 2757 DLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTK 2816
Query: 3171 PHVKRRSDRK------------FPPHPLK---------------HNMHLVPHEIRKCSSS 3203
PH R + K P HP +M+L +
Sbjct: 2817 PHPARTAAGKPLPGKDVSTPVSLPGHPQPFFYSLQSLRPSQVTVKDMYLFSLGSESPKGA 2876
Query: 3204 ITQIVTFHDKVLVAGTNSLLKPITYTKYVSWGFPDRSLRFMSYDQDRLLSTHENLHGGNQ 3263
I IV+ +L N +L P + + SWGF D S SY D++L T ENL +
Sbjct: 2877 IGHIVSTEKTILAVERNKVLLPPLWNRTFSWGFDDFSCCLGSYGSDKVLMTFENLAAWGR 2936
Query: 3264 IQCASASHDGQILVTGADDGLVSVWRIN--KDGPRNLRRLQLEKALCAHTAKITCLHVSQ 3321
CA I+ +G +V VW ++ K PR LR L +AL HT +TCL S
Sbjct: 2937 CLCAVCPSPTTIVTSGTST-VVCVWELSMTKGRPRGLR---LRQALYGHTQAVTCLAASV 2992
Query: 3322 PYMLIVSASDDCTVILWDLSSLVFVRQLPQFPAPISAIYVNDLTGEIVTAAGVLLAVWSI 3381
+ L+VS S DCT ILWDL L V +LP ISAI ++D++G IV+ AG L++W++
Sbjct: 2993 TFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCAGAHLSLWNV 3052
Query: 3382 NGDGLAVINTSQLPSDSILSVTSCTFSDWLDTNWYVTGHQSGAVKVWKMVHCSDEGSSRS 3441
NG LA I T+ P +I W + +TG Q G V+VWK R
Sbjct: 3053 NGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVWKTEDVKMSVPGRP 3112
Query: 3442 KSTNSXXXXXXXXXXXXEYRLVLQKVLKFH----------KHPVTALHLTTDLKQLLSGD 3491
E L L + L VTAL ++ + +LL GD
Sbjct: 3113 AGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGKPSKTSPAVTALAVSRNHTKLLVGD 3172
Query: 3492 SGGHLISWT 3500
G + W+
Sbjct: 3173 ERGRIFCWS 3181
Query: CNT0007486
Subject: sp|Q86JF2|LVSB_DICDI BEACH domain-containing protein lvsBpombe (strain 972 / ATCC 24843) GN=lvs1 PE=1 SV=2
Score = 442 bits (1138), Expect = e-123, Method: Compositional matrix adjust.
Identities = 284/861 (32%), Positives = 440/861 (51%), Gaps = 99/861 (11%)
Query: 2692 LEPLEKIRFRYNCERVVGLDKHDGIFLIGELCLYVIENFYIDDTGCICEKECEDELSVID 2751
+E + I+ YN R+ GL+ +GI L+G+ LY+++NF++ I + ++ S+ID
Sbjct: 1734 IESGDSIQDVYNVSRIFGLEATEGILLLGKQYLYLMDNFFLRSDNEIVDV---NDNSIID 1790
Query: 2752 QALGVKKDVNGGMDFQPKSTPSRGVTKAWVGGRAWAYNGGAWGKEKVCSSGNLPHAWNMW 2811
+ P + + G KV + + W+ W
Sbjct: 1791 ER-------------DPYLQLLHLQSLSSSG--------------KVRRHISKENNWH-W 1822
Query: 2812 KLSSVHEILKRDYQLRPVAIEIFSMDGCNDLLVF-HKKEREEVFKNLVA----MNLPRNS 2866
+ +LKR Y LR V +E+F DG + L + + K R+ +++ LVA ++ S
Sbjct: 1823 DFIDLSLVLKRFYLLRDVGLELFFKDGRSFLTILSNTKNRDSLYQKLVARAPGADVLSTS 1882
Query: 2867 MLDTTISGSMKQESNEGSRLFKIMAKSFS--------KRWQNGEISNFQYLMHLNTLAGR 2918
T++S + + + + + L +A + S KRW+ EISNF YL +NTLAGR
Sbjct: 1883 HFATSMSRDLGKANGKSNFLSSKLANALSFSTTHPATKRWERREISNFNYLQIVNTLAGR 1942
Query: 2919 GYSDLTQYPVFPWVLADYESENLDLSDPKTFRKLEKPMGCQTLEGEEEFKKRYE---SWD 2975
Y+DLTQYPVFPWV+ADY S+ LDL++PKT+R KPMG Q E E +F +RY+ +
Sbjct: 1943 TYNDLTQYPVFPWVIADYTSKELDLNNPKTYRNFCKPMGAQHPERESQFNERYDLLLGLN 2002
Query: 2976 DPEVPKFHYGSHYSSAGIVLFYLLRLPPFSAENQKLQGGQFDHADRLFNSVRDTWLSAAG 3035
D + FHYG+HYSSA IV YL+RL PF LQGGQFDHADRLF S+ W S++
Sbjct: 2003 DSQQQPFHYGTHYSSAMIVCSYLIRLRPFVDSYLALQGGQFDHADRLFYSIEQAWRSSS- 2061
Query: 3036 KGNTSDVKELIPEFFYMPEFLENRFNLDLGEKQS-GEKVGDVVLPPWAKGSTREFIRKHR 3094
K N +DV+ELIPEFFY+ E N D G +Q + DV+LPPWAKG F++K+R
Sbjct: 2062 KENMADVRELIPEFFYLSEMFINGNGFDFGSRQKESTPINDVILPPWAKGDPAIFVQKNR 2121
Query: 3095 EALESDFVSENLHHWIDLIFGYKQRGKAAEEAVNVFYHYTYEGSVDIDSVTDPSLKASIL 3154
EALES +VS +LH WIDL+FG KQRG A A NVF+H +Y+G++D++++ + A+ +
Sbjct: 2122 EALESKYVSAHLHEWIDLVFGCKQRGDEAVAATNVFHHLSYQGAIDLENIENEFELAAAV 2181
Query: 3155 AQINHFGQTPKQLFLKPHVKRRSDRKFPPHPL--------KHNMHLVPHE----IRKCSS 3202
I++FGQTPKQ+F KPH +R D F PL + ++HL+ IR C
Sbjct: 2182 GIIHNFGQTPKQVFKKPHPQRGPD--FTDTPLGPYLFGRFEDSIHLLFQSCSPIIRIC-K 2238
Query: 3203 SITQIVTFHDKVLVAGTNSLLKPITYTKYVSWGFPDRSLRFMSYDQDRLLSTHENLHGGN 3262
+ I K V + P+ +++WG D +++ +S D+ E LH
Sbjct: 2239 KVAHIQYDPSKDEVGAFAADYTPLGPNTFLAWGRVDNTVQLISDQLDKQPVMFEELHSEK 2298
Query: 3263 QIQCASASHDGQILVTGADDGLVSVWRINKDGPRNLRRLQLEKALCAHTAKITCLHVSQP 3322
+ D + +T + D + +W ++ + P + L++ L H +ITC+ V +
Sbjct: 2299 ITHVVAC--DERTFLTASLDLTLRLWTLSTNKP---IKASLKRVLYGHRYRITCVTVCKA 2353
Query: 3323 YMLIVSASDDCTVILWDLSSLVFVRQLPQFPAPISAIYVNDLTGEIVTAAGVLLAVWSIN 3382
+ +IVS +I+WDL+ FV L + PI I VN EI + G V ++N
Sbjct: 2354 FSIIVSGDAGGNLIIWDLNRAEFVSSLSVYKLPIQTIAVNARNAEIAFSTGFYCCVVNVN 2413
Query: 3383 GDGLAVINTSQL----PSDSILSVTSCTF----SDWLDTNWYVTGHQSGAVKVWKMVHCS 3434
G L S++ ++IL SC + S+WL N ++TGH G +++W+
Sbjct: 2414 GKILVKDKLSRIYNENSDENIL--CSCFYTGANSEWLHKNLFITGHPDGIIRIWE----- 2466
Query: 3435 DEGSSRSKSTNSXXXXXXXXXXXXEYRLVLQKVLKFHK----------HPVTALHLTTDL 3484
+ +N+ ++R L + L+ K + +
Sbjct: 2467 -----KRLQSNAKLEAEKNNADRPKWRFHLLRQLQHTKGLGRNRVATRQNIITITPNGQA 2521
Query: 3485 KQLLSGDSGGHLISWTLPDES 3505
+ + +GD G + SW LPD +
Sbjct: 2522 RGIFAGDDKGQVFSWMLPDTT 2542