RetrogeneDB ID: retro_chof_2371

Retrocopy location

• Organism: Sloth (Choloepus hoffmanni)
• Coordinates: scaffold_68904:4947..5979(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: COPS2
• Ensembl ID: ENSCHOG00000013375
• Aliases: None
• Description: COP9 signalosome subunit 2 [Source:HGNC Symbol;Acc:30747]

Sequence

>retro_chof_2371
TATTTGGAGTGCAGTTACACAAGAAATTATTCTGAAAAATCCATTAATCCTATTCTTGATTATATCTCCACTTCTAAACA
GTTGGATTTACTGCAGGAATTCTATGAAACAACACTGGAAGCTTTGAAAGATGCTAAGACTGATAGACTGTGGCTTAAGA
CAAACACAAAGCTTGGAAAATTATATTTAGAATGTGAGGAATATGGAAAGCTTCAAAAAATTTTACTTCAATTACATCAA
TCCTGCGAGACTGATGAAGAAGATGACCTGAAAAAAGGTACACAGTAATTAAAAATATGCGCTTTGGAAATTCAGATGTA
CACAGCACAGAAGACTAACAAAAAGCTTAAAGCACTCTATGAACAGTCACTTCACATCAAGTCTGCCATCCCTCATCCAT
TGATCATGGGAGTCATCAGAGAATGTGGTGATAAAATGCACTTTAGAGAAGGTGAATTTGAAAAGGCACACACTGATTTT
TTTTGAAGTCTTCAAGAATTATGATGAATGGGGGAGTCCCAGATGAATCACTTGCTTAAAATATTTGGTCTTAGCAAATA
TGCTAATGAAATCGGGAATAACTCCATCTGACTCACAGGCCAGGCTGTACAGAAATGATCCAGAAATTCTAGCAATGATG
AATTTAGTAAGTGCCTATCAGAATAATGACATCACTGAATTTGAAAAGATTCTGAAAAAAATCACAGCAACATCATGGAT
GATCCTTTCATAAGGGAACATATTGAAGAGGTTTTGCAAAACACCAGAACACAAGTGGTCATAAAATTAATTAAGCCTTA
CACAAGAATACATATTCCTTTTATTTCTAAGGAGTTAAACATAGATGTAGCTGATGTGGAGAGCTTGCTGGTAGAGTGCA
TATTGGATAACACTGTTCATGGCTGAATTGATCAAGTCAACCAACTCCTTGAACTGGATCATCTGAAGAGGGGTGGTGCA
TGATATACTGCTCTAGATAAATGGACCACCCAATTAAATTCTCTCAACCAGGCTGTAGTCAGTAAACTTGCT

Alignment

ORF - retro_chof_2371 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 76.99 %
• Parental protein coverage: 78.25 %
• Number of stop codons detected: 4
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  YIRSAVTRNYFEKSINCILDYISTNSDFLCQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLE-R
          Y.....TRNY.EKSIN.ILDYIST......Q.DLLQEFYETTLEALKDAK.DRLW.KTNTKLGKLYLE..
Retrocopy YLECSYTRNYSEKSINPILDYISTSK----QLDLLQEFYETTLEALKDAKTDRLWLKTNTKLGKLYLECE

Parental  EYGKLQKIXXXXXXXXXTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLI
          EYGKLQKI.........TD..EDDLKKGTQ.L.I.ALEIQMYTAQK.NKKLKALYEQSLHIKSAIPHPLI
Retrocopy EYGKLQKILLQLHQSCETDE-EDDLKKGTQ*LKICALEIQMYTAQKTNKKLKALYEQSLHIKSAIPHPLI

Parental  MGVIRECGGKMHLREGEFEKAHTDFF-EAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPY
          MGVIRECG.KMH.REGEFEKAHT....E.FKNYDE.GSPR..TCLKYLVLANMLMKSGI.P.DSQ.A..Y
Retrocopy MGVIRECGDKMHFREGEFEKAHTXXX>EVFKNYDEWGSPR*ITCLKYLVLANMLMKSGITPSDSQ-ARLY

Parental  KNDPEILAMTNLVSAYQNNDITEFEKILKT-NHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHI
          .NDPEILAM.NLVSAYQNNDITEFEKILK..NHSNIMDDPFIREHIEE.L.N.RTQV.IKLIKPYTRIHI
Retrocopy RNDPEILAMMNLVSAYQNNDITEFEKILKK<NHSNIMDDPFIREHIEEVLQNTRTQVVIKLIKPYTRIHI

Parental  PFISKXXXXXXXXXXXXXXXXXXXXTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSK
          PFISK....................T.HG.IDQVNQLLELDH.KRGGA.YTALDKWT.QLNSLNQAVVSK
Retrocopy PFISKELNIDVADVESLLVECILDNTVHG*IDQVNQLLELDHLKRGGA*YTALDKWTTQLNSLNQAVVSK

Parental  LA
          LA
Retrocopy LA

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Choloepus hoffmanni was not studied using RNA-Seq expression data.

ChIP-Seq

Choloepus hoffmanni was not studied using ChIP-Seq data.

EST

Choloepus hoffmanni was not studied using EST data.

TSS

Choloepus hoffmanni was not studied using FANTOM5 data.

Lab

retro_chof_2371 was not experimentally validated.

Homology

Retrocopy orthology:

Choloepus hoffmanni does not belong to any of the species groups (eutheria, teleost or neognath), studied for retrocopy-based homology. For more information about studied groups, please go to help section.

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Parental genes homology:

Parental genes homology involve 10 parental genes, and 18 retrocopies.

Species	Parental gene accession	Retrocopies number
Bos taurus	ENSBTAG00000013425	1 retrocopy	retro_btau_452,
Choloepus hoffmanni	ENSCHOG00000013375	7 retrocopies	retro_chof_1083, retro_chof_1288, retro_chof_2209, retro_chof_2371 , retro_chof_2520, retro_chof_2550, retro_chof_678,
Callithrix jacchus	ENSCJAG00000001585	2 retrocopies	retro_cjac_3105, retro_cjac_3117,
Echinops telfairi	ENSETEG00000019523	2 retrocopies	retro_etel_2160, retro_etel_88,
Macaca mulatta	ENSMMUG00000009838	1 retrocopy	retro_mmul_62,
Monodelphis domestica	ENSMODG00000002466	1 retrocopy	retro_mdom_891,
Oryctolagus cuniculus	ENSOCUG00000006455	1 retrocopy	retro_ocun_1296,
Otolemur garnettii	ENSOGAG00000013284	1 retrocopy	retro_ogar_1513,
Tupaia belangeri	ENSTBEG00000008306	1 retrocopy	retro_tbel_4497,
Tursiops truncatus	ENSTTRG00000000462	1 retrocopy	retro_ttru_328,