RetrogeneDB ID:

retro_hsap_2952

Retrocopy
location
Organism:Human (Homo sapiens)
Coordinates:4:83196626..83197753(+)
Located in intron of:None
Retrocopy
information
Ensembl ID:ENSG00000234568
Aliases:None
Status:KNOWN_PSEUDOGENE
Parental gene
information
Parental gene summary:
Parental gene symbol:BIN2
Ensembl ID:ENSG00000110934
Aliases:BIN2, BRAP-1
Description:bridging integrator 2 [Source:HGNC Symbol;Acc:1053]


Retrocopy-Parental alignment summary:






>retro_hsap_2952
AAACTACTAGAGGAGTTGTCTATTCTTTATAATAGTCATACTGGCTCTATGTGACCATCTTCCAAAACATTTCCAACTTG
AGGGATGTCTTCTACAGGGAAATGAGCAAACTGAACCACAATCTCTCCGAGGTGATGAGCAAACTGGAGAAGCAACATTC
CAGTAAAGTCTTTGTGGTGAAGAGACTATCAAGCAGCAGCAGGCGCTCTTTAGTCATTTCTCCCCCAGTTCGAACATCTA
CAGTCTCCAGTCCACTTACCTCACCTACTAGTCCCTCTACACTTTCCTCGAAGAGTAAGAGTGAATCTGTCTCAGCAACT
GAAGATCTGGCACCTGATGCAGCCCAGGGGGAAGACAATTCTGAGATCAAGGAGCTCTTAGAAGATGAGGAAATAGGGAA
GGAAGGATCTGAAGCAAGCTCCTCTGAGGAAGAAGAGCCTCTACTAACCTGCAACGGCCCCTCCCAGGCCCAGCCCTCTC
CTATCATTGAGAGTGCCAGGTCCCAGGAAGAAGTTCCCCCCAGCTCCCCTGCTCTATCACCAGGTGGAGCCCTAAGCCCT
TCAGGACACCCTTTATCATCTGCCGCAGAAGTAGTCCTCCGAACCCGCACCGCAGGTGACAAATCTGAACAATCAAAGAA
GAGAGCCTCTATCCAGAGGACCTCAGCACCCCCTAGTAGGCCTCCTCCACCCAGAGCCACTGCAAGCCCCAGGCCCTCCT
CAGGGAACATACCCTCCAGCCCTCCAGCCTCTGGAGGGGGTTCACCCACCAGCCCTAGGGCCTCCTTGGGGACTGGGACT
CCAAGTCCTAGGACCTCCCTAGAGGTCTCTCCTAATCCAGAACCACCAGAGAAGCCAGTAAGAACTCCTGAGGCCAAAGA
AAATGAAAACATCCACAATCAGAACCTCGAAGAACTTTGTACTTCCCCCACCTTAATGACATCTCACATTGCTTCAGAGC
CTGGAGAGGCAAAGAAGATGGAAGACAAGGAAAATGATAACAAGCTTGTCTCAGCTGACTCCTCGGAGGGCCAAGACCAG
CTTAAAGTCTCCACAGTACCAGACAAGAGCAACCTCACAGCACCTGAACCTCAAGAAGAGGTATCTACAAGTGAAAATGC
ACAACTC

ORF - retro_hsap_2952 Open Reading Frame is not conserved.
Retrocopy - Parental Gene Alignment summary:
Percent Identity: 87.53 %
Parental protein coverage: 70.54 %
Number of stop codons detected: 0
Number of frameshifts detected: 1


Retrocopy - Parental Gene Alignment:

ParentalELLEELPILYNSRIGC-YVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRR
.LLEEL.ILYNS..G..YVTIFQNISNLRDVFYREMSKLNHNL.EVMSKLEKQHS.KVFVVK.LSSSSRR
RetrocopyKLLEELSILYNSHTGS<YVTIFQNISNLRDVFYREMSKLNHNLSEVMSKLEKQHSSKVFVVKRLSSSSRR
ParentalSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEA
SLVISPPVRT.TVSSPLTSPTSPSTLS.KS.SESVSATEDLAPDAAQGEDNSEIKELLE.EEI.KEGSEA
RetrocopySLVISPPVRTSTVSSPLTSPTSPSTLSSKSKSESVSATEDLAPDAAQGEDNSEIKELLEDEEIGKEGSEA
ParentalSSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGS
SSSEE.EPL..CNGP.QAQPSP..E.A.SQEEV.PSS...SPGGALSPSG.P.SSA.EVVLRTRTA...S
RetrocopySSSEEEEPLLTCNGPSQAQPSPIIESARSQEEVPPSSPALSPGGALSPSGHPLSSAAEVVLRTRTAGDKS
ParentalEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPN
EQ.KKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSP.ASGGGSPTSPRASLGTGT.SPRTSLEVSPN
RetrocopyEQSKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPPASGGGSPTSPRASLGTGTPSPRTSLEVSPN
ParentalPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQ
PEPPEKPVRTPEAKENENIHNQN.EELCTSPTLMTS..ASEPGEAKKMEDKE.DNKL.SA.SSEGQDQL.
RetrocopyPEPPEKPVRTPEAKENENIHNQNLEELCTSPTLMTSHIASEPGEAKKMEDKENDNKLVSADSSEGQDQLK
ParentalVSMVPENNNLTAPEPQEEVSTSENPQL
VS.VP...NLTAPEPQEEVSTSEN.QL
RetrocopyVSTVPDKSNLTAPEPQEEVSTSENAQL

Legend:
*Stop codon
>Forward frameshift by one nucleotide
<Reverse frameshift by one nucleotide






RNA-Seq - click to see more details

(Hint: click retrocopy or parental gene accession number on the plot's legend, to show / hide expression level values)

Expression validation based on RNA-Seq data:
Library Retrocopy expression Parental gene expression
bodymap2_adipose 0 .00 RPM 8 .81 RPM
bodymap2_adrenal 0 .02 RPM 33 .84 RPM
bodymap2_brain 0 .00 RPM 3 .05 RPM
bodymap2_breast 0 .00 RPM 2 .76 RPM
bodymap2_colon 0 .00 RPM 2 .32 RPM
bodymap2_heart 0 .00 RPM 1 .83 RPM
bodymap2_kidney 0 .00 RPM 2 .09 RPM
bodymap2_liver 0 .00 RPM 4 .06 RPM
bodymap2_lung 0 .00 RPM 22 .20 RPM
bodymap2_lymph_node 0 .00 RPM 36 .77 RPM
bodymap2_ovary 0 .00 RPM 3 .62 RPM
bodymap2_prostate 0 .00 RPM 4 .24 RPM
bodymap2_skeletal_muscle 0 .00 RPM 0 .60 RPM
bodymap2_testis 0 .00 RPM 11 .97 RPM
bodymap2_thyroid 0 .00 RPM 1 .75 RPM
bodymap2_white_blood_cells 0 .45 RPM 321 .50 RPM

ChIP-Seq - click to see more details

RNA Polymerase II activity near the 5' end of retro_hsap_2952 was not detected

EST - click to see more details

No EST(s) were mapped for retro_hsap_2952 retrocopy.

TSS - click to see more details

No TSS is located nearby retro_hsap_2952 retrocopy 5' end.

Lab - click to see more details

retro_hsap_2952 was not experimentally validated.

Retrocopy orthology:
Retrocopy retro_hsap_2952 has 2 orthologous retrocopies within eutheria group .

Species RetrogeneDB ID
Pan troglodytes retro_ptro_2049
Pongo abelii retro_pabe_2448
Parental genes homology:
Parental genes homology involve 6 parental genes, and 9 retrocopies.

Species Parental gene accession Retrocopies number
Homo sapiens ENSG00000110934 2 retrocopies
retro_hsap_2952 , retro_hsap_3192,
Gorilla gorilla ENSGGOG000000094231 retrocopy
retro_ggor_1336,
Loxodonta africana ENSLAFG000000023871 retrocopy
retro_lafr_1163,
Nomascus leucogenys ENSNLEG000000177741 retrocopy
retro_nleu_1636,
Pongo abelii ENSPPYG000000045262 retrocopies
retro_pabe_2448, retro_pabe_2648,
Pan troglodytes ENSPTRG000000049542 retrocopies
retro_ptro_2049, retro_ptro_2251,

Expression level across human populations :
image/svg+xml GBR_HG00142 GBR_HG00099 GBR_HG00114 GBR_HG00143 GBR_HG00131 GBR_HG00137 GBR_HG00133 GBR_HG00119 GBR_HG00111 GBR_HG00134 FIN_HG00378 FIN_HG00338 FIN_HG00349 FIN_HG00375 FIN_HG00315 FIN_HG00277 FIN_HG00328 FIN_HG00321 FIN_HG00377 FIN_HG00183 TSI_NA20756 TSI_NA20538 TSI_NA20798 TSI_NA20532 TSI_NA20765 TSI_NA20518 TSI_NA20513 TSI_NA20512 TSI_NA20771 TSI_NA20786 YRI_NA19114 YRI_NA19099 YRI_NA18870 YRI_NA18907 YRI_NA19223 YRI_NA19214 YRI_NA18916 YRI_NA19093 YRI_NA19118 YRI_NA19213 Toscaniin Italia: Finnish inFinland: British in England and Scotland: Utah Residents (CEPH) with Northernand Western European Ancestry: Yoruba in Ibadan, Nigeria: CEU_NA12760 CEU_NA12827 CEU_NA12872 CEU_NA12751 CEU_NA12873 CEU_NA12400 CEU_NA11930 CEU_NA12004 CEU_NA11831 CEU_NA11843 No expression ( = 0 RPM ) > 0 RPM = 0.06 RPM Legend:


Library Retrogene expression
CEU_NA11831 0 .02 RPM
CEU_NA11843 0 .03 RPM
CEU_NA11930 0 .03 RPM
CEU_NA12004 0 .04 RPM
CEU_NA12400 0 .00 RPM
CEU_NA12751 0 .05 RPM
CEU_NA12760 0 .00 RPM
CEU_NA12827 0 .05 RPM
CEU_NA12872 0 .00 RPM
CEU_NA12873 0 .06 RPM
FIN_HG00183 0 .00 RPM
FIN_HG00277 0 .00 RPM
FIN_HG00315 0 .06 RPM
FIN_HG00321 0 .00 RPM
FIN_HG00328 0 .00 RPM
FIN_HG00338 0 .00 RPM
FIN_HG00349 0 .00 RPM
FIN_HG00375 0 .00 RPM
FIN_HG00377 0 .05 RPM
FIN_HG00378 0 .00 RPM
GBR_HG00099 0 .06 RPM
GBR_HG00111 0 .06 RPM
GBR_HG00114 0 .00 RPM
GBR_HG00119 0 .00 RPM
GBR_HG00131 0 .06 RPM
GBR_HG00133 0 .02 RPM
GBR_HG00134 0 .00 RPM
GBR_HG00137 0 .03 RPM
GBR_HG00142 0 .00 RPM
GBR_HG00143 0 .00 RPM
TSI_NA20512 0 .00 RPM
TSI_NA20513 0 .00 RPM
TSI_NA20518 0 .00 RPM
TSI_NA20532 0 .03 RPM
TSI_NA20538 0 .00 RPM
TSI_NA20756 0 .00 RPM
TSI_NA20765 0 .04 RPM
TSI_NA20771 0 .00 RPM
TSI_NA20786 0 .00 RPM
TSI_NA20798 0 .00 RPM
YRI_NA18870 0 .03 RPM
YRI_NA18907 0 .00 RPM
YRI_NA18916 0 .04 RPM
YRI_NA19093 0 .00 RPM
YRI_NA19099 0 .00 RPM
YRI_NA19114 0 .00 RPM
YRI_NA19118 0 .00 RPM
YRI_NA19213 0 .00 RPM
YRI_NA19214 0 .00 RPM
YRI_NA19223 0 .02 RPM

Indel association:

No indels were associated with its genomic coordinates. Based on Kabza et al. 2015 (PubMed).



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