RetrogeneDB ID:

retro_hsap_829

Retrocopy
location
Organism:Human (Homo sapiens)
Coordinates:11:122888346..122889369(+)
Located in intron of:None
Retrocopy
information
Ensembl ID:ENSG00000213184
Aliases:None
Status:KNOWN_PSEUDOGENE
Parental gene
information
Parental gene summary:
Parental gene symbol:SAE1
Ensembl ID:ENSG00000142230
Aliases:SAE1, AOS1, HSPC140, SUA1, UBLE1A
Description:SUMO1 activating enzyme subunit 1 [Source:HGNC Symbol;Acc:30660]


Retrocopy-Parental alignment summary:






>retro_hsap_829
ATGGTGGAGAAGGAGGAGGCTGGAGGTGGCATCAGCCAGGAGGAGGCAGGCGCAGTATGACCAGCAGATCTGCCTTTGGG
GACTGGAGGCCCCGAAATGGCTGCGGGCCTCCCAGGTGCTTCTTGCAGGCATGAAAGGACTCGGGGCTGAAATTGCCAAG
AATCTCATCCTGGCAGGAGTGAAAGGACTGACCATGCTGGATCACAAACAGATATCTCCAGAAGAACCCGGAGCTCAGTT
CTTGATTCGTATTGGGTCTGTTGGCCGAAATAGGGCTGAAGCCTCTTTGGAGCGAGCTCAGAATCTTAACCCCATGGTGG
ATGTGAAGTTGGACACTGAGGATATAGAGAAGAAACCAGAGTCATTTTTCACTCAATTTGATGCTGTGTGTTGACTTGCT
GCTCCAGGGCTGTCATAGTTAAGGTTGACCAGATCTGTCACAAAAATAGCATCAAGTTCTTTGCAGGAGATGTTTTTAGC
TACCATGGATACACATTTGCCAATCTAGGAGAACATGAGTTTGTAGAGGAGAAAACTAAAGTTGCTAAAGTTAGCCAAGG
AGTAGAAGATGGGCCTGATACCAAGAGAGTAAAACTTGATTCTTCTGAGACAACGATGGTCAAGAAGAAGGTGGTCTTCT
GCCCCGTTAAAGAAGCGCTGGAGGTGGACTGGAGCAGTAAGAAAGCAAAGGCTGCTCTGAAGCGCACGACCTCCGACCAC
TTTCTCCTTCAAGTGCTCCTAAAGTTCCGCACAGATAAAGGAAGAGATCCCAGTTCTGATACACACGGGGAAGATTCCGA
GTTGTTGCTCCAGATACGAAACGATGTGCTTGACTCACTGGGTATTATTCCTGACCCGCGCTTTATCACGTACTTCTTCT
CTGAGATGGCCCCAGTGTGTGCGGTGGTTGGAGGGATTTTGGCACAGGAAATTGTGAAGGCCCTGTCTCAGCAGGACCCT
CCTCACAACTTCTTCTTCAATGGCATGAAGGGGAATGGGATTCTGGAGTGGCTTGGCCCCAAG

ORF - retro_hsap_829 Open Reading Frame is not conserved.
Retrocopy - Parental Gene Alignment summary:
Percent Identity: 88.79 %
Parental protein coverage: 100.0 %
Number of stop codons detected: 0
Number of frameshifts detected: 2


Retrocopy - Parental Gene Alignment:

ParentalMVEKEEAGGGISEEEA-AQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHE
MVEKEEAGGGIS.EEA.AQYD.QI.LWGLEA.K.LRAS.VLL.G.KGLGAEIAKNLILAGVKGLTMLDH.
RetrocopyMVEKEEAGGGISQEEA>AQYDQQICLWGLEAPKWLRASQVLLAGMKGLGAEIAKNLILAGVKGLTMLDHK
ParentalQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVC-LTCCSRDV
Q..PE.PGAQFLIR.GSVGRNRAEASLERAQNLNPMVDVK.DTEDIEKKPESFFTQFDAVC.LTCCSR.V
RetrocopyQISPEEPGAQFLIRIGSVGRNRAEASLERAQNLNPMVDVKLDTEDIEKKPESFFTQFDAVC<LTCCSRAV
ParentalIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVK
IVKVDQICHKNSIKFF.GDVF.YHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKR.KLDSSETTMVK
RetrocopyIVKVDQICHKNSIKFFAGDVFSYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRVKLDSSETTMVK
ParentalKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLD
KKVVFCPVKEALEVDWSS.KAKAALKRTTSD.FLLQVLLKFRTDKGRDPSSDT..EDSELLLQIRNDVLD
RetrocopyKKVVFCPVKEALEVDWSSKKAKAALKRTTSDHFLLQVLLKFRTDKGRDPSSDTHGEDSELLLQIRNDVLD
ParentalSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
SLGI.PD.....F..Y.FSEMAPVCAVVGGILAQEIVKALSQ.DPPHN..FFF.GMKGNGI.E.LGPK
RetrocopySLGIIPD---PRFITYFFSEMAPVCAVVGGILAQEIVKALSQQDPPHN--FFFNGMKGNGILEWLGPK

Legend:
*Stop codon
>Forward frameshift by one nucleotide
<Reverse frameshift by one nucleotide






RNA-Seq - click to see more details

(Hint: click retrocopy or parental gene accession number on the plot's legend, to show / hide expression level values)

Expression validation based on RNA-Seq data:
Library Retrocopy expression Parental gene expression
bodymap2_adipose 0 .00 RPM 61 .54 RPM
bodymap2_adrenal 0 .02 RPM 64 .36 RPM
bodymap2_brain 0 .00 RPM 67 .30 RPM
bodymap2_breast 0 .00 RPM 50 .97 RPM
bodymap2_colon 0 .00 RPM 115 .15 RPM
bodymap2_heart 0 .00 RPM 27 .41 RPM
bodymap2_kidney 0 .00 RPM 39 .62 RPM
bodymap2_liver 0 .00 RPM 22 .94 RPM
bodymap2_lung 0 .00 RPM 52 .55 RPM
bodymap2_lymph_node 0 .00 RPM 58 .42 RPM
bodymap2_ovary 0 .04 RPM 71 .52 RPM
bodymap2_prostate 0 .00 RPM 109 .22 RPM
bodymap2_skeletal_muscle 0 .00 RPM 47 .83 RPM
bodymap2_testis 0 .00 RPM 103 .26 RPM
bodymap2_thyroid 0 .13 RPM 86 .76 RPM
bodymap2_white_blood_cells 0 .00 RPM 59 .87 RPM

ChIP-Seq - click to see more details

RNA Polymerase II activity near the 5' end of retro_hsap_829 was not detected

EST - click to see more details

No EST(s) were mapped for retro_hsap_829 retrocopy.

TSS - click to see more details

No TSS is located nearby retro_hsap_829 retrocopy 5' end.

Lab - click to see more details

retro_hsap_829 was not experimentally validated.

Retrocopy orthology:
Retrocopy retro_hsap_829 has 4 orthologous retrocopies within eutheria group .

Species RetrogeneDB ID
Pan troglodytes retro_ptro_579
Gorilla gorilla retro_ggor_679
Pongo abelii retro_pabe_742
Macaca mulatta retro_mmul_1087
Parental genes homology:
Parental genes homology involve 9 parental genes, and 9 retrocopies.

Species Parental gene accession Retrocopies number
Canis familiaris ENSCAFG000000041801 retrocopy
retro_cfam_1705,
Dipodomys ordii ENSDORG000000121991 retrocopy
retro_dord_638,
Homo sapiens ENSG00000142230 1 retrocopy
retro_hsap_829 ,
Gorilla gorilla ENSGGOG000000130781 retrocopy
retro_ggor_679,
Macaca mulatta ENSMMUG000000095061 retrocopy
retro_mmul_1087,
Nomascus leucogenys ENSNLEG000000029651 retrocopy
retro_nleu_261,
Nomascus leucogenys ENSNLEG000000029661 retrocopy
retro_nleu_262,
Pongo abelii ENSPPYG000000101681 retrocopy
retro_pabe_742,
Pan troglodytes ENSPTRG000000112021 retrocopy
retro_ptro_579,

Expression level across human populations :
image/svg+xml GBR_HG00142 GBR_HG00099 GBR_HG00114 GBR_HG00143 GBR_HG00131 GBR_HG00137 GBR_HG00133 GBR_HG00119 GBR_HG00111 GBR_HG00134 FIN_HG00378 FIN_HG00338 FIN_HG00349 FIN_HG00375 FIN_HG00315 FIN_HG00277 FIN_HG00328 FIN_HG00321 FIN_HG00377 FIN_HG00183 TSI_NA20756 TSI_NA20538 TSI_NA20798 TSI_NA20532 TSI_NA20765 TSI_NA20518 TSI_NA20513 TSI_NA20512 TSI_NA20771 TSI_NA20786 YRI_NA19114 YRI_NA19099 YRI_NA18870 YRI_NA18907 YRI_NA19223 YRI_NA19214 YRI_NA18916 YRI_NA19093 YRI_NA19118 YRI_NA19213 Toscaniin Italia: Finnish inFinland: British in England and Scotland: Utah Residents (CEPH) with Northernand Western European Ancestry: Yoruba in Ibadan, Nigeria: CEU_NA12760 CEU_NA12827 CEU_NA12872 CEU_NA12751 CEU_NA12873 CEU_NA12400 CEU_NA11930 CEU_NA12004 CEU_NA11831 CEU_NA11843 No expression ( = 0 RPM ) > 0 RPM = 0.03 RPM Legend:


Library Retrogene expression
CEU_NA11831 0 .00 RPM
CEU_NA11843 0 .00 RPM
CEU_NA11930 0 .00 RPM
CEU_NA12004 0 .00 RPM
CEU_NA12400 0 .00 RPM
CEU_NA12751 0 .00 RPM
CEU_NA12760 0 .00 RPM
CEU_NA12827 0 .00 RPM
CEU_NA12872 0 .00 RPM
CEU_NA12873 0 .00 RPM
FIN_HG00183 0 .00 RPM
FIN_HG00277 0 .00 RPM
FIN_HG00315 0 .00 RPM
FIN_HG00321 0 .00 RPM
FIN_HG00328 0 .00 RPM
FIN_HG00338 0 .00 RPM
FIN_HG00349 0 .00 RPM
FIN_HG00375 0 .00 RPM
FIN_HG00377 0 .00 RPM
FIN_HG00378 0 .02 RPM
GBR_HG00099 0 .00 RPM
GBR_HG00111 0 .02 RPM
GBR_HG00114 0 .00 RPM
GBR_HG00119 0 .00 RPM
GBR_HG00131 0 .00 RPM
GBR_HG00133 0 .00 RPM
GBR_HG00134 0 .00 RPM
GBR_HG00137 0 .00 RPM
GBR_HG00142 0 .00 RPM
GBR_HG00143 0 .00 RPM
TSI_NA20512 0 .00 RPM
TSI_NA20513 0 .02 RPM
TSI_NA20518 0 .00 RPM
TSI_NA20532 0 .00 RPM
TSI_NA20538 0 .00 RPM
TSI_NA20756 0 .00 RPM
TSI_NA20765 0 .02 RPM
TSI_NA20771 0 .00 RPM
TSI_NA20786 0 .00 RPM
TSI_NA20798 0 .00 RPM
YRI_NA18870 0 .00 RPM
YRI_NA18907 0 .00 RPM
YRI_NA18916 0 .00 RPM
YRI_NA19093 0 .03 RPM
YRI_NA19099 0 .00 RPM
YRI_NA19114 0 .00 RPM
YRI_NA19118 0 .00 RPM
YRI_NA19213 0 .00 RPM
YRI_NA19214 0 .00 RPM
YRI_NA19223 0 .00 RPM

Indel association:

No indels were associated with its genomic coordinates. Based on Kabza et al. 2015 (PubMed).



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