RetrogeneDB ID: retro_pabe_1414

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 16_random:9949854..9950361(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: SLC25A1
• Ensembl ID: ENSPPYG00000029785
• Aliases: None
• Description: solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 [Source:HGNC Symbol;Acc:10979]

Sequence

>retro_pabe_1414
GAGTTCCTCGGCACCCAGATGCAGGATGCCCAGGGACTGCTGAACAGCAGGCGCGGGCTGCTGTGCGGCTGCTGGCGTGG
CCGAGGCCATGGTGGTCGTATGTCCCATGGAGACCATCAAAGTGAAGTTCATCCAGGACCAGACCTCCCCAAACCCAAGA
ACAGATAATTCTTCGGGGTTAGGGAGATTGTGCGGGATCAAGGGCTGAGGAGACATACCAGGGCCTCAGGGCCGCCGCGC
TGAATCAAGGCTGGAACCAGGCCATTGCTTCTTCGTCCTGACTCCCTGCAGCAACTGGTACCGAAGGGACAAACCCATGA
ACCTGCTGATCACTGGGGTCTTCTGAGCCACTGCGGGCACAGCCAGCGTCTTCGGAAACGCCCCTCTGGACGGGATCGAG
ACCCAGATGCGGGGCCTGGAAGTGCACAAACACCGGAACACGGGACTGCGGCTGCAGATCCCGAGGAAGGAGCGGCTCAA
GGCTTTCACAAGGGCACTGTCCCGCGC

Alignment

ORF - retro_pabe_1414 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 66.48 %
• Parental protein coverage: 85.1 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 5

Retrocopy - Parental Gene Alignment:

Parental  EFLSNHMRDAQGRLDSTRGLLCG-LGAGVAEAVVVVCPMETIKVKFIHDQTSPH-PKYKGFFHGVREIVR
          EFL...M.DAQG.L.S.RGLLCG..G...A..VV..CPMETIKVKFI.DQTSP..PK...FF.GVREIVR
Retrocopy EFLGTQMQDAQGLLNSRRGLLCG>AGVAEAMVVV--CPMETIKVKFIQDQTSPN<PKNR*FF-GVREIVR

Parental  EQGLK-GTYQGLTATVLKQGSNQAIR-FFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPL
          .QGL...TYQGL.A..L.QG.NQAI..FFV.T...NWYR.D...KPMN.LITGVF.A.AG.ASVFGN.PL
Retrocopy DQGLR<ETYQGLRAAALNQGWNQAIA<FFVLTPCSNWYRRD---KPMNLLITGVF*ATAGTASVFGNAPL

Parental  DVIKTRMQGLEAHKYRNTWDCGLQILRKEGLKA-FYKGTVPR
          D.I.T.M.GLE.HK.RNT....LQI.RKE.LKA.F.KGTVPR
Retrocopy DGIETQMRGLEVHKHRNT-GLRLQIPRKERLKA<FHKGTVPR

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	16.70 RPM
SRP007412_cerebellum	0.00 RPM	10.58 RPM
SRP007412_heart	0.00 RPM	5.99 RPM
SRP007412_kidney	0.00 RPM	187.78 RPM
SRP007412_liver	0.00 RPM	61.54 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_1414 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_1414 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_1414 has 2 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_1632
Gorilla gorilla	retro_ggor_1230

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Parental genes homology:

Parental genes homology involve 8 parental genes, and 24 retrocopies.

Species	Parental gene accession	Retrocopies number
Homo sapiens	ENSG00000100075	2 retrocopies	retro_hsap_1632, retro_hsap_804,
Gorilla gorilla	ENSGGOG00000006198	2 retrocopies	retro_ggor_1230, retro_ggor_661,
Macaca mulatta	ENSMMUG00000005431	4 retrocopies	retro_mmul_1077, retro_mmul_1556, retro_mmul_1683, retro_mmul_485,
Nomascus leucogenys	ENSNLEG00000005215	2 retrocopies	retro_nleu_2866, retro_nleu_408,
Ochotona princeps	ENSOPRG00000011649	1 retrocopy	retro_opri_1053,
Pongo abelii	ENSPPYG00000029785	9 retrocopies	retro_pabe_1346, retro_pabe_1414 , retro_pabe_1529, retro_pabe_1671, retro_pabe_3125, retro_pabe_3217, retro_pabe_334, retro_pabe_3564, retro_pabe_719,
Pan troglodytes	ENSPTRG00000014057	3 retrocopies	retro_ptro_1139, retro_ptro_1364, retro_ptro_560,
Tursiops truncatus	ENSTTRG00000006845	1 retrocopy	retro_ttru_228,