RetrogeneDB ID: retro_ggor_705

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 11:36576743..36577621(-)
• Located in intron of: ENSGGOG00000016627

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: WEE2
• Ensembl ID: ENSGGOG00000009609
• Aliases: None
• Description: None

Sequence

>retro_ggor_705
CACCTGGTACATTACTACCCCTCACGGGCAGAAGATAACCATATGATCATTCAGAATGAATACTGCAATGGCAGGAACTT
GCAGGCTGCTATATCTGAAAACACTAAGTCTACTAATCACTTCCAAGAGCCAAAACTCAAGGACATCCTTCTACAGATTT
CCCTTGAACTTAAATACAGCCACAACTCTGGCATGGTACACCCGGATATGAAACCTTGTAAAACCTTCCTTTGTCACAAG
ATGCAAAGTGACTCCTCTGGAGTCACAGAAGTTGAAAATGAAGCTGATTAGTTTCTCTCTGCCCATGTGATATATAAAAT
TGGTGACCTAGGCCATGTGACATCAATAAGCAAACTCAAAGTGGAAAAAGGAGATAGTTGCTTCCTAGCAAATGAGATTT
TGCAAGAGGATTATTAGTACCTTCCCAAAGCAGACCTATTTGCCTTGGGATTAATCACTGCAATGGCTGAAGGAGTAAGG
ACATTACCCATCAACAGTGCTGCAAGGCACCATAACCATGAGAGTAACTTCCCAGACATTCCTCAGGAGCTCTCAGAAGA
CTTTTACAGTCTGCTCAAGCACATGATCCACCCTGATCCAGGAGAGAGACCTTCTGCAGCAGCTCTGGTCAGAAATTGGC
CCTGGCCCTCCCTGGGGAAAGCAGAAGAGCTCTAGCAGCAGCTGAATTTGGAAAAGTCCAAGACAGCTGCACTGGAAAGG
GAACTAAGGGAAGCCCAGCAGGCCCAGTCCCTACAGGGAGACTTCCATCATGGTGACCCTGGGGTCTCTGGGACCACACG
GGATCAGAAAACACCAAATGCCTGGTAGGAGGAAAGAGTGCAAGGTCTTCAAGCTTTACCTCAGGACAGCATGAGCCT

Alignment

ORF - retro_ggor_705 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 69.36 %
• Parental protein coverage: 52.39 %
• Number of stop codons detected: 3
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  HDVKYYQILITINRVQLMYKYCGSSGSLQAAISENTKSGNHFEESKLKDILLQISLGLNYIHNSSMVHLD
          H.V.YY......N.......YC.....LQAAISENTKS.NHF.E.KLKDILLQISL.L.Y.HNS.MVH.D
Retrocopy HLVHYYPSRAEDNHMIIQNEYCNGR-NLQAAISENTKSTNHFQEPKLKDILLQISLELKYSHNSGMVHPD

Parental  IKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKPKVEEGDSRFLANEILQEDY
          .KP...F.CHKMQS.SSGV.E.VENEAD.FLSA.V.YKIGDLGH.TSI.K.KVE.GDS.FLANEILQEDY
Retrocopy MKPCKTFLCHKMQSDSSGVTE-VENEAD*FLSAHVIYKIGDLGHVTSISKLKVEKGDSCFLANEILQEDY

Parental  RHLPKADIFALGLTIAVAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAA
          ..LPKAD.FALGL..A.A.G...LP.N.AA.HH....NFPD.PQELSE.F.SLLK.MI.PD...RPSAAA
Retrocopy *YLPKADLFALGLITAMAEGVRTLPINSAARHHNHESNFPDIPQELSEDFYSLLKHMIHPDPGERPSAAA

Parental  LARNTVLRPSLGKTEELQQQLNLEKFKTATLERELREVQQAQSPQGDTHHGDTGVSGT-HTGSRSTKRLV
          L.RN....PSLGK.EEL.QQLNLEK.KTA.LERELRE.QQAQS.QGD.HHGD.GVSGT.HTGS..TK.LV
Retrocopy LVRNWPW-PSLGKAEEL*QQLNLEKSKTAALERELREAQQAQSLQGDFHHGDPGVSGT<HTGSENTKCLV

Parental  GGKSARSSSFTFCTSQP
          GGKSARSSSFT.....P
Retrocopy GGKSARSSSFTSGQHEP

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.05 RPM	0.24 RPM
SRP007412_cerebellum	0.08 RPM	0.28 RPM
SRP007412_heart	0.03 RPM	0.09 RPM
SRP007412_kidney	0.08 RPM	0.20 RPM
SRP007412_liver	0.03 RPM	0.21 RPM
SRP007412_testis	0.00 RPM	1.66 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_705 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_705 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_867
Pan troglodytes	retro_ptro_601
Pongo abelii	retro_pabe_684

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Parental genes homology:

Parental genes homology involve 7 parental genes, and 8 retrocopies.

Species	Parental gene accession	Retrocopies number
Bos taurus	ENSBTAG00000004658	1 retrocopy	retro_btau_932,
Callithrix jacchus	ENSCJAG00000013627	1 retrocopy	retro_cjac_936,
Dipodomys ordii	ENSDORG00000015156	1 retrocopy	retro_dord_559,
Gorilla gorilla	ENSGGOG00000009609	1 retrocopy	retro_ggor_705 ,
Ochotona princeps	ENSOPRG00000009103	2 retrocopies	retro_opri_358, retro_opri_841,
Pongo abelii	ENSPPYG00000018066	1 retrocopy	retro_pabe_684,
Pan troglodytes	ENSPTRG00000028383	1 retrocopy	retro_ptro_601,