RetrogeneDB ID:

retro_hsap_4907

Retrocopy
location
Organism:Human (Homo sapiens)
Coordinates:X:135377851..135378870(-)
Located in intron of:None
Retrocopy
information
Ensembl ID:ENSG00000230079
Aliases:None
Status:KNOWN_PSEUDOGENE
Parental gene
information
Parental gene summary:
Parental gene symbol:STK24
Ensembl ID:ENSG00000102572
Aliases:STK24, HEL-S-95, MST3, MST3B, STE20, STK3
Description:serine/threonine kinase 24 [Source:HGNC Symbol;Acc:11403]


Retrocopy-Parental alignment summary:






>retro_hsap_4907
ATGAAGGATACAAAAGTATGGATAATAATGGAATATCCTGATGGAGGCTCCACACTAGATCTGTTAGAACCTGGCCCGTT
AGATGAAACCCAGATCATTACTATATTAAGAGAAATACTGAAAGGACTTGATTACCTCCATTCGGAGAAGAAAATCCATA
GAGGTGTTAAAGCGGCCAACGTCCTGCTGTCTGAGCACTGCGAGGTGAAGCTGGTGGACTTTGGCATGGCTGGCCAACTG
GCAGACACCCAGACCAAAAGGAACACTTTTGTGGGCACCCCGTTCTGGATAGCACCCGAGGTCATCAAACAGTCGGCCTA
TGACTCAAAGGCAGACATCTGGTCCCTGGGCATAACAACTATTTAACTTGCAAAAGGAGAACCACCTTATTCCAAGCTGC
ATCCCATGAAAGTTTTATTCCTTATTCCAAAGAACAACCCACCAACGTTGGAAGAAAACTACAGTAAACCCCTCAAGGAG
TTTGTGGAGGCCTGTTTGAATAAAGAGCTGAGCTTTAGACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTACG
CGATACAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTATAAGAGATGGAGGGCAAAGCAGAGCCAAGAAGACT
CGAGCTCCGAGGATTCCAACTCGGAAACAGATGGCCAAGACTCAGTGGGGCAGCGATTCTGGGGACTGGATCTTCACAAT
CCAAGAAAAAGATCCCAAGAATCTTGAGAATGGAGCTCTTCAGCCATCGGATGTAGACAAATAAGATGAAAGACATCCCA
AAGAGGCCTTTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGCTTGCAGAGTTGAAGAGCCAGGCGTGCGGAGGGAA
CTTGGGGTCCACTGAAGAGCTTCGAGGGGCCATCTACCTGGTGGAGGAGGTGTGCCCCCGCATCTCCGACACCATAGTGG
GCCAGCTCCTGCAGCAGCTCCACAGATATTCTCTAAGTGGTGGAGAAACTTCATCCCAC

ORF - retro_hsap_4907 Open Reading Frame is not conserved.
Retrocopy - Parental Gene Alignment summary:
Percent Identity: 83.43 %
Parental protein coverage: 79.35 %
Number of stop codons detected: 2
Number of frameshifts detected 2


Retrocopy - Parental Gene Alignment:

ParentalLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVK
.KDTK.WIIMEY..GGS.LDLLEPGPLDETQI.TILREILKGLDYLHSEKKIHR..KAANVLLSEH.EVK
RetrocopyMKDTKVWIIMEYPDGGSTLDLLEPGPLDETQIITILREILKGLDYLHSEKKIHRGVKAANVLLSEHCEVK
ParentalLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLF
L.DFG.AGQL.DTQ.KRNTFVGTPFW.APEVIKQSAYDSKADIWSLGIT.I.LA.GEPP.S.LHPMKVLF
RetrocopyLVDFGMAGQLADTQTKRNTFVGTPFWIAPEVIKQSAYDSKADIWSLGITTI*LAKGEPPYSKLHPMKVLF
ParentalLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQS
LIPKNNPPTLE.NYSKPLKEFVEACLNKE.SFRPTAKELLKHKFILR..KKTSYLTELIDRYKRW.A.QS
RetrocopyLIPKNNPPTLEENYSKPLKEFVEACLNKELSFRPTAKELLKHKFILRDTKKTSYLTELIDRYKRWRAKQS
ParentalHDDSSSEDSDAETDGQAS-GGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPF-SQCLSTI
..DSSSEDS..ETDGQ.S..GSDSGDWIFTI.EKDPKNLENGALQPSD.D.......PK..F.SQCLSTI
RetrocopyQEDSSSEDSNSETDGQDS>WGSDSGDWIFTIQEKDPKNLENGALQPSDVDK*DERH-PKEAF>SQCLSTI
ParentalISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGGTSSH
ISPL.AEL..KSQACGGNLGS.EELRGAIYL.EE.CP.ISDT.V.QL.Q.L.RYSLSGG.TSSH
RetrocopyISPLLAEL--KSQACGGNLGSTEELRGAIYLVEEVCPRISDTIVGQLLQQLHRYSLSGGETSSH

Legend:
*Stop codon
>Forward frameshift by one nucleotide
<Reverse frameshift by one nucleotide






RNA-Seq - click to see more details

(Hint: click retrocopy or parental gene accession number on the plot's legend, to show / hide expression level values)

Expression validation based on RNA-Seq data:
Library Retrocopy expression Parental gene expression
bodymap2_adipose 0 .30 RPM 131 .75 RPM
bodymap2_adrenal 0 .00 RPM 101 .06 RPM
bodymap2_brain 0 .00 RPM 82 .72 RPM
bodymap2_breast 0 .04 RPM 91 .79 RPM
bodymap2_colon 0 .02 RPM 174 .06 RPM
bodymap2_heart 0 .02 RPM 82 .48 RPM
bodymap2_kidney 0 .00 RPM 126 .87 RPM
bodymap2_liver 0 .00 RPM 23 .64 RPM
bodymap2_lung 0 .00 RPM 145 .27 RPM
bodymap2_lymph_node 0 .00 RPM 138 .59 RPM
bodymap2_ovary 0 .17 RPM 119 .48 RPM
bodymap2_prostate 0 .02 RPM 218 .32 RPM
bodymap2_skeletal_muscle 0 .00 RPM 73 .77 RPM
bodymap2_testis 0 .15 RPM 168 .85 RPM
bodymap2_thyroid 0 .21 RPM 124 .32 RPM
bodymap2_white_blood_cells 0 .00 RPM 216 .21 RPM

ChIP-Seq - click to see more details

RNA Polymerase II actvity near the 5' end of retro_hsap_4907 was not detected

EST - click to see more details

No EST(s) were mapped for retro_hsap_4907 retrocopy.

TSS - click to see more details

No TSS is located nearby retro_hsap_4907 retrocopy 5' end.

Lab - click to see more details

retro_hsap_4907 was not experimentally validated.

Retrocopy orthology:
Retrocopy retro_hsap_4907 has 3 orthologous retrocopies within eutheria group .

Species RetrogeneDB ID
Gorilla gorilla retro_ggor_3065
Macaca mulatta retro_mmul_2640
Callithrix jacchus retro_cjac_4221
Parental genes homology:
Parental genes homology involve 6 parental genes, and 6 retrocopies.

Species Parental gene accession Retrocopies number
Callithrix jacchus ENSCJAG000000045081 retrocopy
retro_cjac_4221,
Cavia porcellus ENSCPOG000000066101 retrocopy
retro_cpor_490,
Homo sapiens ENSG00000102572 1 retrocopy
retro_hsap_4907 ,
Gorilla gorilla ENSGGOG000000019831 retrocopy
retro_ggor_3065,
Macaca mulatta ENSMMUG000000091731 retrocopy
retro_mmul_2640,
Nomascus leucogenys ENSNLEG000000078541 retrocopy
retro_nleu_2352,

Expression level across human populations :
image/svg+xml GBR_HG00142 GBR_HG00099 GBR_HG00114 GBR_HG00143 GBR_HG00131 GBR_HG00137 GBR_HG00133 GBR_HG00119 GBR_HG00111 GBR_HG00134 FIN_HG00378 FIN_HG00338 FIN_HG00349 FIN_HG00375 FIN_HG00315 FIN_HG00277 FIN_HG00328 FIN_HG00321 FIN_HG00377 FIN_HG00183 TSI_NA20756 TSI_NA20538 TSI_NA20798 TSI_NA20532 TSI_NA20765 TSI_NA20518 TSI_NA20513 TSI_NA20512 TSI_NA20771 TSI_NA20786 YRI_NA19114 YRI_NA19099 YRI_NA18870 YRI_NA18907 YRI_NA19223 YRI_NA19214 YRI_NA18916 YRI_NA19093 YRI_NA19118 YRI_NA19213 Toscaniin Italia: Finnish inFinland: British in England and Scotland: Utah Residents (CEPH) with Northernand Western European Ancestry: Yoruba in Ibadan, Nigeria: CEU_NA12760 CEU_NA12827 CEU_NA12872 CEU_NA12751 CEU_NA12873 CEU_NA12400 CEU_NA11930 CEU_NA12004 CEU_NA11831 CEU_NA11843 No expression ( = 0 RPM ) > 0 RPM = 0.07 RPM Legend:


Library Retrogene expression
CEU_NA11831 0 .00 RPM
CEU_NA11843 0 .00 RPM
CEU_NA11930 0 .03 RPM
CEU_NA12004 0 .00 RPM
CEU_NA12400 0 .00 RPM
CEU_NA12751 0 .00 RPM
CEU_NA12760 0 .00 RPM
CEU_NA12827 0 .00 RPM
CEU_NA12872 0 .00 RPM
CEU_NA12873 0 .00 RPM
FIN_HG00183 0 .00 RPM
FIN_HG00277 0 .00 RPM
FIN_HG00315 0 .00 RPM
FIN_HG00321 0 .00 RPM
FIN_HG00328 0 .00 RPM
FIN_HG00338 0 .00 RPM
FIN_HG00349 0 .00 RPM
FIN_HG00375 0 .00 RPM
FIN_HG00377 0 .00 RPM
FIN_HG00378 0 .00 RPM
GBR_HG00099 0 .00 RPM
GBR_HG00111 0 .00 RPM
GBR_HG00114 0 .00 RPM
GBR_HG00119 0 .00 RPM
GBR_HG00131 0 .00 RPM
GBR_HG00133 0 .00 RPM
GBR_HG00134 0 .00 RPM
GBR_HG00137 0 .00 RPM
GBR_HG00142 0 .00 RPM
GBR_HG00143 0 .00 RPM
TSI_NA20512 0 .00 RPM
TSI_NA20513 0 .00 RPM
TSI_NA20518 0 .00 RPM
TSI_NA20532 0 .03 RPM
TSI_NA20538 0 .05 RPM
TSI_NA20756 0 .00 RPM
TSI_NA20765 0 .00 RPM
TSI_NA20771 0 .00 RPM
TSI_NA20786 0 .00 RPM
TSI_NA20798 0 .00 RPM
YRI_NA18870 0 .07 RPM
YRI_NA18907 0 .00 RPM
YRI_NA18916 0 .00 RPM
YRI_NA19093 0 .00 RPM
YRI_NA19099 0 .03 RPM
YRI_NA19114 0 .00 RPM
YRI_NA19118 0 .00 RPM
YRI_NA19213 0 .00 RPM
YRI_NA19214 0 .02 RPM
YRI_NA19223 0 .00 RPM

Indel association:

No indels were associated with its genomic coordinates. Based on Kabza et al. 2015 (PubMed).



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