RetrogeneDB ID: retro_chof_300

Retrocopy location

• Organism: Sloth (Choloepus hoffmanni)
• Coordinates: GeneScaffold_6836:34407..35283(-)
• Located in intron of: ENSCHOG00000011909

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: PLEKHA3
• Ensembl ID: ENSCHOG00000013997
• Aliases: None
• Description: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 [Source:HGNC Symbol;Acc:14338]

Sequence

>retro_chof_300
CAGTGGACCAAGTATCTCACAGGTTGGCAGCCTCGTTGGTTTGTTTTAGATAATGGAATCCTGTCCTACTATGATTAACA
GGATGATATTTGCAAAGGGAGCAAAGAAGTATAAAGATGGCAGTTTGTGAAATTAAAGTCCATTCAGCAGACAACACAAG
AATGGAATTAATCAGTCCAGGAGAGCAGCATTTCTACATGAAAGCAGTGAATGCGGCTGAAAGAGGTGGCTGGTTGCTCT
GGGGAGCTCCAAAGCCTGTTTGACTGATACTAGGACTAAAAAAGAAAAAGAAATAAGTGAAACCAGTGAATCTCTGAAAA
CCAAAATGTCTGAACTCTGCCTCTACTGTGACCTCCTAATGCAAGAAGTTCATACAATCCAAGAGTTTGTTCACCATGAT
GAGAGACATTCATTTTCCAGCATGGAGAACATGAATGAAGCCTCCTCTTTGCTTAGTGCCACCTGTAATACCTTCATCAC
AACACTTGAGGAATGTGTGAGATAGCGAATGCCAAGTTTAAACCTGAGATGTTTCAACTGCCCATCCAGATCCCTTAGTT
TCTCCTGTGTCACCTTCTCCTGTTCAAATGATGAAGCGTTCTGTCAGCCACCCTGGCTCTTGCAGTTCAGAGAGGAGTAC
CCACTCTATAAAAGAGCTAGGATCTACACATCACCGATTATGCCAGCGACGCCGAAGAACCTACTCTGATACAGACTCTT
GTAATGATATTCCACTTGAAGACCCAGATAGACCTGTTCACTGTTCAAGAAATACACTTAATGGAGATTTGGCATCTGTT
AACATTCCTGAAGAAAGCAGATTAATAGCTAAAAAAAAAATCTGATTCAGAAGATCCTCTTTCATCCTTCTCTTCC

Alignment

ORF - retro_chof_300 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 82.27 %
• Parental protein coverage: 98.0 %
• Number of stop codons detected: 1
• Number of frameshifts detected: 5

Retrocopy - Parental Gene Alignment:

Parental  KWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKG-SIKMAVCEIKVHSADNTRMELIIPGEQHFYMKA
          .WT.YLTGWQPRWFVLDNGILSYYD.QDD.CKGSK..SIKMAVCEIKVHSADNTRMELI.PGEQHFYMKA
Retrocopy QWTKYLTGWQPRWFVLDNGILSYYD*QDDICKGSKE<SIKMAVCEIKVHSADNTRMELISPGEQHFYMKA

Parental  VNAAERQRWLVALGSSK-ACLTDTRTKKEKEISETSESLKTKMSELRLYCDLLMQQVHTIQEFVHHDERH
          VNAAER..WL...G..K.ACLTDTRT.................SEL.LYCDLLMQ.VHTIQEFVHHDERH
Retrocopy VNAAERGGWLL-WGAPK<ACLTDTRTXXXXXXXXXXXXXXXXXSELCLYCDLLMQEVHTIQEFVHHDERH

Parental  SSSSVENMNEASSLLSATCNTFITTLEECVK-IANAKFKPEMFQL-SHPDPLVSPVSPSPVQMMKRSVSH
          S.SS.ENMNEASSLLSATCNTFITTLEECV..IANAKFKPEMFQL..HPDPLVSPVSPSPVQMMKRSVSH
Retrocopy SFSSMENMNEASSLLSATCNTFITTLEECVR<IANAKFKPEMFQL<AHPDPLVSPVSPSPVQMMKRSVSH

Parental  PGSCSSERGSHSIKEPGSTHHRLSQRRRRTYSDTDSCNDIPLEDPDRPVHCSRNTLNGDLTSVNIPEESR
          PGSCSSER..HSIKE.GSTHHRL.QRRRRTYSDTDSCNDIPLEDPDRPVHCSRNTLNGDL.SVNIPEESR
Retrocopy PGSCSSERSTHSIKELGSTHHRLCQRRRRTYSDTDSCNDIPLEDPDRPVHCSRNTLNGDLASVNIPEESR

Parental  LMAKKKF-DLEDPLPSFSS
          L.A.....D.EDPL.SFSS
Retrocopy LIAXXXX>DSEDPLSSFSS

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Choloepus hoffmanni was not studied using RNA-Seq expression data.

ChIP-Seq

Choloepus hoffmanni was not studied using ChIP-Seq data.

EST

Choloepus hoffmanni was not studied using EST data.

TSS

Choloepus hoffmanni was not studied using FANTOM5 data.

Lab

retro_chof_300 was not experimentally validated.

Homology

Retrocopy orthology:

Choloepus hoffmanni does not belong to any of the species groups (eutheria, teleost or neognath), studied for retrocopy-based homology. For more information about studied groups, please go to help section.

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Parental genes homology:

Parental genes homology involve 14 parental genes, and 25 retrocopies.

Species	Parental gene accession	Retrocopies number
Choloepus hoffmanni	ENSCHOG00000013997	5 retrocopies	retro_chof_1366, retro_chof_1559, retro_chof_300 , retro_chof_736, retro_chof_985,
Cavia porcellus	ENSCPOG00000003906	1 retrocopy	retro_cpor_487,
Dasypus novemcinctus	ENSDNOG00000002717	1 retrocopy	retro_dnov_107,
Erinaceus europaeus	ENSEEUG00000004169	1 retrocopy	retro_eeur_416,
Homo sapiens	ENSG00000116095	1 retrocopy	retro_hsap_2060,
Macropus eugenii	ENSMEUG00000015317	2 retrocopies	retro_meug_1530, retro_meug_341,
Microcebus murinus	ENSMICG00000009898	1 retrocopy	retro_mmur_617,
Myotis lucifugus	ENSMLUG00000005823	2 retrocopies	retro_mluc_1031, retro_mluc_689,
Oryctolagus cuniculus	ENSOCUG00000005495	1 retrocopy	retro_ocun_1273,
Otolemur garnettii	ENSOGAG00000002724	1 retrocopy	retro_ogar_1845,
Tupaia belangeri	ENSTBEG00000007550	3 retrocopies	retro_tbel_4186, retro_tbel_4555, retro_tbel_4723,
Tarsius syrichta	ENSTSYG00000005341	1 retrocopy	retro_tsyr_869,
Tursiops truncatus	ENSTTRG00000009729	2 retrocopies	retro_ttru_1296, retro_ttru_1497,
Vicugna pacos	ENSVPAG00000003490	3 retrocopies	retro_vpac_487, retro_vpac_578, retro_vpac_619,