RetrogeneDB ID: retro_ggor_115

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 7:127266482..127267682(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSGGOG00000027737
• Aliases: None
• Status: KNOWN_PROTEIN_CODING

Parental gene information

• Parental gene symbol: MAP2K2
• Ensembl ID: ENSGGOG00000008832
• Aliases: None
• Description: None

Sequence

>retro_ggor_115
ATGCTGGCCCGGAGGAAGCCGATGCTGCCGGCGCTCACCATCAACCCTACCATCGCCGAGGGCCCGTCCCCAACCAGCGA
GGGCGCCTCCGAGGCAAACCTGGTGGACCTGCAGAAGAAGCTGGAGGAGCTGGAACTTGACGAGCAGCAGAAGCGGCTGG
AAGCCTTTCTCACCCAGAAAGCCAAGGTCGGCGAACTCAAAGACGATGACTTCGAAAGGATCTCAGAGCTGGGCGCGGGC
AACGGCAGGGTGGTCACCAAAGTCCAGCACAGACCCTCGGGCCTCATCATGGCCAGGAAGCTGATCCACCTTGAGATCAA
GCCGGCCATCCGGAACCAGATCATCCGCGAGCAACAGGTCCTGCACGAGTGCAACTCACCGTACATCGTGGGCTTCTACG
GGGCCTTCTACTGTGACGGGGAGATCAGCATCTGCATGGAGCACATGGATGGCGGCTCCCTGGACCAGGGGCTGAAAGAG
GCCAAGAGGATTCCCGAGGACATCCTGGGGAAAGTCAGCATTGCGGTTCTCCGGGGCTTGGCGTACCTCCGAGAGAAGCA
CCAGATCATGCACCGAAATGTGAAGCCCTCCAACATCCTCGTGAACTCTAGAGGGGAGATCAAGCTGTGTGACTTCGGGG
TGAGCGGCCAGCTCATCGACTCCATGGCCAACTCCTTTGTGGGCACGCGCTCCTACATGGCTCCGGAGCGGTTGCAGGGC
ACACATTACTCGGTGCAGTCGGTCATCTGGAGCATGGGCCTGTCCCTGGTGGAGCTGGCCATCGAAAGCTACCCCATCCC
CCCGCCCGACGCCAAGGAGCTGGAGGCCATCTTTGGCCGGCCCGTGGTCGACAGGGAAGAAGGAGAGCCTCACAGCATCT
CCTCTTGGCCAGGGCCCCCCGGGCGCCCCATCAGCGGTCACGGGATGGACAGCCGGCCCGCCATGGCCATCTTCGAACTG
CTGAACTATATTGCGAAAGAGCCGCCTCCTAAGCTGCCCAACGGTCTGTTCACCCCCGACTTCCAGGAGTTTGTCAATAA
ATGCCTCATCAAAAACCCAACGGAGCGGGCGGACCTAAAGATGTTCACAAACCACGCCTTCATCAAGCGGTCCGAGGTGA
AAGAAGCGGATTTTGCCTGCCAGTTGTGTAAAACCCTGGGGCTGAACCAGCCCGGCACACCCACGCGCACCGCCGTGTAA

Alignment

ORF - retro_ggor_115 Open Reading Frame is conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 92.75 %
• Parental protein coverage: 100. %
• Number of stop codons detected: 0
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDD
          MLARRKP.LPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQK.RLEAFLTQKAKVGELKDD
Retrocopy MLARRKPMLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQK-RLEAFLTQKAKVGELKDD

Parental  DFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSD
          DFERISELGAGNG.VVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRE.QVLHECNSPYIVGFYGAFY.D
Retrocopy DFERISELGAGNGRVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIREQQVLHECNSPYIVGFYGAFYCD

Parental  GEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKL
          GEISICMEHMDGGSLDQ.LKEAKRIPE.ILGKVSIAVLRGLAYLREKHQIMHR.VKPSNILVNSRGEIKL
Retrocopy GEISICMEHMDGGSLDQGLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRNVKPSNILVNSRGEIKL

Parental  CDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFG
          CDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQS.IWSMGLSLVELA...YPIPPPDAKELEAIFG
Retrocopy CDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSVIWSMGLSLVELAIESYPIPPPDAKELEAIFG

Parental  RPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCL
          RPVVD.EEGEPHSIS..P.PPGRP.SGHGMDSRPAMAIFELL.YI..EPPPKLPNG.FTPDFQEFVNKCL
Retrocopy RPVVDREEGEPHSISSWPGPPGRPISGHGMDSRPAMAIFELLNYIAKEPPPKLPNGLFTPDFQEFVNKCL

Parental  IKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
          IKNP.ERADLKM.TNH.FIKRSEV.E.DFA..LCKTL.LNQPGTPTRTAV
Retrocopy IKNPTERADLKMFTNHAFIKRSEVKEADFACQLCKTLGLNQPGTPTRTAV

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.24 RPM	77.78 RPM
SRP007412_cerebellum	0.12 RPM	68.55 RPM
SRP007412_heart	0.34 RPM	49.31 RPM
SRP007412_kidney	0.16 RPM	35.90 RPM
SRP007412_liver	0.58 RPM	37.27 RPM
SRP007412_testis	2.59 RPM	53.87 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_115 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_115 has 2 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_3785
Pan troglodytes	retro_ptro_2566

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Parental genes homology:

Parental genes homology involve 8 parental genes, and 9 retrocopies.

Species	Parental gene accession	Retrocopies number
Callithrix jacchus	ENSCJAG00000015084	1 retrocopy	retro_cjac_4061,
Equus caballus	ENSECAG00000009157	2 retrocopies	retro_ecab_668, retro_ecab_968,
Homo sapiens	ENSG00000126934	1 retrocopy	retro_hsap_3785,
Gorilla gorilla	ENSGGOG00000003687	1 retrocopy	retro_ggor_2650,
Gorilla gorilla	ENSGGOG00000008832	1 retrocopy	retro_ggor_115 ,
Nomascus leucogenys	ENSNLEG00000003013	1 retrocopy	retro_nleu_1121,
Otolemur garnettii	ENSOGAG00000001658	1 retrocopy	retro_ogar_576,
Pan troglodytes	ENSPTRG00000010294	1 retrocopy	retro_ptro_2566,