RetrogeneDB ID: retro_ggor_2075

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 4:163947152..163947868(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: WDR45
• Ensembl ID: ENSGGOG00000000589
• Aliases: None
• Description: None

Sequence

>retro_ggor_2075
CGCATCTATGTGTACTCCTTCCCAGACAATCCTCGAAAGCTGTTTGAGTTTGATACCCGGGTCAACCCCAACGGGCTCTG
TGACCTCTGCCCCAGCCTGGAGAAGCAACTGTTAGTGTTCCCGGGACACAAGTGTGGGAGTCTGCAACTTGTGGACCTGG
CGAGCACAAAGCCTGGCACCATGTCTGCTCCGTTCACCATCAATGCACATCAGAGTGACATAATCTGTGTGTCTCTAAAC
TAGCCAGGCACTGTAGTGGCCTCAGCCTCCCAGAATGGTACCCTTATTCGCCTCTTTGACACACAATTCAAGGAGAAACT
GGTGGAGCTGCACCGAGGCACTGACCCTGCCACCCTCTACTGCATTAACTTCAGCCACGACTCCTCCTTCCTCTGCGCTT
CCAGCGATAAGGGCACCATCCATATCTTTGCTCTCAAGGATACCCACCTTAACCGCTGCTCCGCACTGGCTCCGTGGACA
AGGTGGGGCCTATGATTGGGCAGTACGTGGACTCTCAGTGGAGCCTGGCGAGGTTCACTGTGCCTGCTGAGTCAGCTTGC
ATCTGCTCCTTCGGTCGCAATACTTCCAAGAAATTCAACTCTGTCATTGCCATCTGTGTAGATGGGACCTTCCACAAATA
TGTCTTCACTCCTGATGGAAGCTGCAACAGAGAGGCTTTTGATGTGTACTTTGACATCTGTGATGATGATGACTTT

Alignment

ORF - retro_ggor_2075 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 84.17 %
• Parental protein coverage: 64.15 %
• Number of stop codons detected: 1
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  KLFEFDTRDNP-KAAHPTPHLHTLGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTINAH
          ........DNP.K...........GLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGT.SAPFTINAH
Retrocopy RIYVYSFPDNPRKLFEFDTRVNPNGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTMSAPFTINAH

Parental  QSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTV
          QSDI.CVSLN.PGTVVASASQ.GTLIRLFDTQ.KEKLVEL.RGTDPATLYCINFSHDSSFLCASSDKGT.
Retrocopy QSDIICVSLN*PGTVVASASQNGTLIRLFDTQFKEKLVELHRGTDPATLYCINFSHDSSFLCASSDKGTI

Parental  HIFALKDTRLNRRSALA-RVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDG
          HIFALKDT.LNR.SALA..V.KVGPMIGQYVDSQWSLA.FTVPAESACIC.FGRNTSK..NSVIAICVDG
Retrocopy HIFALKDTHLNRCSALA<SVDKVGPMIGQYVDSQWSLARFTVPAESACICSFGRNTSKKFNSVIAICVDG

Parental  TFHKYVFTPDGNCNREAFDVYLDICDDDDF
          TFHKYVFTPDG.CNREAFDVY.DICDDDDF
Retrocopy TFHKYVFTPDGSCNREAFDVYFDICDDDDF

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.38 RPM	35.92 RPM
SRP007412_cerebellum	0.00 RPM	29.59 RPM
SRP007412_heart	0.13 RPM	28.92 RPM
SRP007412_kidney	0.16 RPM	40.81 RPM
SRP007412_liver	0.13 RPM	32.02 RPM
SRP007412_testis	0.10 RPM	12.74 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_2075 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_2075 has 1 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Macaca mulatta	retro_mmul_1916

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Parental genes homology:

Parental genes homology involve 5 parental genes, and 8 retrocopies.

Species	Parental gene accession	Retrocopies number
Echinops telfairi	ENSETEG00000002062	3 retrocopies	retro_etel_1291, retro_etel_688, retro_etel_712,
Gorilla gorilla	ENSGGOG00000000589	1 retrocopy	retro_ggor_2075 ,
Gorilla gorilla	ENSGGOG00000006132	2 retrocopies	retro_ggor_1376, retro_ggor_2173,
Macaca mulatta	ENSMMUG00000010620	1 retrocopy	retro_mmul_1916,
Pongo abelii	ENSPPYG00000020333	1 retrocopy	retro_pabe_2481,