RetrogeneDB ID: retro_ggor_267

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 1:94558489..94559251(+)
• Located in intron of: ENSGGOG00000013288

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: PRKAR1A
• Ensembl ID: ENSGGOG00000016507
• Aliases: None
• Description: None

Sequence

>retro_ggor_267
TCTTTAGCCAAAGCCATTGAAAAGAATGTGCTGATTTCACATCTTGATGATAATGAAAGAAGTGATATATTTGATGCCAT
GTTTCCAGTCTCCTTTATCACTGGAGAGACAGTGATTCTGCAAGGTGATGAAGGGGATAACTTCTAGGTGATTGAGCAAG
GAGAGAGGGATGTCTGTGTCAATGATGAATGAGCAACCAGTGTTGAAGAAGGAGGGAGCTTTGGAGGATTTGTTTTGATT
TATGGAACACCTAGAGTAGCCACTGTCAAAGCAAAGGCAAATATGAAAGGGTAGTGTATCAACCGAGGCAGCTGTAGAAG
AATCCATATGGGAAGCACACTGAGAATGTGGAAGATGTATGAGGAATTCCTTAGTAAAGTGTCTATTTTAGAGTCTCTGG
ATAAGTGAGAGCATCTTACGGTAGCTGATACATGGGAACCAGTCAAGTTTGAAGATTGGCAGAAGATTGTGGTGCAGGGA
GAACCAGGGGATGAGTTCCTTATTATTCTAGAGGGGCCAGCTGCTATGCTGCAACGTTGGTCAGAAAATGAAGAGTTTGT
TGAAGTGGGAAGATTGGGGCCTTCTGATTATTTTGGTGAATTTGCATTCCTGATGAATCACCCTCCTGATGCCACAGTGG
TTGTACATGGCCCCTTGAAGTACATTAAGCTGGACCAGCCTAGATTTGAAAGTGCTCTTGGCCCAGGCTCAGACCTCCTC
AAACGAAACATCCAGCAGTACAACAGTTTTGTGTCACTGTCT

Alignment

ORF - retro_ggor_267 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 79.92 %
• Parental protein coverage: 66.67 %
• Number of stop codons detected: 4
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  ALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGE
          .LAKAIEKNVL.SHLDDNERSDIFDAMF.VSFI.GETVI.QGDEGDNF.VI.QGE.DV.VN.E.ATSV.E
Retrocopy SLAKAIEKNVLISHLDDNERSDIFDAMFPVSFITGETVILQGDEGDNF*VIEQGERDVCVNDE*ATSVEE

Parental  GGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLT
          GGSFG...LIYGTPR.ATVKAK.N.K...I.R.S.RRI.MGSTLR..KMYEEFLSKVSILESLDK.E.LT
Retrocopy GGSFGGFVLIYGTPRVATVKAKANMKG*CINRGSCRRIHMGSTLRMWKMYEEFLSKVSILESLDK*EHLT

Parental  VADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRA
          VAD..EPV.FED.QKIVVQGEPGDEF.IILEG.AA.LQR.SENEEFVEVGRLGPSDYFGE.A.LMN.P..
Retrocopy VADTWEPVKFEDWQKIVVQGEPGDEFLIILEGPAAMLQRWSENEEFVEVGRLGPSDYFGEFAFLMNHPPD

Parental  ATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLS
          ATVV..GPLK..KLD.PRFE..LGP.SD.LKRNIQQYNSFVSLS
Retrocopy ATVVVHGPLKYIKLDQPRFESALGPGSDLLKRNIQQYNSFVSLS

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.19 RPM	413.27 RPM
SRP007412_cerebellum	0.00 RPM	212.36 RPM
SRP007412_heart	0.06 RPM	131.80 RPM
SRP007412_kidney	0.04 RPM	234.70 RPM
SRP007412_liver	0.08 RPM	144.55 RPM
SRP007412_testis	0.10 RPM	430.04 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_267 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_267 has 1 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Pan troglodytes	retro_ptro_172

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Parental genes homology:

Parental genes homology involve 6 parental genes, and 7 retrocopies.

Species	Parental gene accession	Retrocopies number
Homo sapiens	ENSG00000108946	1 retrocopy	retro_hsap_186,
Gorilla gorilla	ENSGGOG00000016507	1 retrocopy	retro_ggor_267 ,
Macaca mulatta	ENSMMUG00000002194	2 retrocopies	retro_mmul_2498, retro_mmul_393,
Nomascus leucogenys	ENSNLEG00000001982	1 retrocopy	retro_nleu_996,
Pan troglodytes	ENSPTRG00000009579	1 retrocopy	retro_ptro_172,
Ictidomys tridecemlineatus	ENSSTOG00000012903	1 retrocopy	retro_itri_104,