RetrogeneDB ID: retro_ggor_2985

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: X:25499945..25500793(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSGGOG00000023724
• Aliases: None
• Status: KNOWN_PSEUDOGENE

Parental gene information

• Parental gene symbol: METTL1
• Ensembl ID: ENSGGOG00000001411
• Aliases: None
• Description: None

Sequence

>retro_ggor_2985
GTAGAGAAACCCGGGACCGGGATCATGGCAGCTGAGACTTGGAACGTGGCCGAAGCAGAGGCCCCGCAGCCCCAGAAGCG
CTACTACTGGCAATGTGCTCAATCCAACCCCATGGCAGACCACACGCTGCGCTATCCTGTGAAGCCAGAGGAGATGGACT
GGTCTCAGCTATACCCAGAGTTCTTCGCTCCACTCACTCAAAATCAGAGCCACGATGACCCAAAGGATAAGAAAGAAAAG
AGAGCTCAGGCCCAAGCGGAGTCTGCAGACATAGGCTGTGGCTACGGTGGCCTGTTAGTGGAACTATCACCACTGTTCCC
AGACACACTGATTCTGGGTCTGGAGATCCAGGTGAAGGTCTCAGACTGTGTACAAGACCGGATTTGGGCCCTACGTGCAG
CTCCTGGAGGTGGCTTCCAGAACATTGCCTGTCTCTGTAGCAATGCCATGAAGCACCTTCCTAACTTCTACAAGGCCAGC
TGACAAAGATGTTCTTCCTCTTCCCCGACCCACATTTCAAGCAGATAAAGCACAAGCGGCAAATCATCAGTCCCACTCTG
CTAGCAAAATATGCCTACGTGCTGAGAGTTGGGGGGCTGGTATATACCATAACCCATGTGCTGGAGCTACACGACTGGAT
GTGCACTCATTTTGAAGAGCACCCGCTGTTTGAGCGTATGCCTCTGGAGGACCTGAGTGAAGACCCCATTGTGGGACATC
TAGGTACCTCAACTGAGGAGGGGAAGAAAGTTCTACGTAATGAAGGGAAGAATTTCGCAGCCATCTTTCGAAGAATACAA
GATCCTGTCCTCCAGGCAGTGACCCCCCAAACCAGCCTGCCTGGTCAC

Alignment

ORF - retro_ggor_2985 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 91.23 %
• Parental protein coverage: 94.35 %
• Number of stop codons detected: 0
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  VEKPRTGIMAAETWNVAGAEAPPPQKRYYRQRAHSNPMADHTLRYPVKPEEMDWSELYPEFFAPLTQNQS
          VEKP.TGIMAAETWNVA.AEAP.PQKRYY.Q.A.SNPMADHTLRYPVKPEEMDWS.LYPEFFAPLTQNQS
Retrocopy VEKPGTGIMAAETWNVAEAEAPQPQKRYYWQCAQSNPMADHTLRYPVKPEEMDWSQLYPEFFAPLTQNQS

Parental  HDDPKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRIRALRAAPAGGFQ
          HDDPKDKKEKRAQAQ.E.ADIGCGYGGLLVELSPLFPDTLILGLEI.VKVSD.VQDRI.ALRAAP.GGFQ
Retrocopy HDDPKDKKEKRAQAQAESADIGCGYGGLLVELSPLFPDTLILGLEIQVKVSDCVQDRIWALRAAPGGGFQ

Parental  NIACLRSNAMKHLPNFFYK-GQLTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVL
          NIACL.SNAMKHLPN.FYK.GQLTKMFFLFPDPHFK..KHK..IISPTLLA.YAYVLRVGGLVYTIT.VL
Retrocopy NIACLCSNAMKHLPN-FYK<GQLTKMFFLFPDPHFKQIKHKRQIISPTLLAKYAYVLRVGGLVYTITHVL

Parental  ELHDWMCTHFEEHPLFERVPLEDLSEDPIVGHLGTSTEEGKKVLRNGGKNFPAIFRRIQDPVLQAVTPQT
          ELHDWMCTHFEEHPLFER.PLEDLSEDPIVGHLGTSTEEGKKVLRN.GKNF.AIFRRIQDPVLQAVTPQT
Retrocopy ELHDWMCTHFEEHPLFERMPLEDLSEDPIVGHLGTSTEEGKKVLRNEGKNFAAIFRRIQDPVLQAVTPQT

Parental  SLPGH
          SLPGH
Retrocopy SLPGH

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	2.64 RPM
SRP007412_cerebellum	0.00 RPM	1.73 RPM
SRP007412_heart	0.00 RPM	1.25 RPM
SRP007412_kidney	0.00 RPM	11.65 RPM
SRP007412_liver	0.00 RPM	4.80 RPM
SRP007412_testis	0.00 RPM	4.45 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_2985 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_2985 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_4796
Pongo abelii	retro_pabe_3730
Macaca mulatta	retro_mmul_2556

---

Parental genes homology:

Parental genes homology involve 8 parental genes, and 8 retrocopies.

Species	Parental gene accession	Retrocopies number
Callithrix jacchus	ENSCJAG00000006615	1 retrocopy	retro_cjac_2888,
Homo sapiens	ENSG00000037897	1 retrocopy	retro_hsap_4796,
Gorilla gorilla	ENSGGOG00000001411	1 retrocopy	retro_ggor_2985 ,
Microcebus murinus	ENSMICG00000003803	1 retrocopy	retro_mmur_345,
Macaca mulatta	ENSMMUG00000022148	1 retrocopy	retro_mmul_2556,
Nomascus leucogenys	ENSNLEG00000017183	1 retrocopy	retro_nleu_1110,
Pongo abelii	ENSPPYG00000004706	1 retrocopy	retro_pabe_3730,
Tupaia belangeri	ENSTBEG00000011522	1 retrocopy	retro_tbel_3245,