RetrogeneDB ID:

retro_hsap_2129

Retrocopy
location
Organism:Human (Homo sapiens)
Coordinates:2:101041811..101043123(+)
Located in intron of:None
Retrocopy
information
Ensembl ID:ENSG00000238029
Aliases:None
Status:KNOWN_PSEUDOGENE
Parental gene
information
Parental gene summary:
Parental gene symbol:RALBP1
Ensembl ID:ENSG00000017797
Aliases:RALBP1, RIP1, RLIP1, RLIP76
Description:ralA binding protein 1 [Source:HGNC Symbol;Acc:9841]


Retrocopy-Parental alignment summary:






>retro_hsap_2129
GTGAATTACGTAGAGAAGTATGGCATGAAGTGTGAAGGCATCTACAGAGTATCAGGAATTAAATCAAAGATGGATGAGCT
AAAAGCAGCCTATGACCAGGAGAAGTCTACAAACTTGGAAGAATATGACCCTAACACTGTAGCCAGTTTGCGGAAGCAGT
ATTTGTGAGATCTTCCGGAGAATTTGCTTACCAAAGAGCTTATGCCTAGATTTGAAGAGGCTTATGGGAGGACCACAGAG
ACTGAGAAAGTGCAGGAATTCCAGCGTTTACTCAAAGAACTGCCAGAAGGTAACTATCTTCTGATTTCTTTGTTCGTTGT
GCACATGGACCATGTCATCACAAAGGAACTGGAAGCAAAAATGAATATACAGAACATTTATATAGTGGTCAGCCCAACTG
TGCAGATCAGCAATCTAGTCCTGTATGTGTTCTTCACACATGTGCAAGAACTCTTTGGAAATGTGGTTCTAAAGCAAGTG
ACGAAAACTCGGCGATGGTCTAACGTGGCCACGATGCCCACGCTGCCAGAGACCCAGGCAGGCTTCAAGGAGGAGATCAG
GATACAGGAGTTGCTTTTGAATTGTTTACATCAAGATCTGCAGGGTGGGATAAAGGATTTGTCTGAAGAAGAAAGATTAT
GGGAAGTACAAAGAATTTTGACAGCTCTCAGAAGAAAACTGAGAGAAGCTAAAAGACAGGGGTGTGAAACCAAGATTGCA
CAAGAGATAGCCAGTCTTTCAAAAGAGGCTGTTTCCAAAAAAAAAGATGAATGAAAATGAAGAAGTTATAAATATTCTCC
TTGTTCAGGAGAAAGAGATCCTGACTAAACAGGAGGAGCTCCTGGGCATGGAGCAGTTTCTGCGCCGGCAGATTGCCTCA
GAAAAAGAAGAGATTGAGTGCCTCAGAGCCGAGACTGCGGAAATTCAGAGTCACCAGCAGCAGGGCCTAAGCGAGACTGA
GGAGTACTCCTCCGAGAGCGAGAGTGAGGATGAGGAGGAGCTGCAGATCATTCTGGAAGATTTACAGAGACAGAACGAAG
AGCTGGAAATAAAGAACAACCATTTGAATCAAGCAATTCACGAGGAGAGTGAGGCCGTCATCGAGCCGCGCATGCAGCCC
TGGCTGCTCCAGTTGCAGCCAGACAGGGCCAAGCAGCAGGCGCAGGAGGACGAGGAGCCCGAGTGGCGCGGAGGTGCCAT
CCAGACGCCCAAGAATGGCATCCTCGAGCCAGTAGCAGCTAAATAGCCACCAAAGGCAGGCAAGAAGCCGGCAAAGCCAT
TGCCCAGCAGGCACAGGAAGGAGACGTCCATC

ORF - retro_hsap_2129 Open Reading Frame is not conserved.
Retrocopy - Parental Gene Alignment summary:
Percent Identity: 84.55 %
Parental protein coverage: 67.02 %
Number of stop codons detected: 2
Number of frameshifts detected 1


Retrocopy - Parental Gene Alignment:

ParentalIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYDREESTNLEDYEPNTVASLLKQYLRDLPENLLTKELMPR
..YVEKYGMKCEGIYRVSGIKSK.DELKAAYD.E.STNLE.Y.PNTVASL.KQYL.DLPENLLTKELMPR
RetrocopyVNYVEKYGMKCEGIYRVSGIKSKMDELKAAYDQEKSTNLEEYDPNTVASLRKQYL*DLPENLLTKELMPR
ParentalFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRV
FEEA.GRTTETEKVQEFQRLLKELPE.NYLLIS...VHMDHVI.KELE.KMNIQNI.IV.SPTVQISN.V
RetrocopyFEEAYGRTTETEKVQEFQRLLKELPEGNYLLISLFVVHMDHVITKELEAKMNIQNIYIVVSPTVQISNLV
ParentalLYVFFTHVQELFGNVVLKQVMKPLRWSNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKE
LYVFFTHVQELFGNVVLKQV.K..RWSN.ATMPTLPETQAG.KEEIR.QE.LLNCLH.DLQGGIKDLS.E
RetrocopyLYVFFTHVQELFGNVVLKQVTKTRRWSNVATMPTLPETQAGFKEEIRIQELLLNCLHQDLQGGIKDLSEE
ParentalERLWEVQRILTALKRKLREAKRQECETKIAQEIASLSKEDVS-KEEMNENEEVINILLAQENEILTEQEE
ERLWEVQRILTAL.RKLREAKRQ.CETKIAQEIASLSKE.VS....MNENEEVINILL.QE.EILT.QEE
RetrocopyERLWEVQRILTALRRKLREAKRQGCETKIAQEIASLSKEAVS>XXXMNENEEVINILLVQEKEILTKQEE
ParentalLLAMEQFLRRQIASEKEEIERLRAEIAEIQSRQQHGRSETEEYSSESESESEDEEELQIILEDLQRQNEE
LL.MEQFLRRQIASEKEEIE.LRAE.AEIQS.QQ.G.SETEEYS..SESESEDEEELQIILEDLQRQNEE
RetrocopyLLGMEQFLRRQIASEKEEIECLRAETAEIQSHQQQGLSETEEYS--SESESEDEEELQIILEDLQRQNEE
ParentalLEIKNNHLNQAIHEEREAIIELRVQLRLLQMQRAKAEQQAQEDEEPEWRGGAVQPPRDGVLEPKAAKEQP
LEIKNNHLNQAIHEE.EA.IE.R.Q..LLQ.Q...A.QQAQEDEEPEWRGGA.Q.P..G.LEP.AAK..P
RetrocopyLEIKNNHLNQAIHEESEAVIEPRMQPWLLQLQPDRAKQQAQEDEEPEWRGGAIQTPKNGILEPVAAK*PP
ParentalKAGKEPAKPSPSRDRKETSI
KAGK.PAKP.PSR.RKETSI
RetrocopyKAGKKPAKPLPSRHRKETSI

Legend:
*Stop codon
>Forward frameshift by one nucleotide
<Reverse frameshift by one nucleotide






RNA-Seq - click to see more details

(Hint: click retrocopy or parental gene accession number on the plot's legend, to show / hide expression level values)

Expression validation based on RNA-Seq data:
Library Retrocopy expression Parental gene expression
bodymap2_adipose 0 .00 RPM 113 .34 RPM
bodymap2_adrenal 0 .00 RPM 58 .85 RPM
bodymap2_brain 0 .00 RPM 73 .09 RPM
bodymap2_breast 0 .08 RPM 80 .66 RPM
bodymap2_colon 0 .15 RPM 125 .66 RPM
bodymap2_heart 0 .00 RPM 59 .19 RPM
bodymap2_kidney 0 .00 RPM 107 .29 RPM
bodymap2_liver 0 .00 RPM 21 .02 RPM
bodymap2_lung 0 .00 RPM 57 .35 RPM
bodymap2_lymph_node 0 .00 RPM 68 .58 RPM
bodymap2_ovary 0 .00 RPM 55 .92 RPM
bodymap2_prostate 0 .00 RPM 118 .83 RPM
bodymap2_skeletal_muscle 0 .00 RPM 65 .24 RPM
bodymap2_testis 0 .00 RPM 73 .15 RPM
bodymap2_thyroid 0 .00 RPM 78 .77 RPM
bodymap2_white_blood_cells 0 .00 RPM 105 .37 RPM

ChIP-Seq - click to see more details

RNA Polymerase II actvity near the 5' end of retro_hsap_2129 was not detected

EST - click to see more details

No EST(s) were mapped for retro_hsap_2129 retrocopy.

TSS - click to see more details

No TSS is located nearby retro_hsap_2129 retrocopy 5' end.

Lab - click to see more details

retro_hsap_2129 was not experimentally validated.

Retrocopy orthology:
Retrocopy retro_hsap_2129 has 2 orthologous retrocopies within eutheria group .

Species RetrogeneDB ID
Pan troglodytes retro_ptro_1558
Pongo abelii retro_pabe_1922
Parental genes homology:
Parental genes homology involve 6 parental genes, and 10 retrocopies.

Species Parental gene accession Retrocopies number
Homo sapiens ENSG00000017797 2 retrocopies
retro_hsap_2129 , retro_hsap_2734,
Gorilla gorilla ENSGGOG000000231201 retrocopy
retro_ggor_1903,
Macaca mulatta ENSMMUG000000195212 retrocopies
retro_mmul_1000, retro_mmul_1528,
Nomascus leucogenys ENSNLEG000000069501 retrocopy
retro_nleu_2532,
Pongo abelii ENSPPYG000000090102 retrocopies
retro_pabe_1922, retro_pabe_2273,
Pan troglodytes ENSPTRG000000098592 retrocopies
retro_ptro_1558, retro_ptro_1848,

Expression level across human populations :
image/svg+xml GBR_HG00142 GBR_HG00099 GBR_HG00114 GBR_HG00143 GBR_HG00131 GBR_HG00137 GBR_HG00133 GBR_HG00119 GBR_HG00111 GBR_HG00134 FIN_HG00378 FIN_HG00338 FIN_HG00349 FIN_HG00375 FIN_HG00315 FIN_HG00277 FIN_HG00328 FIN_HG00321 FIN_HG00377 FIN_HG00183 TSI_NA20756 TSI_NA20538 TSI_NA20798 TSI_NA20532 TSI_NA20765 TSI_NA20518 TSI_NA20513 TSI_NA20512 TSI_NA20771 TSI_NA20786 YRI_NA19114 YRI_NA19099 YRI_NA18870 YRI_NA18907 YRI_NA19223 YRI_NA19214 YRI_NA18916 YRI_NA19093 YRI_NA19118 YRI_NA19213 Toscaniin Italia: Finnish inFinland: British in England and Scotland: Utah Residents (CEPH) with Northernand Western European Ancestry: Yoruba in Ibadan, Nigeria: CEU_NA12760 CEU_NA12827 CEU_NA12872 CEU_NA12751 CEU_NA12873 CEU_NA12400 CEU_NA11930 CEU_NA12004 CEU_NA11831 CEU_NA11843 No expression ( = 0 RPM ) Legend:


Library Retrogene expression
CEU_NA11831 0 .00 RPM
CEU_NA11843 0 .00 RPM
CEU_NA11930 0 .00 RPM
CEU_NA12004 0 .00 RPM
CEU_NA12400 0 .00 RPM
CEU_NA12751 0 .00 RPM
CEU_NA12760 0 .00 RPM
CEU_NA12827 0 .00 RPM
CEU_NA12872 0 .00 RPM
CEU_NA12873 0 .00 RPM
FIN_HG00183 0 .00 RPM
FIN_HG00277 0 .00 RPM
FIN_HG00315 0 .00 RPM
FIN_HG00321 0 .00 RPM
FIN_HG00328 0 .00 RPM
FIN_HG00338 0 .00 RPM
FIN_HG00349 0 .00 RPM
FIN_HG00375 0 .00 RPM
FIN_HG00377 0 .00 RPM
FIN_HG00378 0 .00 RPM
GBR_HG00099 0 .00 RPM
GBR_HG00111 0 .00 RPM
GBR_HG00114 0 .00 RPM
GBR_HG00119 0 .00 RPM
GBR_HG00131 0 .00 RPM
GBR_HG00133 0 .00 RPM
GBR_HG00134 0 .00 RPM
GBR_HG00137 0 .00 RPM
GBR_HG00142 0 .00 RPM
GBR_HG00143 0 .00 RPM
TSI_NA20512 0 .00 RPM
TSI_NA20513 0 .00 RPM
TSI_NA20518 0 .00 RPM
TSI_NA20532 0 .00 RPM
TSI_NA20538 0 .00 RPM
TSI_NA20756 0 .00 RPM
TSI_NA20765 0 .00 RPM
TSI_NA20771 0 .00 RPM
TSI_NA20786 0 .00 RPM
TSI_NA20798 0 .00 RPM
YRI_NA18870 0 .00 RPM
YRI_NA18907 0 .00 RPM
YRI_NA18916 0 .00 RPM
YRI_NA19093 0 .00 RPM
YRI_NA19099 0 .00 RPM
YRI_NA19114 0 .00 RPM
YRI_NA19118 0 .00 RPM
YRI_NA19213 0 .00 RPM
YRI_NA19214 0 .00 RPM
YRI_NA19223 0 .00 RPM

Indel association:

No indels were associated with its genomic coordinates. Based on Kabza et al. 2015 (PubMed).



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