RetrogeneDB ID:

retro_hsap_3305

Retrocopy
location
Organism:Human (Homo sapiens)
Coordinates:5:37505792..37506960(-)
Located in intron of:ENSG00000082068
Retrocopy
information
Ensembl ID:ENSG00000248216
Aliases:None
Status:KNOWN_PSEUDOGENE
Parental gene
information
Parental gene summary:
Parental gene symbol:KCTD9
Ensembl ID:ENSG00000104756
Aliases:KCTD9, BTBD27
Description:potassium channel tetramerization domain containing 9 [Source:HGNC Symbol;Acc:22401]


Retrocopy-Parental alignment summary:






>retro_hsap_3305
ATGAGGCGGGTGACCCTGTTCCTGAACAGCAGCCCCCAAGAACGGAAAGGTGGTTGCTGTATATGGAACTTTATCTGATT
TGCTTTCTGTGGCCAGCAGTAAACTCAGCATAAAAGCCACCAGTGTGTATAATGAGAAAGGTGGACTGACTGATGATATT
GCTTTGATCAGGGATGATGATGTTTTATTTGTGTGTGAGGGAGAGCCATTTATTGATCTTCAGACAGATTCTAAGCCTCC
TGAAGGATTGTTAGGATTCCACACAGAGTGGCTAACATTAAATGTTGGAGGGAGGTACTTTACAACTACACGGAGCACTT
TAGCGAATAAAGAACCTGACAGTATGCTGGCCCACATGCTTAAGAACAGAGGTGTCTGGGGAAATAAGCAAGATCATAGA
GGAGCCTTCTTAATTGACCAAAGTCCTGAGTACTTTGAACCCACTTTGAACTACTTGTGTCATGGACAGCTCATTGTAAA
TGATGGCATTAATTTATTGGGTGTGTTAGAAGAAGCAAGATTTTTTGGTATTGACTCACTGATTGAACACCTAGAAGTGG
CAATAAAGAATTCTCAATCACCAGAGGATCATTCACCAATATCTCGAAAGGAATTTGTCCGATTTTTGATAGCAACTCCA
ACCAAGTCAGAACTGTGATACCAGAGTTTGAACTTCAGTGGTGCTGATGTTTCTCGTTAGGACCTTCGATACATTAACTT
CAAAATGGCCAATTTAAGCCGCTGCAATCTTGCACATGCAAATCTTTACTGTGCAAATCTTGAATGAGGTGATCTCTCTG
GATCAGTGCTTGACTGTGCAAATCTCCAGGGAGTCAAGATGCTCTGTTCTAATGCAGAAGGAGCATCCCTGAAACTGTGT
AATTTTGAGGATCTTTCTGGTCTTAAAGCCAATTTAGAAGGTGCTAATCTGAAAGGTGTGGATATGGAAGGAAGTCAGAT
GACAGGAATTAACTTGAGAGTGGCTACCTTAAAAAATGCAAAGTTGAAGAATTGTAACCTCAGAGGAGCAACTCTGGCAG
GAACCAATTTAGAGAACTGTGATCTGTCTGGGTGTGATCTTCAAGAAGCCAACTTGAGAGGGTCCAACGTGTAGGGAGCT
ATATTTGAAGAGATGCTGACACCACTATACATGTCGCAAAATGTCAGA

ORF - retro_hsap_3305 Open Reading Frame is not conserved.
Retrocopy - Parental Gene Alignment summary:
Percent Identity: 92.56 %
Parental protein coverage: 100. %
Number of stop codons detected: 4
Number of frameshifts detected 1


Retrocopy - Parental Gene Alignment:

ParentalMRRVTLFLNGSP-KNGKVVAVYGTLSDLLSVASSKLGIKATSVYNGKGGLIDDIALIRDDDVLFVCEGEP
MRRVTLFLN.SP.KNGKVVAVYGTLSDLLSVASSKL.IKATSVYN.KGGL.DDIALIRDDDVLFVCEGEP
RetrocopyMRRVTLFLNSSP>KNGKVVAVYGTLSDLLSVASSKLSIKATSVYNEKGGLTDDIALIRDDDVLFVCEGEP
ParentalFIDPQTDSKPPEGLLGFHTDWLTLNVGGRYFTTTRSTLVNKEPDSMLAHMFKDKGVWGNKQDHRGAFLID
FID.QTDSKPPEGLLGFHT.WLTLNVGGRYFTTTRSTL.NKEPDSMLAHM.K..GVWGNKQDHRGAFLID
RetrocopyFIDLQTDSKPPEGLLGFHTEWLTLNVGGRYFTTTRSTLANKEPDSMLAHMLKNRGVWGNKQDHRGAFLID
ParentalRSPEYFEPILNYLRHGQLIVNDGINLLGVLEEARFFGIDSLIEHLEVAIKNSQPPEDHSPISRKEFVRFL
.SPEYFEP.LNYL.HGQLIVNDGINLLGVLEEARFFGIDSLIEHLEVAIKNSQ.PEDHSPISRKEFVRFL
RetrocopyQSPEYFEPTLNYLCHGQLIVNDGINLLGVLEEARFFGIDSLIEHLEVAIKNSQSPEDHSPISRKEFVRFL
ParentalLATPTKSELRCQGLNFSGADLSRLDLRYINFKMANLSRCNLAHANLCCANLERADLSGSVLDCANLQGVK
.ATPTKSEL..Q.LNFSGAD.SR.DLRYINFKMANLSRCNLAHANL.CANLE..DLSGSVLDCANLQGVK
RetrocopyIATPTKSEL*YQSLNFSGADVSR*DLRYINFKMANLSRCNLAHANLYCANLE*GDLSGSVLDCANLQGVK
ParentalMLCSNAEGASLKLCNFEDPSGLKANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTD
MLCSNAEGASLKLCNFED.SGLKANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGT.
RetrocopyMLCSNAEGASLKLCNFEDLSGLKANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTN
ParentalLENCDLSGCDLQEANLRGSNVKGAIFEEMLTPLHMSQSVR
LENCDLSGCDLQEANLRGSNV.GAIFEEMLTPL.MSQ.VR
RetrocopyLENCDLSGCDLQEANLRGSNV*GAIFEEMLTPLYMSQNVR

Legend:
*Stop codon
>Forward frameshift by one nucleotide
<Reverse frameshift by one nucleotide






RNA-Seq - click to see more details

(Hint: click retrocopy or parental gene accession number on the plot's legend, to show / hide expression level values)

Expression validation based on RNA-Seq data:
Library Retrocopy expression Parental gene expression
bodymap2_adipose 0 .00 RPM 41 .80 RPM
bodymap2_adrenal 0 .06 RPM 30 .52 RPM
bodymap2_brain 0 .00 RPM 20 .46 RPM
bodymap2_breast 0 .10 RPM 45 .72 RPM
bodymap2_colon 0 .00 RPM 43 .14 RPM
bodymap2_heart 0 .02 RPM 81 .03 RPM
bodymap2_kidney 0 .00 RPM 37 .12 RPM
bodymap2_liver 0 .00 RPM 9 .44 RPM
bodymap2_lung 0 .00 RPM 36 .80 RPM
bodymap2_lymph_node 0 .00 RPM 24 .21 RPM
bodymap2_ovary 0 .00 RPM 24 .92 RPM
bodymap2_prostate 0 .00 RPM 45 .83 RPM
bodymap2_skeletal_muscle 0 .00 RPM 32 .43 RPM
bodymap2_testis 0 .09 RPM 56 .47 RPM
bodymap2_thyroid 0 .08 RPM 36 .29 RPM
bodymap2_white_blood_cells 0 .00 RPM 19 .10 RPM

ChIP-Seq - click to see more details

RNA Polymerase II actvity near the 5' end of retro_hsap_3305 was not detected

EST - click to see more details

No EST(s) were mapped for retro_hsap_3305 retrocopy.

TSS - click to see more details

No TSS is located nearby retro_hsap_3305 retrocopy 5' end.

Lab - click to see more details

retro_hsap_3305 was not experimentally validated.

Retrocopy orthology:
Retrocopy retro_hsap_3305 has 3 orthologous retrocopies within eutheria group .

Species RetrogeneDB ID
Pan troglodytes retro_ptro_2166
Gorilla gorilla retro_ggor_1309
Pongo abelii retro_pabe_2725
Parental genes homology:
Parental genes homology involve 4 parental genes, and 11 retrocopies.

Species Parental gene accession Retrocopies number
Homo sapiens ENSG00000104756 4 retrocopies
retro_hsap_1730, retro_hsap_3305 , retro_hsap_4037, retro_hsap_4156,
Homo sapiens ENSG000001679771 retrocopy
retro_hsap_2224,
Macaca mulatta ENSMMUG000000101513 retrocopies
retro_mmul_1083, retro_mmul_1218, retro_mmul_2072,
Pan troglodytes ENSPTRG000000200923 retrocopies
retro_ptro_1225, retro_ptro_2166, retro_ptro_2825,

Expression level across human populations :
image/svg+xml GBR_HG00142 GBR_HG00099 GBR_HG00114 GBR_HG00143 GBR_HG00131 GBR_HG00137 GBR_HG00133 GBR_HG00119 GBR_HG00111 GBR_HG00134 FIN_HG00378 FIN_HG00338 FIN_HG00349 FIN_HG00375 FIN_HG00315 FIN_HG00277 FIN_HG00328 FIN_HG00321 FIN_HG00377 FIN_HG00183 TSI_NA20756 TSI_NA20538 TSI_NA20798 TSI_NA20532 TSI_NA20765 TSI_NA20518 TSI_NA20513 TSI_NA20512 TSI_NA20771 TSI_NA20786 YRI_NA19114 YRI_NA19099 YRI_NA18870 YRI_NA18907 YRI_NA19223 YRI_NA19214 YRI_NA18916 YRI_NA19093 YRI_NA19118 YRI_NA19213 Toscaniin Italia: Finnish inFinland: British in England and Scotland: Utah Residents (CEPH) with Northernand Western European Ancestry: Yoruba in Ibadan, Nigeria: CEU_NA12760 CEU_NA12827 CEU_NA12872 CEU_NA12751 CEU_NA12873 CEU_NA12400 CEU_NA11930 CEU_NA12004 CEU_NA11831 CEU_NA11843 No expression ( = 0 RPM ) > 0 RPM = 0.06 RPM Legend:


Library Retrogene expression
CEU_NA11831 0 .02 RPM
CEU_NA11843 0 .00 RPM
CEU_NA11930 0 .03 RPM
CEU_NA12004 0 .00 RPM
CEU_NA12400 0 .00 RPM
CEU_NA12751 0 .02 RPM
CEU_NA12760 0 .00 RPM
CEU_NA12827 0 .00 RPM
CEU_NA12872 0 .00 RPM
CEU_NA12873 0 .00 RPM
FIN_HG00183 0 .00 RPM
FIN_HG00277 0 .00 RPM
FIN_HG00315 0 .00 RPM
FIN_HG00321 0 .00 RPM
FIN_HG00328 0 .00 RPM
FIN_HG00338 0 .00 RPM
FIN_HG00349 0 .00 RPM
FIN_HG00375 0 .00 RPM
FIN_HG00377 0 .00 RPM
FIN_HG00378 0 .02 RPM
GBR_HG00099 0 .00 RPM
GBR_HG00111 0 .00 RPM
GBR_HG00114 0 .03 RPM
GBR_HG00119 0 .02 RPM
GBR_HG00131 0 .00 RPM
GBR_HG00133 0 .00 RPM
GBR_HG00134 0 .02 RPM
GBR_HG00137 0 .00 RPM
GBR_HG00142 0 .06 RPM
GBR_HG00143 0 .00 RPM
TSI_NA20512 0 .00 RPM
TSI_NA20513 0 .02 RPM
TSI_NA20518 0 .03 RPM
TSI_NA20532 0 .03 RPM
TSI_NA20538 0 .00 RPM
TSI_NA20756 0 .00 RPM
TSI_NA20765 0 .00 RPM
TSI_NA20771 0 .00 RPM
TSI_NA20786 0 .03 RPM
TSI_NA20798 0 .00 RPM
YRI_NA18870 0 .00 RPM
YRI_NA18907 0 .00 RPM
YRI_NA18916 0 .02 RPM
YRI_NA19093 0 .00 RPM
YRI_NA19099 0 .00 RPM
YRI_NA19114 0 .03 RPM
YRI_NA19118 0 .02 RPM
YRI_NA19213 0 .02 RPM
YRI_NA19214 0 .00 RPM
YRI_NA19223 0 .00 RPM

Indel association:

No indels were associated with its genomic coordinates. Based on Kabza et al. 2015 (PubMed).



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