RetrogeneDB ID: retro_ggor_1865

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 3:91130332..91131955(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: NARG2
• Ensembl ID: ENSGGOG00000022206
• Aliases: None
• Description: None

Sequence

>retro_ggor_1865
CAGAGAGAGCAGAGGAGTTATGTGGACTTGTTGGTTAAATATACAAAGATTTCTGCAAATTCCAAAACTATCAGAATAAA
GAAAAAATGACTTCTTGTAGTACTTAGATATGAAAAAAACATGTGAATGAAGAAGTTATTGAGTTCCTAAAGTTTTTGCA
GAATTCTGCAAAGAAATGTGCACAGGATTATAATATGCTTTCTGATGATGCTTGTCTCTTCACAGTGAAATTTTTAAGAG
CTTGCACTGAACAACTGAAAAAGTTCCTAGAATTCTATACTCTCCACGAGGTCACCAGCTTAATGATATTCTTCCCATTC
AGAGTAGAGATGGAATTAAAGTTAGAAAAATCTCTTCTTGCACTGGGCAGGGTAAAATATGTGAAAACAGTATTTCCCTC
AATGCTTATAAAGTTGCAGCTCTCAAAAGATGATATATCTGCCACTGAATTGCCAGAATGAACGGCTGAAGCTATGCATT
ATTATATTAGAAAAGATCCAAATGCAGAGGAGCTTATTTCAAGATATCACCCTCAGCTAGCTCTAACTAGTCAATCATTA
TTTACTTTATTAAATAATCATGGACCAATGTACAAGGAACCTTGGGAACTTTCAGTATTGATTCAAGTAATACCTGTTGC
AGGTTCAAAACCAGTTAAAGTAATATATATTAATTCGCCACTTCCCCAAAATAAAATAACTATGAGAGAGAGAAAACAAT
CTTTCATGAAGTTCCATTAAAATTTATGATGCCCCAAAACACATTTGTTCCAGTATCTGCAGTCTTTATGGACAAACCTG
AAGAGTTTATATCTGAAATGGACATGTCCCATGAATTCAATGAGTGCCGAAAAATTGAGACTCTTGAAAACTTGTATCTG
GATTTTGATGATGAGGTCACAGAACTTGAAACTTTTGGAGTAACCACCACCAAAGCATCAAAGTCACCAATTCCAGCAAG
TACTTCCACAGTACCTAACATGACAGATGCTTCTACAGCCCCCAAAGCAGTAACTAAATCTGTGGCACCAAGTGCACCAG
ACATTTCTGCTAATTCTAGAAGTTCATCTCAGATTCTGATTGAACAATGGCAAAAGGAGAAACAACTGGTCACTGGTATG
GATGGTGGCCCTGAAGAGTGCAAAAATAAAGATGATCAGAGTTTGAATCATGTGGTGATAAGGTATCAAATTCTGACAAG
TCTTTGATGCAAGATAGTGACTTGAAAACATCTGATGCCTTACAGTTAGAAAATTCTTAGGAAATTGAAACTTCTAATAA
AAATGATATGACTATAGATATGGAACATGCTGATGGTGAAAGACCCAATGTTCTGGAAAACCTAAACAACTCAAAGGAAA
AGACTGTTAGATCAGAAGCAGCTAAAACTGAAGATACAGTTCTCTTCAGCAGTGATACAGATGAGGAGTGTTTAATCATT
GATAGAGAGTGTAAAAATAATAGCGATGGAAAGACAGATGTTGTGGGTTCTAACTTAAGTTTTAGATCAGCTAGTCCAAA
TTCTTCCTCAGGACAGGCTTCCGTAGGAAAACAGACTACTACTGTTTGTAGGCCTGCAGAGTCATGTGTTTTTTAAAAAA
ACTTATCAAATGAGCATATAAAA

Alignment

ORF - retro_ggor_1865 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 83.3 %
• Parental protein coverage: 54.55 %
• Number of stop codons detected: 4
• Number of frameshifts detected: 4

Retrocopy - Parental Gene Alignment:

Parental  QREQRSYVDLLVKYAKIPANSKAVGINK-NDYLQYLDMKK-HVNEEVTEFLKFLQNSAKKCAQDYNMLSD
          QREQRSYVDLLVKY.KI.ANSK...I.K.ND.L.YLDMKK.HVNEEV.EFLKFLQNSAKKCAQDYNMLSD
Retrocopy QREQRSYVDLLVKYTKISANSKTIRIKK>NDFL*YLDMKK>HVNEEVIEFLKFLQNSAKKCAQDYNMLSD

Parental  DARLFTEKILRACIEQVKKYSEFYTLHEVTSLMGFFPFRVEMGLKLEKTLLALGSVKYVKTVFPSMPIKL
          DA.LFT.K.LRAC.EQ.KK..EFYTLHEVTSLM.FFPFRVEM.LKLEK.LLALG.VKYVKTVFPSM.IKL
Retrocopy DACLFTVKFLRACTEQLKKFLEFYTLHEVTSLMIFFPFRVEMELKLEKSLLALGRVKYVKTVFPSMLIKL

Parental  QLSKDDITTIETSEQTAEAMHYDISKDPNAEKLVSRYHPQIALTSQSLFTLLNNHGPTYKEQWEIPVCIQ
          QLSKDDI...E..E.TAEAMHY.I.KDPNAE.L.SRYHPQ.ALTSQSLFTLLNNHGP.YKE.WE..V.IQ
Retrocopy QLSKDDISATELPE*TAEAMHYYIRKDPNAEELISRYHPQLALTSQSLFTLLNNHGPMYKEPWELSVLIQ

Parental  VIPVAGSKPVKVIYINSPLPQKKMTMRERNQ-IFHEVPLKFMMSKNTSVPVSAVFMDKPEEFISEMDMSC
          VIPVAGSKPVKVIYINSPLPQ.K.TMRER.Q.IFHEVPLKFMM..NT.VPVSAVFMDKPEEFISEMDMS.
Retrocopy VIPVAGSKPVKVIYINSPLPQNKITMRERKQ<IFHEVPLKFMMPQNTFVPVSAVFMDKPEEFISEMDMSH

Parental  EVNECRKIESLENLYLDFDDDVTELETFGVTTTKASKSPSPASTSTVPNMTDAPTAPKAGTTTVAPSAPD
          E.NECRKIE.LENLYLDFDD.VTELETFGVTTTKASKSP.PASTSTVPNMTDA.TAPKA.T..VAPSAPD
Retrocopy EFNECRKIETLENLYLDFDDEVTELETFGVTTTKASKSPIPASTSTVPNMTDASTAPKAVTKSVAPSAPD

Parental  ISANSRSLSQILMEQLQKEKQLVTGMDGGPEECKTKDDQG-FESC-EKVSNSDKPLIQDSDLKTSDALLL
          ISANSRS.SQIL.EQ.QKEKQLVTGMDGGPEECK.KDDQ..FESC..KVSNSDK.L.QDSDLKTSDAL.L
Retrocopy ISANSRSSSQILIEQWQKEKQLVTGMDGGPEECKNKDDQS<FESCGDKVSNSDKSLMQDSDLKTSDALQL

Parental  ENSQEIETSNKNDMTVDMVHADGEKPNVLENLDNSKEKTVGSEAAKTEDTVLCSSDTDEECLIIDTECKN
          ENS.EIETSNKNDMT.DM.HADGE.PNVLENL.NSKEKTV.SEAAKTEDTVL.SSDTDEECLIID.ECKN
Retrocopy ENS*EIETSNKNDMTIDMEHADGERPNVLENLNNSKEKTVRSEAAKTEDTVLFSSDTDEECLIIDRECKN

Parental  NSDGKTAVVGSNLSSRPASPNSSSGQASVGNQTNTACSPEESCVLKKPIKRVYKK
          NSDGKT.VVGSNLS.R.ASPNSSSGQASVG.QT.T.C.P.ESCV..K.......K
Retrocopy NSDGKTDVVGSNLSFRSASPNSSSGQASVGKQTTTVCRPAESCVF*KNLSNEHIK

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	9.11 RPM
SRP007412_cerebellum	0.00 RPM	14.34 RPM
SRP007412_heart	0.00 RPM	3.66 RPM
SRP007412_kidney	0.00 RPM	20.16 RPM
SRP007412_liver	0.00 RPM	17.62 RPM
SRP007412_testis	0.10 RPM	38.23 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_1865 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_1865 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_2672
Pan troglodytes	retro_ptro_1801
Pongo abelii	retro_pabe_2217

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Parental genes homology:

Parental genes homology involve 4 parental genes, and 4 retrocopies.

Species	Parental gene accession	Retrocopies number
Homo sapiens	ENSG00000128915	1 retrocopy	retro_hsap_2672,
Gorilla gorilla	ENSGGOG00000022206	1 retrocopy	retro_ggor_1865 ,
Pongo abelii	ENSPPYG00000006527	1 retrocopy	retro_pabe_2217,
Pan troglodytes	ENSPTRG00000007133	1 retrocopy	retro_ptro_1801,