RetrogeneDB ID: retro_ggor_2689

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 8:124679636..124680343(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: MRS2
• Ensembl ID: ENSGGOG00000009098
• Aliases: None
• Description: None

Sequence

>retro_ggor_2689
TCTGACCTGTGTGGGCCCGCCGGCTCTGCGTAGCAGGTGCAATGCACGGGTTTAGAACTTCTGATGTCTCTCAAGCCACT
GTAGGCAGTGTAGCCCCAGTATTTACCGCAACAAAATTTGACAAACAGGGAAATGTTACTCCTTTTGAAAGGAAGAAAAC
TGACTTATACCAAGAGTTAGGTCTTCAAGCCAGAGACTTGAGATTTCAGCATGTAGTGAACATCACAACCAGAAACGGCA
GGTTTATCATGACAATGGAGTATTTGAAAGCTGTGATAACTCCAGAGTGTCTCCTGATATTAGATGATGGTAATTTAAAC
TTAGAGCAATGGCTGTTCTGGGAACTCCCTTCACAGTTGTCTGGAGAGGGTCAACCTGTTACATACTCTTTACCTTTTGA
GTTTAGTGCTATGGAAGCACCCCTGCAATACTGGATCAACCCCCTTTAGAGGAAACGTAGCGTTTTGCAGACACTGACCT
TTGAGACCTTAGAAGCTTTCAAACATTCTTCTGTGGACAAAAGCTAACCGCATATTTTACTACAGAATGACAAAAGTCTA
TCAGAGTTAGAAACAGATATTAAAATTTTCCAAGAGTCAGTTTTGGAGATCTTGGGTGAGGAAAACTTACTAGAAGAGCT
CTGTCTATCAAAATGGAGTGACCCACCAGTCTTTGAAAAGAGCAGTACTGGGATTCGCCATGCAGAA

Alignment

ORF - retro_ggor_2689 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 75. %
• Parental protein coverage: 54.36 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  AQLCGPD-RLRVAGEVHRFRTSDVSQATLASVAPVFTVTKFDKQGNVTSFERKKTELYQELGLQARDLRF
          ..LCGP..RL.VAG..H.FRTSDVSQAT..SVAPVFT.TKFDKQGNVT.FERKKT.LYQELGLQARDLRF
Retrocopy SDLCGPA<RLCVAGAMHGFRTSDVSQATVGSVAPVFTATKFDKQGNVTPFERKKTDLYQELGLQARDLRF

Parental  QHVMSITVRNNRIIMRMEVKYFIFISVITPECLLILDYRNLNLEQWLFRELPSQLSGEGQLVTYPLPFEF
          QHV..IT.RN.R.I..M...Y.....VITPECLLILD..NLNLEQWLF.ELPSQLSGEGQ.VTY.LPFEF
Retrocopy QHVVNITTRNGRFI--MTMEYLK--AVITPECLLILDDGNLNLEQWLFWELPSQLSGEGQPVTYSLPFEF

Parental  RAIEALLQYWINTLQGKLSILQPLILETLDALVDPKHSSVDRSKLHILLQNGKSLSELETDIKIFKESIL
          .A.EA.LQYWIN.L..K.S.LQ.L..ETL.A....KHSSVD.S..HILLQN.KSLSELETDIKIF.ES.L
Retrocopy SAMEAPLQYWINPL*RKRSVLQTLTFETLEAF---KHSSVDKS*PHILLQNDKSLSELETDIKIFQESVL

Parental  EILDEEELLEELCVSKWSDPQVFEKSSAGIDHAE
          EIL.EE.LLEELC.SKWSDP.VFEKSS.GI.HAE
Retrocopy EILGEENLLEELCLSKWSDPPVFEKSSTGIRHAE

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	15.35 RPM
SRP007412_cerebellum	0.00 RPM	17.93 RPM
SRP007412_heart	0.00 RPM	7.38 RPM
SRP007412_kidney	0.00 RPM	39.78 RPM
SRP007412_liver	0.00 RPM	16.57 RPM
SRP007412_testis	1.97 RPM	16.89 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_2689 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_2689 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_4006
Pan troglodytes	retro_ptro_2720
Macaca mulatta	retro_mmul_2312

---

Parental genes homology:

Parental genes homology involve 7 parental genes, and 8 retrocopies.

Species	Parental gene accession	Retrocopies number
Dasypus novemcinctus	ENSDNOG00000006424	1 retrocopy	retro_dnov_1486,
Equus caballus	ENSECAG00000013105	1 retrocopy	retro_ecab_1032,
Homo sapiens	ENSG00000124532	1 retrocopy	retro_hsap_4006,
Gorilla gorilla	ENSGGOG00000009098	1 retrocopy	retro_ggor_2689 ,
Macaca mulatta	ENSMMUG00000001018	2 retrocopies	retro_mmul_2312, retro_mmul_878,
Pongo abelii	ENSPPYG00000016278	1 retrocopy	retro_pabe_939,
Pan troglodytes	ENSPTRG00000017774	1 retrocopy	retro_ptro_2720,