RetrogeneDB ID: retro_ggor_521

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 10:82283704..82284597(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: RPL5
• Ensembl ID: ENSGGOG00000002699
• Aliases: None
• Description: None

Sequence

>retro_ggor_521
CTGTCCCACAGGATAGGGTTGGTTAAAGTTGTTGAGAATAAGTCCTACTTTAAGAGGTACCAAGTGAAATTTAGAAGATG
ATGATAGGGTAAAACTGATTATTATGCTCAGAAACACTGGTGATACAGGATAAAAATAAACATGACACACCCAAATACAG
GATGATAGTTTGTGTAACAAACAGAGATATCATTGGTCAGATTGCTTACTCCCATCTAGAAGGGGATATATAGTCTGCAC
AGCATATGCACATGAACTGCCAAAATATGGCATGAAGTTTGGCCTGACAAATGATGCTGCAATGTATTGTACTGTCCTGC
TGCTGGCCCACAGGCTTCTCAGTAAGTTTGGCATGGATAAGATCTGTGAACGCCAAGTGGAGGTGACTGGAGATGAATAC
AATGTGGAAGGCATTGATGGTCAGCCAGGTGCCTTTACCTGCTATTTGGATGCAGGCCTTGCTAGAACTGCAATAAAGTT
TTGGGGGCACTGAAGGGAGGTGTGGATGGAGGCTTGTCTATCCCTCACAGTACCAAATGCCTCCCTAGTTATGATTCTGA
AAGCAAGGAATTTAATGCAGAAGTACACCAGAAGCATATCATGGGCCAGAATGTTGCAGATTACTCTTGCTACTTAATGG
AGGAAGATGAAGATGCTCAAAAGGAATAATTCTGTCAATACATAAAGAACGGCGTAACCCCAGACGTGATGGAAGAGATG
ATAAGAAAGCTTATGCTGCTATATGAGAGAATCCAGCCTGGGAGAAGAAGCCCAAGAAAGAAGTTAAAAAGAAGAGGTGG
TACTGCCCCAAAATGTCCCTTGCTCAGAATAAAGATCAGGTAGCTCAAAAGAAGGCAAGCTTTTTCAGAGCTCAAGAGCG
GGCTGCTGTGAGC

Alignment

ORF - retro_ggor_521 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 78.69 %
• Parental protein coverage: 99.01 %
• Number of stop codons detected: 5
• Number of frameshifts detected: 4

Retrocopy - Parental Gene Alignment:

Parental  LFRRMGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKR-LVIQDKNKYNTPKYRMIVRVTNRDIICQIA
          L..R.G.VKVV.NK.YFKRYQVKFRR...GKTDYYA.K..LVIQDKNK..TPKYRMIV.VTNRDII.QIA
Retrocopy LSHRIGLVKVVENKSYFKRYQVKFRR***GKTDYYAQKH<LVIQDKNKHDTPKYRMIVCVTNRDIIGQIA

Parental  YARIEGDM-IVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVTGDEYNVES
          Y...EGD..IVC.AYAHELPKYG.K.GLTN.AA.YCT.LLLA.RLL..FGMDKI.E.QVEVTGDEYNVE.
Retrocopy YSHLEGDI<IVCTAYAHELPKYGMKFGLTNDAAMYCTVLLLAHRLLSKFGMDKICERQVEVTGDEYNVEG

Parental  IDGQPGAFTCYLDAGLARTTTGNKVFG-ALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQN
          IDGQPGAFTCYLDAGLART....K..G.ALKG.VDGGLSIPHSTK..P.YDSESKEFNAEVH.KHIMGQN
Retrocopy IDGQPGAFTCYLDAGLARTAI--KFWG<ALKGGVDGGLSIPHSTKCLPSYDSESKEFNAEVHQKHIMGQN

Parental  VADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMY-KKAHAAIRENPVYEKKPKKEVKKKRWNRPKMS
          VADY..YLMEEDEDA.K..F.QYIKN.VTPD.MEEM..KKA.AAI.ENP..EKKPKKEVKKKRW..PKMS
Retrocopy VADYSCYLMEEDEDAQKE*FCQYIKNGVTPDVMEEMI<KKAYAAI*ENPAWEKKPKKEVKKKRWYCPKMS

Parental  LAQKKDRVAQKKASFLRAQERAAES
          LAQ.KD.VAQKKASF.RAQERAA.S
Retrocopy LAQNKDQVAQKKASFFRAQERAAVS

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.05 RPM	103.48 RPM
SRP007412_cerebellum	0.00 RPM	127.93 RPM
SRP007412_heart	0.00 RPM	69.95 RPM
SRP007412_kidney	0.00 RPM	355.82 RPM
SRP007412_liver	0.00 RPM	276.52 RPM
SRP007412_testis	0.00 RPM	255.68 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_521 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_521 has 2 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_590
Pan troglodytes	retro_ptro_433

---

Parental genes homology:

Parental genes homology involve 14 parental genes, and 141 retrocopies.

Species	Parental gene accession	Retrocopies number
Erinaceus europaeus	ENSEEUG00000002852	1 retrocopy	retro_eeur_620,
Echinops telfairi	ENSETEG00000009889	8 retrocopies	retro_etel_1044, retro_etel_1089, retro_etel_1103, retro_etel_1264, retro_etel_2028, retro_etel_64, retro_etel_785, retro_etel_814,
Homo sapiens	ENSG00000122406	30 retrocopies	retro_hsap_1266, retro_hsap_138, retro_hsap_1469, retro_hsap_1539, retro_hsap_1588, retro_hsap_1767, retro_hsap_183, retro_hsap_1989, retro_hsap_2143, retro_hsap_2385, retro_hsap_2594, retro_hsap_2600, retro_hsap_2777, retro_hsap_2962, retro_hsap_3105, retro_hsap_3178, retro_hsap_3181, retro_hsap_3209, retro_hsap_3430, retro_hsap_3520, retro_hsap_3941, retro_hsap_4048, retro_hsap_4104, retro_hsap_486, retro_hsap_590, retro_hsap_632, retro_hsap_646, retro_hsap_742, retro_hsap_780, retro_hsap_827,
Gorilla gorilla	ENSGGOG00000002699	24 retrocopies	retro_ggor_1129, retro_ggor_1172, retro_ggor_1206, retro_ggor_1342, retro_ggor_1343, retro_ggor_1656, retro_ggor_1934, retro_ggor_2052, retro_ggor_2130, retro_ggor_2178, retro_ggor_2243, retro_ggor_2318, retro_ggor_233, retro_ggor_2380, retro_ggor_264, retro_ggor_2649, retro_ggor_2715, retro_ggor_2755, retro_ggor_457, retro_ggor_521 , retro_ggor_553, retro_ggor_622, retro_ggor_647, retro_ggor_996,
Macropus eugenii	ENSMEUG00000006361	3 retrocopies	retro_meug_1168, retro_meug_1537, retro_meug_2146,
Myotis lucifugus	ENSMLUG00000008956	1 retrocopy	retro_mluc_925,
Monodelphis domestica	ENSMODG00000011635	1 retrocopy	retro_mdom_748,
Nomascus leucogenys	ENSNLEG00000010500	2 retrocopies	retro_nleu_2102, retro_nleu_39,
Ornithorhynchus anatinus	ENSOANG00000004669	1 retrocopy	retro_oana_97,
Otolemur garnettii	ENSOGAG00000013246	6 retrocopies	retro_ogar_1164, retro_ogar_134, retro_ogar_1627, retro_ogar_2374, retro_ogar_2633, retro_ogar_707,
Petromyzon marinus	ENSPMAG00000002040	1 retrocopy	retro_pmar_23,
Pongo abelii	ENSPPYG00000001152	32 retrocopies	retro_pabe_1053, retro_pabe_1219, retro_pabe_1274, retro_pabe_1307, retro_pabe_1331, retro_pabe_1501, retro_pabe_1918, retro_pabe_1931, retro_pabe_2019, retro_pabe_2123, retro_pabe_2238, retro_pabe_2457, retro_pabe_246, retro_pabe_247, retro_pabe_2640, retro_pabe_2641, retro_pabe_2658, retro_pabe_2813, retro_pabe_2841, retro_pabe_2909, retro_pabe_3247, retro_pabe_3320, retro_pabe_3360, retro_pabe_3534, retro_pabe_446, retro_pabe_447, retro_pabe_480, retro_pabe_51, retro_pabe_562, retro_pabe_572, retro_pabe_637, retro_pabe_740,
Pan troglodytes	ENSPTRG00000000963	30 retrocopies	retro_ptro_1038, retro_ptro_1068, retro_ptro_1184, retro_ptro_1326, retro_ptro_139, retro_ptro_1519, retro_ptro_1524, retro_ptro_1568, retro_ptro_169, retro_ptro_1744, retro_ptro_1878, retro_ptro_2005, retro_ptro_2241, retro_ptro_2262, retro_ptro_2264, retro_ptro_2329, retro_ptro_2391, retro_ptro_2674, retro_ptro_2742, retro_ptro_2785, retro_ptro_2941, retro_ptro_3027, retro_ptro_366, retro_ptro_433, retro_ptro_460, retro_ptro_470, retro_ptro_528, retro_ptro_577, retro_ptro_866, retro_ptro_997,
Sarcophilus harrisii	ENSSHAG00000006417	1 retrocopy	retro_shar_202,