RetrogeneDB ID: retro_mmul_249

Retrocopy location

• Organism: Rhesus macaque (Macaca mulatta)
• Coordinates: 15:57934755..57935700(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSMMUG00000018395
• Aliases: None
• Status: KNOWN_PROTEIN_CODING

Parental gene information

• Parental gene symbol: RRAGB
• Ensembl ID: ENSMMUG00000017635
• Aliases: None
• Description: ras-related GTP-binding protein B [Source:RefSeq peptide;Acc:NP_001244373]

Sequence

>retro_mmul_249
GTGATGCCAAATACAGCCATGAAGAAAAAGGTGCTGCTGATGGGGAAGAGCGGGTCGGGGAAGACCAGCATGAGGTCGAT
TATCTTCGCCAATTATATTGCTCGCGACACCCGGCGCCTGGGGGCCACCATTGACGTGGAGCACTCCCACGTCCGATTCC
TGGGGAACCTGGTGCTGAACCTGTGGGACTGTGGCGGTCAGGACACCTTCATGGAAAATTACTTCACCAGCCAGCGAGAC
AATATTTTCCGTAACGTGGAAGTTTTGATTTACGTGTTTGACGTGGAGAGCCGCGAACTGGAAAAGGACATGCATTATTA
CCAGTCGTGTCTGGAGGCCATCCTCCAGAACTCTCCCGACGCCAAAATCTTCTGCCTGGTGCACAAAATGGATCTGGTTC
AGGAGGATCAGCGCGACCTGATTTTTAAAGAGCGAGAGGAAGACCTGAGGCGTCTGTCTCGCCCGCTGGAGTGTGCTTGT
TTTCGAACGTCCATCTGGGATGAGACGCTCTACAAAGCCTGGTCCAGCATCGTCTACCAGCTGATTCCCAACGTTCAGCA
GCTGGAGATGAACCTCAGGAATTTTGCCCAAATCATTGAGGCCGATGAAGTTCTCCTGTTCGAAAGAGCTACGTTCTTGG
TTATTTCCCACTACCAGTGCAAAGAGCAGCGCGACGTCCACCGGTTTGAGAAGATCAGCAACATCATCAAACAGTTCAAG
CTGAGCTGCAGTAAATTGGCCGCTTCCTTCCAGAGCATGGAAGTTAGGAATTCCAACTTCGCTGCTTTCATCGACATCTT
CACTTCAAACACGTACGTGATGGTGGTCATGTCAGACCCGTCGATCCCTTCTGCGGCCACTCTGATCAACATTCGCAATG
CCCGGAAACACTTTGAGAAGCTGGAGAGAGTGGATGGCCCCAAGCACAGTCTTCTTATGCGTTGA

Alignment

ORF - retro_mmul_249 Open Reading Frame is conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 98.09 %
• Parental protein coverage: 90.75 %
• Number of stop codons detected: 0
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  VLPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTF
          V.PNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTF
Retrocopy VMPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTF

Parental  MENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDL
          MENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDL
Retrocopy MENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDL

Parental  IFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAEIIEADEVLLFERA
          IFKEREEDLRRLSRPLEC.CFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFA.IIEADEVLLFERA
Retrocopy IFKEREEDLRRLSRPLECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERA

Parental  TFLVISHYQCKEQRDAHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDP
          TFLVISHYQCKEQRD.HRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDP
Retrocopy TFLVISHYQCKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDP

Parental  SIPSAATLINIRNARKHFEKLERVDGPKQCLLMR
          SIPSAATLINIRNARKHFEKLERVDGPK..LLMR
Retrocopy SIPSAATLINIRNARKHFEKLERVDGPKHSLLMR

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	60.28 RPM	15.58 RPM
SRP007412_brain_prefrontal_cortex	65.76 RPM	12.45 RPM
SRP007412_cerebellum	45.20 RPM	10.91 RPM
SRP007412_heart	23.61 RPM	6.01 RPM
SRP007412_kidney	32.86 RPM	7.28 RPM
SRP007412_liver	18.84 RPM	2.77 RPM
SRP007412_testis	25.18 RPM	4.26 RPM

ChIP-Seq

Macaca mulatta was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_mmul_249 retrocopy.

TSS

Macaca mulatta was not studied using FANTOM5 data.

Lab

retro_mmul_249 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_mmul_249 has 8 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_4
Pan troglodytes	retro_ptro_48
Pongo abelii	retro_pabe_191
Callithrix jacchus	retro_cjac_117
Mus musculus	retro_mmus_159
Sus scrofa	retro_sscr_15
Canis familiaris	retro_cfam_421
Equus caballus	retro_ecab_608

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Parental genes homology:

Parental genes homology involve 21 parental genes, and 21 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000012920	1 retrocopy	retro_amel_1842,
Canis familiaris	ENSCAFG00000016503	1 retrocopy	retro_cfam_421,
Callithrix jacchus	ENSCJAG00000007317	1 retrocopy	retro_cjac_117,
Cavia porcellus	ENSCPOG00000011266	1 retrocopy	retro_cpor_86,
Equus caballus	ENSECAG00000006020	1 retrocopy	retro_ecab_608,
Felis catus	ENSFCAG00000013932	1 retrocopy	retro_fcat_21,
Homo sapiens	ENSG00000083750	1 retrocopy	retro_hsap_4,
Gorilla gorilla	ENSGGOG00000011501	1 retrocopy	retro_ggor_65,
Loxodonta africana	ENSLAFG00000016144	1 retrocopy	retro_lafr_102,
Myotis lucifugus	ENSMLUG00000015720	1 retrocopy	retro_mluc_40,
Macaca mulatta	ENSMMUG00000017635	1 retrocopy	retro_mmul_249 ,
Mustela putorius furo	ENSMPUG00000003730	1 retrocopy	retro_mputfur_87,
Mus musculus	ENSMUSG00000041658	1 retrocopy	retro_mmus_159,
Nomascus leucogenys	ENSNLEG00000016350	1 retrocopy	retro_nleu_13,
Oryctolagus cuniculus	ENSOCUG00000008666	1 retrocopy	retro_ocun_166,
Otolemur garnettii	ENSOGAG00000000345	1 retrocopy	retro_ogar_675,
Procavia capensis	ENSPCAG00000003417	1 retrocopy	retro_pcap_6,
Pongo abelii	ENSPPYG00000020398	1 retrocopy	retro_pabe_191,
Pan troglodytes	ENSPTRG00000021955	1 retrocopy	retro_ptro_48,
Rattus norvegicus	ENSRNOG00000003160	1 retrocopy	retro_rnor_2,
Sus scrofa	ENSSSCG00000029800	1 retrocopy	retro_sscr_15,