RetrogeneDB ID: retro_mmus_578

Retrocopy location

• Organism: Mouse (Mus musculus)
• Coordinates: 10:82223135..82223519(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: Mpc2
• Ensembl ID: ENSMUSG00000026568
• Aliases: Mpc2, 0610006C01Rik, 2010002I07Rik, 2610205H19Rik, AA108335, Brp44, ESTM43
• Description: mitochondrial pyruvate carrier 2 [Source:MGI Symbol;Acc:MGI:1917706]

Sequence

>retro_mmus_578
ATGGCAGCTGCTGGTGCCCGAGGCCTGTGGACCACCTACCACCAACTCATGGATAAAGTGGACTTGTTGCTGCCAAAGAA
ATTGAGGCTGCTTTATCACCTGGCAGGCCCCAGAACAGTTTTTTTCCTGGGCTCCAATAATGAAATGGGGATTGGTATGT
GTTGGATTAGCTGACATGACATGGTCAGACCTACAGAGAAACTCAGTGCAGCTCATTCCACTGTGCTGATGGCTACAGGG
TTTATTTGGTCAAGATACTCACTTATAATTATACCAAAAAATTGGAGTTTGTTCGCTGTTAATTTCTTTGTGGGGTCAGC
AGGAGCCTCTCAGCCGTTTAGGATTTGGAGATATAATCAAGAACTCAAAGGAAATCCAGTAAGA

Alignment

ORF - retro_mmus_578 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 73.64 %
• Parental protein coverage: 100. %
• Number of stop codons detected: 1
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  MAAAGARGLRATYHRLMDKVELLLPKKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLA--DMARPAEKLS
          MAAAGARGL..TYH.LMDKV.LLLPKKLR.LY.H.AGPRTVFF.......G.........DM.RP.EKLS
Retrocopy MAAAGARGLWTTYHQLMDKVDLLLPKKLRLLY-HLAGPRTVFFLGSNNEMGIGMCWIS*HDMVRPTEKLS

Parental  TAQSTVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGSAGASQLFRIWRYNQELKSKGIQ
          .A.STVLMATGFIWSRYSL.IIPKNWSLFAVNFFVGSAGASQ.FRIWRYNQELK.....
Retrocopy AAHSTVLMATGFIWSRYSLIIIPKNWSLFAVNFFVGSAGASQPFRIWRYNQELKGNPVR

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	0.02 RPM	34.37 RPM
SRP007412_cerebellum	0.09 RPM	22.84 RPM
SRP007412_heart	0.00 RPM	122.28 RPM
SRP007412_kidney	0.08 RPM	106.05 RPM
SRP007412_liver	0.03 RPM	97.14 RPM
SRP007412_testis	0.09 RPM	115.31 RPM

ChIP-Seq

RNA Polymerase II actvity near the 5' end of retro_mmus_578 was not detected

EST

No EST(s) were mapped for retro_mmus_578 retrocopy.

TSS

No TSS is located nearby retro_mmus_578 retrocopy 5' end.

Lab

retro_mmus_578 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_mmus_578 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 17 parental genes, and 43 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000006273	2 retrocopies	retro_amel_527, retro_amel_987,
Bos taurus	ENSBTAG00000020968	2 retrocopies	retro_btau_1459, retro_btau_557,
Canis familiaris	ENSCAFG00000015358	2 retrocopies	retro_cfam_1350, retro_cfam_1897,
Choloepus hoffmanni	ENSCHOG00000007752	6 retrocopies	retro_chof_1286, retro_chof_1294, retro_chof_2021, retro_chof_23, retro_chof_47, retro_chof_835,
Callithrix jacchus	ENSCJAG00000016985	1 retrocopy	retro_cjac_4207,
Cavia porcellus	ENSCPOG00000003860	1 retrocopy	retro_cpor_494,
Dasypus novemcinctus	ENSDNOG00000011180	1 retrocopy	retro_dnov_475,
Microcebus murinus	ENSMICG00000011691	5 retrocopies	retro_mmur_1158, retro_mmur_1503, retro_mmur_317, retro_mmur_348, retro_mmur_986,
Myotis lucifugus	ENSMLUG00000011873	1 retrocopy	retro_mluc_610,
Macaca mulatta	ENSMMUG00000010387	1 retrocopy	retro_mmul_432,
Mus musculus	ENSMUSG00000026568	3 retrocopies	retro_mmus_1651, retro_mmus_578 , retro_mmus_647,
Otolemur garnettii	ENSOGAG00000003130	3 retrocopies	retro_ogar_1494, retro_ogar_1992, retro_ogar_2653,
Sus scrofa	ENSSSCG00000006304	1 retrocopy	retro_sscr_241,
Tupaia belangeri	ENSTBEG00000014189	9 retrocopies	retro_tbel_1099, retro_tbel_1446, retro_tbel_1614, retro_tbel_1847, retro_tbel_2174, retro_tbel_3168, retro_tbel_433, retro_tbel_4444, retro_tbel_734,
Tarsius syrichta	ENSTSYG00000010251	3 retrocopies	retro_tsyr_10, retro_tsyr_141, retro_tsyr_1810,
Tursiops truncatus	ENSTTRG00000008566	1 retrocopy	retro_ttru_1743,
Vicugna pacos	ENSVPAG00000010556	1 retrocopy	retro_vpac_51,