RetrogeneDB ID: retro_ptro_160

Retrocopy location

• Organism: Chimpanzee (Pan troglodytes)
• Coordinates: 1:77363352..77364098(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSPTRG00000041210
• Aliases: None
• Status: KNOWN_PSEUDOGENE

Parental gene information

• Parental gene symbol: TPI1
• Ensembl ID: ENSPTRG00000004595
• Aliases: None
• Description: Pan troglodytes triosephosphate isomerase 1 (TPI1), mRNA. [Source:RefSeq mRNA;Acc:NM_001071782]

Sequence

>retro_ptro_160
ATGGCGCCCTCCAGGAAGTTCTTCGTTGGGGGGAACTGGAAGATGAACGGGCGAAAGCAGAGTCTGCGGGAGCTCACCGC
ACTCTGAATGCGGCCAAGGTGCCGGCCAACACCGAGGTGGTTTGTGCTCCGCCTACTGCCTATATCGACTTCGCCCGGCA
GAAGCTAGATCCCAAGATTGCTGTGGCTGCGCAGAACTGCTACAAAGTGACTAATGGGGCTTTTACTGGGGAGATCAGCC
CTGGCATGATCAAAGACTGCGGAGCCACGTGGGTGGTCCTGGGGCACTCAGAGAGAAGGCATGTCTTTGGGGAGTCAGAT
GAGCTGATTGGGCAGAAAGTGGCCCATGCTCTGGCAGAGGGACTCGGAGTAATCGCCTGCACTGGGGAGAAGCTAGATGA
AAGGGAAGCTGGCATCACTGAGAAGGTTGTTTTCGAGCAGACAAAGGTCATCGCAGATAACGTGAAGGACTGGAGCAAGG
TCGTCCTAGCCTATGAGCCTGTGTGGGCCATTGGTACTGGCAAGACTGCAACACCCCAACAGGACCAGGAAGTACACGAG
AAGCTCCGAGGATGGCTTAAGTCCAACGTCTCTGATGCGGTGGCTTAGAGCACCCGTATCATTTATGGAGGCTCTGTGAC
TGGGGCAACCTGCAAGGAGCTGGCCAGCCAGCCTGGCGTGAATGGCTTCCTTGTGGGTGGTGCTTCCCTCAAGCCCGAAT
TCGTGGACATCATCAATGCCAAACAA

Alignment

ORF - retro_ptro_160 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 96.0 %
• Parental protein coverage: 100.0 %
• Number of stop codons detected: 1
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  MAPSRKFFVGGNWKMNGRKQSLGELIG-TLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYK
          MAPSRKFFVGGNWKMNGRKQSL.EL...TLNAAKVPA.TEVVCAPPTAYIDFARQKLDPKIAVAAQNCYK
Retrocopy MAPSRKFFVGGNWKMNGRKQSLRELTA<TLNAAKVPANTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYK

Parental  VTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGI
          VTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIAC.GEKLDEREAGI
Retrocopy VTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACTGEKLDEREAGI

Parental  TEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIY
          TEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQ.QEVHEKLRGWLKSNVSDAVA.STRIIY
Retrocopy TEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQDQEVHEKLRGWLKSNVSDAVA*STRIIY

Parental  GGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ
          GGSVTGATCKELASQP.V.GFLVGGASLKPEFVDIINAKQ
Retrocopy GGSVTGATCKELASQPGVNGFLVGGASLKPEFVDIINAKQ

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	3.40 RPM	602.46 RPM
SRP007412_cerebellum	0.65 RPM	278.72 RPM
SRP007412_heart	0.58 RPM	265.67 RPM
SRP007412_kidney	0.47 RPM	371.36 RPM
SRP007412_liver	0.52 RPM	210.35 RPM
SRP007412_testis	0.42 RPM	142.16 RPM

ChIP-Seq

Pan troglodytes was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_ptro_160 retrocopy.

TSS

Pan troglodytes was not studied using FANTOM5 data.

Lab

retro_ptro_160 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ptro_160 has 2 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_171
Gorilla gorilla	retro_ggor_151

---

Parental genes homology:

Parental genes homology involve 13 parental genes, and 32 retrocopies.

Species	Parental gene accession	Retrocopies number
Callithrix jacchus	ENSCJAG00000007348	2 retrocopies	retro_cjac_2190, retro_cjac_2370,
Homo sapiens	ENSG00000111669	3 retrocopies	retro_hsap_3038, retro_hsap_3510, retro_hsap_3784,
Gorilla gorilla	ENSGGOG00000002623	1 retrocopy	retro_ggor_151,
Macropus eugenii	ENSMEUG00000006977	5 retrocopies	retro_meug_1348, retro_meug_1520, retro_meug_1934, retro_meug_267, retro_meug_512,
Myotis lucifugus	ENSMLUG00000024989	4 retrocopies	retro_mluc_1090, retro_mluc_1311, retro_mluc_1777, retro_mluc_1807,
Macaca mulatta	ENSMMUG00000005194	2 retrocopies	retro_mmul_1864, retro_mmul_250,
Mustela putorius furo	ENSMPUG00000016774	1 retrocopy	retro_mputfur_136,
Mus musculus	ENSMUSG00000023456	4 retrocopies	retro_mmus_1180, retro_mmus_3260, retro_mmus_532, retro_mmus_558,
Nomascus leucogenys	ENSNLEG00000004821	2 retrocopies	retro_nleu_1120, retro_nleu_847,
Otolemur garnettii	ENSOGAG00000031254	1 retrocopy	retro_ogar_109,
Pan troglodytes	ENSPTRG00000004595	4 retrocopies	retro_ptro_160 , retro_ptro_1999, retro_ptro_2382, retro_ptro_2565,
Rattus norvegicus	ENSRNOG00000015290	1 retrocopy	retro_rnor_1304,
Rattus norvegicus	ENSRNOG00000050669	2 retrocopies	retro_rnor_2615, retro_rnor_787,