RetrogeneDB ID: retro_ptro_2537

Retrocopy location

• Organism: Chimpanzee (Pan troglodytes)
• Coordinates: 7:62452448..62453140(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: SAPCD2
• Ensembl ID: ENSPTRG00000021589
• Aliases: None
• Description: suppressor APC domain containing 2 [Source:HGNC Symbol;Acc:28055]

Sequence

>retro_ptro_2537
CCCGCCGAGGCGGCGCAGTGCCCCGCGGGGCCCGAGCGGTTCCAGAGCGCTGCGCTGGAACGGAGACCCGGCGCGGACGC
AGGTGCAGCGGCCTGCAGCGCCTTGGAGGCGGATTCAGGGGATGCCCGGCGGACCCCTGTGCCCGAGGGGAACACCGGAG
GCACACCATCACCAGCGGCGTGGACTGCGGCCTGCTGAAGCAGATGAAGGAGCTGGAGCAGGAGAAGGAGGTGCTGCTGC
AGGGTTTGGAGATGATGGCGCAGGGCCGCGATTGGTACCAGCAGCAGCTGCAACAAGTGCAGGAGCGCCAGTGCCGCCTG
GGCCAGAGCAGAGCCAGCGCCGACTTTGGGGCCGTGGGGAGCCCTCGCCCACTGGGACGGCTACTGCCCAAGGTACAGGA
GGTGGCCCGGTGGCTGGGGGAGCTGCTGGCTGAGGCCTGTGCCTGTCGGGCCCTGCCCACATCCTCCTCCGGGCCCCCTT
GCTCTGCCCTGACGTCCACCTCGTCCCCGGGCTGGCAGCAGCAGATCATCCTCATGCTGAAGGAGCAGAACCGACTCCTC
ACCCAGGAGGTGACCGAGAAGAGTGAGCGCATCACGCAGCTGGAGCAGGAGAAGTCGGCGCTCATTAAGCAGCTATTTGA
GGCCCGCGCCCTGAGCCAGCAGGATGGGGGTCCTCTGGACTCCACCTTTATC

Alignment

ORF - retro_ptro_2537 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 80.6 %
• Parental protein coverage: 100. %
• Number of stop codons detected: 0
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  PAEAAPCPAELERSQSAALEPSSSADAGAVACRALEADSGDARRAPR-ARGERRRHTITSGVDCGLLKQM
          PAEAA.CPA..ER.QSAALE....ADAGA.AC.ALEADSGDARR.P..ARGE.RRHTITSGVDCG.....
Retrocopy PAEAAQCPAGPERFQSAALERRPGADAGAAACSALEADSGDARRTPV<ARGEHRRHTITSGVDCGXXXXX

Parental  KELEQEKEVLLQGLEMMARGRDWYQQQLQRVQERQRRLGQSRASADFGAAGSPRPLGRLLPKVQEVARCL
          .............LEMMA.GRDWYQQQLQ.VQERQ.RLGQSRASADFGA.GSPRPLGRLLPKVQEVAR.L
Retrocopy XXXXXXXXXXXXXLEMMAQGRDWYQQQLQQVQERQCRLGQSRASADFGAVGSPRPLGRLLPKVQEVARWL

Parental  GELLAAACASRALPPSSSGPPCPALRSTSPPVWQQQTILMLKEQNRLLTQEVTEKSERITQLEQEKSALI
          GELLA.ACA.RALP.SSSGPPC.AL.STS.P.WQQQ.ILMLKEQNRLLTQEVTEKSERITQLEQEKSALI
Retrocopy GELLAEACACRALPTSSSGPPCSALTSTSSPGWQQQIILMLKEQNRLLTQEVTEKSERITQLEQEKSALI

Parental  KQLFEARALSQQDGGPLDSTFI
          KQLFEARALSQQDGGPLDSTFI
Retrocopy KQLFEARALSQQDGGPLDSTFI

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	0.59 RPM
SRP007412_cerebellum	0.00 RPM	0.29 RPM
SRP007412_heart	0.00 RPM	0.03 RPM
SRP007412_kidney	0.00 RPM	0.81 RPM
SRP007412_liver	0.00 RPM	0.00 RPM
SRP007412_testis	0.00 RPM	0.11 RPM

ChIP-Seq

Pan troglodytes was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_ptro_2537 retrocopy.

TSS

Pan troglodytes was not studied using FANTOM5 data.

Lab

retro_ptro_2537 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ptro_2537 has 1 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_3738

---

Parental genes homology:

Parental genes homology involve 5 parental genes, and 16 retrocopies.

Species	Parental gene accession	Retrocopies number
Homo sapiens	ENSG00000186193	2 retrocopies	retro_hsap_3734, retro_hsap_3738,
Macaca mulatta	ENSMMUG00000007112	1 retrocopy	retro_mmul_1682,
Nomascus leucogenys	ENSNLEG00000008908	2 retrocopies	retro_nleu_2867, retro_nleu_2939,
Pongo abelii	ENSPPYG00000019804	5 retrocopies	retro_pabe_3124, retro_pabe_3222, retro_pabe_3223, retro_pabe_3233, retro_pabe_3527,
Pan troglodytes	ENSPTRG00000021589	6 retrocopies	retro_ptro_2530, retro_ptro_2532, retro_ptro_2534, retro_ptro_2537 , retro_ptro_2543, retro_ptro_2992,