RetrogeneDB ID: retro_ptro_789

Retrocopy location

• Organism: Chimpanzee (Pan troglodytes)
• Coordinates: 12:110841366..110841687(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSPTRG00000018060
• Aliases: None
• Status: KNOWN_PSEUDOGENE

Parental gene information

• Parental gene symbol: HMGA1
• Ensembl ID: ENSPTRG00000040884
• Aliases: None
• Description: Pan troglodytes high mobility group AT-hook 1 (HMGA1), mRNA. [Source:RefSeq mRNA;Acc:NM_001246496]

Sequence

>retro_ptro_789
ATGAGCGAGTCGAGCTCGAAGTCCAGCCAGCCCTTGGCCTCCAAGCAGGAAAAGGAGGGCACTGAGAAGCGGGGCCGGGG
CAGGCCGCGCAAGCAGCCTCCGATGAGTCCTGGGACAGCGCTTGTAGGGAGTCAGAAGGAGCCCAGCGAAGTGCCAACAC
CTAAGAGACCTCGGGGCCGACCAAAGGGAAGCAAAAACAAGGGTGCCGCCAAGACCCGGAAAACCACCATAACTCCAGGA
AGGAAACCAAGGGGCAGACCCAAAAAACTGGAGAAGTAGGAAGAGGAGGGCATCTCGCAAGAGTCCTCGGAGGAGGAGCA
G

Alignment

ORF - retro_ptro_789 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 96.26 %
• Parental protein coverage: 100. %
• Number of stop codons detected: 1
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  MSESSSKSSQPLASKQEKDGTEKRGRGRPRKQPPVSPGTALVGSQKEPSEVPTPKRPRGRPKGSKNKGAA
          MSESSSKSSQPLASKQEK.GTEKRGRGRPRKQPP.SPGTALVGSQKEPSEVPTPKRPRGRPKGSKNKGAA
Retrocopy MSESSSKSSQPLASKQEKEGTEKRGRGRPRKQPPMSPGTALVGSQKEPSEVPTPKRPRGRPKGSKNKGAA

Parental  KTRKTTTTPGRKPRGRPKKLEKEEEEGISQESSEEEQ
          KTRKTT.TPGRKPRGRPKKLEK.EEEGISQESSEEEQ
Retrocopy KTRKTTITPGRKPRGRPKKLEK*EEEGISQESSEEEQ

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.11 RPM	59.04 RPM
SRP007412_cerebellum	0.11 RPM	58.65 RPM
SRP007412_heart	0.03 RPM	20.23 RPM
SRP007412_kidney	0.00 RPM	17.89 RPM
SRP007412_liver	0.10 RPM	50.67 RPM
SRP007412_testis	0.11 RPM	41.84 RPM

ChIP-Seq

Pan troglodytes was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_ptro_789 retrocopy.

TSS

Pan troglodytes was not studied using FANTOM5 data.

Lab

retro_ptro_789 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ptro_789 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 10 parental genes, and 24 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000001061	1 retrocopy	retro_amel_1637,
Callithrix jacchus	ENSCJAG00000015226	2 retrocopies	retro_cjac_1197, retro_cjac_3158,
Homo sapiens	ENSG00000137309	4 retrocopies	retro_hsap_1175, retro_hsap_2277, retro_hsap_4663, retro_hsap_695,
Myotis lucifugus	ENSMLUG00000010085	2 retrocopies	retro_mluc_1619, retro_mluc_2429,
Macaca mulatta	ENSMMUG00000019529	2 retrocopies	retro_mmul_1276, retro_mmul_2406,
Mus musculus	ENSMUSG00000046711	1 retrocopy	retro_mmus_188,
Nomascus leucogenys	ENSNLEG00000008303	1 retrocopy	retro_nleu_1097,
Pongo abelii	ENSPPYG00000029838	4 retrocopies	retro_pabe_1941, retro_pabe_2441, retro_pabe_3623, retro_pabe_960,
Pan troglodytes	ENSPTRG00000040884	6 retrocopies	retro_ptro_1611, retro_ptro_2053, retro_ptro_3098, retro_ptro_499, retro_ptro_789 , retro_ptro_807,
Rattus norvegicus	ENSRNOG00000000488	1 retrocopy	retro_rnor_164,