RetrogeneDB ID: retro_ptro_844

Retrocopy location

• Organism: Chimpanzee (Pan troglodytes)
• Coordinates: 13:97690312..97690871(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: PSMA6
• Ensembl ID: ENSPTRG00000006264
• Aliases: None
• Description: Pan troglodytes proteasome (prosome, macropain) subunit, alpha type, 6 (PSMA6), mRNA. [Source:RefSeq mRNA;Acc:NM_001246657]

Sequence

>retro_ptro_844
TCCAGCACTGGTTTTGACCGCCAGCTTATAATTTTTTCACCCAAGGTCCAGCTCTACCAAGTACAATATGCTTTTAAGGC
TATTAACCAGGGTGGCCTTACATCAGTAGCTGTCAGAAAGAAAGACTGTGCAGTAATTGTCACACAGAAGATAGTACCTG
ACAAATTATTGGATTCCAGGACTCACTTATTCAAGATGACCAAAAACACTGGCCGTGTGATCACAGGAGTGACAGCTGAC
AGCAGATCCCGGGAACAGAGGGCGCAATATAAGGCAGCTAATTGCAAACACAAGTATGGCTATTAGATTCCTGTGGACAT
GCTGTGTAAAAGGAATTGCTGATATTACTCGGGTCTATACACAGAATGCTGAAATGAGGCCTCTTGGTTGTTGTATGATT
TTAATTAGTATATTTGAAGAACTAGGCCCTCGGGTGTACAAGTGTGATGCTGCGGGTTACTACTGTGGGTTTAAAGCCAC
TGCAGCAGGAGTTAAACAAGCCGAGTCAACCAGCTTCCTTGAAGTGAAGAAGAAATTTGCCTGGACATTTGAACACAGT

Alignment

ORF - retro_ptro_844 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 79.06 %
• Parental protein coverage: 77.24 %
• Number of stop codons detected: 1
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  SSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITE
          SS.GFDR...IFSP...LYQV.YAFKAINQGGLTSVAVR.KDCAVIVTQK.VPDKLLDS.T..HLFK.T.
Retrocopy SSTGFDRQLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTQKIVPDKLLDSRT--HLFKMTK

Parental  NIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKR-IADISQVYTQNAEMRPLGCCMILIGI
          N.G.V.TG.TADSRS..QRA.Y.AAN.K.KYGY.IPVDMLCKR.IADI..VYTQNAEMRPLGCCMILI.I
Retrocopy NTGRVITGVTADSRSREQRAQYKAANCKHKYGY*IPVDMLCKR>IADITRVYTQNAEMRPLGCCMILISI

Parental  DEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQT
          .EE.GP.VYKCD.AGYYCGFKATAAGVKQ.ESTSFLE..VKKKF.WTFE..
Retrocopy FEELGPRVYKCDAAGYYCGFKATAAGVKQAESTSFLE--VKKKFAWTFEHS

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.02 RPM	37.36 RPM
SRP007412_cerebellum	0.04 RPM	34.20 RPM
SRP007412_heart	0.00 RPM	50.92 RPM
SRP007412_kidney	0.00 RPM	52.36 RPM
SRP007412_liver	0.03 RPM	95.62 RPM
SRP007412_testis	0.00 RPM	167.98 RPM

ChIP-Seq

Pan troglodytes was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_ptro_844 retrocopy.

TSS

Pan troglodytes was not studied using FANTOM5 data.

Lab

retro_ptro_844 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ptro_844 has 1 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_1228

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Parental genes homology:

Parental genes homology involve 14 parental genes, and 48 retrocopies.

Species	Parental gene accession	Retrocopies number
Canis familiaris	ENSCAFG00000013409	2 retrocopies	retro_cfam_1581, retro_cfam_743,
Echinops telfairi	ENSETEG00000004892	1 retrocopy	retro_etel_1775,
Felis catus	ENSFCAG00000026276	1 retrocopy	retro_fcat_973,
Homo sapiens	ENSG00000100902	2 retrocopies	retro_hsap_1228, retro_hsap_4923,
Macropus eugenii	ENSMEUG00000016537	1 retrocopy	retro_meug_1217,
Microcebus murinus	ENSMICG00000000083	4 retrocopies	retro_mmur_104, retro_mmur_165, retro_mmur_752, retro_mmur_80,
Myotis lucifugus	ENSMLUG00000010228	1 retrocopy	retro_mluc_822,
Macaca mulatta	ENSMMUG00000016544	1 retrocopy	retro_mmul_343,
Mustela putorius furo	ENSMPUG00000016288	1 retrocopy	retro_mputfur_1089,
Mus musculus	ENSMUSG00000021024	1 retrocopy	retro_mmus_654,
Otolemur garnettii	ENSOGAG00000008492	10 retrocopies	retro_ogar_1273, retro_ogar_1397, retro_ogar_1928, retro_ogar_1950, retro_ogar_2021, retro_ogar_2073, retro_ogar_2274, retro_ogar_2488, retro_ogar_2521, retro_ogar_3089,
Pan troglodytes	ENSPTRG00000006264	2 retrocopies	retro_ptro_3297, retro_ptro_844 ,
Rattus norvegicus	ENSRNOG00000007114	4 retrocopies	retro_rnor_1724, retro_rnor_1960, retro_rnor_854, retro_rnor_924,
Tupaia belangeri	ENSTBEG00000011241	17 retrocopies	retro_tbel_1304, retro_tbel_1415, retro_tbel_1789, retro_tbel_2028, retro_tbel_2466, retro_tbel_2519, retro_tbel_3227, retro_tbel_3280, retro_tbel_3535, retro_tbel_4181, retro_tbel_4183, retro_tbel_4357, retro_tbel_4465, retro_tbel_4495, retro_tbel_509, retro_tbel_602, retro_tbel_725,