RetrogeneDB ID: retro_ggor_1022

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 14:2519653..2520293(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSGGOG00000002390
• Aliases: None
• Status: KNOWN_PSEUDOGENE

Parental gene information

• Parental gene symbol: RBBP4
• Ensembl ID: ENSGGOG00000011313
• Aliases: None
• Description: None

Sequence

>retro_ggor_1022
ATGGCCGTCAAGGAAGCAACCTTCGATGATGGAGTGGAAGATGAGTGATCAACGATGAGTACAAAATATGGAAAAAAAAA
CACCCCTTTTCTTTACCATTTGGTGATGACCCATGCTCTGGAGTGGCCAGCCTAACTGTCCAGTGGCTTCCAGATGAAAC
CAGACCAGAAGGGAAAGATTTCAGCATTCATCGACTTGTCCCGAGGACACACACATTGGATGAACAAAACCATCTTGTTA
TAGCCAGTGTGCAACCCCTAATGATGATGCTCAGTTTGATGCGTCACACTACGACAGTGAGAAAGGAGAATTTGGAGGTT
TTGGTTCAGTTAGTGGCAAAATTGAAATAGAAATCAAGATCAACCATGAAGGAGAAGTAAACAGGGCCTGTTACATGCCC
CAGAACCCTTGTATCATCACAACAAAGACTCCTTCCAGTGATGTTCTTGTCTTTGACTATACAAAACATCCTTCTAAACC
AGATCCTTCTGGAGAGTGCAACCCAGACTTGCGTCTCTGTGGACATCAGAAGGAAGGCTATGGGCTTTCAAGGAACCCAA
ATCTCAGTGGGCATTTACTTAGTGCTTCAGATGACCACACTATCTGCCTGTGGGACATCGGTGCCATTCCAAAGGAGGGA

Alignment

ORF - retro_ggor_1022 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 82.73 %
• Parental protein coverage: 50.23 %
• Number of stop codons detected: 0
• Number of frameshifts detected: 4

Retrocopy - Parental Gene Alignment:

Parental  MADKEAAFDDAVEER-VINEEYKIWKKN-TPFLYDLVMTHALEWP-SLTAQWLPDVTSYRPEGKDFSIHR
          MA.KEA.FDD.VE...VIN.EYKIW....TPFLY.LVMTHALEWP.SLT.QWLPD.T..RPEGKDFSIHR
Retrocopy MAVKEATFDDGVEDE<VINDEYKIWXXX>TPFLYHLVMTHALEWP<SLTVQWLPDET--RPEGKDFSIHR

Parental  LVLGTHTSDEQNHLVIASVQ-LPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMP
          LV..THT.DEQNHLVIASVQ..PNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRA.YMP
Retrocopy LVPRTHTLDEQNHLVIASVQ<TPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRACYMP

Parental  QNPCIIATKTPSSDVLVLDYTKHP-KPDLSGDCNSDLHLHGHQKKGYGLSW-PNLSGHLLSASDDHTIYP
          QNPCII.TKTPSSDVLV.DYTKHP.KPD.SG.CN.DL.L.GHQK.GYGLS..PNLSGHLLSASDDHTI..
Retrocopy QNPCIITTKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLCGHQKEGYGLSRNPNLSGHLLSASDDHTICL

Parental  WDISAVPKEG
          WDI.A.PKEG
Retrocopy WDIGAIPKEG

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	2.11 RPM	33.86 RPM
SRP007412_cerebellum	1.46 RPM	32.70 RPM
SRP007412_heart	0.44 RPM	7.54 RPM
SRP007412_kidney	1.10 RPM	47.84 RPM
SRP007412_liver	0.90 RPM	30.97 RPM
SRP007412_testis	7.77 RPM	172.29 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_1022 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_1022 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_1305
Pan troglodytes	retro_ptro_896
Pongo abelii	retro_pabe_1093

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Parental genes homology:

Parental genes homology involve 12 parental genes, and 29 retrocopies.

Species	Parental gene accession	Retrocopies number
Callithrix jacchus	ENSCJAG00000001021	7 retrocopies	retro_cjac_1157, retro_cjac_1787, retro_cjac_1873, retro_cjac_244, retro_cjac_2557, retro_cjac_2719, retro_cjac_2939,
Cavia porcellus	ENSCPOG00000015352	3 retrocopies	retro_cpor_154, retro_cpor_27, retro_cpor_899,
Gorilla gorilla	ENSGGOG00000011313	4 retrocopies	retro_ggor_1022 , retro_ggor_1314, retro_ggor_1867, retro_ggor_2428,
Gorilla gorilla	ENSGGOG00000013437	1 retrocopy	retro_ggor_1366,
Macaca mulatta	ENSMMUG00000009940	1 retrocopy	retro_mmul_75,
Mustela putorius furo	ENSMPUG00000015214	1 retrocopy	retro_mputfur_104,
Otolemur garnettii	ENSOGAG00000011632	2 retrocopies	retro_ogar_3079, retro_ogar_3297,
Petromyzon marinus	ENSPMAG00000007189	1 retrocopy	retro_pmar_26,
Rattus norvegicus	ENSRNOG00000021492	1 retrocopy	retro_rnor_1270,
Sarcophilus harrisii	ENSSHAG00000010923	1 retrocopy	retro_shar_399,
Tupaia belangeri	ENSTBEG00000002236	3 retrocopies	retro_tbel_1360, retro_tbel_1718, retro_tbel_3802,
Vicugna pacos	ENSVPAG00000011876	4 retrocopies	retro_vpac_333, retro_vpac_419, retro_vpac_652, retro_vpac_94,