RetrogeneDB ID: retro_ggor_1763

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 2b:22608176..22609447(-)
• Located in intron of: ENSGGOG00000003782

Retrocopy information

• Ensembl ID: ENSGGOG00000023113
• Aliases: None
• Status: KNOWN_PSEUDOGENE

Parental gene information

• Parental gene symbol: G3BP2
• Ensembl ID: ENSGGOG00000014947
• Aliases: None
• Description: None

Sequence

>retro_ggor_1763
ATGGTGATGGAGAAGGTTAGTCCCCTGCTGGTTGGGTGGGAATTTGTGAGACAGCATTACACACTGCTGAACTAGGCCCC
AGACATGCTGCATAGATTTTATGGAAGGAACTCTTCTTCTGTCCATGGGGGGATTGGATTCAAACAGAAAGCTAGCAGAT
GCAGTTTACAGACAGAAAGAAATCCACAGGAAAGTGATGTCACGAAACTTCAGCAACTGCCACATCAAGATTCTCCATGC
TGATGCTTATGCCACGCTAAATGATGGTGTGGTAGTCCAGGTGTTGGGGCTTCTGTCTAACAACAACCAGGCTTTGAGGA
GATTCATGCAGATGTTTGTACTTGCTCCTGAGGGGTCTGTTGCAAATCAGTTCTATGTTCACAATGATATCTTCAGATAG
CAAGATGAGGTCTTTGGTGGGTTTGTCACTGAGCCTCAGGAGGAGTCTGAAGAAGTAGTAGAGGAACCTGAAGAAAAGAC
AGCAAACACCTCAGGTGGTACCTGATGATTCTGGAACTTTCTGTGATCAGGCAGTTGTCAGTAATGACGTGGAAGAACAT
TTAGAGGAGCCAGTTGCTGAACTGGAGCCTGATCCTGAACCAGAACCAGAACAAGAATGTGTATCTGAAATCCAAGAGGA
AAAGTCTGAGCTAGTATTAGAAGAAACTGCTCCTGAGGATGCTCAGAAGAGTTCTTCTCCAGCACCTGCAGACATATCTC
AGACAGTACGGGAAGAGTTGAGGACATTTTCTTGGGCGTCTGTGACCAGTAACAACCTTCAACCCAGTGGAGCTGTTCCA
GTTACTCGGATACCTCCTTATGTTGGTAAAGTACTAGCTTCACAGCCCTGTACAGAGTCTAAGCCTGAATCTCAGATTCC
ACCACAGAGACCTCAAAGGGATCAAAGGATGTGGGAACAACGAATAAATATTCCTCCCCAAAAGGGACCCAGACCGATCT
GTGAGGCTGGTGAGCAAGGTGACATTGAACCCCAAAGAGTGGTGAGACACCCTGACAAGTCACCAACTCTTCATTGGCAA
CCTGCCTCATGAAGTGGACAAATCAGAACTTAAAGATTTCTTTCAAAATTATGGGAACGTGGTGGAGTTGCACATTAACA
GTGGTGGGAAATTACCCAGTTTTGGTTTTGTTTTGATGATTCTGAGCCTGTTCAGAAGGTCCTTCGCAACAGGCCCATCA
TGTTCAGAGATGAGGTCTGTCTGAATGTGGAAGAGAAGAAGACTCGAGCTGCCAGGGAAGGGGACTGACGA

Alignment

ORF - retro_ggor_1763 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 57.41 %
• Parental protein coverage: 86.72 %
• Number of stop codons detected: 3
• Number of frameshifts detected: 4

Retrocopy - Parental Gene Alignment:

Parental  MVMEKPSPLLVGREFVRQYYTLLNKAPEYLHRFYGRNSSYVHGGV-DASGKPQEAVYGQNDIHHKVLSLN
          MVMEK.SPLLVG.EFVRQ.YTLLN.AP..LHRFYGRNSS.VHGG..D...K...AVY.Q..IH.KV.S.N
Retrocopy MVMEKVSPLLVGWEFVRQHYTLLN*APDMLHRFYGRNSSSVHGGI>DSNRKLADAVYRQKEIHRKVMSRN

Parental  FSECHTKIRHVDAHATLSDGVVVQVMGLLSNSGQPERKFMQTFVLAPEGSVPNKFYVHNDMFRYEDEVFG
          FS.CH.KI.H.DA.ATL.DGVVVQV.GLLSN..Q..R.FMQ.FVLAPEGSV.N.FYVHND.FR..DEVFG
Retrocopy FSNCHIKILHADAYATLNDGVVVQVLGLLSNNNQALRRFMQMFVLAPEGSVANQFYVHNDIFR*QDEVFG

Parental  DSEPELDEESEDEVEEEQEE-RQPSPEPVQENANSGYYEA---HPVTNGIEEPLEESSHEPEPEPESETK
          ....E..EESE.EV.EE.EE.RQ..P..V..........A.....V....EEP..E....PEPEPE.E..
Retrocopy GFVTEPQEESE-EVVEEPEE>RQQTPQVVPDDSGTFCDQAVVSNDVEEHLEEPVAELEPDPEPEPEQECV

Parental  T---EELKPQVEEKNLEELEEKSTTPPPAEPVSLPQEPPKAFSWASVTSKNLPPSGTVSSSGIPPHV-KA
          ....EE....V.E....E...KS..P.PA.......E....FSWASVTS.NL.PSG.V....IPP.V.K.
Retrocopy SEIQEEKSELVLEETAPEDAQKSSSPAPADISQTVREELRTFSWASVTSNNLQPSGAVPVTRIPPYVGKV

Parental  PVSQPRVEAKPEVQSQPPRV-REQRPRE-RPGFPP-RGPRPGRGDMEQNDSDNRRIIRYPD-SHQLFVGN
          ..SQP..E.KPE.Q..P.R..R.QR..E.R...PP..GPRP.....EQ.D....R..R.PD.SHQLF.GN
Retrocopy LASQPCTESKPESQIPPQRPQRDQRMWEQRINIPPQKGPRPICEAGEQGDIEPQRVVRHPD>SHQLFIGN

Parental  LPHDIDENELKEFFMSFGNVVELRINTKGVGGKLPN-FGFVVFDDSEPVQRILIAKPIMFRGEVRLNVEE
          LPH..D..ELK.FF...GNVVEL.IN....GGKLP..F.F..FDDSEPVQ..L...PIMFR.EV.LNVEE
Retrocopy LPHEVDKSELKDFFQNYGNVVELHINS---GGKLPS<FWFC-FDDSEPVQKVLRNRPIMFRDEVCLNVEE

Parental  KKTRAARERETR
          KKTRAARE...R
Retrocopy KKTRAAREGD*R

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	4.80 RPM	232.24 RPM
SRP007412_cerebellum	3.31 RPM	110.00 RPM
SRP007412_heart	1.72 RPM	15.89 RPM
SRP007412_kidney	5.89 RPM	90.65 RPM
SRP007412_liver	3.32 RPM	36.72 RPM
SRP007412_testis	10.57 RPM	233.00 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_1763 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_1763 has 2 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_2322
Pan troglodytes	retro_ptro_1696

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Parental genes homology:

Parental genes homology involve 5 parental genes, and 5 retrocopies.

Species	Parental gene accession	Retrocopies number
Callithrix jacchus	ENSCJAG00000019897	1 retrocopy	retro_cjac_4164,
Echinops telfairi	ENSETEG00000016219	1 retrocopy	retro_etel_86,
Gorilla gorilla	ENSGGOG00000014947	1 retrocopy	retro_ggor_1763 ,
Otolemur garnettii	ENSOGAG00000000157	1 retrocopy	retro_ogar_810,
Ictidomys tridecemlineatus	ENSSTOG00000012975	1 retrocopy	retro_itri_1853,