RetrogeneDB ID: retro_mmul_2295

Retrocopy location

• Organism: Rhesus macaque (Macaca mulatta)
• Coordinates: 8:76336798..76337196(+)
• Located in intron of: ENSMMUG00000009755

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: RGS10
• Ensembl ID: ENSMMUG00000021610
• Aliases: None
• Description: regulator of G-protein signaling 10 [Source:RefSeq peptide;Acc:NP_001248583]

Sequence

>retro_mmul_2295
TACATCCATGACAGTAATAGCAGTTCTGGCAGCAGCCACCAGCGCCTCAAGAGCACAGCCAAACGGGTGGCTTTCCTGGA
TAATCCGGTGGAAGACCTAGAAGGCATGACAAAATTTAGGAAATTTTTTAAAAAGAAATTCAATGAAGAAAATATTTTGT
TTTGGCTAGCATGTAAAGATTTCTTTTTTTAATGCAAGATAAGCAGATGCAGGAAAAGGCAAAGGAGGTCTACATGACCT
TTCTTTCCAGTAAGGCCTCGTCAGAAGTCAAAAAGAGGCAGTCTTCGCTCAACAAAAAGATTCTGGAAGAATCACATCCT
CTGATGTTCCAGGAACTCCAGGACTGGATCTTCAATCTCACCAAGTACAACAGCTACAGTAGCTGCTTAAAGTTTGAC

Alignment

ORF - retro_mmul_2295 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 66.67 %
• Parental protein coverage: 80.24 %
• Number of stop codons detected: 0
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  HIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFSEENVLFWLACED-FKKMQDKTQ
          .IHDS..SS.SSHQ.LKSTAK..A.L.N..ED.EG...FR.F.KK.F.EEN.LFWLAC.D.F.......Q
Retrocopy YIHDSNSSSGSSHQRLKSTAKRVAFLDNPVEDLEGMTKFRKFFKKKFNEENILFWLACKD<FLFLMQDKQ

Parental  MQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSD
          MQEKAKE.YMTFLSSKASS.V....QS.LN.KILEE.HPLMFQ.LQD.IFNL.KY.SYS..LK.D
Retrocopy MQEKAKEVYMTFLSSKASSEVK-KRQSSLNKKILEESHPLMFQELQDWIFNLTKYNSYSSCLKFD

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	0.00 RPM	2.24 RPM
SRP007412_brain_prefrontal_cortex	0.00 RPM	2.22 RPM
SRP007412_cerebellum	0.06 RPM	1.29 RPM
SRP007412_heart	0.00 RPM	1.00 RPM
SRP007412_kidney	0.00 RPM	2.00 RPM
SRP007412_liver	0.12 RPM	0.59 RPM
SRP007412_testis	0.45 RPM	0.15 RPM

ChIP-Seq

Macaca mulatta was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_mmul_2295 retrocopy.

TSS

Macaca mulatta was not studied using FANTOM5 data.

Lab

retro_mmul_2295 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_mmul_2295 has 2 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Gorilla gorilla	retro_ggor_2669
Pongo abelii	retro_pabe_3268

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Parental genes homology:

Parental genes homology involve 5 parental genes, and 5 retrocopies.

Species	Parental gene accession	Retrocopies number
Gorilla gorilla	ENSGGOG00000008414	1 retrocopy	retro_ggor_2669,
Macaca mulatta	ENSMMUG00000021610	1 retrocopy	retro_mmul_2295 ,
Nomascus leucogenys	ENSNLEG00000016735	1 retrocopy	retro_nleu_2034,
Procavia capensis	ENSPCAG00000003150	1 retrocopy	retro_pcap_59,
Pongo abelii	ENSPPYG00000002702	1 retrocopy	retro_pabe_3268,