RetrogeneDB ID: retro_ggor_2205

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 5:116336906..116337816(+)
• Located in intron of: ENSGGOG00000011786

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: None
• Ensembl ID: ENSGGOG00000025675
• Aliases: None
• Description: Elongation factor 1-alpha [Source:UniProtKB/TrEMBL;Acc:G3S518]

Sequence

>retro_ggor_2205
TATCTCCTTCTGACTTACACACTGGGTGTGAAACAGCTAATTGCTGGAGTTAACAAAATGGATTCCACTTAGCCGCCCTA
CAAACAGAAGAGATACAAGGAAATGGTTAAGGAAGTCAGCCCTTACAATAAGAAAGTTGGCCACAACCCCAACACAGTAG
CATTTGTGCCCATTTCTGGTTGGAATGATGGCAACATGCTGTGGCTAAGTGCTAACATGCCTTGGTTCAAGGGATGGAAA
GTCACCTGTAAAGATGGCAAATGCCAGTGTAAACACCCTGCTTGAAGCTCTGGATTGCATCTTACTACCAATTTGTCCAA
CTGACAAGCCCTTGTGTCTGTCTCTCCAAAATATCTACAAAATTGGTGGTATTGGTACTATCTCTGTAGGCCAAGTGGAG
ACTGGTGTCAGCATAGAGGTCACCTTGGCTCCAGTCAACGTTACAACTAAAGCCAAATGTGTTGCAATATACCATGAAGC
TTTGAGTGAAGTTTTTCCTGGGAACAATGGGGGCTTCAACATCAAGAACATATCTGTCAAAAATGTTCATCATGGCAATG
TTGCTGGTGACAGAAAAAATGACCCACCAATGGAAGCAGCTGGCTTCACTGCTCAGGTGATTATCCTGAACCACCCAGTC
CAAATCAATGCTGGCTATGCTCCTGTAATGGACTGCCACATGGCTCACACTGCCTGCAAGTTTCCTGAGCTGAAGGGAAA
GACGGATTGCCATTCTGGTAAGCTGAAAGATGGCCCTAAATTCTTGAAATCTGGTAATGCTCCCATCTTTGATAAAATTC
CTGGCAAGCCCACACGTGTGTTGAGAGCTTCTGACTATCCTTCTTTGGGTTGTTTTGTTGTTCATAATGTAAGACAAACA
GTTGCTGTGAGTGTCATCAAAACAGAGGAT

Alignment

ORF - retro_ggor_2205 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 72.4 %
• Parental protein coverage: 66.45 %
• Number of stop codons detected: 1
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  HALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPS
          ..LL.YTLGVKQLI.GVNKMDST.PPY.QKRY.E.VKEVS.Y.KK.G.NP.TVAFVPISGWN..NML..S
Retrocopy YLLLTYTLGVKQLIAGVNKMDST*PPYKQKRYKEMVKEVSPYNKKVGHNPNTVAFVPISGWNDGNMLWLS

Parental  ANMPWFKGWKVTRKDG-NASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKP
          ANMPWFKGWKVT.KDG.NAS..TLLEALDCIL.P..PTDKPL.L.LQ..YKIGGIGT..VG.VETGV...
Retrocopy ANMPWFKGWKVTCKDG>NASVNTLLEALDCILLPICPTDKPLCLSLQNIYKIGGIGTISVGQVETGV---

Parental  GMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQV
          ...VT.APVNVTT..K.V...HEALSE..PG.N.GFN.KN.SVK.V..GNVAGD.KNDPPMEAAGFTAQV
Retrocopy SIEVTLAPVNVTTKAKCVAIYHEALSEVFPGNNGGFNIKNISVKNVHHGNVAGDRKNDPPMEAAGFTAQV

Parental  IILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVES
          IILNHP.QI.AGYAPV.DCH.AH.ACKF.ELK.K.D..SG.KL.DGPKFLKSG.A.I.D..PGKP..V..
Retrocopy IILNHPVQINAGYAPVMDCHMAHTACKFPELKGKTDCHSG-KLKDGPKFLKSGNAPIFDKIPGKPTRVLR

Parental  FSDYPPLGRFAVRDMRQTVAVGVIKAVD
          .SDYP.LG.F.V...RQTVAV.VIK..D
Retrocopy ASDYPSLGCFVVHNVRQTVAVSVIKTED

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.05 RPM	813.64 RPM
SRP007412_cerebellum	0.16 RPM	767.71 RPM
SRP007412_heart	0.03 RPM	312.04 RPM
SRP007412_kidney	0.33 RPM	4298.85 RPM
SRP007412_liver	0.13 RPM	2725.93 RPM
SRP007412_testis	0.10 RPM	1470.18 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_2205 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_2205 has 1 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_3239

---

Parental genes homology:

Parental genes homology involve 13 parental genes, and 87 retrocopies.

Species	Parental gene accession	Retrocopies number
Canis familiaris	ENSCAFG00000013249	1 retrocopy	retro_cfam_1007,
Dipodomys ordii	ENSDORG00000009629	1 retrocopy	retro_dord_509,
Equus caballus	ENSECAG00000022260	1 retrocopy	retro_ecab_802,
Erinaceus europaeus	ENSEEUG00000000342	3 retrocopies	retro_eeur_407, retro_eeur_492, retro_eeur_625,
Echinops telfairi	ENSETEG00000004236	14 retrocopies	retro_etel_1189, retro_etel_1248, retro_etel_1260, retro_etel_1429, retro_etel_1436, retro_etel_1472, retro_etel_1578, retro_etel_1602, retro_etel_1682, retro_etel_1808, retro_etel_2135, retro_etel_366, retro_etel_411, retro_etel_830,
Gorilla gorilla	ENSGGOG00000025675	20 retrocopies	retro_ggor_1193, retro_ggor_1258, retro_ggor_1305, retro_ggor_1444, retro_ggor_1529, retro_ggor_20, retro_ggor_2006, retro_ggor_2021, retro_ggor_2056, retro_ggor_2066, retro_ggor_2205 , retro_ggor_2526, retro_ggor_2637, retro_ggor_2826, retro_ggor_322, retro_ggor_375, retro_ggor_790, retro_ggor_860, retro_ggor_919, retro_ggor_978,
Loxodonta africana	ENSLAFG00000028081	1 retrocopy	retro_lafr_651,
Microcebus murinus	ENSMICG00000015319	21 retrocopies	retro_mmur_1027, retro_mmur_1116, retro_mmur_1145, retro_mmur_1182, retro_mmur_1190, retro_mmur_12, retro_mmur_1282, retro_mmur_1316, retro_mmur_1339, retro_mmur_1343, retro_mmur_1350, retro_mmur_1568, retro_mmur_171, retro_mmur_26, retro_mmur_273, retro_mmur_49, retro_mmur_682, retro_mmur_729, retro_mmur_825, retro_mmur_877, retro_mmur_9,
Monodelphis domestica	ENSMODG00000018533	4 retrocopies	retro_mdom_1053, retro_mdom_1146, retro_mdom_311, retro_mdom_792,
Mus musculus	ENSMUSG00000037742	15 retrocopies	retro_mmus_1349, retro_mmus_1518, retro_mmus_1667, retro_mmus_1783, retro_mmus_1816, retro_mmus_1849, retro_mmus_1850, retro_mmus_1864, retro_mmus_1909, retro_mmus_2363, retro_mmus_2583, retro_mmus_2902, retro_mmus_3249, retro_mmus_480, retro_mmus_483,
Pongo abelii	ENSPPYG00000016777	1 retrocopy	retro_pabe_12,
Ictidomys tridecemlineatus	ENSSTOG00000007687	4 retrocopies	retro_itri_1509, retro_itri_1740, retro_itri_1816, retro_itri_195,
Drosophila melanogaster	FBgn0000557	1 retrocopy	retro_dmel_9,