RetrogeneDB ID: retro_pabe_145

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 4:196299142..196300078(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSPPYG00000015262
• Aliases: None
• Status: KNOWN_PROTEIN_CODING

Parental gene information

• Parental gene symbol: YY1
• Ensembl ID: ENSPPYG00000025949
• Aliases: None
• Description: YY1 transcription factor [Source:HGNC Symbol;Acc:12856]

Sequence

>retro_pabe_145
ATGAACCAGCAACTGAAGAAACTGGCAAAGACGAGACGCCAGAAAGGCCTGGGTGGAAGAGCCCCCAGTGGGGCTAAGCC
CAGGCACGACAAGGCAAGCCAAGACCTGCAGGCGGAAATAGAACCTGTCAGTGTGGTGTGGGCCTTATGTGATGGCTATG
TGTGCTATGAGCCTGGCCCTCAGGCTCTCGGAGAGGATGATTTCTCAGACTGTTACATAGAATGCATCATAAGGGGTGAG
TTTTCTCAACCCATCCTGGAAGAGGACTCACGTTTTGAGTCCTTGGAATACCTAAAGAAAGGATCAGAACAAGAGCTTTC
TCAAAAGGTTCTCGAAGCAAGCTCCCTTCTTGAATGTTCTTTGGAATACATGAAAAAAGGGGCAAAGAAAGAGCTTCCTC
AAAAGATAGTTGGAGAGAATTCGCTTGAGTATTCTGAGTACATGACAGGCAAGAAGCTTCCGCCTGGAGGAATACCCGGC
ATTGACTTATCAGATCCTAAACAGCTCGCAGAATTTGCTAGAAAGAAGCCCCCCATAAATAAAGAATATGACAGCCTCAG
CGCGATCGCTTGTCCTCAGAGTGGATGCACTAAGAAGTTGAGGAATAGAGCTGCCCTGAGAAAGCATCTCCTCATTCATG
GTCCCCGAAACCACGTCTGTGCGGAATGTGGGAAAGCGTTCGTTGAGAGCTCAAAACTAAAAAGACATTTCCTGGTTCAT
ACTGGAGAGAAGCCGTTTCAGTGCACTTTTGAAGGGTGCGGAAAACGCTTCTCTCTGGACTTTAATTTGCGTACACATGT
ACGCATCCACACGGGGGAGAAACGTTTTGTGTGTCCCTTTCAAGGCTGTAACAGGAGGTTTATTCAGTCAAATAACCTGA
AAGCCCACATCCTAACCCATGCAAATACGAACGAGAATGAACAAGATGGAAAGTAG

Alignment

ORF - retro_pabe_145 Open Reading Frame is conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 76.0 %
• Parental protein coverage: 92.59 %
• Number of stop codons detected: 0
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  EQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPHKGCTKMFRD
          ..I.GENS...YSEYMTGKKLPPGGIPGIDLSDPKQLAEFAR.KP...KE.D....IACP..GCTK..R.
Retrocopy QKIVGENSL-EYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARKKPPINKEYDSLSAIACPQSGCTKKLRN

Parental  NSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTG
          ..A.RKHL..HGPR.HVCAECGKAFVESSKLKRH.LVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTG
Retrocopy RAALRKHLLIHGPRNHVCAECGKAFVESSKLKRHFLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTG

Parental  DRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ
          ....VCPF.GCN..F.QS.NLK.HILTHA....N.
Retrocopy EKRFVCPFQGCNRRFIQSNNLKAHILTHANTNENE

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	8.79 RPM
SRP007412_cerebellum	0.00 RPM	19.09 RPM
SRP007412_heart	0.00 RPM	5.72 RPM
SRP007412_kidney	0.00 RPM	9.78 RPM
SRP007412_liver	0.00 RPM	9.61 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_145 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_145 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_145 has 4 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_106
Pan troglodytes	retro_ptro_45
Gorilla gorilla	retro_ggor_190
Equus caballus	retro_ecab_97

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Parental genes homology:

Parental genes homology involve 10 parental genes, and 22 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000011146	1 retrocopy	retro_amel_2,
Callithrix jacchus	ENSCJAG00000016853	2 retrocopies	retro_cjac_1931, retro_cjac_4045,
Equus caballus	ENSECAG00000005805	1 retrocopy	retro_ecab_97,
Homo sapiens	ENSG00000100811	2 retrocopies	retro_hsap_106, retro_hsap_97,
Gorilla gorilla	ENSGGOG00000026332	2 retrocopies	retro_ggor_190, retro_ggor_2,
Mus musculus	ENSMUSG00000021264	1 retrocopy	retro_mmus_190,
Nomascus leucogenys	ENSNLEG00000000999	3 retrocopies	retro_nleu_1092, retro_nleu_116, retro_nleu_2225,
Otolemur garnettii	ENSOGAG00000006955	4 retrocopies	retro_ogar_1231, retro_ogar_1804, retro_ogar_1857, retro_ogar_289,
Pongo abelii	ENSPPYG00000025949	3 retrocopies	retro_pabe_145 , retro_pabe_3616, retro_pabe_534,
Pan troglodytes	ENSPTRG00000006717	3 retrocopies	retro_ptro_3093, retro_ptro_45, retro_ptro_494,