RetrogeneDB ID: retro_pabe_1512

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 17:53309876..53310288(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: FAM136A
• Ensembl ID: ENSPPYG00000012323
• Aliases: None
• Description: family with sequence similarity 136, member A [Source:HGNC Symbol;Acc:25911]

Sequence

>retro_pabe_1512
ATGGCAGAGCTGCAGCAGCTGTGGGTGCAGGAGGTGGTGGACTCCATGGTGAAGAGTCTGGAGAGAGAGAACATCTGGAA
GATGCAGGGTCTCATGTTCTGGTGCAGCATCAGCTGTTGTGAGAACAGCCAGGCTTCCATGCAGTAGTAGGTGCACCAGT
GCATCAAAGCACTGCCATGTGCCTCTGGCTCAAGCCCAGGCTTTGGTCACCAGTGAGTTGGAGAAGTTCCAGGACCACCT
GGCCCGGTGCGCCATGCATTGCAACAACGAAGCCAAAGATTCAATGGATGCTGGGAGTAAGGAGCTTCAGGTGAAGCAGC
AGCTGGACGGTTGTGTGACCAAGTGTGTGGATGACCACATGCACCTCATCCCAACTATGACCAAGAAGATGAAGGAGGCT
CTCTTATCAATG

Alignment

ORF - retro_pabe_1512 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 86.23 %
• Parental protein coverage: 98.55 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  MAELQQLRVQEAVDSMVKSLERENIRKMQGLMFRCSASCCEDSQASMKQ-VHQCIE-RCHVPLAQAQALV
          MAELQQL.VQE.VDSMVKSLERENI.KMQGLMF.CS.SCCE.SQASM...VHQCI...CHVPLAQAQALV
Retrocopy MAELQQLWVQEVVDSMVKSLERENIWKMQGLMFWCSISCCENSQASMQ**VHQCIK>HCHVPLAQAQALV

Parental  TSELEKFQDRLARCTMHCNDKAKDSIDAGSKELQVKQQLDSCVTKCVDDHMHLIPTMTKKMKEALLSI
          TSELEKFQD.LARC.MHCN..AKDS.DAGSKELQVKQQLD.CVTKCVDDHMHLIPTMTKKMKEALLS.
Retrocopy TSELEKFQDHLARCAMHCNNEAKDSMDAGSKELQVKQQLDGCVTKCVDDHMHLIPTMTKKMKEALLSM

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.28 RPM	14.10 RPM
SRP007412_cerebellum	0.24 RPM	13.74 RPM
SRP007412_heart	0.03 RPM	8.82 RPM
SRP007412_kidney	0.23 RPM	20.85 RPM
SRP007412_liver	0.06 RPM	14.66 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_1512 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_1512 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_1512 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_1855
Pan troglodytes	retro_ptro_1237
Gorilla gorilla	retro_ggor_2155

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Parental genes homology:

Parental genes homology involve 18 parental genes, and 73 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000015992	1 retrocopy	retro_amel_1454,
Bos taurus	ENSBTAG00000008674	2 retrocopies	retro_btau_37, retro_btau_88,
Canis familiaris	ENSCAFG00000003353	2 retrocopies	retro_cfam_1042, retro_cfam_148,
Cavia porcellus	ENSCPOG00000009117	1 retrocopy	retro_cpor_221,
Dasypus novemcinctus	ENSDNOG00000019447	7 retrocopies	retro_dnov_2036, retro_dnov_2465, retro_dnov_2612, retro_dnov_324, retro_dnov_620, retro_dnov_873, retro_dnov_901,
Felis catus	ENSFCAG00000008119	1 retrocopy	retro_fcat_1459,
Homo sapiens	ENSG00000035141	5 retrocopies	retro_hsap_1855, retro_hsap_2599, retro_hsap_2683, retro_hsap_3136, retro_hsap_3413,
Gorilla gorilla	ENSGGOG00000023247	6 retrocopies	retro_ggor_1361, retro_ggor_1625, retro_ggor_2155, retro_ggor_2356, retro_ggor_53, retro_ggor_8,
Macropus eugenii	ENSMEUG00000015791	8 retrocopies	retro_meug_1126, retro_meug_1351, retro_meug_1545, retro_meug_167, retro_meug_2131, retro_meug_219, retro_meug_457, retro_meug_719,
Macaca mulatta	ENSMMUG00000007962	5 retrocopies	retro_mmul_1421, retro_mmul_1772, retro_mmul_220, retro_mmul_327, retro_mmul_656,
Monodelphis domestica	ENSMODG00000011533	1 retrocopy	retro_mdom_65,
Mus musculus	ENSMUSG00000057497	2 retrocopies	retro_mmus_240, retro_mmus_3101,
Pongo abelii	ENSPPYG00000012323	6 retrocopies	retro_pabe_1512 , retro_pabe_1917, retro_pabe_2297, retro_pabe_2618, retro_pabe_2828, retro_pabe_3032,
Pan troglodytes	ENSPTRG00000012030	6 retrocopies	retro_ptro_1237, retro_ptro_1523, retro_ptro_1809, retro_ptro_2120, retro_ptro_2318, retro_ptro_3063,
Rattus norvegicus	ENSRNOG00000016273	1 retrocopy	retro_rnor_1679,
Sus scrofa	ENSSSCG00000026446	6 retrocopies	retro_sscr_1075, retro_sscr_229, retro_sscr_230, retro_sscr_309, retro_sscr_335, retro_sscr_914,
Tupaia belangeri	ENSTBEG00000017418	8 retrocopies	retro_tbel_1377, retro_tbel_1875, retro_tbel_2479, retro_tbel_2516, retro_tbel_3373, retro_tbel_3703, retro_tbel_401, retro_tbel_999,
Tursiops truncatus	ENSTTRG00000001198	5 retrocopies	retro_ttru_1110, retro_ttru_1771, retro_ttru_1903, retro_ttru_396, retro_ttru_550,