RetrogeneDB ID: retro_ptro_2733

Retrocopy location

• Organism: Chimpanzee (Pan troglodytes)
• Coordinates: 8:23128793..23129050(-)
• Located in intron of: ENSPTRG00000020100

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: COX6B1
• Ensembl ID: ENSPTRG00000010854
• Aliases: None
• Description: Cytochrome c oxidase subunit VIb polypeptide 1 (Ubiquitous) [Source:UniProtKB/TrEMBL;Acc:K7CTL6]

Sequence

>retro_ptro_2733
AGCACCTTGGCAAAAGACATGGAGACCAAAATCAAGAACTACAAGACTGTCCCTTTTGACAGATGCTTCCCCAACCAGAC
TAGGAACTGCTGGCAGAACTTCCTGGATTTCCACCTCTGTGAGAAGGCAACAACCGCTGAAGGGTGTGATGTCTCTATGT
GTGAATGATACCAGTGTGTGTACAAGTTCTTCTGCCCTGCTCCTGGGTTTCAGTCTAGCATGACAGCTGGGCTAAAGGCA
CATTTCCTGGAAAGATC

Alignment

ORF - retro_ptro_2733 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 66.29 %
• Parental protein coverage: 98.88 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  STMAEDMETKIKNYKTAPFDSRFPNQNQTRNCWQNYLDFHRCQKAMTAKGGDISVCEWYQRVYQSLCPT-
          ST.A.DMETKIKNYKT.PFD..FP..NQTRNCWQN.LDFH.C.KA.TA.G.D.S.CE.YQ.VY...CP..
Retrocopy STLAKDMETKIKNYKTVPFDRCFP--NQTRNCWQNFLDFHLCEKATTAEGCDVSMCE*YQCVYKFFCPA<

Parental  SWVTDWDEQRAEGTFPGKI
          SWV.......A.GTFPGKI
Retrocopy SWVSV*HDSWAKGTFPGKI

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.02 RPM	105.24 RPM
SRP007412_cerebellum	0.00 RPM	32.23 RPM
SRP007412_heart	0.23 RPM	100.26 RPM
SRP007412_kidney	0.03 RPM	133.19 RPM
SRP007412_liver	0.75 RPM	52.64 RPM
SRP007412_testis	0.00 RPM	18.55 RPM

ChIP-Seq

Pan troglodytes was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_ptro_2733 retrocopy.

TSS

Pan troglodytes was not studied using FANTOM5 data.

Lab

retro_ptro_2733 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ptro_2733 has 2 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_4032
Macaca mulatta	retro_mmul_2327

---

Parental genes homology:

Parental genes homology involve 22 parental genes, and 79 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000000563	3 retrocopies	retro_amel_1653, retro_amel_581, retro_amel_775,
Canis familiaris	ENSCAFG00000006913	7 retrocopies	retro_cfam_1614, retro_cfam_1760, retro_cfam_517, retro_cfam_6, retro_cfam_775, retro_cfam_830, retro_cfam_929,
Callithrix jacchus	ENSCJAG00000010211	5 retrocopies	retro_cjac_1513, retro_cjac_2007, retro_cjac_268, retro_cjac_2870, retro_cjac_2924,
Equus caballus	ENSECAG00000012317	3 retrocopies	retro_ecab_1051, retro_ecab_190, retro_ecab_719,
Felis catus	ENSFCAG00000006378	5 retrocopies	retro_fcat_107, retro_fcat_2017, retro_fcat_293, retro_fcat_758, retro_fcat_783,
Homo sapiens	ENSG00000126267	5 retrocopies	retro_hsap_1762, retro_hsap_2906, retro_hsap_3807, retro_hsap_4032, retro_hsap_4089,
Microcebus murinus	ENSMICG00000009902	5 retrocopies	retro_mmur_1099, retro_mmur_1413, retro_mmur_1588, retro_mmur_77, retro_mmur_809,
Myotis lucifugus	ENSMLUG00000011365	4 retrocopies	retro_mluc_2244, retro_mluc_2455, retro_mluc_55, retro_mluc_933,
Macaca mulatta	ENSMMUG00000016765	5 retrocopies	retro_mmul_1212, retro_mmul_1227, retro_mmul_1655, retro_mmul_1989, retro_mmul_2327,
Monodelphis domestica	ENSMODG00000013962	1 retrocopy	retro_mdom_1046,
Mustela putorius furo	ENSMPUG00000006258	1 retrocopy	retro_mputfur_998,
Mus musculus	ENSMUSG00000036751	1 retrocopy	retro_mmus_2498,
Nomascus leucogenys	ENSNLEG00000011283	5 retrocopies	retro_nleu_1914, retro_nleu_2396, retro_nleu_2829, retro_nleu_2845, retro_nleu_978,
Oryctolagus cuniculus	ENSOCUG00000009606	2 retrocopies	retro_ocun_1797, retro_ocun_840,
Oryzias latipes	ENSORLG00000006070	1 retrocopy	retro_olat_4,
Pan troglodytes	ENSPTRG00000010854	4 retrocopies	retro_ptro_1209, retro_ptro_1964, retro_ptro_2583, retro_ptro_2733 ,
Pteropus vampyrus	ENSPVAG00000012821	8 retrocopies	retro_pvam_1031, retro_pvam_1044, retro_pvam_1331, retro_pvam_303, retro_pvam_336, retro_pvam_576, retro_pvam_717, retro_pvam_757,
Rattus norvegicus	ENSRNOG00000024309	1 retrocopy	retro_rnor_201,
Sorex araneus	ENSSARG00000010771	1 retrocopy	retro_sara_51,
Sus scrofa	ENSSSCG00000002907	2 retrocopies	retro_sscr_780, retro_sscr_89,
Tarsius syrichta	ENSTSYG00000014563	8 retrocopies	retro_tsyr_1179, retro_tsyr_1257, retro_tsyr_1260, retro_tsyr_1897, retro_tsyr_44, retro_tsyr_486, retro_tsyr_78, retro_tsyr_80,
Tursiops truncatus	ENSTTRG00000002241	2 retrocopies	retro_ttru_619, retro_ttru_94,