RetrogeneDB ID: retro_chof_2177

Retrocopy location

• Organism: Sloth (Choloepus hoffmanni)
• Coordinates: scaffold_55676:7145..7837(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: CLIC4
• Ensembl ID: ENSCHOG00000007591
• Aliases: None
• Description: chloride intracellular channel 4 [Source:HGNC Symbol;Acc:13518]

Sequence

>retro_chof_2177
GCTGGTAGTGATGGTGAAAGCATAGGAAACTGTACCTTTTCCCAGAGGCTCTTCATGATTCTTTGGCTCAGATGAGTTGT
GTTTAGTGTTATGACCAATCATTGACCTAAAAGGAAAGCCTGCAGACCTGCAGAACTTGGCTCCCGGGACCCACCTACCA
TTTATAACTTTCAACAATGAAGTCAAAGCAGATGTAAATAAGATTGAGGAATTTCTTGAAAAAAGTCTTATGCCCTCCCA
AGTGCTTAAAGCTTTCACCAAAGCACCCAGAGTCCAATACTGCTGGATTGGACATCTATGCCAAATTCTCTGCATGTAAC
AAGAATTCAAGGCCAGAGGGCTAAGGAAACACTGGAGAGGGGTCTCTTGAAAATACTGCAGAAACTGGTTGAATATCTGA
ATTCTCCCCTCCCTGATGAAATTGATGAGAATAGTATGGAGGATATTAAATTTTCTAAGTGAAAATTTCTGGATGGCAAT
GAAATGACATTAGCTGATTGCAACCTGCTCCTAAACTGCACATTGTCAAGATGGTGGCCAAGAAGAATCACAATTTTGAT
ATCCCAAAAGAAATGACTGGCATCTAGAGATACTTAACTAATGCTTATGTTAGGGATGAGTTCACCAGAACCTGTCCCAG
TGATAAGGAGGGTGAAATAGCATATAGAGATGTAGCCACAAGACTCACCAAG

Alignment

ORF - retro_chof_2177 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 84.62 %
• Parental protein coverage: 100. %
• Number of stop codons detected: 4
• Number of frameshifts detected: 4

Retrocopy - Parental Gene Alignment:

Parental  AGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVD-LKRK-PADLQNLAPGTHPPFITFNNEVKTDVNKIE
          AGSDGESIGNC.FSQRLFMILWL..VVFSV.T....KRK.PADLQNLAPGTH.PFITFNNEVK.DVNKIE
Retrocopy AGSDGESIGNCTFSQRLFMILWLR*VVFSVMTNH*PKRK>PADLQNLAPGTHLPFITFNNEVKADVNKIE

Parental  EFLE-EVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPE-ANEALERGLLKTLQKLDEYLNSPLP
          EFLE..VLCPPK.LKLSPKHPESNTAG.DI.AKFSA..KNSRPE.A.E.LERGLLK.LQKL.EYLNSPLP
Retrocopy EFLE>KVLCPPKCLKLSPKHPESNTAGLDIYAKFSACNKNSRPE>AKETLERGLLKILQKLVEYLNSPLP

Parental  DEIDENSMEDIKFSTRKFLDGNEMTLADCNLL-PKLHIVKVVAKKYRNFDIPKGMTGIWRYLTNAYSRDE
          DEIDENSMEDIKFS..KFLDGNEMTLADCNLL.PKLHIVK.VAKK..NFDIPK.MTGI.RYLTNAY.RDE
Retrocopy DEIDENSMEDIKFSK*KFLDGNEMTLADCNLL<PKLHIVKMVAKKNHNFDIPKEMTGI*RYLTNAYVRDE

Parental  FTNTCPSDKEVEIAYSDVAKRLTK
          FT.TCPSDKE.EIAY.DVA.RLTK
Retrocopy FTRTCPSDKEGEIAYRDVATRLTK

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Choloepus hoffmanni was not studied using RNA-Seq expression data.

ChIP-Seq

Choloepus hoffmanni was not studied using ChIP-Seq data.

EST

Choloepus hoffmanni was not studied using EST data.

TSS

Choloepus hoffmanni was not studied using FANTOM5 data.

Lab

retro_chof_2177 was not experimentally validated.

Homology

Retrocopy orthology:

Choloepus hoffmanni does not belong to any of the species groups (eutheria, teleost or neognath), studied for retrocopy-based homology. For more information about studied groups, please go to help section.

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Parental genes homology:

Parental genes homology involve 16 parental genes, and 36 retrocopies.

Species	Parental gene accession	Retrocopies number
Choloepus hoffmanni	ENSCHOG00000007591	10 retrocopies	retro_chof_1284, retro_chof_1401, retro_chof_1446, retro_chof_1654, retro_chof_2177 , retro_chof_2673, retro_chof_784, retro_chof_789, retro_chof_808, retro_chof_947,
Callithrix jacchus	ENSCJAG00000020833	2 retrocopies	retro_cjac_1713, retro_cjac_461,
Cavia porcellus	ENSCPOG00000004010	1 retrocopy	retro_cpor_1490,
Homo sapiens	ENSG00000169504	2 retrocopies	retro_hsap_4143, retro_hsap_4678,
Gorilla gorilla	ENSGGOG00000005586	2 retrocopies	retro_ggor_1579, retro_ggor_2783,
Macropus eugenii	ENSMEUG00000008789	1 retrocopy	retro_meug_780,
Macaca mulatta	ENSMMUG00000002416	2 retrocopies	retro_mmul_1183, retro_mmul_2488,
Mus musculus	ENSMUSG00000037242	2 retrocopies	retro_mmus_2259, retro_mmus_945,
Nomascus leucogenys	ENSNLEG00000008997	3 retrocopies	retro_nleu_1457, retro_nleu_1785, retro_nleu_2168,
Otolemur garnettii	ENSOGAG00000014620	1 retrocopy	retro_ogar_2672,
Pongo abelii	ENSPPYG00000001715	3 retrocopies	retro_pabe_219, retro_pabe_3466, retro_pabe_3632,
Pan troglodytes	ENSPTRG00000000350	3 retrocopies	retro_ptro_2816, retro_ptro_3107, retro_ptro_396,
Pteropus vampyrus	ENSPVAG00000005838	1 retrocopy	retro_pvam_812,
Ictidomys tridecemlineatus	ENSSTOG00000002184	1 retrocopy	retro_itri_52,
Tarsius syrichta	ENSTSYG00000008978	1 retrocopy	retro_tsyr_252,
Vicugna pacos	ENSVPAG00000007699	1 retrocopy	retro_vpac_475,