RetrogeneDB ID:

retro_hsap_213

Retrocopy
location
Organism:Human (Homo sapiens)
Coordinates:1:118092036..118092472(+)
Located in intron of:None
Retrocopy
information
Ensembl ID:ENSG00000226755
Aliases:None
Status:KNOWN_PSEUDOGENE
Parental gene
information
Parental gene summary:
Parental gene symbol:VPS25
Ensembl ID:ENSG00000131475
Aliases:VPS25, DERP9, EAP20, FAP20
Description:vacuolar protein sorting 25 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:28122]


Retrocopy-Parental alignment summary:






>retro_hsap_213
ATGGTGACGAATTTCAAGTGGTTGTGGCAGTATCGCTTTCCCGCCCTTTACATTACAGCTGAACGTGGCCACTTGGCAGA
AGCAGCTGGCCACCTGGTGTTTGTTGGTTCTGTCCATCTGCTGCCTGCACAGACAGTCAAGCATGATGGTTATGGATGCT
CAGGAGATCCTGCTCTTCAGCAACATCAAGCTGTGGAAGCTTCCTGTGGGATCAATCCAGGTTGTATTAGAGGAACTGAG
GAAGAATGGGAACTTACAGTGGCTGGATAAGAGCAAGTCTAGTTTCCTAATCATGTGGCGGAGGCCAGAAGAATGGGGAA
AACTCATCTATCAGTGGGTCTCCAGGAGTGGCCAGAACAACTCCGTACTTAGCCTGTATGAGCTGACCAATGGGGAAGAC
ATAGAGAATGAGGTGTTCCACGGACTAAAGGAGGCC

ORF - retro_hsap_213 Open Reading Frame is not conserved.
Retrocopy - Parental Gene Alignment summary:
Percent Identity: 77.7 %
Parental protein coverage: 83.52 %
Number of stop codons detected: 0
Number of frameshifts detected 1


Retrocopy - Parental Gene Alignment:

ParentalMAMSFEWPWQYRF-PPFFTLQPNVDTRQKQLAAWCSLVLSFCRLHKQSSMTVMEAQESPLFNNVKLQRKL
M...F.W.WQYRF.PPF.TLQ.NV.T.QKQLA.WC.LVLS.C.LH.QSSM.VM.AQE..LF.N.KL..KL
RetrocopyMVTNFKWLWQYRF>PPF-TLQLNVATWQKQLATWCLLVLSICCLHRQSSMMVMDAQEILLFSNIKLW-KL
ParentalPVESIQIVLEELRKKGNLEWLDKSKSSFLIMWRRPEEWGKLIYQWVSRSGQNNSVFTLYELTNGEDTEDE
PV.SIQ.VLEELRK.GNL.WLDKSKSSFLIMWRRPEEWGKLIYQWVSRSGQNNSV..LYELTNGED.E.E
RetrocopyPVGSIQVVLEELRKNGNLQWLDKSKSSFLIMWRRPEEWGKLIYQWVSRSGQNNSVLSLYELTNGEDIENE
ParentalEFHGLDEA
.FHGL.EA
RetrocopyVFHGLKEA

Legend:
*Stop codon
>Forward frameshift by one nucleotide
<Reverse frameshift by one nucleotide






RNA-Seq - click to see more details

(Hint: click retrocopy or parental gene accession number on the plot's legend, to show / hide expression level values)

Expression validation based on RNA-Seq data:
Library Retrocopy expression Parental gene expression
bodymap2_adipose 0 .00 RPM 13 .78 RPM
bodymap2_adrenal 0 .00 RPM 21 .53 RPM
bodymap2_brain 0 .00 RPM 8 .20 RPM
bodymap2_breast 0 .00 RPM 14 .55 RPM
bodymap2_colon 0 .00 RPM 10 .92 RPM
bodymap2_heart 0 .00 RPM 8 .62 RPM
bodymap2_kidney 0 .00 RPM 35 .88 RPM
bodymap2_liver 0 .02 RPM 23 .66 RPM
bodymap2_lung 0 .00 RPM 11 .76 RPM
bodymap2_lymph_node 0 .00 RPM 12 .61 RPM
bodymap2_ovary 0 .00 RPM 20 .61 RPM
bodymap2_prostate 0 .00 RPM 19 .92 RPM
bodymap2_skeletal_muscle 0 .00 RPM 11 .42 RPM
bodymap2_testis 0 .09 RPM 18 .99 RPM
bodymap2_thyroid 0 .00 RPM 22 .45 RPM
bodymap2_white_blood_cells 0 .00 RPM 22 .88 RPM

ChIP-Seq - click to see more details

RNA Polymerase II actvity near the 5' end of retro_hsap_213 was not detected

EST - click to see more details

No EST(s) were mapped for retro_hsap_213 retrocopy.

TSS - click to see more details

No TSS is located nearby retro_hsap_213 retrocopy 5' end.

Lab - click to see more details

retro_hsap_213 was not experimentally validated.

Retrocopy orthology:
Retrocopy retro_hsap_213 has 4 orthologous retrocopies within eutheria group .

Species RetrogeneDB ID
Pan troglodytes retro_ptro_334
Gorilla gorilla retro_ggor_284
Pongo abelii retro_pabe_427
Macaca mulatta retro_mmul_406
Parental genes homology:
Parental genes homology involve 9 parental genes, and 11 retrocopies.

Species Parental gene accession Retrocopies number
Callithrix jacchus ENSCJAG000000132761 retrocopy
retro_cjac_2959,
Homo sapiens ENSG00000131475 1 retrocopy
retro_hsap_213 ,
Gorilla gorilla ENSGGOG000000160411 retrocopy
retro_ggor_284,
Macropus eugenii ENSMEUG000000116112 retrocopies
retro_meug_1247, retro_meug_1681,
Macaca mulatta ENSMMUG000000021491 retrocopy
retro_mmul_406,
Nomascus leucogenys ENSNLEG000000117971 retrocopy
retro_nleu_1862,
Ochotona princeps ENSOPRG000000125741 retrocopy
retro_opri_1071,
Pongo abelii ENSPPYG000000083771 retrocopy
retro_pabe_427,
Pan troglodytes ENSPTRG000000092202 retrocopies
retro_ptro_1624, retro_ptro_334,

Expression level across human populations :
image/svg+xml GBR_HG00142 GBR_HG00099 GBR_HG00114 GBR_HG00143 GBR_HG00131 GBR_HG00137 GBR_HG00133 GBR_HG00119 GBR_HG00111 GBR_HG00134 FIN_HG00378 FIN_HG00338 FIN_HG00349 FIN_HG00375 FIN_HG00315 FIN_HG00277 FIN_HG00328 FIN_HG00321 FIN_HG00377 FIN_HG00183 TSI_NA20756 TSI_NA20538 TSI_NA20798 TSI_NA20532 TSI_NA20765 TSI_NA20518 TSI_NA20513 TSI_NA20512 TSI_NA20771 TSI_NA20786 YRI_NA19114 YRI_NA19099 YRI_NA18870 YRI_NA18907 YRI_NA19223 YRI_NA19214 YRI_NA18916 YRI_NA19093 YRI_NA19118 YRI_NA19213 Toscaniin Italia: Finnish inFinland: British in England and Scotland: Utah Residents (CEPH) with Northernand Western European Ancestry: Yoruba in Ibadan, Nigeria: CEU_NA12760 CEU_NA12827 CEU_NA12872 CEU_NA12751 CEU_NA12873 CEU_NA12400 CEU_NA11930 CEU_NA12004 CEU_NA11831 CEU_NA11843 No expression ( = 0 RPM ) > 0 RPM = 0.07 RPM Legend:


Library Retrogene expression
CEU_NA11831 0 .00 RPM
CEU_NA11843 0 .00 RPM
CEU_NA11930 0 .00 RPM
CEU_NA12004 0 .00 RPM
CEU_NA12400 0 .00 RPM
CEU_NA12751 0 .00 RPM
CEU_NA12760 0 .00 RPM
CEU_NA12827 0 .00 RPM
CEU_NA12872 0 .03 RPM
CEU_NA12873 0 .00 RPM
FIN_HG00183 0 .00 RPM
FIN_HG00277 0 .07 RPM
FIN_HG00315 0 .00 RPM
FIN_HG00321 0 .00 RPM
FIN_HG00328 0 .00 RPM
FIN_HG00338 0 .02 RPM
FIN_HG00349 0 .00 RPM
FIN_HG00375 0 .02 RPM
FIN_HG00377 0 .00 RPM
FIN_HG00378 0 .04 RPM
GBR_HG00099 0 .00 RPM
GBR_HG00111 0 .00 RPM
GBR_HG00114 0 .00 RPM
GBR_HG00119 0 .00 RPM
GBR_HG00131 0 .00 RPM
GBR_HG00133 0 .02 RPM
GBR_HG00134 0 .02 RPM
GBR_HG00137 0 .03 RPM
GBR_HG00142 0 .00 RPM
GBR_HG00143 0 .00 RPM
TSI_NA20512 0 .00 RPM
TSI_NA20513 0 .02 RPM
TSI_NA20518 0 .00 RPM
TSI_NA20532 0 .03 RPM
TSI_NA20538 0 .05 RPM
TSI_NA20756 0 .00 RPM
TSI_NA20765 0 .04 RPM
TSI_NA20771 0 .00 RPM
TSI_NA20786 0 .05 RPM
TSI_NA20798 0 .00 RPM
YRI_NA18870 0 .00 RPM
YRI_NA18907 0 .00 RPM
YRI_NA18916 0 .04 RPM
YRI_NA19093 0 .00 RPM
YRI_NA19099 0 .00 RPM
YRI_NA19114 0 .00 RPM
YRI_NA19118 0 .00 RPM
YRI_NA19213 0 .02 RPM
YRI_NA19214 0 .00 RPM
YRI_NA19223 0 .00 RPM

Indel association:

No indels were associated with its genomic coordinates. Based on Kabza et al. 2015 (PubMed).



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