RetrogeneDB ID: retro_mmus_1812

Retrocopy location

• Organism: Mouse (Mus musculus)
• Coordinates: 19:13791964..13792514(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: Cops8
• Ensembl ID: ENSMUSG00000034432
• Aliases: Cops8, 9430009J09Rik, AA408242, Csn8, Sgn8
• Description: COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana) [Source:MGI Symbol;Acc:MGI:1915363]

Sequence

>retro_mmus_1812
AGTTTTAGAAAGCTGCTGGATTAGTCTGAGAGCCTCAAGCTTGAGACTCCAGGAGGAATTGCCACACCATCAGTGTATGA
TCAGCTTCTAACTTTGTATTTACTCAAGAAAGACAAAAATAATACAAGATATCTTTGGAAGAGTATACTACCTGCCATAA
AGTTTGCAAATTCTGAACTTGGGTAAATTTGGTCAGTTGGACAGCAAATCTTACAAATAGCTTTTCCCAGGATCTATGCC
ACCATCAATGCCTACCAGTGCTGAAGACTGTACAGCAAATTATGAAAACCCTTAGAGATTCAATGAGGAGACAGTCCTTT
GCCCTGGACTCTCAAGGTTATAACTCCATAATTATAGATGATATCACAGACTTTGACAGGCTTAATGTGGAAGAGTCTAT
GAAAGCTGTGTTGTAATAAGGATTGCAGGCAGACTCCACCACAAGAATGGTTCTTTCCAGGAATCAGCCTCAGGAGCCCT
GGATATTTCTTTGAACATGTTTATTCTCCTATCAGAGTCTCCTCCCGTTCTTCCAATCCCCAATGATGAG

Alignment

ORF - retro_mmus_1812 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 65.59 %
• Parental protein coverage: 88.04 %
• Number of stop codons detected: 4
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  SFRKLLDQCENQELEAPGGIATPPVYGQLLALYLLQNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRI
          SFRKLLD..E...LE.PGGIATP.VY.QLL.LYLL..D.NN.RYLWK.I.PAIK.ANSELG.IWSVGQ.I
Retrocopy SFRKLLD*SESLKLETPGGIATPSVYDQLLTLYLLKKDKNNTRYLWKSILPAIKFANSELG*IWSVGQQI

Parental  WQRDFPGIYTTINAHQW-SETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGVLE
          .Q..FP.IY.TINA.Q....TVQ.IM..LRD..RR..FAL.SQ.Y.SII.DD...F..L.VEE..K.VL.
Retrocopy LQIAFPRIYATINAYQC<LKTVQQIMKTLRDSMRRQSFALDSQGYNSIIIDDITDFDRLNVEESMKAVL*

Parental  QGWQADSTTRMVLPR-KPASGTLDVSLNRFIPLSEPAPVPPIPNEQ
          .G.QADSTTRMVL.R...ASG.LD.SLN.FI.LSE..PV.PIPN..
Retrocopy *GLQADSTTRMVLSR<ESASGALDISLNMFILLSESPPVLPIPNDE

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	0.00 RPM	66.89 RPM
SRP007412_cerebellum	0.00 RPM	54.71 RPM
SRP007412_heart	0.00 RPM	53.45 RPM
SRP007412_kidney	0.00 RPM	38.94 RPM
SRP007412_liver	0.00 RPM	20.04 RPM
SRP007412_testis	0.00 RPM	36.64 RPM

ChIP-Seq

RNA Polymerase II actvity near the 5' end of retro_mmus_1812 was not detected

EST

No EST(s) were mapped for retro_mmus_1812 retrocopy.

TSS

No TSS is located nearby retro_mmus_1812 retrocopy 5' end.

Lab

retro_mmus_1812 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_mmus_1812 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 20 parental genes, and 44 retrocopies.

Species	Parental gene accession	Retrocopies number
Bos taurus	ENSBTAG00000005854	3 retrocopies	retro_btau_1315, retro_btau_1401, retro_btau_1402,
Canis familiaris	ENSCAFG00000030168	1 retrocopy	retro_cfam_1327,
Callithrix jacchus	ENSCJAG00000002267	1 retrocopy	retro_cjac_4193,
Dasypus novemcinctus	ENSDNOG00000015309	5 retrocopies	retro_dnov_1157, retro_dnov_1306, retro_dnov_149, retro_dnov_1701, retro_dnov_527,
Felis catus	ENSFCAG00000013789	1 retrocopy	retro_fcat_1648,
Homo sapiens	ENSG00000198612	2 retrocopies	retro_hsap_2657, retro_hsap_4869,
Loxodonta africana	ENSLAFG00000008617	1 retrocopy	retro_lafr_928,
Macropus eugenii	ENSMEUG00000008189	3 retrocopies	retro_meug_583, retro_meug_609, retro_meug_701,
Macaca mulatta	ENSMMUG00000021605	1 retrocopy	retro_mmul_2610,
Monodelphis domestica	ENSMODG00000007474	1 retrocopy	retro_mdom_1295,
Mustela putorius furo	ENSMPUG00000000068	1 retrocopy	retro_mputfur_176,
Mus musculus	ENSMUSG00000034432	1 retrocopy	retro_mmus_1812 ,
Nomascus leucogenys	ENSNLEG00000010706	2 retrocopies	retro_nleu_1528, retro_nleu_2002,
Oryctolagus cuniculus	ENSOCUG00000007341	4 retrocopies	retro_ocun_1549, retro_ocun_1579, retro_ocun_428, retro_ocun_550,
Pongo abelii	ENSPPYG00000013308	1 retrocopy	retro_pabe_3787,
Rattus norvegicus	ENSRNOG00000019635	3 retrocopies	retro_rnor_1005, retro_rnor_1078, retro_rnor_975,
Ictidomys tridecemlineatus	ENSSTOG00000022662	4 retrocopies	retro_itri_1065, retro_itri_1383, retro_itri_1737, retro_itri_296,
Tupaia belangeri	ENSTBEG00000015944	1 retrocopy	retro_tbel_4315,
Tarsius syrichta	ENSTSYG00000002196	7 retrocopies	retro_tsyr_1053, retro_tsyr_1559, retro_tsyr_165, retro_tsyr_1695, retro_tsyr_1874, retro_tsyr_448, retro_tsyr_943,
Tursiops truncatus	ENSTTRG00000013614	1 retrocopy	retro_ttru_1448,