RetrogeneDB ID: retro_pabe_445

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 1:136754767..136756068(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: LPCAT2
• Ensembl ID: ENSPPYG00000007358
• Aliases: None
• Description: lysophosphatidylcholine acyltransferase 2 [Source:HGNC Symbol;Acc:26032]

Sequence

>retro_pabe_445
GTACGAATGTCCTGCATTGCCTTCCTCTTCGTCTGGCCAGTGGCCATGCTTTCCACCTTTGGCTATCCTGCTCAAATCCT
GCAACCCTGCCAAGAGTTGGAGAAAAAAAACAGGTGAAACCAGTACTCAAGCTCATGCTTCAGGTGGCTTTCTTTTTAGC
TGGGTTCCTGGCTAAAGTGAAAGGGAAAAAGGCAACCCAAGACAAGGCCCCTATCTTCGTTACAGCACCACGGTCCACTT
TCTTTGACTCAATCCCCTGTGTGGTGGCGGGGTTACCCTCAGTGGTCTCTGCAAGTCAAAATGTGCAGATCCCATTGGCT
GGGAAATTCCTACTGTCAACACAGCTGGTGCTTGTGATCCGAGAAGACCCCAATTCCAGGAAGAATACTAAGGATGAAAT
CTTGAAGTGAGTGACATTTGGAAAGAAGTGGCCACAGATTCTGATTTTCCTAGAAGGTGTGTGCACCAATCGCTCCCGTC
TAGTCACTTTTAAACTAGAGGCCTTCTGTCCAGGTGTTCCTGTGTAGCCAGTGCTGCTCAGGTACCCAAACACCCTGGAC
ATGGCAATCTGGACCTGGCAGGGATTTACAGCCTTCCAGGCCTGTATGTTGACACTCAGTCAACTCTTCACCAGGGTAGA
AGTTGAGTTTATGCCTGTTTATATCCCAAATGATGAAGAAAAAAAAGACCCCATCCTTTTTGCCAATACAGTACACATCA
GACACGGCAAATGCTCTAGGGGTGCCTGGGACAGGGCACACTTATAAAGACTGCAGACTGATGATCTCTGCAGGTAACCT
TCAACTACCCATAGAACTGGCTTGGTGGAATTTACAAAAATTAACCAGAAGTTGAAGTTAGATAGGGATAACATTCATCA
GCATTTGGATGAATATGCTGCAATTGCAGTTGCCTCAAAAGGAGGGAAGACAGGAATTGAAGAATTTTCAAGTTATTTAA
AACTCCCAATTTCAGAGCCCTTGAGACAACCCCCTGCCCTCTTTGGCAGGAATAATGATGGCAGCATAGACTTCAGAGAG
TATGTAATAGGTCTGACTGTTCTATGCAATCCTGCCAACATTGAAAAGAGTCTGCAAATGTCCTTTAAGCTTTTTGATCT
TGATGCGGATGGTTTAATAACAGAACAGGAGTTCGCTGCTATACTTCAGGCAGCTTTTGGAGTGCCAGATCTTGATGTTT
CCAGGCTCTTTCAGGAAATAGCTGGACAGAAATCAGTGTACATTTTATATGAGAGATTTAAGAAATTTGCCCTGAAGCAT
CCAGCATATCCCAAGTTATTT

Alignment

ORF - retro_pabe_445 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 61.33 %
• Parental protein coverage: 93.49 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 4

Retrocopy - Parental Gene Alignment:

Parental  VLLVALILLLAWPFAAISTVCCPEKLT-HPVTGWRRKITQTA-LKFLGRAMFFSMGFIVAVKGKIASPLE
          V.......L..WP.A..ST...P......P...W......T..LK......FF..GF...VKGK.A....
Retrocopy VRMSCIAFLFVWPVAMLSTFGYPAQIL>NPAKSWXXXXGETS>LKLMLQVAFFLAGFLAKVKGKKATQDK

Parental  APVFVAAPHSTFFDGIACVVAGLPSIVSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKNTINEILKRTT
          AP.FV.AP.STFFD.I.CVVAGLPS.VS...N.Q.PL.G..L...Q.VLV.R.DP.SRKNT..EILK..T
Retrocopy APIFVTAPRSTFFDSIPCVVAGLPSVVSASQNVQIPLAGKFLLSTQLVLVIREDPNSRKNTKDEILK*VT

Parental  SGGEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPILLRYPNNLDTVTWTWQGYTFIQLCMLTFCQL
          .G..WPQIL.F.EG.CTNRS.L.TFK..AF.PGVPV.P.LLRYPN.LD...WTWQG.T..Q.CMLT..QL
Retrocopy FGKKWPQILIFLEGVCTNRSRLVTFKLEAFCPGVPV*PVLLRYPNTLDMAIWTWQGFTAFQACMLTLSQL

Parental  FTKVEVEFMPVQVPNDEEKNDPVLFANKVR-NLMAEALGIPVTDHTYEDCRLMISAGQLTLPME-AGLVE
          FT.VEVEFMPV..PNDE...DP.LFAN.V.....A.ALG.P.T.HTY.DCRLMISAG.L.LP.E..GLVE
Retrocopy FTRVEVEFMPVYIPNDEXXXDPILFANTVH>SDTANALGVPGTGHTYKDCRLMISAGNLQLPIE<TGLVE

Parental  FTKISRKLKLDWDGVRKHLDEYASIASSSKGGRIGIEEFAKYLKLPVSDVLRQLFALFDRNHDGSIDFRE
          FTKI..KLKLD.D....HLDEYA.IA..SKGG..GIEEF..YLKLP.S..LRQ..ALF.RN.DGSIDFRE
Retrocopy FTKINQKLKLDRDNIHQHLDEYAAIAVASKGGKTGIEEFSSYLKLPISEPLRQPPALFGRNNDGSIDFRE

Parental  YVIGLAVLCNPSNTEEIIQVAFKLFDVDEDGYITEEEFSTILQASLGVPDLDVSGLFKEIAQGDS--ISY
          YVIGL.VLCNP.N.E...Q..FKLFD.D.DG.ITE.EF..ILQA..GVPDLDVS.LF.EIA...S..I.Y
Retrocopy YVIGLTVLCNPANIEKSLQMSFKLFDLDADGLITEQEFAAILQAAFGVPDLDVSRLFQEIAGQKSVYILY

Parental  EEFKSFALKHPEYAKIF
          E.FK.FALKHP.Y.K.F
Retrocopy ERFKKFALKHPAYPKLF

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.06 RPM	2.05 RPM
SRP007412_cerebellum	0.12 RPM	1.09 RPM
SRP007412_heart	0.00 RPM	2.77 RPM
SRP007412_kidney	0.00 RPM	2.39 RPM
SRP007412_liver	0.00 RPM	4.50 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_445 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_445 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_445 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 20 parental genes, and 21 retrocopies.

Species	Parental gene accession	Retrocopies number
Bos taurus	ENSBTAG00000019272	1 retrocopy	retro_btau_64,
Callithrix jacchus	ENSCJAG00000012902	1 retrocopy	retro_cjac_2945,
Dasypus novemcinctus	ENSDNOG00000006859	1 retrocopy	retro_dnov_1735,
Dipodomys ordii	ENSDORG00000013193	1 retrocopy	retro_dord_399,
Equus caballus	ENSECAG00000009649	1 retrocopy	retro_ecab_865,
Erinaceus europaeus	ENSEEUG00000014277	1 retrocopy	retro_eeur_109,
Homo sapiens	ENSG00000087253	1 retrocopy	retro_hsap_185,
Gorilla gorilla	ENSGGOG00000005144	1 retrocopy	retro_ggor_266,
Loxodonta africana	ENSLAFG00000003965	1 retrocopy	retro_lafr_66,
Myotis lucifugus	ENSMLUG00000004008	1 retrocopy	retro_mluc_88,
Macaca mulatta	ENSMMUG00000004478	1 retrocopy	retro_mmul_392,
Mus musculus	ENSMUSG00000033192	1 retrocopy	retro_mmus_270,
Nomascus leucogenys	ENSNLEG00000001258	1 retrocopy	retro_nleu_994,
Pongo abelii	ENSPPYG00000007358	1 retrocopy	retro_pabe_445 ,
Pan troglodytes	ENSPTRG00000008124	2 retrocopies	retro_ptro_171, retro_ptro_2928,
Pteropus vampyrus	ENSPVAG00000007801	1 retrocopy	retro_pvam_173,
Rattus norvegicus	ENSRNOG00000016643	1 retrocopy	retro_rnor_309,
Sorex araneus	ENSSARG00000011914	1 retrocopy	retro_sara_88,
Sarcophilus harrisii	ENSSHAG00000012383	1 retrocopy	retro_shar_116,
Tursiops truncatus	ENSTTRG00000001182	1 retrocopy	retro_ttru_188,