RetrogeneDB ID: retro_btau_449

Retrocopy location

• Organism: Cow (Bos taurus)
• Coordinates: 11:71628295..71628937(-)
• Located in intron of: ENSBTAG00000031335

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: BNIP3L
• Ensembl ID: ENSBTAG00000021307
• Aliases: None
• Description: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [Source:UniProtKB/Swiss-Prot;Acc:Q3T013]

Sequence

>retro_btau_449
ATGTCACCTCATTTAGTAGAACAGCCACTGCCCCTGCACAACAACAACTGTGAGAGAGGTGAACAGTCTCTGCCACTGCC
TGCTGGCCTCAACAGTTCCTGGGTGGAGCTCCCCGTGAACAGCAGCAATGGCAACGATAATGGCAATGGGAAGAATGGGG
GGCTGGAGCACGTACCTTCCCATACTCCATCCATAGCGGGGACATGGAGAAGATTCTTTTGGATGCACAGCATGAATCCA
GACAGAGCAGTTCAAGAAGCAGTTCTCACTGCAACAGCCCTTCCACAAGATGGGCAGGTCATGTTTGATATGGAAATGCA
CACCAGCAAGGACCATAGCTCTCAGTCAGAAGAAGTTGCAGAAGGCGAGAAAGAAGTGGATGCTCTGAAGAAAAGCATAG
TCTGGGTGTCTGACTGATCCAGTAGACCTGAAAACATTCTACCCAAGGAGTTCCACTTCAGGCACCCTAAACATTCCATT
TCCTTAAGCATGAGTTAAAGTGGGGCCATGAAGAAAGGGGGGATCTTCTCTGCAGAGTTTCTTAAGGTATTCATTCCATC
TCTCTTCCTCTTCCATGTTTTGGCTTTGGGGCTCAGCATCTACATTGGAAAATGACTGAGCACACCTTCTGCCAGCACCT
AC

Alignment

ORF - retro_btau_449 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 84.62 %
• Parental protein coverage: 100.0 %
• Number of stop codons detected: 3
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  MSSHLVEQPPPPHNNNNNCEEGEQSLPPPAGLNSSWVELPMNSSNGNDNGNGKNGGLEHVPSSS-SIHNG
          MS.HLVEQP.P.HNNN..CE.GEQSLP.PAGLNSSWVELP.NSSNGNDNGNGKNGGLEHVPS...SIH.G
Retrocopy MSPHLVEQPLPLHNNN--CERGEQSLPLPAGLNSSWVELPVNSSNGNDNGNGKNGGLEHVPSHT<SIHSG

Parental  DMEKILLDAQHESGQSSSRGSSHCDSPSPQ-EDGQIMFDVEMHTSKDHSSQSEEEVAEGEKEVDALKKSV
          DMEKILLDAQHES.QSSSR.SSHC...SP...DGQ.MFD.EMHTSKDHSSQSEE.VAEGEKEVDALKKS.
Retrocopy DMEKILLDAQHESRQSSSRSSSHCN--SPS>QDGQVMFDMEMHTSKDHSSQSEE-VAEGEKEVDALKKSI

Parental  DWVSDWSSRPENIPPKEFHFRHPKRSVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSHVLALGLGIYIG
          .WVSD.SSRPENI.PKEFHFRHPK.S.SLSM..SGAMKKGGIFSAEFLKVFIPSLFL.HVLALGL.IYIG
Retrocopy VWVSD*SSRPENILPKEFHFRHPKHSISLSMS*SGAMKKGGIFSAEFLKVFIPSLFLFHVLALGLSIYIG

Parental  KRLSTPSASTY
          K.LSTPSASTY
Retrocopy K*LSTPSASTY

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
ERP005899_liver	0.00 RPM	47.29 RPM
ERP005899_muscle	0.00 RPM	53.95 RPM
SRP017611_brain	0.00 RPM	51.02 RPM
SRP017611_kidney	0.00 RPM	58.09 RPM
SRP017611_liver	0.00 RPM	39.42 RPM
SRP030211_testis	0.03 RPM	44.41 RPM

ChIP-Seq

Bos taurus was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_btau_449 retrocopy.

TSS

Bos taurus was not studied using FANTOM5 data.

Lab

retro_btau_449 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_btau_449 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 21 parental genes, and 36 retrocopies.

Species	Parental gene accession	Retrocopies number
Bos taurus	ENSBTAG00000021307	4 retrocopies	retro_btau_1148, retro_btau_1170, retro_btau_1790, retro_btau_449 ,
Choloepus hoffmanni	ENSCHOG00000007732	3 retrocopies	retro_chof_2356, retro_chof_2475, retro_chof_980,
Dasypus novemcinctus	ENSDNOG00000016179	1 retrocopy	retro_dnov_2101,
Dipodomys ordii	ENSDORG00000009336	1 retrocopy	retro_dord_169,
Erinaceus europaeus	ENSEEUG00000006302	1 retrocopy	retro_eeur_269,
Echinops telfairi	ENSETEG00000012037	3 retrocopies	retro_etel_1178, retro_etel_1428, retro_etel_603,
Felis catus	ENSFCAG00000030159	2 retrocopies	retro_fcat_616, retro_fcat_944,
Macropus eugenii	ENSMEUG00000011173	1 retrocopy	retro_meug_962,
Myotis lucifugus	ENSMLUG00000014949	1 retrocopy	retro_mluc_2192,
Mustela putorius furo	ENSMPUG00000000829	1 retrocopy	retro_mputfur_297,
Mus musculus	ENSMUSG00000022051	2 retrocopies	retro_mmus_482, retro_mmus_849,
Oryctolagus cuniculus	ENSOCUG00000010542	1 retrocopy	retro_ocun_1460,
Otolemur garnettii	ENSOGAG00000003163	2 retrocopies	retro_ogar_1039, retro_ogar_2651,
Ochotona princeps	ENSOPRG00000016284	1 retrocopy	retro_opri_1105,
Rattus norvegicus	ENSRNOG00000009820	1 retrocopy	retro_rnor_1183,
Sus scrofa	ENSSSCG00000009658	1 retrocopy	retro_sscr_511,
Ictidomys tridecemlineatus	ENSSTOG00000004029	1 retrocopy	retro_itri_1525,
Tupaia belangeri	ENSTBEG00000006361	2 retrocopies	retro_tbel_3371, retro_tbel_4006,
Tarsius syrichta	ENSTSYG00000011036	4 retrocopies	retro_tsyr_1182, retro_tsyr_1602, retro_tsyr_162, retro_tsyr_1997,
Tursiops truncatus	ENSTTRG00000004862	1 retrocopy	retro_ttru_725,
Vicugna pacos	ENSVPAG00000000509	2 retrocopies	retro_vpac_349, retro_vpac_534,