RetrogeneDB ID: retro_chof_2381

Retrocopy location

• Organism: Sloth (Choloepus hoffmanni)
• Coordinates: scaffold_69972:4629..5632(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: KRT5
• Ensembl ID: ENSCHOG00000011913
• Aliases: None
• Description: keratin 5 [Source:HGNC Symbol;Acc:6442]

Sequence

>retro_chof_2381
GTGTGGTTCCTGGAGCAGCAGAACAAGATGCTGGAGACCAAGTGGAGCCTCCTGCAGCAGCAGAAGACTGCTGGGAGCAA
AATGGACAACTTGTTCGAGAGCTACATCAACCACCTTCGGCGGCAGCACGAGGCGCTGAGCCAGGAGAAGCTGAAGCTGG
AGGCGGAGCTTGGCAACATGCAGGGGCTGGTGGAAGACTTCAAGAATAAGTATGAGGATGAGATCAACAAGCGAACAGAA
ATAGAGAATGAATTTGTCCTTATCAAGAAGGATGTGGATGAAGCTTACATGAACAAAGTGGAGCTGGAGTCCCGCCTGGA
AGGGCTGACCGATGAGATTAACTTCCTCAGGCAGCTATTCGAAGCGGAGATCCGTGAGCTGCAGGCCTAGATCTCGGACA
CGTCAATGGTCCTCTCCATGCACAACAGCCGCTCCCTGGACCTGGATGGCATCATTGCTGAGGTCAAGCCCAGTATGAGG
AATCGCCAACCGCAGCCGGGCTGAGGCCGAGAGCATGTACTAGATCAAGTACGAGGAGCTGCAGACGCTGGCCGGGAATT
ATGGGGATGACCTCCGCTGCACGAAGACGGAGATCTCCGAGATGAACCGATCCATCAGCCGGCTCCAGGCTGAGATCGAG
GGCCTGAAGGGCCAGAGGGCTTCCCTGGAGGCTGCCATTGCTGATGCCGAGCAGCGTGGGGAGCTGGCCATTAAGGACGC
CAATGCCAAGTTGGGCCAGCTGGAGGCTGCCCTGCATCAGGCCAAGCAGGACATGGCGCGGCAGCTGCGCGAGTATCAGG
AGCTGATGAACGTCAAACTGGCCCTGGATATGGAGATTGCCACCTACCGCAAGCTGCTGGAGGGCGAGGAGAGCCGGCTG
GAATCTGGGATGCAGAATGTGAGTATTCATACGAAGACTTCCAGTGGCTACTACTCAGGTCCACTGAGCCCCGTCTTTGG
AGGCCTCACAGGCACTGGCAACAACTACTCCTTCAGCTCTGGT

Alignment

ORF - retro_chof_2381 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 64.83 %
• Parental protein coverage: 57.38 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  VRFLEQQNKVLDTKWTLLQEQGTKTIRQNLDPLFEQYINNLRRQLDSILGERGRLDAELRNMQDLVEDFK
          V.FLEQQNK.L.TKW.LLQ.Q..KT.....D.LFE.YIN.LRRQ......E...L.AEL.NMQ.LVEDFK
Retrocopy VWFLEQQNKMLETKWSLLQQQ--KTAGSKMDNLFESYINHLRRQHEALSQEKLKLEAELGNMQGLVEDFK

Parental  NKYEDEINKRTTAENEFVMLKKDVDAAYMNKVELEAKADALMDEINFLKIFFEAELSQMQTHISDTSVVL
          NKYEDEINKRT..ENEFV..KKDVD.AYMNKVELE.....L.DEINFL...FEAE....Q..ISDTS.VL
Retrocopy NKYEDEINKRTEIENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLFEAEIRELQA*ISDTSMVL

Parental  SMDNNRSLDLDSIIAEVK-AQYED-IANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMI
          SM.N.RSLDLD.IIAEVK.AQYE..IANRSR.EAES.Y..KYEELQ..AG..GDDLR.TK.EISEMNR.I
Retrocopy SMHNSRSLDLDGIIAEVK<AQYEE<IANRSRAEAESMY*IKYEELQTLAGNYGDDLRCTKTEISEMNRSI

Parental  QRLRAEIDNVKKQCANLQSAIAEAEQRGELALKDARNKLAELEDALQKAKQDMARLLKEYQELMNTKLAL
          .RL.AEI...K.Q.A.L..AIA.AEQRGELA.KDA..KL..LE.AL..AKQDMAR.L.EYQELMN.KLAL
Retrocopy SRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLGQLEAALHQAKQDMARQLREYQELMNVKLAL

Parental  DVEIATYRKLLEGEECRLTGEGVGPVNISVVTNSISSAYGGGGGLGGGFGGSVGGPFGGALSGG
          D.EIATYRKLLEGEE.RL.....G..N.S..T...S..Y...G.L...FGG..G.......S.G
Retrocopy DMEIATYRKLLEGEESRLES---GMQNVSIHTKTSSGYY--SGPLSPVFGGLTGTGNNYSFSSG

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Choloepus hoffmanni was not studied using RNA-Seq expression data.

ChIP-Seq

Choloepus hoffmanni was not studied using ChIP-Seq data.

EST

Choloepus hoffmanni was not studied using EST data.

TSS

Choloepus hoffmanni was not studied using FANTOM5 data.

Lab

retro_chof_2381 was not experimentally validated.

Homology

Retrocopy orthology:

Choloepus hoffmanni does not belong to any of the species groups (eutheria, teleost or neognath), studied for retrocopy-based homology. For more information about studied groups, please go to help section.

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Parental genes homology:

Parental genes homology involve 7 parental genes, and 25 retrocopies.

Species	Parental gene accession	Retrocopies number
Choloepus hoffmanni	ENSCHOG00000003743	10 retrocopies	retro_chof_1530, retro_chof_1645, retro_chof_2414, retro_chof_2471, retro_chof_2544, retro_chof_2704, retro_chof_322, retro_chof_693, retro_chof_750, retro_chof_915,
Choloepus hoffmanni	ENSCHOG00000011913	4 retrocopies	retro_chof_1848, retro_chof_2381 , retro_chof_2385, retro_chof_778,
Erinaceus europaeus	ENSEEUG00000009412	1 retrocopy	retro_eeur_521,
Echinops telfairi	ENSETEG00000007907	1 retrocopy	retro_etel_1586,
Nomascus leucogenys	ENSNLEG00000017746	5 retrocopies	retro_nleu_2270, retro_nleu_2596, retro_nleu_354, retro_nleu_457, retro_nleu_852,
Pongo abelii	ENSPPYG00000004548	1 retrocopy	retro_pabe_1103,
Vicugna pacos	ENSVPAG00000011707	3 retrocopies	retro_vpac_334, retro_vpac_551, retro_vpac_555,