RetrogeneDB ID: retro_mdom_1120

Retrocopy location

• Organism: Opossum (Monodelphis domestica)
• Coordinates: 3:157687632..157688321(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSMODG00000006744
• Aliases: None
• Status: KNOWN_PSEUDOGENE

Parental gene information

• Parental gene symbol: VDAC1
• Ensembl ID: ENSMODG00000014157
• Aliases: None
• Description: voltage-dependent anion channel 1 [Source:HGNC Symbol;Acc:12669]

Sequence

>retro_mdom_1120
ACTTACTATGACTTAGGAAATGCTGCCAAAAATGTCTTCAACCAAGGATGTGGGTTTGGTGCTTAAAATAGATCTTAGAA
CCAAGTCTTCCAGTGGAGTGGAATTTTCCACATCTGATCAGTCATTCATATACTGGTACAGGGAAAGCTTCAGGTAACTT
GAAAACAAGGTACAAAATCTCTATGGCTATGGGTTTACCTTCATTCAAAAATGGAAAACAGAAAATACTCTGAGGATAGA
AATCAACATGGAGAATAAATTGGCTGATGGTTTGAAGCTGACTCTTGACACCATATTTGTACCAAACACAGACAAGAAGA
GTGGTAAATTAAAACTTCCTCTAGATGAGACATTTCAGTCTTGGTGGAAATGTTGACTAATTTCTCTGGACCAACCATCT
ATGGCTGGGCTGTATTGGCTTATGAAGGATGGTTTGCTGGCTATCAAATGAGTTTTGATACAGCCAAATCCAAACGATCT
CAGAATAATTTTGCCCTGGTTATAAAGGTGCTGACTTCCAATTGCATAAACGTGTGAATGATGGCACTGAATTTGGAAGG
TCATTCTACCAAATAGTTAATGAGAAGATCAAAAATTTGATAAATCTTGCTTGGACAGCTCCAGTAATTTACAACACCCA
TTTTGGCATTGCTGCTAAGTATAAGGTGGATCACAAAACTTCTCTATCT

Alignment

ORF - retro_mdom_1120 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 54.01 %
• Parental protein coverage: 80.92 %
• Number of stop codons detected: 1
• Number of frameshifts detected: 5

Retrocopy - Parental Gene Alignment:

Parental  TYADLGKSARDVF-TKGYGFGLIKLDLKTKSENGLEF-TSSGS-ANTETSKVSGS-LETKYK-WSEYGLT
          TY.DLG..A..VF.TK..G....K.DL.TKS..G.EF.TS..S...T.T.K.SG..LE.K......YG.T
Retrocopy TYYDLGNAAKNVF>TKDVGL-VLKIDLRTKSSSGVEFSTSDQS>SYTGTGKASGN<LENKVQNLYGYGFT

Parental  FIEKWNTDNTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAK-IKSGYKREHINLGCDMDFDISGPSIR
          FI.KW.T.NTL..EI..E..LA.GLKLT.D..F.PNT.KK..K.IK....R..I.....M....SGP.I.
Retrocopy FIQKWKTENTLRIEINMENKLADGLKLTLDTIFVPNTDKKSGK<IKTS-SR*DISVLVEMLTNFSGPTIY

Parental  GAVVLGYEGWLAGYQMNFETSKSRVTQSNFAV-GYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNL
          G..VL.YEGW.AGYQM.F.T.KS...Q.NFA..GYK...FQLH..VNDGTEFG.S.YQ.VN.K.....NL
Retrocopy GWAVLAYEGWFAGYQMSFDTAKSKRSQNNFAL<GYKGADFQLHKRVNDGTEFGRSFYQIVNEKIKNLINL

Parental  AWTAG-NSNTRFGIAAKYQIDPEASFS
          AWTA....NT.FGIAAKY..D...S.S
Retrocopy AWTAPVIYNTHFGIAAKYKVDHKTSLS

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	0.00 RPM	1450.15 RPM
SRP007412_cerebellum	0.00 RPM	1413.55 RPM
SRP007412_heart	0.00 RPM	2849.54 RPM
SRP007412_kidney	0.00 RPM	1752.70 RPM
SRP007412_liver	0.00 RPM	458.17 RPM
SRP007412_testis	0.00 RPM	70.13 RPM

ChIP-Seq

Monodelphis domestica was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_mdom_1120 retrocopy.

TSS

Monodelphis domestica was not studied using FANTOM5 data.

Lab

retro_mdom_1120 was not experimentally validated.

Homology

Retrocopy orthology:

Monodelphis domestica does not belong to any of the species groups (eutheria, teleost or neognath), studied for retrocopy-based homology. For more information about studied groups, please go to help section.

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Parental genes homology:

Parental genes homology involve 30 parental genes, and 122 retrocopies.

Species	Parental gene accession	Retrocopies number
Canis familiaris	ENSCAFG00000000985	1 retrocopy	retro_cfam_1728,
Choloepus hoffmanni	ENSCHOG00000005631	6 retrocopies	retro_chof_1774, retro_chof_2420, retro_chof_813, retro_chof_858, retro_chof_866, retro_chof_99,
Callithrix jacchus	ENSCJAG00000013556	8 retrocopies	retro_cjac_1216, retro_cjac_1669, retro_cjac_1728, retro_cjac_2677, retro_cjac_3183, retro_cjac_3864, retro_cjac_454, retro_cjac_907,
Cavia porcellus	ENSCPOG00000023840	2 retrocopies	retro_cpor_1061, retro_cpor_699,
Dasypus novemcinctus	ENSDNOG00000002680	5 retrocopies	retro_dnov_1367, retro_dnov_2117, retro_dnov_271, retro_dnov_30, retro_dnov_90,
Dipodomys ordii	ENSDORG00000000714	1 retrocopy	retro_dord_636,
Equus caballus	ENSECAG00000012365	2 retrocopies	retro_ecab_831, retro_ecab_832,
Felis catus	ENSFCAG00000008421	1 retrocopy	retro_fcat_1592,
Homo sapiens	ENSG00000213585	13 retrocopies	retro_hsap_1119, retro_hsap_1250, retro_hsap_2250, retro_hsap_2805, retro_hsap_308, retro_hsap_3527, retro_hsap_4287, retro_hsap_458, retro_hsap_4721, retro_hsap_4831, retro_hsap_4872, retro_hsap_4930, retro_hsap_847,
Gorilla gorilla	ENSGGOG00000010880	3 retrocopies	retro_ggor_693, retro_ggor_875, retro_ggor_981,
Loxodonta africana	ENSLAFG00000028818	1 retrocopy	retro_lafr_161,
Macaca mulatta	ENSMMUG00000016235	6 retrocopies	retro_mmul_1023, retro_mmul_1070, retro_mmul_1305, retro_mmul_1851, retro_mmul_2417, retro_mmul_2613,
Monodelphis domestica	ENSMODG00000014157	1 retrocopy	retro_mdom_1120 ,
Monodelphis domestica	ENSMODG00000015526	5 retrocopies	retro_mdom_1130, retro_mdom_1331, retro_mdom_1869, retro_mdom_420, retro_mdom_669,
Mustela putorius furo	ENSMPUG00000010220	1 retrocopy	retro_mputfur_83,
Mus musculus	ENSMUSG00000020402	3 retrocopies	retro_mmus_2013, retro_mmus_3079, retro_mmus_3124,
Nomascus leucogenys	ENSNLEG00000008023	11 retrocopies	retro_nleu_1044, retro_nleu_1318, retro_nleu_1561, retro_nleu_189, retro_nleu_1991, retro_nleu_2707, retro_nleu_3019, retro_nleu_433, retro_nleu_492, retro_nleu_873, retro_nleu_880,
Oryctolagus cuniculus	ENSOCUG00000009369	3 retrocopies	retro_ocun_1253, retro_ocun_1428, retro_ocun_583,
Otolemur garnettii	ENSOGAG00000030742	2 retrocopies	retro_ogar_1197, retro_ogar_2876,
Ochotona princeps	ENSOPRG00000006605	2 retrocopies	retro_opri_397, retro_opri_467,
Pongo abelii	ENSPPYG00000015781	6 retrocopies	retro_pabe_1042, retro_pabe_1733, retro_pabe_273, retro_pabe_2913, retro_pabe_3756, retro_pabe_700,
Pan troglodytes	ENSPTRG00000017235	12 retrocopies	retro_ptro_1593, retro_ptro_1900, retro_ptro_249, retro_ptro_2905, retro_ptro_3138, retro_ptro_3215, retro_ptro_3246, retro_ptro_345, retro_ptro_588, retro_ptro_682, retro_ptro_84, retro_ptro_861,
Rattus norvegicus	ENSRNOG00000006375	8 retrocopies	retro_rnor_1235, retro_rnor_1398, retro_rnor_1482, retro_rnor_1594, retro_rnor_1664, retro_rnor_776, retro_rnor_777, retro_rnor_947,
Sorex araneus	ENSSARG00000008221	6 retrocopies	retro_sara_115, retro_sara_327, retro_sara_355, retro_sara_533, retro_sara_668, retro_sara_702,
Sus scrofa	ENSSSCG00000014296	2 retrocopies	retro_sscr_346, retro_sscr_801,
Ictidomys tridecemlineatus	ENSSTOG00000007764	3 retrocopies	retro_itri_1137, retro_itri_1506, retro_itri_693,
Tupaia belangeri	ENSTBEG00000003852	4 retrocopies	retro_tbel_1282, retro_tbel_2613, retro_tbel_3818, retro_tbel_4546,
Tarsius syrichta	ENSTSYG00000007346	1 retrocopy	retro_tsyr_161,
Tursiops truncatus	ENSTTRG00000016856	2 retrocopies	retro_ttru_1347, retro_ttru_752,
Vicugna pacos	ENSVPAG00000010448	1 retrocopy	retro_vpac_38,