RetrogeneDB ID: retro_pabe_603

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 10:67342150..67343041(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: KRT19
• Ensembl ID: ENSPPYG00000008416
• Aliases: None
• Description: keratin, type I cytoskeletal 19 [Source:RefSeq peptide;Acc:NP_001126058]

Sequence

>retro_pabe_603
CTGGCCTCCTACCTGGCCAAGGTGAACGCCCTGGAAGAGGTCACCTGAGAGCTGGGGGTGAAGGCCCATGGCTGATACCA
GAAGCAAGGGCCTGGGCCCTCCTGTGACTTACACCCACTACTTCAAGACCATCAGGGACTTATGGGACAAGATTCTCACT
GCCACCATTGAGAACTTCAGGATTGTCCTGATGACCAACAGCACCCATCTGGCTGCAGATGACTTCCGAACCAAGTTTAA
GGAGCTGGCCCTGGGTCTGAGCCTGGAGATCCACATCAACGTTCTGTGCAGGGTGCTGGGCGAGCTGAGCCTGGCCAGGA
CTGACCTGGAGATGGGGATGTAAAGCCTGAAGGAGGAGCTGGCCTACCTGAAGAAAAATTACCAGAAAGGAATTGGTGCC
CTGAGGGGCCAGGTGGGAGGCCTAGTCAGTGTGGTGATAGATTCCCCTCCAGGCGTCAACCCAGCCTAGATCCTGAACAA
CGACCTGAGAAGCAAATAGGAGGTCTTGGCTGAGCAGAACTAGGAGGGTGCTGAAGCCTGGTTAACCAGCCAGTCCCAGG
AACCGAATCAGGAGGTTGCCAGCCACATGAGCAGCTCCAGATGAGCAAATTCAAGGTCACTGACCTGCAGTGAACCCCCC
AGGGTTTTGACATTGAGCTGCAGTTGCAGCTCAGCATGAAAGCCGCCCTGGAAGGCACACTGGAAGAAACAAGGGCCCTC
TTTGGAGCCAAGCTGGCACAGATCCAGGTGCTGGTCAGGGGTGTTGAAGCCCAGCAGGGCGACATGGGTGCTGACAGCCA
GCAGCAGAACCAGCACCAGCAGTTCATGGACATCAAGTCTCAGCTGGAGGAGGAGATTACTATCTACTGAAGCCTGTCCT
TGGGCCAGGAT

Alignment

ORF - retro_pabe_603 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 63.46 %
• Parental protein coverage: 74.5 %
• Number of stop codons detected: 8
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  LASYLDKVRALEAANGELEVKIRDWYQKQGPGPSRD-YSHYYTTIQDLRDKILGATIENSRIVLQIDNAR
          LASYL.KV.ALE....EL.VK....YQKQGPGPS.D.Y.HY..TI.DL.DKIL.ATIEN.RIVL......
Retrocopy LASYLAKVNALEEVT*ELGVKAHG*YQKQGPGPSCD>YTHYFKTIRDLWDKILTATIENFRIVLMTNSTH

Parental  LAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARTDLEMQIEGLKEELAYLKKNHEEEISTLRGQV
          LAADDFRTKF..E.AL..S.E..IN.L.RVL.EL.LARTDLEM....LKEELAYLKKN....I..LRGQV
Retrocopy LAADDFRTKFK-ELALGLSLEIHINVLCRVLGELSLARTDLEMGM*SLKEELAYLKKNYQKGIGALRGQV

Parental  GGQVSVEVDSAPGTDLAKILS-DMRSQYEVMAEQNRKDAEAWFTSRTEELNREVAGHT-EQLQMSRSEVT
          GG.VSV..DS.PG...A.IL..D.RS..EV.AEQN...AEAW.TS...E.N.EVA.H..EQLQMS...VT
Retrocopy GGLVSVVIDSPPGVNPA*ILNNDLRSK*EVLAEQN*EGAEAWLTSQSQEPNQEVASHM<EQLQMSKFKVT

Parental  DLRRTLQGLEIELQSQLSMKAALEDTLAETEARFGAQLAHIQALISGIEAQLGDVRADSERQNQEYQRLM
          DL..T.QG..IELQ.QLSMKAALE.TL.ET.A.FGA.LA.IQ.L..G.EAQ.GD..ADS..QNQ..Q..M
Retrocopy DLQ*TPQGFDIELQLQLSMKAALEGTLEETRALFGAKLAQIQVLVRGVEAQQGDMGADSQQQNQ-HQQFM

Parental  DIKSRLEQEIATYRSLLEGQE
          DIKS.LE.EI..Y.SL..GQ.
Retrocopy DIKSQLEEEITIY*SLSLGQD

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	1.60 RPM
SRP007412_cerebellum	0.00 RPM	3.53 RPM
SRP007412_heart	0.00 RPM	0.00 RPM
SRP007412_kidney	0.00 RPM	27.81 RPM
SRP007412_liver	0.00 RPM	2.66 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_603 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_603 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_603 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_585
Pan troglodytes	retro_ptro_430
Gorilla gorilla	retro_ggor_518

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Parental genes homology:

Parental genes homology involve 14 parental genes, and 45 retrocopies.

Species	Parental gene accession	Retrocopies number
Callithrix jacchus	ENSCJAG00000029756	9 retrocopies	retro_cjac_1151, retro_cjac_1812, retro_cjac_2347, retro_cjac_2646, retro_cjac_3108, retro_cjac_3198, retro_cjac_3237, retro_cjac_3358, retro_cjac_633,
Equus caballus	ENSECAG00000014086	2 retrocopies	retro_ecab_76, retro_ecab_931,
Echinops telfairi	ENSETEG00000007881	6 retrocopies	retro_etel_1217, retro_etel_1319, retro_etel_191, retro_etel_480, retro_etel_685, retro_etel_95,
Homo sapiens	ENSG00000171345	3 retrocopies	retro_hsap_3486, retro_hsap_585, retro_hsap_959,
Gorilla gorilla	ENSGGOG00000016901	3 retrocopies	retro_ggor_2352, retro_ggor_518, retro_ggor_773,
Macropus eugenii	ENSMEUG00000016158	3 retrocopies	retro_meug_1860, retro_meug_403, retro_meug_826,
Macaca mulatta	ENSMMUG00000018653	4 retrocopies	retro_mmul_1770, retro_mmul_717, retro_mmul_774, retro_mmul_790,
Nomascus leucogenys	ENSNLEG00000010787	3 retrocopies	retro_nleu_1609, retro_nleu_2204, retro_nleu_800,
Oryctolagus cuniculus	ENSOCUG00000016132	1 retrocopy	retro_ocun_1884,
Otolemur garnettii	ENSOGAG00000024306	1 retrocopy	retro_ogar_1301,
Ochotona princeps	ENSOPRG00000007908	2 retrocopies	retro_opri_337, retro_opri_673,
Pongo abelii	ENSPPYG00000008416	3 retrocopies	retro_pabe_2880, retro_pabe_603 , retro_pabe_820,
Pan troglodytes	ENSPTRG00000009168	3 retrocopies	retro_ptro_2074, retro_ptro_2359, retro_ptro_430,
Ictidomys tridecemlineatus	ENSSTOG00000014403	2 retrocopies	retro_itri_1514, retro_itri_697,