RetrogeneDB ID:

retro_hsap_1890

Retrocopy
location
Organism:Human (Homo sapiens)
Coordinates:18:57597140..57597586(+)
Located in intron of:None
Retrocopy
information
Ensembl ID:ENSG00000267066
Aliases:None
Status:KNOWN_PSEUDOGENE
Parental gene
information
Parental gene summary:
Parental gene symbol:PLEKHB2
Ensembl ID:ENSG00000115762
Aliases:PLEKHB2, EVT2
Description:pleckstrin homology domain containing, family B (evectins) member 2 [Source:HGNC Symbol;Acc:19236]


Retrocopy-Parental alignment summary:






>retro_hsap_1890
AAAGACTGCATGCTGCAGATTGTTTGCTCAGATGGGAAAACAATTAGTCTTTGTGCAGAAAACACAGTGATTGCTTGGCT
TGGAAATTTACACTCCAAGATTCCAGGACAAACACAGCCTATGTGGGCTCCACAGTCATGACTGATGAGACACCCGTGGT
TTCCTCCCCTCCACCACACACGGCCTATGCTGCACCAGCCACTGAGGAATAGGGCTATGAGCCATACAGTGGTGTGTGCC
TGCCAGGAACTCAAATTGTCTATGCTGCTAATGGACAGGCGTATGCTGTGCCCTACCAGTACTCGTATGCAGGACTTTAT
GGACAGCAGCCTGCTAACCAAGTCATCATTCAAGAGTGATATCGAGACAATGACAGTGACCTGGCAGTGGGCATGTTGGC
AGGAGTGGCCATAGTCATGCCCTTAGGGTCTCTATTCTTGGTCTTC

ORF - retro_hsap_1890 Open Reading Frame is not conserved.
Retrocopy - Parental Gene Alignment summary:
Percent Identity: 83.33 %
Parental protein coverage: 67.42 %
Number of stop codons detected: 2
Number of frameshifts detected 1


Retrocopy - Parental Gene Alignment:

ParentalKDCMLQIVCRDGKTISLCAEST-DDCLAWKFTLQDSRTNTAYVGSAVMTDETSVVSSPPPYTAYAAPAPE
KDCMLQIVC.DGKTISLCAE.T..DCLAWKFTLQDSRTNTAYVGS.VMTDET.VVSSPPP.TAYAAPA.E
RetrocopyKDCMLQIVCSDGKTISLCAENT<SDCLAWKFTLQDSRTNTAYVGSTVMTDETPVVSSPPPHTAYAAPATE
ParentalAYGYGPYGGAYPPGTQVVYAANGQAYAVPYQYPYAGLYGQQPANQVIIRERYRDNDSDLALGMLAGAATG
..GY.PY.G...PGTQ.VYAANGQAYAVPYQY.YAGLYGQQPANQVII.E.YRDNDSDLA.GMLAG.A..
RetrocopyE*GYEPYSGVCLPGTQIVYAANGQAYAVPYQYSYAGLYGQQPANQVIIQE*YRDNDSDLAVGMLAGVAIV
ParentalMALGSLFWVF
M.LGSLF.VF
RetrocopyMPLGSLFLVF

Legend:
*Stop codon
>Forward frameshift by one nucleotide
<Reverse frameshift by one nucleotide






RNA-Seq - click to see more details

(Hint: click retrocopy or parental gene accession number on the plot's legend, to show / hide expression level values)

Expression validation based on RNA-Seq data:
Library Retrocopy expression Parental gene expression
bodymap2_adipose 0 .00 RPM 81 .22 RPM
bodymap2_adrenal 0 .00 RPM 75 .39 RPM
bodymap2_brain 0 .00 RPM 230 .49 RPM
bodymap2_breast 0 .00 RPM 66 .60 RPM
bodymap2_colon 0 .00 RPM 74 .91 RPM
bodymap2_heart 0 .00 RPM 63 .28 RPM
bodymap2_kidney 0 .00 RPM 224 .98 RPM
bodymap2_liver 0 .00 RPM 22 .94 RPM
bodymap2_lung 0 .00 RPM 133 .02 RPM
bodymap2_lymph_node 0 .00 RPM 90 .91 RPM
bodymap2_ovary 0 .00 RPM 56 .06 RPM
bodymap2_prostate 0 .00 RPM 69 .89 RPM
bodymap2_skeletal_muscle 0 .00 RPM 28 .26 RPM
bodymap2_testis 0 .00 RPM 112 .18 RPM
bodymap2_thyroid 0 .00 RPM 120 .26 RPM
bodymap2_white_blood_cells 0 .00 RPM 228 .89 RPM

ChIP-Seq - click to see more details

RNA Polymerase II actvity near the 5' end of retro_hsap_1890 was not detected

EST - click to see more details

No EST(s) were mapped for retro_hsap_1890 retrocopy.

TSS - click to see more details

No TSS is located nearby retro_hsap_1890 retrocopy 5' end.

Lab - click to see more details

retro_hsap_1890 was not experimentally validated.

Retrocopy orthology:
Retrocopy retro_hsap_1890 has 1 orthologous retrocopies within eutheria group .

Species RetrogeneDB ID
Pongo abelii retro_pabe_1570
Parental genes homology:
Parental genes homology involve 12 parental genes, and 15 retrocopies.

Species Parental gene accession Retrocopies number
Bos taurus ENSBTAG000000009412 retrocopies
retro_btau_1134, retro_btau_1635,
Cavia porcellus ENSCPOG000000263291 retrocopy
retro_cpor_985,
Equus caballus ENSECAG000000173311 retrocopy
retro_ecab_1069,
Felis catus ENSFCAG000000270631 retrocopy
retro_fcat_213,
Homo sapiens ENSG00000115762 1 retrocopy
retro_hsap_1890 ,
Meleagris gallopavo ENSMGAG000000010521 retrocopy
retro_mgal_17,
Monodelphis domestica ENSMODG000000186341 retrocopy
retro_mdom_720,
Nomascus leucogenys ENSNLEG000000106982 retrocopies
retro_nleu_1471, retro_nleu_2016,
Oryctolagus cuniculus ENSOCUG000000242821 retrocopy
retro_ocun_654,
Otolemur garnettii ENSOGAG000000284082 retrocopies
retro_ogar_2771, retro_ogar_703,
Pongo abelii ENSPPYG000000127401 retrocopy
retro_pabe_1570,
Ictidomys tridecemlineatus ENSSTOG000000205091 retrocopy
retro_itri_56,

Expression level across human populations :
image/svg+xml GBR_HG00142 GBR_HG00099 GBR_HG00114 GBR_HG00143 GBR_HG00131 GBR_HG00137 GBR_HG00133 GBR_HG00119 GBR_HG00111 GBR_HG00134 FIN_HG00378 FIN_HG00338 FIN_HG00349 FIN_HG00375 FIN_HG00315 FIN_HG00277 FIN_HG00328 FIN_HG00321 FIN_HG00377 FIN_HG00183 TSI_NA20756 TSI_NA20538 TSI_NA20798 TSI_NA20532 TSI_NA20765 TSI_NA20518 TSI_NA20513 TSI_NA20512 TSI_NA20771 TSI_NA20786 YRI_NA19114 YRI_NA19099 YRI_NA18870 YRI_NA18907 YRI_NA19223 YRI_NA19214 YRI_NA18916 YRI_NA19093 YRI_NA19118 YRI_NA19213 Toscaniin Italia: Finnish inFinland: British in England and Scotland: Utah Residents (CEPH) with Northernand Western European Ancestry: Yoruba in Ibadan, Nigeria: CEU_NA12760 CEU_NA12827 CEU_NA12872 CEU_NA12751 CEU_NA12873 CEU_NA12400 CEU_NA11930 CEU_NA12004 CEU_NA11831 CEU_NA11843 No expression ( = 0 RPM ) > 0 RPM = 0.04 RPM Legend:


Library Retrogene expression
CEU_NA11831 0 .00 RPM
CEU_NA11843 0 .00 RPM
CEU_NA11930 0 .00 RPM
CEU_NA12004 0 .00 RPM
CEU_NA12400 0 .00 RPM
CEU_NA12751 0 .00 RPM
CEU_NA12760 0 .00 RPM
CEU_NA12827 0 .00 RPM
CEU_NA12872 0 .00 RPM
CEU_NA12873 0 .00 RPM
FIN_HG00183 0 .00 RPM
FIN_HG00277 0 .04 RPM
FIN_HG00315 0 .00 RPM
FIN_HG00321 0 .00 RPM
FIN_HG00328 0 .00 RPM
FIN_HG00338 0 .00 RPM
FIN_HG00349 0 .00 RPM
FIN_HG00375 0 .00 RPM
FIN_HG00377 0 .00 RPM
FIN_HG00378 0 .00 RPM
GBR_HG00099 0 .00 RPM
GBR_HG00111 0 .00 RPM
GBR_HG00114 0 .00 RPM
GBR_HG00119 0 .00 RPM
GBR_HG00131 0 .00 RPM
GBR_HG00133 0 .00 RPM
GBR_HG00134 0 .00 RPM
GBR_HG00137 0 .00 RPM
GBR_HG00142 0 .00 RPM
GBR_HG00143 0 .00 RPM
TSI_NA20512 0 .00 RPM
TSI_NA20513 0 .00 RPM
TSI_NA20518 0 .00 RPM
TSI_NA20532 0 .00 RPM
TSI_NA20538 0 .00 RPM
TSI_NA20756 0 .00 RPM
TSI_NA20765 0 .00 RPM
TSI_NA20771 0 .00 RPM
TSI_NA20786 0 .00 RPM
TSI_NA20798 0 .00 RPM
YRI_NA18870 0 .03 RPM
YRI_NA18907 0 .00 RPM
YRI_NA18916 0 .00 RPM
YRI_NA19093 0 .00 RPM
YRI_NA19099 0 .00 RPM
YRI_NA19114 0 .00 RPM
YRI_NA19118 0 .00 RPM
YRI_NA19213 0 .00 RPM
YRI_NA19214 0 .00 RPM
YRI_NA19223 0 .00 RPM

Indel association:

No indels were associated with its genomic coordinates. Based on Kabza et al. 2015 (PubMed).



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