RetrogeneDB ID: retro_ptro_727

Retrocopy location

• Organism: Chimpanzee (Pan troglodytes)
• Coordinates: 12:134046239..134046732(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: PTP4A2
• Ensembl ID: ENSPTRG00000000467
• Aliases: None
• Description: protein tyrosine phosphatase type IVA, member 2 [Source:HGNC Symbol;Acc:9635]

Sequence

>retro_ptro_727
ATGGACTGTTCAGCCCCTGTGGAGATTTACAGGAACATGCATTTTCTCATAACCCACAAGTCTACCAGTGCCACTGCAAC
AAGTTCACAGAGGAATGTGAGACGTGTGGAGTGACACCTTTGGTTTGAGTTTGTGATGCTACATTTGGTAAAGTTCCAGT
TGAAAAAGAAGGAATCCACATTTTAGATTGGTCTTTTGACGATGAAGCTCCACCACCTAATCAGATAGCAGATGACTGGC
TAAACCTGTTAATCACCAAAGGGCGTGAAAAGCCAGGTTGCTGCCTTGCAGTGCATTGTGCTGTGGGATTGGGAAGGGCA
CCTGTGCTGGCAGCGCTTGCTTTGAATATGGAATTAAGTATGAAGATGCAGTTCAGTTTATAAGACAAAAAAGAAGGGGA
GCATTCAATTCCAAACAGCTGCTTTACTTGGAGAAATGCCGACCTAAGGGGCAATTACACTTCAGAGATACCAGTGGGCA
TTGCTGTGTTCAG

Alignment

ORF - retro_ptro_727 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 69.82 %
• Parental protein coverage: 100. %
• Number of stop codons detected: 1
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  MNRPAPVEISYENMRFLITHNPTNATL-NKFTEELKKYGVTTLFRVCDATYEKAPVEKEGNHVLDWPFDD
          M...APVEI.Y.NM.FLITH..T.AT..NKFTEE....GVT.L..VCDAT..K.PVEKEG.H.LDW.FDD
Retrocopy MDCSAPVEI-YRNMHFLITHKSTSATA<NKFTEECETCGVTPLV*VCDATFGKVPVEKEGIHILDWSFDD

Parental  GAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCVA-GLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAF
          .APPPNQI.DDWLNLL.TK.RE.PGCC.AVHC...G.G........A..E.G.KYEDAVQFIRQKRRGAF
Retrocopy EAPPPNQIADDWLNLLITKGREKPGCCLAVHCAV<GIGKG-TCAGSACFEYGIKYEDAVQFIRQKRRGAF

Parental  NSKQLLYLEKYRPKMRLRFRDTNGHCCVQ
          NSKQLLYLEK.RPK..L.FRDT.GHCCVQ
Retrocopy NSKQLLYLEKCRPKGQLHFRDTSGHCCVQ

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.25 RPM	48.49 RPM
SRP007412_cerebellum	0.07 RPM	29.93 RPM
SRP007412_heart	0.00 RPM	84.15 RPM
SRP007412_kidney	0.21 RPM	45.84 RPM
SRP007412_liver	0.00 RPM	32.21 RPM
SRP007412_testis	0.95 RPM	82.62 RPM

ChIP-Seq

Pan troglodytes was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_ptro_727 retrocopy.

TSS

Pan troglodytes was not studied using FANTOM5 data.

Lab

retro_ptro_727 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ptro_727 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_1069
Gorilla gorilla	retro_ggor_843
Pongo abelii	retro_pabe_890

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Parental genes homology:

Parental genes homology involve 7 parental genes, and 17 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000017806	1 retrocopy	retro_amel_1484,
Choloepus hoffmanni	ENSCHOG00000010834	1 retrocopy	retro_chof_2029,
Macropus eugenii	ENSMEUG00000002037	1 retrocopy	retro_meug_2,
Microcebus murinus	ENSMICG00000001424	5 retrocopies	retro_mmur_1393, retro_mmur_1475, retro_mmur_338, retro_mmur_822, retro_mmur_910,
Macaca mulatta	ENSMMUG00000012930	1 retrocopy	retro_mmul_1235,
Pan troglodytes	ENSPTRG00000000467	4 retrocopies	retro_ptro_1212, retro_ptro_562, retro_ptro_654, retro_ptro_727 ,
Pan troglodytes	ENSPTRG00000018314	4 retrocopies	retro_ptro_1657, retro_ptro_2239, retro_ptro_3190, retro_ptro_360,