RetrogeneDB ID: retro_ggor_1646

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 2a:92394837..92395707(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: CNN2
• Ensembl ID: ENSGGOG00000028153
• Aliases: None
• Description: None

Sequence

>retro_ggor_1646
TTCAACAAGGGCCCCTCCTACAGGCTCTTGGCGGACGTCCAGAGCAGGCTTCTGTCCAAATATGACTCCCAGAAGGAGGC
AGAGCTCCGCAGCTGGATCAAGGGATTCACTGGCCTCTCCATCCGCCCCAACTTCCAGAAGGGCCTGAAGGATGGGATTA
TTTTATGCACACTCGTGAACAAACTGCAGCCGGGCTCAGTCCCCAAGATCAACGGCTTCCGTGTAGAACTGGCACCAGCT
AGAAAACCTCTCCAACTTCCTCAAGGCCATGGTCAGCTACGGCATGATCCCGTGGACCTATTTGAGACCAACAACCTGTT
CGAGAGTGGGAACGATATGCAGGTGCGGGTGTCTCTTCTCGCCCTGGCAGGGAAGGCCAAGACTAAGGGGCTGCAGAGCG
GGGTGGACATCCGTGACAAGTACTCAGAGAAGCAGAACTTCGACGACAACACCATGAAGGCCAGCCAGCGCGTCATCCGG
CTGCATATTACCAACAAATGTGCCAGTCAGTCAGGCATGACTGCATACGGCTCGAGGAGGCATCTCTACGACCCCAAGAA
CCGCATCCTGCCCCCCATGGACAACTCGACCATCAGCCTCCAGATGGGTACAAACAAGTGCGCCAGCCAGGTGGGCATGA
CGGCTCCCGGGAACCAGCAGCACATCTATGACACCAAGTTGGGAATCGACAAGTGTGAGAACTCCTCCATGTCCCTGAAG
ATGGGCTACACGCAGGTCGCCAATCACAGCAGCCAGGTCTTTGGCCTAGGCCGGCAAATATACGAACCCAAGTACTAGCC
GGGTGGCCCAGTGGCCCACGGGGCTCCCTACGCCGGCAACTGCCCAGGGCCAGGGGAGGCCCCTTACTAC

Alignment

ORF - retro_ggor_1646 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 79.39 %
• Parental protein coverage: 95.15 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  FNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSIPKI
          FNKGPSY.L.A.V..RLLSKYD.QKEAELR.WI.G.TGLSI.P.FQKGLKDG.ILCTL.NKLQPGS.PKI
Retrocopy FNKGPSYRLLADVQSRLLSKYDSQKEAELRSWIKGFTGLSIRPNFQKGLKDGIILCTLVNKLQPGSVPKI

Parental  N-RSMQNWHQLENLSNFIKAMVSYGM-NPVDLFEANDLFESGNMTQVQVSLLALAGKAKTKGLQSGVDIG
          N..S..NWHQLENLSNF.KAMVSYGM..PVDLFE.N.LFESGN..QV.VSLLALAGKAKTKGLQSGVDI.
Retrocopy N>ASV*NWHQLENLSNFLKAMVSYGM<DPVDLFETNNLFESGNDMQVRVSLLALAGKAKTKGLQSGVDIR

Parental  VKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDHSTISLQMGTN
          .KYSEKQ..NFDD.TMKA.Q.VI.L...TNKCASQSGMTAYG.RRHLYDPKN.ILPPMD.STISLQMGTN
Retrocopy DKYSEKQ--NFDDNTMKASQRVIRLHI-TNKCASQSGMTAYGSRRHLYDPKNRILPPMDNSTISLQMGTN

Parental  KCASQVGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTVADGA
          KCASQVGMTAPG...HIYDTKLG.DKC.NSSMSL.MGYTQ.AN.S.QVFGLGRQIY.PKY.P.G.VA.GA
Retrocopy KCASQVGMTAPGNQQHIYDTKLGIDKCENSSMSLKMGYTQVANHSSQVFGLGRQIYEPKY*PGGPVAHGA

Parental  PSGTGDCPDPGEVPEY
          P...G.CP.PGE.P.Y
Retrocopy PY-AGNCPGPGEAPYY

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	3.21 RPM	7.82 RPM
SRP007412_cerebellum	0.24 RPM	5.12 RPM
SRP007412_heart	0.00 RPM	32.30 RPM
SRP007412_kidney	0.37 RPM	44.49 RPM
SRP007412_liver	0.05 RPM	54.07 RPM
SRP007412_testis	1.76 RPM	10.26 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_1646 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_1646 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 13 parental genes, and 53 retrocopies.

Species	Parental gene accession	Retrocopies number
Bos taurus	ENSBTAG00000020764	1 retrocopy	retro_btau_612,
Dipodomys ordii	ENSDORG00000001141	1 retrocopy	retro_dord_672,
Erinaceus europaeus	ENSEEUG00000015171	1 retrocopy	retro_eeur_581,
Homo sapiens	ENSG00000064666	16 retrocopies	retro_hsap_1168, retro_hsap_1575, retro_hsap_1697, retro_hsap_2127, retro_hsap_2495, retro_hsap_255, retro_hsap_2576, retro_hsap_2764, retro_hsap_3505, retro_hsap_4168, retro_hsap_4170, retro_hsap_4175, retro_hsap_4257, retro_hsap_4269, retro_hsap_4326, retro_hsap_943,
Gorilla gorilla	ENSGGOG00000013870	1 retrocopy	retro_ggor_2312,
Gorilla gorilla	ENSGGOG00000028153	9 retrocopies	retro_ggor_1199, retro_ggor_1271, retro_ggor_1555, retro_ggor_1612, retro_ggor_1646 , retro_ggor_1922, retro_ggor_2370, retro_ggor_305, retro_ggor_762,
Myotis lucifugus	ENSMLUG00000013160	4 retrocopies	retro_mluc_1536, retro_mluc_1965, retro_mluc_2047, retro_mluc_2210,
Macaca mulatta	ENSMMUG00000015306	1 retrocopy	retro_mmul_1131,
Mus musculus	ENSMUSG00000004665	2 retrocopies	retro_mmus_1824, retro_mmus_2317,
Nomascus leucogenys	ENSNLEG00000001161	2 retrocopies	retro_nleu_1757, retro_nleu_2893,
Otolemur garnettii	ENSOGAG00000010144	2 retrocopies	retro_ogar_1416, retro_ogar_1733,
Pongo abelii	ENSPPYG00000009302	12 retrocopies	retro_pabe_1299, retro_pabe_1397, retro_pabe_1838, retro_pabe_1920, retro_pabe_2171, retro_pabe_2249, retro_pabe_2900, retro_pabe_3512, retro_pabe_3515, retro_pabe_3543, retro_pabe_3823, retro_pabe_407,
Ictidomys tridecemlineatus	ENSSTOG00000028367	1 retrocopy	retro_itri_326,