RetrogeneDB ID: retro_pabe_1093

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 14:20948714..20949980(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: RBBP4
• Ensembl ID: ENSPPYG00000001588
• Aliases: RBBP4, RBBP-4
• Description: histone-binding protein RBBP4 [Source:RefSeq peptide;Acc:NP_001124686]

Sequence

>retro_pabe_1093
ATGGCCGTCAAGGAAGCAGCCTTTGATGAGGGAGTGGAAGACCAGTGATCAACGATGAGTACAAAATACGGAAAAAAAAC
ACCCCTTTTCTTTACGATTTGGAGATGACCCATGCTCTGGAGTGGCCAGCTTAACTGCCCAGTGGCTTCCAGATGAAACC
AGACCAGAAGGGAAAGATTTCAGCATTCATCGACTTGTCCTGGGGACACACACATTGGATGAAAAAAAAATCTTGTTATA
GCCAGTGTGCAACCCCTAATGATAGTGCTCAGTTTGATGCGTCACACTATGACAGTGAGAAAGGAGAATTTGGAGGTTTT
GGTTCAGTTAGTGGAAAAATTGAAATAGAAATCAAGATCAACCGTGAAGGAGAAGTAAACAGGGCCCGTTATATGCCCCA
GAACCCTTGCATCTTTGCAACAAAGACTCCTTCCAGTGATGTTCTTGTCTTTGACTATACAAAACACCCTTCTAAACCAG
ATCCTTCTGGAGAGTGCAACCCAGACTTGCGTCTCCATGGACGTCAGAAGGAAGGCTATGGGCTTTCACGGAACGCACAA
TCTCGGTGGGTACTTACTTAGTGCTTCAGATGACCACACCATCTGCCTGTGGGACATCAGTGCCATTCCAAAGGAGGGAA
AAGTGGATGCGAGGACCATCTTTACAGGGCATACAGCTGTAGCAGAAGATGTTTTCTGGCATCTGCTTCATGAGTCTCTG
TTTAGGTCAGTTGCTGATGATCAGAAACTTATGATTTGGGATACTCGTTCAAAAAATACTTCCAAACCAAGCCACTCAGT
TGACGCTTACACTGCTGAAGTGAACTGCCTCTCTTTCAATCCTTATGGTGAGTTCATTCTTGCTACAGGATCAGCTGACA
AGACTGTTGCCTTGTGGGATCTGAGAAATCTGAAACTTAAGTTACATTCCTTTGAGTCACATAAGGATGAAATATTCCAG
GTTCAGTGGTCACCTCACGATGAGACTATTTTGGCTTCCAGTGGTACTGATCACAGACTGAATGTCTGGGATTTAAGTAA
AATCACAGAGGAACAATCCCCAGAAGATGCAGAAGACGGGCCACCAGAGTTGTTTATTCATGGTGGTCGCACTGCCAAGA
TACTTGATTTCTCCTGGAATCCCAATGAACCTCAGATGATTTGTTCTGTATCAGAAAACAACATCATGGAAGTGTGGCAA
ATGGCAGAGAACATTTCTAACGGTGAAGAACCTGAAAGGAGTGTGGATCCAGAAGGACAAGGGTCC

Alignment

ORF - retro_pabe_1093 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 87.21 %
• Parental protein coverage: 100.0 %
• Number of stop codons detected: 0
• Number of frameshifts detected: 5

Retrocopy - Parental Gene Alignment:

Parental  MADKEAAFDDAVEER-VINEEYKIWKKNTPFLYDLVMTHALEWP-SLTAQWLPDVTRPEGKDFSIHRLVL
          MA.KEAAFD..VE...VIN.EYKI....TPFLYDL.MTHALEWP.SLTAQWLPD.TRPEGKDFSIHRLVL
Retrocopy MAVKEAAFDEGVEDQ<VINDEYKIRXXXTPFLYDLEMTHALEWP<SLTAQWLPDETRPEGKDFSIHRLVL

Parental  GTHTSDEQNHL-VIASVQ-LPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQN
          GTHT.D....L.VIASVQ..PND.AQFDASHYDSEKGEFGGFGSVSGKIEIEIKIN.EGEVNRARYMPQN
Retrocopy GTHTLDXXXXL<VIASVQ<TPNDSAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINREGEVNRARYMPQN

Parental  PCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNP-NLSGHLLSASDDHTICLW
          PCI.ATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRL.G.QKEGYGLS.N..NL.G.LLSASDDHTICLW
Retrocopy PCIFATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLHGRQKEGYGLSRNA>NLGGYLLSASDDHTICLW

Parental  DISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE
          DISA.PKEGKV.DA.TIFTGHTAV.EDV.WHLLHESLF.SVADDQKLMIWDTRS.NTSKPSHSVDA.TAE
Retrocopy DISAIPKEGKV-DARTIFTGHTAVAEDVFWHLLHESLFRSVADDQKLMIWDTRSKNTSKPSHSVDAYTAE

Parental  VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW
          VNCLSFNPY.EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH.ETILASSGTD.RLNVW
Retrocopy VNCLSFNPYGEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHDETILASSGTDHRLNVW

Parental  DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPE
          DLSKI.EEQSPEDAEDGPPE.LFIHGG.TAKI.DFSWNPNEP..ICSVSE.NIM.VWQMAENI.N.E.PE
Retrocopy DLSKITEEQSPEDAEDGPPE-LFIHGGRTAKILDFSWNPNEPQMICSVSENNIMEVWQMAENISNGEEPE

Parental  GSVDPEGQGS
          .SVDPEGQGS
Retrocopy RSVDPEGQGS

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	32.18 RPM
SRP007412_cerebellum	0.00 RPM	38.18 RPM
SRP007412_heart	0.00 RPM	15.80 RPM
SRP007412_kidney	0.00 RPM	25.66 RPM
SRP007412_liver	0.00 RPM	25.34 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_1093 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_1093 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_1093 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_1305
Pan troglodytes	retro_ptro_896
Gorilla gorilla	retro_ggor_1022

---

Parental genes homology:

Parental genes homology involve 21 parental genes, and 55 retrocopies.

Species	Parental gene accession	Retrocopies number
Bos taurus	ENSBTAG00000005904	2 retrocopies	retro_btau_1610, retro_btau_630,
Canis familiaris	ENSCAFG00000010527	1 retrocopy	retro_cfam_1550,
Choloepus hoffmanni	ENSCHOG00000004066	6 retrocopies	retro_chof_1382, retro_chof_1649, retro_chof_1867, retro_chof_2116, retro_chof_2327, retro_chof_908,
Callithrix jacchus	ENSCJAG00000001021	7 retrocopies	retro_cjac_1157, retro_cjac_1787, retro_cjac_1873, retro_cjac_244, retro_cjac_2557, retro_cjac_2719, retro_cjac_2939,
Cavia porcellus	ENSCPOG00000015352	3 retrocopies	retro_cpor_154, retro_cpor_27, retro_cpor_899,
Equus caballus	ENSECAG00000022784	1 retrocopy	retro_ecab_767,
Echinops telfairi	ENSETEG00000020008	4 retrocopies	retro_etel_1088, retro_etel_1462, retro_etel_1877, retro_etel_676,
Felis catus	ENSFCAG00000027017	1 retrocopy	retro_fcat_1507,
Homo sapiens	ENSG00000162521	6 retrocopies	retro_hsap_1305, retro_hsap_2675, retro_hsap_2814, retro_hsap_3292, retro_hsap_3600, retro_hsap_3601,
Macropus eugenii	ENSMEUG00000014379	1 retrocopy	retro_meug_1032,
Myotis lucifugus	ENSMLUG00000000749	2 retrocopies	retro_mluc_2275, retro_mluc_892,
Macaca mulatta	ENSMMUG00000009940	1 retrocopy	retro_mmul_75,
Mustela putorius furo	ENSMPUG00000015214	1 retrocopy	retro_mputfur_104,
Mus musculus	ENSMUSG00000057236	1 retrocopy	retro_mmus_356,
Nomascus leucogenys	ENSNLEG00000002805	6 retrocopies	retro_nleu_1061, retro_nleu_1179, retro_nleu_1194, retro_nleu_1356, retro_nleu_1379, retro_nleu_2982,
Petromyzon marinus	ENSPMAG00000007189	1 retrocopy	retro_pmar_26,
Pongo abelii	ENSPPYG00000001588	6 retrocopies	retro_pabe_1093 , retro_pabe_2210, retro_pabe_2720, retro_pabe_2958, retro_pabe_3529, retro_pabe_3611,
Pteropus vampyrus	ENSPVAG00000010981	2 retrocopies	retro_pvam_1094, retro_pvam_902,
Rattus norvegicus	ENSRNOG00000021492	1 retrocopy	retro_rnor_1270,
Sarcophilus harrisii	ENSSHAG00000010923	1 retrocopy	retro_shar_399,
Ictidomys tridecemlineatus	ENSSTOG00000012011	1 retrocopy	retro_itri_1168,