RetrogeneDB ID: retro_pabe_2430

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 4:39745918..39746220(+)
• Located in intron of: ENSPPYG00000014666

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: CNEP1R1
• Ensembl ID: ENSPPYG00000007335
• Aliases: CNEP1R1, TMEM188
• Description: Nuclear envelope phosphatase-regulatory subunit 1 [Source:UniProtKB/Swiss-Prot;Acc:Q5R7J7]

Sequence

>retro_pabe_2430
CACATCTTTTGTTTATGGTCCACTGTGAGGCACTGGACAACAATTCTTAGAACCATGTTCATCTGTACAGCTGCTAGGCT
GGGAACTGGTTAATAAGAGATCCCAAGACACAAAAGCGTTTTCATCCCTCATTATGAAATCATCTATTTTTCACTGGCTG
TTGCGGTTTGTTCTTGCTGGAATACATAAGAGGGTAGTAGCACCATTGATTTGAGCAGCTTGGTATCAAATCGTGTTTGC
AGATTACAATACACCCTGTGATGTAGGAAAATATAATTTTGAAGTCAAGGCCTTATGTGGAG

Alignment

ORF - retro_pabe_2430 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 51.82 %
• Parental protein coverage: 84.8 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 3

Retrocopy - Parental Gene Alignment:

Parental  YIHCLQPATGRWRMLLIVVSVCTATG-AWNWLI-DPETQKVSFFTSLWNHPFFTISCITLIGLFF-AGIH
          .I.CL......W...L.....CTA...A.NWLI.DP.TQK..F..SL.NH.FFT..C....GLF..AGIH
Retrocopy HIFCLWSTVRHWTTILRTMFICTAAR<AGNWLIRDPKTQK-RFHPSL*NHLFFTGCC----GLFL<AGIH

Parental  KRVVAPSIIAARCRTVLAEYNMSCDDTGK-LILKPRPHVQ
          KRVVAP.I.AA....V.A.YN..C.D.GK..ILK.RP.V.
Retrocopy KRVVAPLI*AAWYQIVFADYNTPC-DVGK>IILKSRPYVE

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	5.20 RPM
SRP007412_cerebellum	0.00 RPM	11.07 RPM
SRP007412_heart	0.03 RPM	4.30 RPM
SRP007412_kidney	0.10 RPM	3.55 RPM
SRP007412_liver	0.03 RPM	2.91 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_2430 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_2430 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_2430 has 1 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Macaca mulatta	retro_mmul_1873

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Parental genes homology:

Parental genes homology involve 17 parental genes, and 23 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000006491	1 retrocopy	retro_amel_732,
Callithrix jacchus	ENSCJAG00000001997	1 retrocopy	retro_cjac_4204,
Cavia porcellus	ENSCPOG00000012791	1 retrocopy	retro_cpor_669,
Erinaceus europaeus	ENSEEUG00000005737	1 retrocopy	retro_eeur_211,
Felis catus	ENSFCAG00000023936	1 retrocopy	retro_fcat_1713,
Homo sapiens	ENSG00000205423	1 retrocopy	retro_hsap_4886,
Gorilla gorilla	ENSGGOG00000025211	1 retrocopy	retro_ggor_3051,
Loxodonta africana	ENSLAFG00000012573	1 retrocopy	retro_lafr_907,
Myotis lucifugus	ENSMLUG00000006900	2 retrocopies	retro_mluc_1437, retro_mluc_2115,
Macaca mulatta	ENSMMUG00000008365	3 retrocopies	retro_mmul_1586, retro_mmul_1873, retro_mmul_2624,
Mustela putorius furo	ENSMPUG00000003109	1 retrocopy	retro_mputfur_453,
Nomascus leucogenys	ENSNLEG00000000727	2 retrocopies	retro_nleu_1341, retro_nleu_831,
Oryctolagus cuniculus	ENSOCUG00000005923	1 retrocopy	retro_ocun_1267,
Otolemur garnettii	ENSOGAG00000015665	1 retrocopy	retro_ogar_2835,
Pongo abelii	ENSPPYG00000007335	3 retrocopies	retro_pabe_1396, retro_pabe_2430 , retro_pabe_3799,
Pan troglodytes	ENSPTRG00000041682	1 retrocopy	retro_ptro_3255,
Ictidomys tridecemlineatus	ENSSTOG00000001179	1 retrocopy	retro_itri_350,