RetrogeneDB ID:

retro_hsap_779

Retrocopy
location
Organism:Human (Homo sapiens)
Coordinates:11:50227331..50228443(+)
Located in intron of:None
Retrocopy
information
Ensembl ID:ENSG00000255500
Aliases:None
Status:KNOWN_PSEUDOGENE
Parental gene
information
Parental gene summary:
Parental gene symbol:PANK3
Ensembl ID:ENSG00000120137
Aliases:None
Description:pantothenate kinase 3 [Source:HGNC Symbol;Acc:19365]


Retrocopy-Parental alignment summary:






>retro_hsap_779
ATGAAGATCAAAGATGGCAAGAAATCCTCTTTCCCATGGTTTGGCATGGACATTGGGGGAACTCTAGTAAACCTCTCGTA
CTTTGAACCTATTGCTATCACAGCAGAGGAAGAACAAGAAGAAGTTGAGAGTTTAAAAAGTATTCGAAAATATTTGATTT
CTAATGTAGCATGTGGATCCACCGGCATTAGGGATGTACACCTTGAACTGAAAGATTTAACACTTTTTGGCCGAAGAGGG
AACTTGCACTTTATCAGGTTTCCAACCCAGGACCTGCCTACTTTTATCCAAATGGGAAGAGATAAAAACTTCTCAATATT
GCAAACGGTGCTATGTGCTACAGGAGGTGGTGCCTACAAGTTTGAAAAAGATTTTCGCACAATTGGAAACCTCCACCTGC
ACAAACTGGATGAACTTGACTGCCTTGTAAAGGGCTTGCTGTATATAGACTGTTGGTTTCAATGGGCATGCGGAGTGCTA
TTATTTAGCTAATGCCTCAGAACCTCAGCAATGCCAAAAGATGCCTTTTAACCTGGATGATCCCTACCCACTGCTTGTAG
TGAACATTGGCTCAGGAGCCAGTATTTTAGCAGTCCATTCCAAAGACATCTATAAACGAATGACTGGGACAAGCCTTGGG
GAGGGTACCTTTCTGGGTTTATGCAGTTTATTGACTGGCTGTGAAAGTTTTGAAGAGGCTCTTGAAATGGCATTCCAAAG
GTGACAGCACATAAGCTGACAAGCTGACCCATGATATTTATGGAGGAGATCATGAAAGATTTGGTTTGCCAGGTTGAGCT
GTAGCATCTAGTTTTAGGAATATGATTTATAAGGAGAAGCGAGAATCATCTGTTAGTAAAGAAGATCTGGCAAGAGCTAC
TTTAGTTACTATCACCAATAACTTTGGTTCTGTGGCACGAATGTGTGCTGTTAATGAGAAAATAAACAGAGTTGTCTTTG
TTGGAAACGTTTTATGTGTCAATACCCTCTCAATGAAACTTTTGGCATATGCACCGGATCTTTCGTCAAAAGGTCAACTG
AAAGCATTGTTTCTAGAACATGAGGGATACTTTGGAGCAGTTAGTGCACTTCTTGGGCTGCCAAATTTCAGC

ORF - retro_hsap_779 Open Reading Frame is not conserved.
Retrocopy - Parental Gene Alignment summary:
Percent Identity: 90.11 %
Parental protein coverage: 100. %
Number of stop codons detected: 3
Number of frameshifts detected 3


Retrocopy - Parental Gene Alignment:

ParentalMKIKDAKKPSFPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGSTGIRDVHLEL
MKIKD.KK.SFPWFGMDIGGTLV.LSYFEPI.ITAEEEQEEVESLKSIRKYL.SNVA.GSTGIRDVHLEL
RetrocopyMKIKDGKKSSFPWFGMDIGGTLVNLSYFEPIAITAEEEQEEVESLKSIRKYLISNVACGSTGIRDVHLEL
ParentalKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDKNFSTLQTVLCATGGGAYKFEKDFRTIGNLHLHKLDELD
KDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDKNFS.LQTVLCATGGGAYKFEKDFRTIGNLHLHKLDELD
RetrocopyKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDKNFSILQTVLCATGGGAYKFEKDFRTIGNLHLHKLDELD
ParentalCLV-KGLLY-IDSVSFNGQAECYYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRV
CLV.KGL...I..V.FNG.AECYY.ANASEP..CQKMPFNLDDPYPLLVVNIGSG.SILAVHSKD.YKR.
RetrocopyCLV<KGLAV<I*TVGFNGHAECYYLANASEPQQCQKMPFNLDDPYPLLVVNIGSGASILAVHSKDIYKRM
ParentalTGTSLGGGTFLGLCSLLTGCESFEEALEMA-SKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIY
TGTSLG.GTFLGLCSLLTGCESFEEALEMA.SKGDST.ADKL..DIYGGD.ERFGLPG.AVASSF.NMIY
RetrocopyTGTSLGEGTFLGLCSLLTGCESFEEALEMA>SKGDST*ADKLTHDIYGGDHERFGLPG*AVASSFRNMIY
ParentalKEKRE-SVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQL
KEKRE.SVSKEDLARATLVTITNN.GSVARMCAVNEKINRVVFVGN.L.VNTLSMKLLAYA.D..SKGQL
RetrocopyKEKRESSVSKEDLARATLVTITNNFGSVARMCAVNEKINRVVFVGNVLCVNTLSMKLLAYAPDLSSKGQL
ParentalKALFLEHEGYFGAVGALLGLPNFS
KALFLEHEGYFGAV.ALLGLPNFS
RetrocopyKALFLEHEGYFGAVSALLGLPNFS

Legend:
*Stop codon
>Forward frameshift by one nucleotide
<Reverse frameshift by one nucleotide






RNA-Seq - click to see more details

(Hint: click retrocopy or parental gene accession number on the plot's legend, to show / hide expression level values)

Expression validation based on RNA-Seq data:
Library Retrocopy expression Parental gene expression
bodymap2_adipose 0 .00 RPM 71 .50 RPM
bodymap2_adrenal 0 .00 RPM 80 .83 RPM
bodymap2_brain 0 .00 RPM 89 .73 RPM
bodymap2_breast 0 .00 RPM 88 .02 RPM
bodymap2_colon 0 .00 RPM 75 .39 RPM
bodymap2_heart 0 .00 RPM 57 .34 RPM
bodymap2_kidney 0 .00 RPM 105 .39 RPM
bodymap2_liver 0 .00 RPM 126 .13 RPM
bodymap2_lung 0 .00 RPM 78 .90 RPM
bodymap2_lymph_node 0 .00 RPM 64 .89 RPM
bodymap2_ovary 0 .00 RPM 119 .25 RPM
bodymap2_prostate 0 .00 RPM 70 .32 RPM
bodymap2_skeletal_muscle 0 .00 RPM 32 .27 RPM
bodymap2_testis 0 .06 RPM 102 .37 RPM
bodymap2_thyroid 0 .00 RPM 76 .34 RPM
bodymap2_white_blood_cells 0 .00 RPM 110 .21 RPM

ChIP-Seq - click to see more details

RNA Polymerase II actvity near the 5' end of retro_hsap_779 was not detected

EST - click to see more details

No EST(s) were mapped for retro_hsap_779 retrocopy.

TSS - click to see more details

No TSS is located nearby retro_hsap_779 retrocopy 5' end.

Lab - click to see more details

retro_hsap_779 was not experimentally validated.

Retrocopy orthology:
Retrocopy retro_hsap_779 has 2 orthologous retrocopies within eutheria group .

Species RetrogeneDB ID
Pan troglodytes retro_ptro_608
Gorilla gorilla retro_ggor_646
Parental genes homology:
Parental genes homology involve 8 parental genes, and 17 retrocopies.

Species Parental gene accession Retrocopies number
Choloepus hoffmanni ENSCHOG000000116334 retrocopies
retro_chof_1188, retro_chof_1391, retro_chof_1837, retro_chof_830,
Callithrix jacchus ENSCJAG000000155501 retrocopy
retro_cjac_2037,
Homo sapiens ENSG00000120137 1 retrocopy
retro_hsap_779 ,
Gorilla gorilla ENSGGOG000000049471 retrocopy
retro_ggor_646,
Nomascus leucogenys ENSNLEG000000048965 retrocopies
retro_nleu_1430, retro_nleu_144, retro_nleu_2975, retro_nleu_3058, retro_nleu_3099,
Pongo abelii ENSPPYG000000160241 retrocopy
retro_pabe_2848,
Pan troglodytes ENSPTRG000000175091 retrocopy
retro_ptro_608,
Tursiops truncatus ENSTTRG000000161573 retrocopies
retro_ttru_1947, retro_ttru_29, retro_ttru_994,

Expression level across human populations :
image/svg+xml GBR_HG00142 GBR_HG00099 GBR_HG00114 GBR_HG00143 GBR_HG00131 GBR_HG00137 GBR_HG00133 GBR_HG00119 GBR_HG00111 GBR_HG00134 FIN_HG00378 FIN_HG00338 FIN_HG00349 FIN_HG00375 FIN_HG00315 FIN_HG00277 FIN_HG00328 FIN_HG00321 FIN_HG00377 FIN_HG00183 TSI_NA20756 TSI_NA20538 TSI_NA20798 TSI_NA20532 TSI_NA20765 TSI_NA20518 TSI_NA20513 TSI_NA20512 TSI_NA20771 TSI_NA20786 YRI_NA19114 YRI_NA19099 YRI_NA18870 YRI_NA18907 YRI_NA19223 YRI_NA19214 YRI_NA18916 YRI_NA19093 YRI_NA19118 YRI_NA19213 Toscaniin Italia: Finnish inFinland: British in England and Scotland: Utah Residents (CEPH) with Northernand Western European Ancestry: Yoruba in Ibadan, Nigeria: CEU_NA12760 CEU_NA12827 CEU_NA12872 CEU_NA12751 CEU_NA12873 CEU_NA12400 CEU_NA11930 CEU_NA12004 CEU_NA11831 CEU_NA11843 No expression ( = 0 RPM ) > 0 RPM = 0.04 RPM Legend:


Library Retrogene expression
CEU_NA11831 0 .00 RPM
CEU_NA11843 0 .00 RPM
CEU_NA11930 0 .00 RPM
CEU_NA12004 0 .00 RPM
CEU_NA12400 0 .00 RPM
CEU_NA12751 0 .00 RPM
CEU_NA12760 0 .04 RPM
CEU_NA12827 0 .00 RPM
CEU_NA12872 0 .00 RPM
CEU_NA12873 0 .00 RPM
FIN_HG00183 0 .00 RPM
FIN_HG00277 0 .00 RPM
FIN_HG00315 0 .00 RPM
FIN_HG00321 0 .00 RPM
FIN_HG00328 0 .00 RPM
FIN_HG00338 0 .00 RPM
FIN_HG00349 0 .00 RPM
FIN_HG00375 0 .02 RPM
FIN_HG00377 0 .00 RPM
FIN_HG00378 0 .00 RPM
GBR_HG00099 0 .00 RPM
GBR_HG00111 0 .00 RPM
GBR_HG00114 0 .00 RPM
GBR_HG00119 0 .00 RPM
GBR_HG00131 0 .00 RPM
GBR_HG00133 0 .00 RPM
GBR_HG00134 0 .00 RPM
GBR_HG00137 0 .00 RPM
GBR_HG00142 0 .00 RPM
GBR_HG00143 0 .00 RPM
TSI_NA20512 0 .00 RPM
TSI_NA20513 0 .00 RPM
TSI_NA20518 0 .00 RPM
TSI_NA20532 0 .00 RPM
TSI_NA20538 0 .00 RPM
TSI_NA20756 0 .00 RPM
TSI_NA20765 0 .02 RPM
TSI_NA20771 0 .00 RPM
TSI_NA20786 0 .03 RPM
TSI_NA20798 0 .00 RPM
YRI_NA18870 0 .00 RPM
YRI_NA18907 0 .00 RPM
YRI_NA18916 0 .00 RPM
YRI_NA19093 0 .00 RPM
YRI_NA19099 0 .00 RPM
YRI_NA19114 0 .03 RPM
YRI_NA19118 0 .00 RPM
YRI_NA19213 0 .02 RPM
YRI_NA19214 0 .00 RPM
YRI_NA19223 0 .00 RPM

Indel association:

No indels were associated with its genomic coordinates. Based on Kabza et al. 2015 (PubMed).



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